Details for: IL6ST

Gene ID: 3572

Symbol: IL6ST

Ensembl ID: ENSG00000134352

Description: interleukin 6 cytokine family signal transducer

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 505.8979
    Cell Significance Index: -78.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 309.7459
    Cell Significance Index: -78.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 188.6890
    Cell Significance Index: -77.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 177.3877
    Cell Significance Index: -72.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 175.0393
    Cell Significance Index: -82.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 155.6421
    Cell Significance Index: -80.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 75.4549
    Cell Significance Index: -72.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.2115
    Cell Significance Index: -79.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.9642
    Cell Significance Index: -80.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 27.0174
    Cell Significance Index: -59.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.1687
    Cell Significance Index: -68.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0403
    Cell Significance Index: -79.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.6560
    Cell Significance Index: 95.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.3172
    Cell Significance Index: 123.7600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.0054
    Cell Significance Index: 24.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.3176
    Cell Significance Index: 64.7500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.3341
    Cell Significance Index: 24.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2507
    Cell Significance Index: 309.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0249
    Cell Significance Index: 401.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4973
    Cell Significance Index: 39.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1237
    Cell Significance Index: 83.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0866
    Cell Significance Index: 139.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9853
    Cell Significance Index: 45.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9605
    Cell Significance Index: 26.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9373
    Cell Significance Index: 48.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9006
    Cell Significance Index: 323.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8817
    Cell Significance Index: 108.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8421
    Cell Significance Index: 42.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7995
    Cell Significance Index: 12.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7732
    Cell Significance Index: 11.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6966
    Cell Significance Index: 75.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6847
    Cell Significance Index: 14.6400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6084
    Cell Significance Index: 3.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5949
    Cell Significance Index: 537.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5844
    Cell Significance Index: 105.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5787
    Cell Significance Index: 255.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5747
    Cell Significance Index: 115.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5697
    Cell Significance Index: 43.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5089
    Cell Significance Index: 277.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3764
    Cell Significance Index: 17.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3753
    Cell Significance Index: 259.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3446
    Cell Significance Index: 9.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1471
    Cell Significance Index: 277.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1054
    Cell Significance Index: 6.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1018
    Cell Significance Index: 10.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0874
    Cell Significance Index: 161.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0799
    Cell Significance Index: 50.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0746
    Cell Significance Index: 12.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0731
    Cell Significance Index: 112.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0695
    Cell Significance Index: 0.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0686
    Cell Significance Index: 1.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0448
    Cell Significance Index: 20.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0081
    Cell Significance Index: 0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0219
    Cell Significance Index: -16.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0314
    Cell Significance Index: -42.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0472
    Cell Significance Index: -2.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0663
    Cell Significance Index: -8.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0669
    Cell Significance Index: -12.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0683
    Cell Significance Index: -38.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0712
    Cell Significance Index: -44.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1604
    Cell Significance Index: -2.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1716
    Cell Significance Index: -1.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1900
    Cell Significance Index: -5.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1940
    Cell Significance Index: -13.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2027
    Cell Significance Index: -42.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2029
    Cell Significance Index: -7.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2267
    Cell Significance Index: -23.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2436
    Cell Significance Index: -70.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2512
    Cell Significance Index: -36.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2675
    Cell Significance Index: -31.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3071
    Cell Significance Index: -13.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3118
    Cell Significance Index: -35.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3166
    Cell Significance Index: -36.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3471
    Cell Significance Index: -2.8300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4265
    Cell Significance Index: -2.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4701
    Cell Significance Index: -24.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4812
    Cell Significance Index: -6.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4949
    Cell Significance Index: -12.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5375
    Cell Significance Index: -34.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5490
    Cell Significance Index: -28.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5691
    Cell Significance Index: -67.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5912
    Cell Significance Index: -9.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6386
    Cell Significance Index: -66.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6875
    Cell Significance Index: -43.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7805
    Cell Significance Index: -52.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8060
    Cell Significance Index: -49.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8754
    Cell Significance Index: -21.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8957
    Cell Significance Index: -70.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9242
    Cell Significance Index: -12.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9829
    Cell Significance Index: -20.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0289
    Cell Significance Index: -23.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0374
    Cell Significance Index: -45.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0388
    Cell Significance Index: -27.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1074
    Cell Significance Index: -67.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2193
    Cell Significance Index: -46.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3652
    Cell Significance Index: -29.0800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.6080
    Cell Significance Index: -16.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7107
    Cell Significance Index: -54.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The IL6ST gene is a transmembrane protein that belongs to the cytokine receptor superfamily. It is characterized by the presence of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains immunoglobulin-like domains, while the intracellular domain contains tyrosine kinase domains. The IL6ST protein is a coreceptor that interacts with the IL-6 receptor, facilitating the binding of IL-6 and other related cytokines. **Pathways and Functions** The IL6ST gene is involved in various signaling pathways, including: 1. **Cytokine-mediated signaling pathway**: IL6ST interacts with the IL-6 receptor to activate downstream signaling molecules, leading to the regulation of immune responses, inflammation, and cellular differentiation. 2. **Coreceptor activity**: IL6ST serves as a coreceptor for the IL-6 receptor, enhancing its binding affinity and facilitating signal transduction. 3. **Glycogen metabolic process**: IL6ST is involved in the regulation of glycogen metabolism, particularly in skeletal muscle cells. 4. **Growth factor binding**: IL6ST interacts with growth factors, such as leukemia inhibitory factor (LIF), to regulate cellular growth and differentiation. 5. **Protein binding**: IL6ST interacts with various proteins, including oncostatin-M and IL-11, to regulate cellular signaling and differentiation. **Clinical Significance** Dysregulation of the IL6ST gene has been implicated in various diseases, including: 1. **Autoimmune disorders**: Altered expression of IL6ST has been observed in autoimmune diseases such as rheumatoid arthritis and lupus. 2. **Cancer**: IL6ST is overexpressed in certain types of cancer, including breast and prostate cancer, where it promotes tumor growth and metastasis. 3. **Inflammatory disorders**: IL6ST is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD). 4. **Neurological disorders**: IL6ST is involved in the regulation of neuronal cell death and survival, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. In summary, the IL6ST gene plays a crucial role in various cellular processes, including immune responses, inflammation, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining human health.

Genular Protein ID: 932836312

Symbol: IL6RB_HUMAN

Name: CDw130

UniProtKB Accession Codes:

P40189 A0N0L4 Q5FC04 Q9UQ41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 EMDB 10 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2261637

Title: Molecular cloning and expression of an IL-6 signal transducer, gp130.

PubMed ID: 2261637

DOI: 10.1016/0092-8674(90)90411-7

PubMed ID: 10880057

Title: Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.

PubMed ID: 10880057

DOI: 10.1172/jci7479

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 11098061

Title: Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130.

PubMed ID: 11098061

DOI: 10.1074/jbc.m009979200

PubMed ID: 8999038

Title: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation.

PubMed ID: 8999038

DOI: 10.1074/jbc.271.51.32635

PubMed ID: 9406996

Title: Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

PubMed ID: 9406996

PubMed ID: 10811661

Title: Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling.

PubMed ID: 10811661

DOI: 10.1074/jbc.m907658199

PubMed ID: 11121117

Title: Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.

PubMed ID: 11121117

DOI: 10.1046/j.1432-1327.2001.01867.x

PubMed ID: 11238858

Title: Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.

PubMed ID: 11238858

DOI: 10.1128/jvi.75.7.3325-3334.2001

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19386761

Title: Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

PubMed ID: 19386761

DOI: 10.1091/mbc.e09-02-0168

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19915009

Title: N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

PubMed ID: 19915009

DOI: 10.1074/jbc.m109.075952

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21990364

Title: Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.

PubMed ID: 21990364

DOI: 10.1074/jbc.m111.295758

PubMed ID: 23294003

Title: gp130 activation is regulated by D2-D3 interdomain connectivity.

PubMed ID: 23294003

DOI: 10.1042/bj20121660

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25731159

Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.

PubMed ID: 25731159

DOI: 10.1038/nature14228

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 26927669

Title: Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.

PubMed ID: 26927669

DOI: 10.1172/jci84620

PubMed ID: 30279168

Title: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

PubMed ID: 30279168

DOI: 10.1126/scisignal.aar7388

PubMed ID: 9501088

Title: Crystal structure of a cytokine-binding region of gp130.

PubMed ID: 9501088

DOI: 10.1093/emboj/17.6.1665

PubMed ID: 11251120

Title: Structure of an extracellular gp130 cytokine receptor signaling complex.

PubMed ID: 11251120

DOI: 10.1126/science.1058308

PubMed ID: 14527405

Title: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.

PubMed ID: 14527405

DOI: 10.1016/s1097-2765(03)00365-4

PubMed ID: 12829785

Title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.

PubMed ID: 12829785

DOI: 10.1126/science.1083901

PubMed ID: 20489211

Title: Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.

PubMed ID: 20489211

DOI: 10.1074/jbc.c110.129502

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 25242236

Title: Low incidence of IL6ST (gp130) mutations in exon 6 in lung cancer of a Chinese cohort.

PubMed ID: 25242236

DOI: 10.1016/j.cancergen.2014.07.003

PubMed ID: 24629561

Title: Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels.

PubMed ID: 24629561

DOI: 10.1016/j.metabol.2014.02.005

PubMed ID: 28747427

Title: A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

PubMed ID: 28747427

DOI: 10.1084/jem.20161810

PubMed ID: 30309848

Title: Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function.

PubMed ID: 30309848

DOI: 10.3324/haematol.2018.194233

PubMed ID: 31914175

Title: Absence of GP130 cytokine receptor signaling causes extended Stueve-Wiedemann syndrome.

PubMed ID: 31914175

DOI: 10.1084/jem.20191306

PubMed ID: 32207811

Title: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.

PubMed ID: 32207811

DOI: 10.1084/jem.20191804

PubMed ID: 33517393

Title: Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy.

PubMed ID: 33517393

DOI: 10.1093/hmg/ddab035

PubMed ID: 33771552

Title: Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome.

PubMed ID: 33771552

DOI: 10.1016/j.jaci.2021.02.044

Sequence Information:

  • Length: 918
  • Mass: 103537
  • Checksum: 6510A4409FFCF08C
  • Sequence:
    • MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 
ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL TVRNLVGKSD AAVLTIPACD 
FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT 
YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD 
QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK 
SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN 
TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS 
ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV 
NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 
MPKSYLPQTV RQGGYMPQ

Genular Protein ID: 3194981963

Symbol: A0A0A0N0L2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0N0L2

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 3 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 857
  • Mass: 96276
  • Checksum: 726208A5073B5451
  • Sequence:
    • MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 
ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL TVRNLVGKSD AAVLTIPACD 
FQGNLAESKC YLITVTPVYA DGPGSPESIK AYLKQAPPSK GPTVRTKKVG KNEAVLEWDQ 
LPVDVQNGFI RNYTIFYRTI IGNETAVNVD SSHTEYTLSS LTSDTLYMVR MAAYTDEGGK 
DGPEFTFTTP KFAQGEIEAI VVPVCLAFLL TTLLGVLFCF NKRDLIKKHI WPNVPDPSKS 
HIAQWSPHTP PRHNFNSKDQ MYSDGNFTDV SVVEIEANDK KPFPEDLKSL DLFKKEKINT 
EGHSSGIGGS SCMSSSRPSI SSSDENESSQ NTSSTVQYST VVHSGYRHQV PSVQVFSRSE 
STQPLLDSEE RPEDLQLVDH VDGGDGILPR QQYFKQNCSQ HESSPDISHF ERSKQVSSVN 
EEDFVRLKQQ ISDHISQSCG SGQMKMFQEV SAADAFGPGT EGQVERFETV GMEAATDEGM 
PKSYLPQTVR QGGYMPQ

Genular Protein ID: 2241992979

Symbol: Q17RA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q17RA0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 GO 4 Gene3D 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 918
  • Mass: 103622
  • Checksum: FB7FBEEEC68742AC
  • Sequence:
    • MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 
ISGLPPEKPK NLSCIVNEGK KMRCEWDRGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYVATL TVRNLVGKSD AAVLTIPACD 
FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT 
YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD 
QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK 
SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN 
TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS 
ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV 
NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 
MPKSYLPQTV RQGGYMPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.