Gene IL1A - ENSG00000115008 | NCBI Gene ID: 3552

Details for: IL1A

Gene ID: 3552

Symbol: IL1A

Ensembl ID: ENSG00000115008

Description: interleukin 1 alpha

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 processing
(R-HSA-448706)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Leishmania infection
(R-HSA-9658195)
Parasitic infection pathways
(R-HSA-9824443)
Programmed cell death
(R-HSA-5357801)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Apoptotic process
(GO:0006915)
Cell surface
(GO:0009986)
Cellular response to heat
(GO:0034605)
Cellular response to lipopolysaccharide
(GO:0071222)
Connective tissue replacement involved in inflammatory response wound healing
(GO:0002248)
Copper ion binding
(GO:0005507)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Cytosol
(GO:0005829)
Ectopic germ cell programmed cell death
(GO:0035234)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fever generation
(GO:0001660)
Heart development
(GO:0007507)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interleukin-1 receptor binding
(GO:0005149)
Intracellular sodium ion homeostasis
(GO:0006883)
Keratinization
(GO:0031424)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of establishment of sertoli cell barrier
(GO:1904445)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Nucleus
(GO:0005634)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of neutrophil migration
(GO:1902624)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of steroid biosynthetic process
(GO:0010893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein binding
(GO:0005515)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of nitric-oxide synthase activity
(GO:0050999)
Response to copper ion
(GO:0046688)
Response to gamma radiation
(GO:0010332)
Response to hypoxia
(GO:0001666)
Response to l-ascorbic acid
(GO:0033591)
Response to organonitrogen compound
(GO:0010243)
Response to ozone
(GO:0010193)
Spermatogenesis
(GO:0007283)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.55
Marker Score: 2287
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 871
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71829
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48055
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.98
Marker Score: 2478
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.95
Marker Score: 1796
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5341
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.87
Marker Score: 2141
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.84
Marker Score: 345
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 641
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.77
Marker Score: 508
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1481
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.71
Marker Score: 747
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 471
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.55
Marker Score: 14143
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.53
Marker Score: 18192
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 278
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.45
Marker Score: 1175
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 434
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.44
Marker Score: 626
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.42
Marker Score: 183
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.41
Marker Score: 396
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.4
Marker Score: 443
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 373
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.33
Marker Score: 294
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.33
Marker Score: 1991
Cell Name: macrophage (CL0000235)
Fold Change: 0.33
Marker Score: 364
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.32
Marker Score: 268
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.31
Marker Score: 153
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.3
Marker Score: 180
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.29
Marker Score: 121
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.28
Marker Score: 4434
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.27
Marker Score: 425
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.26
Marker Score: 109
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 89
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.25
Marker Score: 118
Cell Name: neutrophil (CL0000775)
Fold Change: 0.24
Marker Score: 149
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.24
Marker Score: 137
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.22
Marker Score: 231
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.22
Marker Score: 1080
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.22
Marker Score: 148
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.21
Marker Score: 112
Cell Name: monocyte (CL0000576)
Fold Change: 0.21
Marker Score: 274
Cell Name: microglial cell (CL0000129)
Fold Change: 0.21
Marker Score: 374
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2
Marker Score: 485
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.2
Marker Score: 73
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.2
Marker Score: 101
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.18
Marker Score: 119
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.17
Marker Score: 79
Cell Name: basal cell (CL0000646)
Fold Change: 0.17
Marker Score: 223
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.17
Marker Score: 346
Cell Name: secretory cell (CL0000151)
Fold Change: 0.16
Marker Score: 296
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.16
Marker Score: 178
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.15
Marker Score: 378
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.15
Marker Score: 1183.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.15
Marker Score: 5074.5
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.15
Marker Score: 146
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.14
Marker Score: 1216
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.14
Marker Score: 93
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.14
Marker Score: 44
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.14
Marker Score: 132.5
Cell Name: promonocyte (CL0000559)
Fold Change: 0.14
Marker Score: 87
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.13
Marker Score: 163.5
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.13
Marker Score: 29
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.12
Marker Score: 43
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.12
Marker Score: 103
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.12
Marker Score: 6634
Cell Name: mast cell (CL0000097)
Fold Change: 0.12
Marker Score: 68
Cell Name: fibroblast (CL0000057)
Fold Change: 0.1
Marker Score: 95
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.1
Marker Score: 43
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.09
Marker Score: 94
Cell Name: granulocyte (CL0000094)
Fold Change: 0.09
Marker Score: 42
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.09
Marker Score: 63
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.09
Marker Score: 59
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.09
Marker Score: 47
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.09
Marker Score: 17
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.09
Marker Score: 31
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.08
Marker Score: 17
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.08
Marker Score: 23
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.08
Marker Score: 237
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.08
Marker Score: 21
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.08
Marker Score: 39
Cell Name: plasma cell (CL0000786)
Fold Change: 0.08
Marker Score: 91
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.08
Marker Score: 131
Cell Name: malignant cell (CL0001064)
Fold Change: 0.08
Marker Score: 1051
Cell Name: B cell (CL0000236)
Fold Change: 0.08
Marker Score: 74
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 0.08
Marker Score: 21
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.08
Marker Score: 68
Cell Name: goblet cell (CL0000160)
Fold Change: 0.07
Marker Score: 496
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.07
Marker Score: 26
Cell Name: muscle cell (CL0000187)
Fold Change: 0.07
Marker Score: 21
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.07
Marker Score: 34

Hover over a box to see details here...

**Key characteristics:** - IL1A is a pleiotropic cytokine with multiple biological activities. - It is a cytokine of the interleukin-1 family. - It is produced in response to various stimuli, including infection, injury, and tissue damage. - It has both pro-inflammatory and anti-inflammatory effects. **Pathways and functions:** - IL1A signaling pathway is activated by various receptors, including IL1RA and IL1RB. - It is involved in the regulation of inflammation, cell death, and tissue repair. - It promotes the recruitment of immune cells, including neutrophils, macrophages, and dendritic cells. - It also stimulates the activation of inflammatory signaling pathways, such as the p38 MAPK and JNK pathways. - IL1A has both pro-apoptotic and pro-proliferative effects on immune cells. **Clinical significance:** - IL1A is a key cytokine in the pathogenesis of various diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. - It is also involved in the regulation of inflammation in the brain and other organs. - Blockade of IL1A signaling has been shown to be effective in reducing inflammation and tissue damage. **Additional information:** - IL1A is a highly conserved cytokine that is expressed in humans, rodents, and insects. - It is a secreted protein that is produced and released by cells. - It is a potent inflammatory cytokine that can induce a wide range of inflammatory responses.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-1 alpha

Genular Protein ID: 1807812833

Symbol: IL1A_HUMAN

Name: Interleukin-1 alpha

UniProtKB Accession Codes:

P01583 Q53QF9 Q7RU02

Database IDs:

Citations:

PubMed ID: 2989698

Title: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.

PubMed ID: 2989698

DOI: 10.1038/315641a0

PubMed ID: 3486405

Title: Complete nucleotide sequence of the gene for human interleukin 1 alpha.

PubMed ID: 3486405

DOI: 10.1093/nar/14.8.3167

PubMed ID: 2994016

Title: Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor.

PubMed ID: 2994016

DOI: 10.1093/nar/13.16.5869

PubMed ID: 2635664

Title: Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta.

PubMed ID: 2635664

PubMed ID: 3485152

Title: Recombinant human interleukin 1 alpha: purification and biological characterization.

PubMed ID: 3485152

PubMed ID: 3493774

Title: cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line.

PubMed ID: 3493774

DOI: 10.1016/0006-291x(87)90671-1

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3281727

Title: Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow.

PubMed ID: 3281727

PubMed ID: 2950091

Title: The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

PubMed ID: 2950091

DOI: 10.1016/s0021-9258(18)61450-4

PubMed ID: 3258335

Title: Phosphorylation of intracellular precursors of human IL-1.

PubMed ID: 3258335

PubMed ID: 2115174

Title: Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

PubMed ID: 2115174

DOI: 10.1073/pnas.87.14.5548

PubMed ID: 8346241

Title: The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.

PubMed ID: 8346241

DOI: 10.1073/pnas.90.15.7245

PubMed ID: 14687581

Title: Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.

PubMed ID: 14687581

DOI: 10.1016/j.cyto.2003.08.013

PubMed ID: 15679580

Title: Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure.

PubMed ID: 15679580

DOI: 10.1111/j.0906-6705.2005.00226.x

PubMed ID: 17507369

Title: Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components.

PubMed ID: 17507369

DOI: 10.1074/mcp.m600455-mcp200

PubMed ID: 26439902

Title: IL-1alpha is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.

PubMed ID: 26439902

DOI: 10.1038/srep14756

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 2346741

Title: Structure of interleukin 1 alpha at 2.7-A resolution.

PubMed ID: 2346741

DOI: 10.1021/bi00463a009

PubMed ID: 21270123

Title: The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.

PubMed ID: 21270123

DOI: 10.1074/jbc.m110.201954

Sequence Information:

Length: 271
Mass: 30607
Checksum: CBCCC49569D9ED40
Sequence:

MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS 
KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS 
NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI 
TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP 
NLFIATKQDY WVCLAGGPPS ITDFQILENQ A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL1A

Associated with

Cells (max top 100)

Other Information

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. PubMed ID: 2989698

Complete nucleotide sequence of the gene for human interleukin 1 alpha. PubMed ID: 3486405

Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor. PubMed ID: 2994016

Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta. PubMed ID: 2635664

Recombinant human interleukin 1 alpha: purification and biological characterization. PubMed ID: 3485152

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line. PubMed ID: 3493774

A sequence-based map of the nine genes of the human interleukin-1 cluster. PubMed ID: 11991722

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. PubMed ID: 3281727

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. PubMed ID: 2950091

Phosphorylation of intracellular precursors of human IL-1. PubMed ID: 3258335

Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. PubMed ID: 2115174

The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. PubMed ID: 8346241

Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells. PubMed ID: 14687581

Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. PubMed ID: 15679580

Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. PubMed ID: 17507369

IL-1alpha is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. PubMed ID: 26439902

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

Structure of interleukin 1 alpha at 2.7-A resolution. PubMed ID: 2346741

The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion. PubMed ID: 21270123