Details for: IL1A

Gene ID: 3552

Symbol: IL1A

Ensembl ID: ENSG00000115008

Description: interleukin 1 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.0101
    Cell Significance Index: 364.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 6.2598
    Cell Significance Index: 51.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 5.3140
    Cell Significance Index: 59.3900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 5.2621
    Cell Significance Index: 34.9300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.7368
    Cell Significance Index: 21.7800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.0031
    Cell Significance Index: 8.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0029
    Cell Significance Index: -2.1900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9653
    Cell Significance Index: 11.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5386
    Cell Significance Index: 4.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4935
    Cell Significance Index: 60.6800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.4568
    Cell Significance Index: 5.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3971
    Cell Significance Index: 83.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3840
    Cell Significance Index: 209.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.3711
    Cell Significance Index: 274.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3639
    Cell Significance Index: 9.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3329
    Cell Significance Index: 38.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2452
    Cell Significance Index: 44.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1736
    Cell Significance Index: 97.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1461
    Cell Significance Index: 2.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0625
    Cell Significance Index: 39.0600
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.0416
    Cell Significance Index: 0.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0394
    Cell Significance Index: 0.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0138
    Cell Significance Index: 1.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0077
    Cell Significance Index: 1.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0015
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0052
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0079
    Cell Significance Index: -3.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0185
    Cell Significance Index: -6.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0199
    Cell Significance Index: -0.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0205
    Cell Significance Index: -2.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0205
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0230
    Cell Significance Index: -10.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0274
    Cell Significance Index: -7.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0298
    Cell Significance Index: -0.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0319
    Cell Significance Index: -6.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0331
    Cell Significance Index: -4.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0360
    Cell Significance Index: -4.9500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0417
    Cell Significance Index: -0.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0495
    Cell Significance Index: -6.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0501
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0555
    Cell Significance Index: -0.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0684
    Cell Significance Index: -1.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0779
    Cell Significance Index: -10.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0936
    Cell Significance Index: -4.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0961
    Cell Significance Index: -6.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1005
    Cell Significance Index: -4.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1061
    Cell Significance Index: -2.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1065
    Cell Significance Index: -7.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1072
    Cell Significance Index: -6.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1098
    Cell Significance Index: -6.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1354
    Cell Significance Index: -10.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1356
    Cell Significance Index: -7.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1390
    Cell Significance Index: -6.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1413
    Cell Significance Index: -4.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1420
    Cell Significance Index: -3.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1430
    Cell Significance Index: -4.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1530
    Cell Significance Index: -1.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1689
    Cell Significance Index: -6.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1732
    Cell Significance Index: -7.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1771
    Cell Significance Index: -9.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1813
    Cell Significance Index: -2.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1839
    Cell Significance Index: -2.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1856
    Cell Significance Index: -3.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1899
    Cell Significance Index: -4.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1912
    Cell Significance Index: -7.2400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1975
    Cell Significance Index: -2.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1984
    Cell Significance Index: -3.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2012
    Cell Significance Index: -7.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2125
    Cell Significance Index: -6.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2149
    Cell Significance Index: -2.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2181
    Cell Significance Index: -7.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2253
    Cell Significance Index: -7.1800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2310
    Cell Significance Index: -3.0700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2359
    Cell Significance Index: -2.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2396
    Cell Significance Index: -8.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2480
    Cell Significance Index: -6.6500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2496
    Cell Significance Index: -2.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2516
    Cell Significance Index: -4.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2523
    Cell Significance Index: -7.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2535
    Cell Significance Index: -5.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2559
    Cell Significance Index: -6.7300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2591
    Cell Significance Index: -2.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2657
    Cell Significance Index: -6.7700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2707
    Cell Significance Index: -3.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2723
    Cell Significance Index: -5.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2882
    Cell Significance Index: -7.1900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2883
    Cell Significance Index: -2.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2912
    Cell Significance Index: -8.3900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2936
    Cell Significance Index: -3.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3011
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3033
    Cell Significance Index: -3.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL-1α exhibits several key characteristics that enable it to exert its pro-inflammatory effects: 1. **Structure**: IL-1α is a 153-amino acid protein that belongs to the cytokine family. It consists of four conserved domains: the signal peptide, the transmembrane domain, the extracellular domain, and the intracellular domain. 2. **Function**: IL-1α is a potent pro-inflammatory cytokine that promotes the activation of immune cells, the production of other cytokines, and the recruitment of immune cells to sites of inflammation. 3. **Expression**: IL-1α is expressed by various cell types, including macrophages, dendritic cells, and epithelial cells, in response to inflammatory stimuli. 4. **Binding**: IL-1α binds to the IL-1 receptor (IL-1R) on the surface of target cells, triggering a signaling cascade that leads to the activation of transcription factors and the production of inflammatory mediators. **Pathways and Functions** IL-1α plays a critical role in various signaling pathways that regulate immune responses, inflammation, and cellular homeostasis: 1. **Apoptotic process**: IL-1α can induce apoptosis in certain cell types, including cancer cells, by activating the caspase cascade. 2. **Cell recruitment (pro-inflammatory response)**: IL-1α recruits immune cells, such as neutrophils and macrophages, to sites of inflammation. 3. **Cytokine-mediated signaling pathway**: IL-1α activates the JAK-STAT pathway, leading to the production of other cytokines and inflammatory mediators. 4. **Negative regulation of cell population proliferation**: IL-1α can inhibit the proliferation of certain cell types, including cancer cells. 5. **Positive regulation of angiogenesis**: IL-1α promotes the formation of new blood vessels, which is essential for tissue repair and regeneration. **Clinical Significance** Dysregulation of IL-1α has been implicated in various diseases, including: 1. **Autoimmune disorders**: IL-1α has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Inflammatory bowel disease**: IL-1α promotes inflammation in the gut, contributing to the development of inflammatory bowel disease. 3. **Cancer**: IL-1α can promote tumor growth and metastasis by activating the JAK-STAT pathway and promoting angiogenesis. 4. **Neurological disorders**: IL-1α has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, IL-1α is a critical cytokine that regulates immune responses, inflammation, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its role in human disease.

Genular Protein ID: 1807812833

Symbol: IL1A_HUMAN

Name: Interleukin-1 alpha

UniProtKB Accession Codes:

P01583 Q53QF9 Q7RU02

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 GO 51 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2989698

Title: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.

PubMed ID: 2989698

DOI: 10.1038/315641a0

PubMed ID: 3486405

Title: Complete nucleotide sequence of the gene for human interleukin 1 alpha.

PubMed ID: 3486405

DOI: 10.1093/nar/14.8.3167

PubMed ID: 2994016

Title: Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor.

PubMed ID: 2994016

DOI: 10.1093/nar/13.16.5869

PubMed ID: 2635664

Title: Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta.

PubMed ID: 2635664

PubMed ID: 3485152

Title: Recombinant human interleukin 1 alpha: purification and biological characterization.

PubMed ID: 3485152

PubMed ID: 3493774

Title: cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line.

PubMed ID: 3493774

DOI: 10.1016/0006-291x(87)90671-1

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3281727

Title: Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow.

PubMed ID: 3281727

PubMed ID: 2950091

Title: The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

PubMed ID: 2950091

DOI: 10.1016/s0021-9258(18)61450-4

PubMed ID: 3258335

Title: Phosphorylation of intracellular precursors of human IL-1.

PubMed ID: 3258335

PubMed ID: 2115174

Title: Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

PubMed ID: 2115174

DOI: 10.1073/pnas.87.14.5548

PubMed ID: 8346241

Title: The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.

PubMed ID: 8346241

DOI: 10.1073/pnas.90.15.7245

PubMed ID: 14687581

Title: Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.

PubMed ID: 14687581

DOI: 10.1016/j.cyto.2003.08.013

PubMed ID: 15679580

Title: Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure.

PubMed ID: 15679580

DOI: 10.1111/j.0906-6705.2005.00226.x

PubMed ID: 17507369

Title: Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components.

PubMed ID: 17507369

DOI: 10.1074/mcp.m600455-mcp200

PubMed ID: 26439902

Title: IL-1alpha is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.

PubMed ID: 26439902

DOI: 10.1038/srep14756

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 2346741

Title: Structure of interleukin 1 alpha at 2.7-A resolution.

PubMed ID: 2346741

DOI: 10.1021/bi00463a009

PubMed ID: 21270123

Title: The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.

PubMed ID: 21270123

DOI: 10.1074/jbc.m110.201954

Sequence Information:

  • Length: 271
  • Mass: 30607
  • Checksum: CBCCC49569D9ED40
  • Sequence:
    • MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS 
KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS 
NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI 
TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP 
NLFIATKQDY WVCLAGGPPS ITDFQILENQ A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.