Details for: IGSF1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 10.7176
Cell Significance Index: -5.0600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 5.7345
Cell Significance Index: 96.4500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 5.1427
Cell Significance Index: -4.9100 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.5087
Cell Significance Index: 41.3400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.8189
Cell Significance Index: 39.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.7737
Cell Significance Index: 56.8100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.1178
Cell Significance Index: 68.5300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7694
Cell Significance Index: 20.6200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.7047
Cell Significance Index: 82.1300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4921
Cell Significance Index: 93.6600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4281
Cell Significance Index: 84.9600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3345
Cell Significance Index: 20.0800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2655
Cell Significance Index: 5.6600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.2198
Cell Significance Index: 2.3900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2167
Cell Significance Index: 23.5700 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.1950
Cell Significance Index: 1.2000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1900
Cell Significance Index: 18.8000 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.1800
Cell Significance Index: 1.2300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.1653
Cell Significance Index: 1.1200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1587
Cell Significance Index: 143.2700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1423
Cell Significance Index: 0.8600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1319
Cell Significance Index: 8.8700 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.1315
Cell Significance Index: 1.0500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1104
Cell Significance Index: 17.9600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1101
Cell Significance Index: 5.7200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0922
Cell Significance Index: 2.3700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0864
Cell Significance Index: 5.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0785
Cell Significance Index: 5.8500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0724
Cell Significance Index: 1.2400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0421
Cell Significance Index: 1.4800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0410
Cell Significance Index: 1.1800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0325
Cell Significance Index: 2.0000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0300
Cell Significance Index: 3.4200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.0195
Cell Significance Index: 0.1500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0124
Cell Significance Index: 8.5500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0071
Cell Significance Index: 9.6000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0052
Cell Significance Index: 0.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0045
Cell Significance Index: 0.9000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0045
Cell Significance Index: 1.9800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0044
Cell Significance Index: 1.5700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.0038
Cell Significance Index: 0.1200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0035
Cell Significance Index: 5.4100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0028
Cell Significance Index: 5.1900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0027
Cell Significance Index: 5.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0019
Cell Significance Index: -0.3200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0019
Cell Significance Index: -1.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0020
Cell Significance Index: -1.5000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0023
Cell Significance Index: -1.2700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0024
Cell Significance Index: -0.4400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0042
Cell Significance Index: -2.7000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0064
Cell Significance Index: -1.3500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0064
Cell Significance Index: -4.8800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0068
Cell Significance Index: -4.9700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0076
Cell Significance Index: -3.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0082
Cell Significance Index: -4.4900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0093
Cell Significance Index: -1.3500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0093
Cell Significance Index: -2.6800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0095
Cell Significance Index: -0.4300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0115
Cell Significance Index: -1.3200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0137
Cell Significance Index: -1.7500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0150
Cell Significance Index: -0.4200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0175
Cell Significance Index: -0.2500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0232
Cell Significance Index: -1.7800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0236
Cell Significance Index: -0.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0282
Cell Significance Index: -3.4700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0336
Cell Significance Index: -4.6200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0337
Cell Significance Index: -1.2800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0339
Cell Significance Index: -1.5000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0386
Cell Significance Index: -4.9900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0390
Cell Significance Index: -0.8100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0396
Cell Significance Index: -0.4100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0396
Cell Significance Index: -4.1300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0416
Cell Significance Index: -0.7000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0458
Cell Significance Index: -1.1100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0474
Cell Significance Index: -5.5900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0477
Cell Significance Index: -4.8700 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0541
Cell Significance Index: -0.7300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0599
Cell Significance Index: -3.7800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0675
Cell Significance Index: -1.1300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0676
Cell Significance Index: -5.3500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0703
Cell Significance Index: -2.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0709
Cell Significance Index: -3.9800 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0769
Cell Significance Index: -0.9300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0796
Cell Significance Index: -1.9100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0824
Cell Significance Index: -3.3800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0831
Cell Significance Index: -1.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0845
Cell Significance Index: -3.9400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0848
Cell Significance Index: -4.4500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0859
Cell Significance Index: -5.5400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0906
Cell Significance Index: -4.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0939
Cell Significance Index: -4.8900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1029
Cell Significance Index: -1.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1035
Cell Significance Index: -4.8700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1047
Cell Significance Index: -3.6400 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.1072
Cell Significance Index: -1.3600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1075
Cell Significance Index: -3.5200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1099
Cell Significance Index: -3.8500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1145
Cell Significance Index: -1.6900 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1153
Cell Significance Index: -2.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1190
Cell Significance Index: -3.7900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2850782811
Symbol: IGSF1_HUMAN
Name: Immunoglobulin superfamily member 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9729118
Title: Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25.
PubMed ID: 9729118
PubMed ID: 9521868
Title: Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25.
PubMed ID: 9521868
PubMed ID: 11854097
Title: Expression profile of active genes in the human pituitary gland.
PubMed ID: 11854097
PubMed ID: 9205841
Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9205841
PubMed ID: 15772651
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 11266516
Title: Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).
PubMed ID: 11266516
PubMed ID: 12421765
Title: Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.
PubMed ID: 12421765
DOI: 10.1101/gr.406902
PubMed ID: 12385827
Title: Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors.
PubMed ID: 12385827
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23143598
Title: Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.
PubMed ID: 23143598
DOI: 10.1038/ng.2453
PubMed ID: 23092983
Title: Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
PubMed ID: 23092983
DOI: 10.1038/tp.2012.102
Sequence Information:
- Length: 1336
- Mass: 148936
- Checksum: 7D0D2C36FD1CE8B8
- Sequence:
MTLDRPGEGA TMLKTFTVLL FCIRMSLGMT SIVMDPQPEL WIESNYPQAP WENITLWCRS PSRISSKFLL LKDKTQMTWI RPSHKTFQVS FLIGALTESN AGLYRCCYWK ETGWSKPSKV LELEAPGQLP KPIFWIQAET PALPGCNVNI LCHGWLQDLV FMLFKEGYAE PVDYQVPTGT MAIFSIDNLT PEDEGVYICR THIQMLPTLW SEPSNPLKLV VAGLYPKPTL TAHPGPIMAP GESLNLRCQG PIYGMTFALM RVEDLEKSFY HKKTIKNEAN FFFQSLKIQD TGHYLCFYYD ASYRGSLLSD VLKIWVTDTF PKTWLLARPS AVVQMGQNVS LRCRGPVDGV GLALYKKGED KPLQFLDATS IDDNTSFFLN NVTYSDTGIY SCHYLLTWKT SIRMPSHNTV ELMVVDKPPK PSLSAWPSTV FKLGKAITLQ CRVSHPVLEF SLEWEERETF QKFSVNGDFI ISNVDGKGTG TYSCSYRVET HPNIWSHRSE PLKLMGPAGY LTWNYVLNEA IRLSLIMQLV ALLLVVLWIR WKCRRLRIRE AWLLGTAQGV TMLFIVTALL CCGLCNGVLI EETEIVMPTP KPELWAETNF PLAPWKNLTL WCRSPSGSTK EFVLLKDGTG WIATRPASEQ VRAAFPLGAL TQSHTGSYHC HSWEEMAVSE PSEALELVGT DILPKPVISA SPTIRGQELQ LRCKGWLAGM GFALYKEGEQ EPVQQLGAVG REAFFTIQRM EDKDEGNYSC RTHTEKRPFK WSEPSEPLEL VIKEMYPKPF FKTWASPVVT PGARVTFNCS TPHQHMSFIL YKDGSEIASS DRSWASPGAS AAHFLIISVG IGDGGNYSCR YYDFSIWSEP SDPVELVVTE FYPKPTLLAQ PGPVVFPGKS VILRCQGTFQ GMRFALLQEG AHVPLQFRSV SGNSADFLLH TVGAEDSGNY SCIYYETTMS NRGSYLSMPL MIWVTDTFPK PWLFAEPSSV VPMGQNVTLW CRGPVHGVGY ILHKEGEATS MQLWGSTSND GAFPITNISG TSMGRYSCCY HPDWTSSIKI QPSNTLELLV TGLLPKPSLL AQPGPMVAPG ENMTLQCQGE LPDSTFVLLK EGAQEPLEQQ RPSGYRADFW MPAVRGEDSG IYSCVYYLDS TPFAASNHSD SLEIWVTDKP PKPSLSAWPS TMFKLGKDIT LQCRGPLPGV EFVLEHDGEE APQQFSEDGD FVINNVEGKG IGNYSCSYRL QAYPDIWSEP SDPLELVGAA GPVAQECTVG NIVRSSLIVV VVVALGVVLA IEWKKWPRLR TRGSETDGRD QTIALEECNQ EGEPGTPANS PSSTSQRISV ELPVPI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.