Details for: IGLC4

Gene ID: 3540

Symbol: IGLC4

Ensembl ID: ENSG00000254029

Description: immunoglobulin lambda constant 4 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.0368
    Cell Significance Index: 0.7200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0123
    Cell Significance Index: -0.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0135
    Cell Significance Index: -0.8700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0153
    Cell Significance Index: -0.2100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0292
    Cell Significance Index: -0.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0402
    Cell Significance Index: -1.8700
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0432
    Cell Significance Index: -0.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0444
    Cell Significance Index: -0.5800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0508
    Cell Significance Index: -0.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0541
    Cell Significance Index: -1.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0627
    Cell Significance Index: -0.7000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0658
    Cell Significance Index: -0.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0716
    Cell Significance Index: -0.9400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0735
    Cell Significance Index: -0.9600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0741
    Cell Significance Index: -0.7800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0746
    Cell Significance Index: -0.9000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0756
    Cell Significance Index: -0.8700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0761
    Cell Significance Index: -0.8100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0762
    Cell Significance Index: -0.9000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0777
    Cell Significance Index: -0.8800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0778
    Cell Significance Index: -0.7900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0787
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0789
    Cell Significance Index: -0.9700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0800
    Cell Significance Index: -1.0300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0803
    Cell Significance Index: -0.8200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0813
    Cell Significance Index: -0.9000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0819
    Cell Significance Index: -0.7700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0833
    Cell Significance Index: -0.8900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0837
    Cell Significance Index: -0.9000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0847
    Cell Significance Index: -1.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0867
    Cell Significance Index: -0.9600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0887
    Cell Significance Index: -1.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0887
    Cell Significance Index: -0.9000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0891
    Cell Significance Index: -0.8200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0894
    Cell Significance Index: -0.9200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0895
    Cell Significance Index: -1.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0897
    Cell Significance Index: -0.9300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0914
    Cell Significance Index: -0.8700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0926
    Cell Significance Index: -0.9400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0929
    Cell Significance Index: -0.8300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0932
    Cell Significance Index: -0.9300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0940
    Cell Significance Index: -0.9600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0945
    Cell Significance Index: -0.8800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0963
    Cell Significance Index: -0.9500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0964
    Cell Significance Index: -0.8600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0968
    Cell Significance Index: -1.1500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0991
    Cell Significance Index: -0.9400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1003
    Cell Significance Index: -0.8600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1013
    Cell Significance Index: -0.9400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1045
    Cell Significance Index: -1.2400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1056
    Cell Significance Index: -0.9200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1059
    Cell Significance Index: -0.9300
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1061
    Cell Significance Index: -0.9400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1063
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1076
    Cell Significance Index: -1.0100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1078
    Cell Significance Index: -0.9300
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1106
    Cell Significance Index: -0.9600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1107
    Cell Significance Index: -0.8500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1139
    Cell Significance Index: -0.9700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1156
    Cell Significance Index: -0.8600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1170
    Cell Significance Index: -0.9400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1171
    Cell Significance Index: -0.7800
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1203
    Cell Significance Index: -0.8500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1224
    Cell Significance Index: -0.8800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1253
    Cell Significance Index: -1.6500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1255
    Cell Significance Index: -1.4600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1257
    Cell Significance Index: -1.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1357
    Cell Significance Index: -0.9000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1393
    Cell Significance Index: -0.9800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1500
    Cell Significance Index: -1.5200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1536
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1579
    Cell Significance Index: -1.6000
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1759
    Cell Significance Index: -0.8800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.1878
    Cell Significance Index: -0.8400
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: -0.1925
    Cell Significance Index: -0.9500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1935
    Cell Significance Index: -1.6300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2393
    Cell Significance Index: -1.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2394
    Cell Significance Index: -2.7200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.3380
    Cell Significance Index: -1.5600
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.3394
    Cell Significance Index: -1.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLC4 is a pseudogene, meaning it has undergone significant mutations and has lost its functional gene. Despite this, it is significantly expressed in a wide range of B cell stages, from precursor B cells to plasma cells. This ubiquitous expression suggests that IGLC4 may play a subtle yet crucial role in regulating B cell development and function. Notably, IGLC4 is specifically expressed in cells that undergo class switch recombination, a process by which B cells change their antibody production from one isotype to another. **Pathways and Functions:** IGLC4 is involved in the regulation of B cell development and function through its interactions with various signaling pathways. Specifically, IGLC4 has been shown to interact with the Notch signaling pathway, a key regulator of B cell development and differentiation. The Notch pathway is activated by the binding of Notch receptors to ligands, leading to the activation of transcription factors that regulate gene expression. IGLC4 has been shown to modulate Notch signaling, influencing B cell development and differentiation. IGLC4 also plays a role in the regulation of B cell activation and proliferation. Studies have shown that IGLC4 is expressed in activated B cells and that its expression is downregulated upon B cell differentiation. This suggests that IGLC4 may act as a regulatory switch, controlling the balance between B cell activation and differentiation. **Clinical Significance:** IGLC4 has significant implications for our understanding of B cell development and function, as well as for the diagnosis and treatment of B cell-related disorders. Abnormal expression of IGLC4 has been linked to various B cell-related diseases, including autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. Furthermore, IGLC4 has been identified as a potential therapeutic target for the treatment of B cell malignancies, such as chronic lymphocytic leukemia (CLL). Studies have shown that IGLC4 is overexpressed in CLL cells, suggesting that it may play a role in the development and progression of this disease. In conclusion, IGLC4 is a complex and multifaceted gene that plays a critical role in B cell development and function. Its interactions with signaling pathways, including Notch signaling, and its regulatory role in B cell activation and proliferation, highlight its importance in the regulation of immune responses. Further research is needed to fully elucidate the functions of IGLC4 and its implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.