Details for: IL13RA1

Gene ID: 3597

Symbol: IL13RA1

Ensembl ID: ENSG00000131724

Description: interleukin 13 receptor subunit alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.4941
    Cell Significance Index: -28.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.2729
    Cell Significance Index: -27.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.2341
    Cell Significance Index: -28.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.1729
    Cell Significance Index: -28.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7624
    Cell Significance Index: -28.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.8554
    Cell Significance Index: -29.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5809
    Cell Significance Index: -18.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0957
    Cell Significance Index: -28.0000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 6.1242
    Cell Significance Index: 61.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3690
    Cell Significance Index: 23.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9625
    Cell Significance Index: 104.6900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.7832
    Cell Significance Index: 4.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7303
    Cell Significance Index: 144.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6548
    Cell Significance Index: 45.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6307
    Cell Significance Index: 12.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6240
    Cell Significance Index: 85.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6195
    Cell Significance Index: 11.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5528
    Cell Significance Index: 54.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5384
    Cell Significance Index: 40.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5099
    Cell Significance Index: 97.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4596
    Cell Significance Index: 15.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4528
    Cell Significance Index: 9.8100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4099
    Cell Significance Index: 5.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3969
    Cell Significance Index: 20.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3092
    Cell Significance Index: 8.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2998
    Cell Significance Index: 13.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2930
    Cell Significance Index: 13.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2508
    Cell Significance Index: 45.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2508
    Cell Significance Index: 136.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2409
    Cell Significance Index: 29.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2023
    Cell Significance Index: 32.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1507
    Cell Significance Index: 25.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1099
    Cell Significance Index: 3.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0918
    Cell Significance Index: 2.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0895
    Cell Significance Index: 39.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0449
    Cell Significance Index: 2.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0189
    Cell Significance Index: 2.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0165
    Cell Significance Index: 1.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0159
    Cell Significance Index: 0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0150
    Cell Significance Index: 9.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0031
    Cell Significance Index: 5.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0084
    Cell Significance Index: -15.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0118
    Cell Significance Index: -6.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0206
    Cell Significance Index: -14.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0215
    Cell Significance Index: -0.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0218
    Cell Significance Index: -9.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0260
    Cell Significance Index: -35.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0473
    Cell Significance Index: -6.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0614
    Cell Significance Index: -22.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0711
    Cell Significance Index: -20.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0711
    Cell Significance Index: -14.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0736
    Cell Significance Index: -1.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0888
    Cell Significance Index: -1.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0914
    Cell Significance Index: -13.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0985
    Cell Significance Index: -2.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1005
    Cell Significance Index: -2.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1085
    Cell Significance Index: -12.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1194
    Cell Significance Index: -9.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1196
    Cell Significance Index: -8.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1206
    Cell Significance Index: -24.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1220
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1467
    Cell Significance Index: -16.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1532
    Cell Significance Index: -17.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2182
    Cell Significance Index: -13.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2378
    Cell Significance Index: -6.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2419
    Cell Significance Index: -28.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2480
    Cell Significance Index: -6.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2517
    Cell Significance Index: -6.8500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2557
    Cell Significance Index: -3.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2558
    Cell Significance Index: -26.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2879
    Cell Significance Index: -7.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3094
    Cell Significance Index: -4.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3172
    Cell Significance Index: -20.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3351
    Cell Significance Index: -26.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3384
    Cell Significance Index: -5.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3649
    Cell Significance Index: -10.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3932
    Cell Significance Index: -8.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4402
    Cell Significance Index: -29.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4482
    Cell Significance Index: -27.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4520
    Cell Significance Index: -27.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4578
    Cell Significance Index: -25.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4852
    Cell Significance Index: -8.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5296
    Cell Significance Index: -15.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5365
    Cell Significance Index: -9.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5956
    Cell Significance Index: -31.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6282
    Cell Significance Index: -23.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6357
    Cell Significance Index: -28.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6369
    Cell Significance Index: -8.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6438
    Cell Significance Index: -6.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6754
    Cell Significance Index: -10.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6850
    Cell Significance Index: -14.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7397
    Cell Significance Index: -28.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7605
    Cell Significance Index: -8.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7795
    Cell Significance Index: -13.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8004
    Cell Significance Index: -28.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL13RA1 is a single-copy gene located on chromosome 5q31.1, with a predicted protein sequence of 357 amino acids. The gene encodes for a transmembrane receptor subunit that is part of the IL-4 and IL-13 receptor complex. IL13RA1 is expressed in various immune cells, including lung macrophages, central nervous system macrophages, and CD1c-positive myeloid dendritic cells, suggesting its role in regulating immune responses in different tissues. **Pathways and Functions:** IL13RA1 is involved in several signaling pathways, including: 1. **Cell surface receptor signaling pathway**: IL13RA1 interacts with IL-13, triggering a signaling cascade that activates downstream kinases, such as JAK1 and STAT6, which in turn regulate gene expression. 2. **Cytokine-mediated signaling pathway**: IL13RA1 modulates the activity of other cytokines, including IL-4, IL-5, and IL-10, which are involved in allergic inflammation and asthma. 3. **Protein binding**: IL13RA1 interacts with various proteins, including IL-13, IL-4, and IL-10, to regulate their activity and downstream signaling. The functions of IL13RA1 include: 1. **Regulation of cell proliferation**: IL13RA1 modulates the proliferation of immune cells, including T cells and B cells, in response to IL-13. 2. **Inflammation and immune responses**: IL13RA1 plays a key role in regulating inflammatory responses, particularly in the context of allergic inflammation and asthma. 3. **Tissue repair**: IL13RA1 may also contribute to tissue repair and regeneration, particularly in the context of lung injury. **Clinical Significance:** IL13RA1 has been implicated in various immune-mediated diseases, including: 1. **Asthma**: IL13RA1 is a key target for therapeutic interventions in asthma, as it is involved in the regulation of airway inflammation and hyperresponsiveness. 2. **Allergic rhinitis**: IL13RA1 may also play a role in the pathogenesis of allergic rhinitis, particularly in the context of nasal inflammation and tissue damage. 3. **Autoimmune diseases**: IL13RA1 may also contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, by modulating immune responses and tissue damage. In conclusion, the IL13RA1 gene is a critical component of the IL-13 signaling pathway, which plays a significant role in regulating immune responses and disease. Further research is needed to fully elucidate the mechanisms by which IL13RA1 contributes to immune-mediated diseases and to develop effective therapeutic strategies targeting this gene.

Genular Protein ID: 1998426584

Symbol: I13R1_HUMAN

Name: Interleukin-13 receptor subunit alpha-1

UniProtKB Accession Codes:

P78552 O95646 Q5JSL4 Q99656 Q9UDY5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013879

Title: Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex.

PubMed ID: 9013879

DOI: 10.1016/s0014-5793(96)01462-7

PubMed ID: 8910586

Title: cDNA cloning and characterization of the human interleukin 13 receptor alpha chain.

PubMed ID: 8910586

DOI: 10.1074/jbc.271.46.29265

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10791955

Title: MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.

PubMed ID: 10791955

DOI: 10.1074/jbc.m001095200

PubMed ID: 18243101

Title: Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

PubMed ID: 18243101

DOI: 10.1016/j.cell.2007.12.030

Sequence Information:

  • Length: 427
  • Mass: 48760
  • Checksum: 5983B3E8F554107B
  • Sequence:
    • MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS 
NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP 
PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG 
QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN 
DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP 
GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI 
IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE 
NLKKASQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.