Details for: IL6ST

Gene ID: 3572

Symbol: IL6ST

Ensembl ID: ENSG00000134352

Description: interleukin 6 cytokine family signal transducer

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.85
    Marker Score: 5,595
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.49
    Marker Score: 118,800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.46
    Marker Score: 3,693
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.22
    Marker Score: 1,599
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.15
    Marker Score: 1,780
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.9
    Marker Score: 3,108
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.79
    Marker Score: 2,379
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.68
    Marker Score: 970
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.59
    Marker Score: 6,786
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.52
    Marker Score: 1,468
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.46
    Marker Score: 571
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.45
    Marker Score: 9,500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.45
    Marker Score: 880
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.39
    Marker Score: 1,331
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.38
    Marker Score: 4,573
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.36
    Marker Score: 4,297
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.33
    Marker Score: 4,653
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.3
    Marker Score: 739
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.29
    Marker Score: 1,970
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.22
    Marker Score: 2,120
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.2
    Marker Score: 918
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.19
    Marker Score: 1,962
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.18
    Marker Score: 502
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.17
    Marker Score: 1,298
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.17
    Marker Score: 475
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.16
    Marker Score: 9,019
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.12
    Marker Score: 1,912
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.1
    Marker Score: 3,676
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.08
    Marker Score: 1,185
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.07
    Marker Score: 109,413
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.06
    Marker Score: 3,379
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.05
    Marker Score: 43,747
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.04
    Marker Score: 1,021
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.04
    Marker Score: 22,946
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.02
    Marker Score: 5,145
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.01
    Marker Score: 2,509
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.99
    Marker Score: 1,243
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.99
    Marker Score: 4,368
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.98
    Marker Score: 31,817
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.98
    Marker Score: 421
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.97
    Marker Score: 10,366
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.96
    Marker Score: 2,068
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.96
    Marker Score: 475
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.95
    Marker Score: 946
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.94
    Marker Score: 2,238
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.94
    Marker Score: 12,649
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.93
    Marker Score: 2,072
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.92
    Marker Score: 529
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.92
    Marker Score: 1,367
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.87
    Marker Score: 2,315
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.85
    Marker Score: 693
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.85
    Marker Score: 27,675
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.85
    Marker Score: 1,535
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.84
    Marker Score: 4,586
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.84
    Marker Score: 466
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.83
    Marker Score: 926
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.83
    Marker Score: 2,142
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.83
    Marker Score: 7,047
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.83
    Marker Score: 465
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.82
    Marker Score: 449
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.81
    Marker Score: 1,748
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.81
    Marker Score: 3,206
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.81
    Marker Score: 8,872
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.8
    Marker Score: 7,512
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.8
    Marker Score: 700
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.8
    Marker Score: 466
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.8
    Marker Score: 7,745
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.8
    Marker Score: 4,812
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.79
    Marker Score: 4,508
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.78
    Marker Score: 5,832
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.77
    Marker Score: 4,034
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.77
    Marker Score: 667
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.76
    Marker Score: 707
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.75
    Marker Score: 420
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.74
    Marker Score: 6,185
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.74
    Marker Score: 9,360
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.73
    Marker Score: 6,423
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.69
    Marker Score: 1,153
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.68
    Marker Score: 1,808
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.67
    Marker Score: 610
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.66
    Marker Score: 930
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.66
    Marker Score: 1,940
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.66
    Marker Score: 10,647
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.65
    Marker Score: 7,110
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.62
    Marker Score: 3,950
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.61
    Marker Score: 6,739
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.61
    Marker Score: 1,672
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.61
    Marker Score: 3,021
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.61
    Marker Score: 938
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6
    Marker Score: 1,253
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.6
    Marker Score: 1,314
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.58
    Marker Score: 1,676
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.58
    Marker Score: 1,039
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.58
    Marker Score: 393
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.57
    Marker Score: 1,067
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.57
    Marker Score: 393
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.56
    Marker Score: 443
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.56
    Marker Score: 1,584
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.56
    Marker Score: 339
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.55
    Marker Score: 980

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The IL6ST gene is a transmembrane protein that belongs to the cytokine receptor superfamily. It is characterized by the presence of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains immunoglobulin-like domains, while the intracellular domain contains tyrosine kinase domains. The IL6ST protein is a coreceptor that interacts with the IL-6 receptor, facilitating the binding of IL-6 and other related cytokines. **Pathways and Functions** The IL6ST gene is involved in various signaling pathways, including: 1. **Cytokine-mediated signaling pathway**: IL6ST interacts with the IL-6 receptor to activate downstream signaling molecules, leading to the regulation of immune responses, inflammation, and cellular differentiation. 2. **Coreceptor activity**: IL6ST serves as a coreceptor for the IL-6 receptor, enhancing its binding affinity and facilitating signal transduction. 3. **Glycogen metabolic process**: IL6ST is involved in the regulation of glycogen metabolism, particularly in skeletal muscle cells. 4. **Growth factor binding**: IL6ST interacts with growth factors, such as leukemia inhibitory factor (LIF), to regulate cellular growth and differentiation. 5. **Protein binding**: IL6ST interacts with various proteins, including oncostatin-M and IL-11, to regulate cellular signaling and differentiation. **Clinical Significance** Dysregulation of the IL6ST gene has been implicated in various diseases, including: 1. **Autoimmune disorders**: Altered expression of IL6ST has been observed in autoimmune diseases such as rheumatoid arthritis and lupus. 2. **Cancer**: IL6ST is overexpressed in certain types of cancer, including breast and prostate cancer, where it promotes tumor growth and metastasis. 3. **Inflammatory disorders**: IL6ST is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD). 4. **Neurological disorders**: IL6ST is involved in the regulation of neuronal cell death and survival, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. In summary, the IL6ST gene plays a crucial role in various cellular processes, including immune responses, inflammation, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining human health.

Genular Protein ID: 932836312

Symbol: IL6RB_HUMAN

Name: CDw130

UniProtKB Accession Codes:

P40189 A0N0L4 Q5FC04 Q9UQ41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 EMDB 8 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 14 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2261637

Title: Molecular cloning and expression of an IL-6 signal transducer, gp130.

PubMed ID: 2261637

DOI: 10.1016/0092-8674(90)90411-7

PubMed ID: 10880057

Title: Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.

PubMed ID: 10880057

DOI: 10.1172/jci7479

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 11098061

Title: Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130.

PubMed ID: 11098061

DOI: 10.1074/jbc.m009979200

PubMed ID: 8999038

Title: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation.

PubMed ID: 8999038

DOI: 10.1074/jbc.271.51.32635

PubMed ID: 9406996

Title: Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

PubMed ID: 9406996

PubMed ID: 10811661

Title: Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling.

PubMed ID: 10811661

DOI: 10.1074/jbc.m907658199

PubMed ID: 11121117

Title: Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.

PubMed ID: 11121117

DOI: 10.1046/j.1432-1327.2001.01867.x

PubMed ID: 11238858

Title: Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.

PubMed ID: 11238858

DOI: 10.1128/jvi.75.7.3325-3334.2001

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19386761

Title: Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

PubMed ID: 19386761

DOI: 10.1091/mbc.e09-02-0168

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19915009

Title: N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

PubMed ID: 19915009

DOI: 10.1074/jbc.m109.075952

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21990364

Title: Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.

PubMed ID: 21990364

DOI: 10.1074/jbc.m111.295758

PubMed ID: 23294003

Title: gp130 activation is regulated by D2-D3 interdomain connectivity.

PubMed ID: 23294003

DOI: 10.1042/bj20121660

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25731159

Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.

PubMed ID: 25731159

DOI: 10.1038/nature14228

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 26927669

Title: Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.

PubMed ID: 26927669

DOI: 10.1172/jci84620

PubMed ID: 30279168

Title: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

PubMed ID: 30279168

DOI: 10.1126/scisignal.aar7388

PubMed ID: 9501088

Title: Crystal structure of a cytokine-binding region of gp130.

PubMed ID: 9501088

DOI: 10.1093/emboj/17.6.1665

PubMed ID: 11251120

Title: Structure of an extracellular gp130 cytokine receptor signaling complex.

PubMed ID: 11251120

DOI: 10.1126/science.1058308

PubMed ID: 14527405

Title: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.

PubMed ID: 14527405

DOI: 10.1016/s1097-2765(03)00365-4

PubMed ID: 12829785

Title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.

PubMed ID: 12829785

DOI: 10.1126/science.1083901

PubMed ID: 20489211

Title: Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.

PubMed ID: 20489211

DOI: 10.1074/jbc.c110.129502

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 25242236

Title: Low incidence of IL6ST (gp130) mutations in exon 6 in lung cancer of a Chinese cohort.

PubMed ID: 25242236

DOI: 10.1016/j.cancergen.2014.07.003

PubMed ID: 24629561

Title: Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels.

PubMed ID: 24629561

DOI: 10.1016/j.metabol.2014.02.005

PubMed ID: 28747427

Title: A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

PubMed ID: 28747427

DOI: 10.1084/jem.20161810

PubMed ID: 30309848

Title: Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function.

PubMed ID: 30309848

DOI: 10.3324/haematol.2018.194233

PubMed ID: 31914175

Title: Absence of GP130 cytokine receptor signaling causes extended Stueve-Wiedemann syndrome.

PubMed ID: 31914175

DOI: 10.1084/jem.20191306

PubMed ID: 32207811

Title: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.

PubMed ID: 32207811

DOI: 10.1084/jem.20191804

PubMed ID: 33517393

Title: Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy.

PubMed ID: 33517393

DOI: 10.1093/hmg/ddab035

PubMed ID: 33771552

Title: Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome.

PubMed ID: 33771552

DOI: 10.1016/j.jaci.2021.02.044

Sequence Information:

  • Length: 918
  • Mass: 103537
  • Checksum: 6510A4409FFCF08C
  • Sequence:
    • MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 
ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL TVRNLVGKSD AAVLTIPACD 
FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT 
YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD 
QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK 
SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN 
TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS 
ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV 
NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 
MPKSYLPQTV RQGGYMPQ

Genular Protein ID: 2241992979

Symbol: Q17RA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q17RA0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GO 2 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 918
  • Mass: 103622
  • Checksum: FB7FBEEEC68742AC
  • Sequence:
    • MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 
ISGLPPEKPK NLSCIVNEGK KMRCEWDRGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYVATL TVRNLVGKSD AAVLTIPACD 
FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT 
YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD 
QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK 
SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN 
TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS 
ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV 
NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 
MPKSYLPQTV RQGGYMPQ

Genular Protein ID: 3194981963

Symbol: A0A0A0N0L2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0N0L2

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 3 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 857
  • Mass: 96276
  • Checksum: 726208A5073B5451
  • Sequence:
    • MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 
ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL TVRNLVGKSD AAVLTIPACD 
FQGNLAESKC YLITVTPVYA DGPGSPESIK AYLKQAPPSK GPTVRTKKVG KNEAVLEWDQ 
LPVDVQNGFI RNYTIFYRTI IGNETAVNVD SSHTEYTLSS LTSDTLYMVR MAAYTDEGGK 
DGPEFTFTTP KFAQGEIEAI VVPVCLAFLL TTLLGVLFCF NKRDLIKKHI WPNVPDPSKS 
HIAQWSPHTP PRHNFNSKDQ MYSDGNFTDV SVVEIEANDK KPFPEDLKSL DLFKKEKINT 
EGHSSGIGGS SCMSSSRPSI SSSDENESSQ NTSSTVQYST VVHSGYRHQV PSVQVFSRSE 
STQPLLDSEE RPEDLQLVDH VDGGDGILPR QQYFKQNCSQ HESSPDISHF ERSKQVSSVN 
EEDFVRLKQQ ISDHISQSCG SGQMKMFQEV SAADAFGPGT EGQVERFETV GMEAATDEGM 
PKSYLPQTVR QGGYMPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.