Details for: IL13RA1

Gene ID: 3597

Symbol: IL13RA1

Ensembl ID: ENSG00000131724

Description: interleukin 13 receptor subunit alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.26
    Marker Score: 2582
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.08
    Marker Score: 1033
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.6
    Marker Score: 655
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.6
    Marker Score: 1529
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.47
    Marker Score: 878
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.41
    Marker Score: 3653
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.41
    Marker Score: 509
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.28
    Marker Score: 874
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.25
    Marker Score: 5396
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.25
    Marker Score: 32022
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.24
    Marker Score: 10684
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.24
    Marker Score: 2192
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.23
    Marker Score: 1227
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.22
    Marker Score: 7826
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2450
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.15
    Marker Score: 768
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.14
    Marker Score: 983
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.14
    Marker Score: 273
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.11
    Marker Score: 8685.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.11
    Marker Score: 2024
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.11
    Marker Score: 2815
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.08
    Marker Score: 60538
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.08
    Marker Score: 537
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.07
    Marker Score: 1556
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.07
    Marker Score: 5753
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.05
    Marker Score: 2104
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.05
    Marker Score: 5519
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.05
    Marker Score: 1040
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.03
    Marker Score: 863.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.02
    Marker Score: 1479
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.02
    Marker Score: 4899
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.01
    Marker Score: 8737
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 289
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1
    Marker Score: 6059.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47952
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.99
    Marker Score: 2263
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.99
    Marker Score: 676
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.99
    Marker Score: 1007
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.98
    Marker Score: 3796
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.98
    Marker Score: 208
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.96
    Marker Score: 1325
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.95
    Marker Score: 1019
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.94
    Marker Score: 1049
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.93
    Marker Score: 238
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.93
    Marker Score: 2119
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.92
    Marker Score: 633
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.9
    Marker Score: 3095
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.9
    Marker Score: 2209
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.9
    Marker Score: 1427
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.88
    Marker Score: 224
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.88
    Marker Score: 5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.87
    Marker Score: 790
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.87
    Marker Score: 201
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.87
    Marker Score: 1284
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4806
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.84
    Marker Score: 452
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.84
    Marker Score: 3109
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.84
    Marker Score: 1610
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 638
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.83
    Marker Score: 2613
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.83
    Marker Score: 410
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.83
    Marker Score: 235
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.82
    Marker Score: 1719
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.82
    Marker Score: 425
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.82
    Marker Score: 733
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.82
    Marker Score: 1591
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.8
    Marker Score: 375
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8
    Marker Score: 9005
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.8
    Marker Score: 185
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.8
    Marker Score: 297.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 912
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.78
    Marker Score: 454
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.78
    Marker Score: 247
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.78
    Marker Score: 2029
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.77
    Marker Score: 1473
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.77
    Marker Score: 12397
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.77
    Marker Score: 1908
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.77
    Marker Score: 3180
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.77
    Marker Score: 363
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.76
    Marker Score: 188
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.76
    Marker Score: 479
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 693
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.75
    Marker Score: 437
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.75
    Marker Score: 756
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 240
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.74
    Marker Score: 1296
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1176
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.73
    Marker Score: 1333
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.73
    Marker Score: 200

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Other Information

**Key characteristics:** * The IL13RA1 gene is located on chromosome 12 and encodes a protein of 137 amino acids. * It is a member of the interleukin-13 receptor family, which is a group of cell surface receptors that are expressed on various immune cells. * The IL13RA1 receptor is a type I cytokine receptor, which means that it is a receptor for secreted cytokines. * The receptor is expressed on a variety of cell types, including macrophages, dendritic cells, and lymphocytes. * Upon binding to a cytokine, the IL13RA1 receptor transduces a signal through the intracellular signaling pathway. **Pathways and functions:** * The IL13RA1 receptor is a key regulator of immune responses. * It is involved in the regulation of macrophage function, including the production of inflammatory cytokines. * The receptor is also involved in the regulation of dendritic cell function, including the presentation of antigens to T cells. * Dysregulation of the IL13RA1 receptor has been linked to a number of diseases, including asthma, allergy, and cancer. **Clinical significance:** The IL13RA1 gene has been implicated in a variety of human diseases, including asthma, allergy, and cancer. In asthma, the IL13RA1 receptor is expressed on airway epithelial cells and macrophages, and it is known to play a role in the development and progression of the disease. In allergy, the IL13RA1 receptor is expressed on mast cells and basophils, and it is thought to play a role in the release of inflammatory mediators in allergic responses. In cancer, the IL13RA1 receptor is expressed on tumor cells and immune cells, and it is thought to play a role in the growth and metastasis of cancer.

Genular Protein ID: 1998426584

Symbol: I13R1_HUMAN

Name: Interleukin-13 receptor subunit alpha-1

UniProtKB Accession Codes:

P78552 O95646 Q5JSL4 Q99656 Q9UDY5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013879

Title: Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex.

PubMed ID: 9013879

DOI: 10.1016/s0014-5793(96)01462-7

PubMed ID: 8910586

Title: cDNA cloning and characterization of the human interleukin 13 receptor alpha chain.

PubMed ID: 8910586

DOI: 10.1074/jbc.271.46.29265

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10791955

Title: MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.

PubMed ID: 10791955

DOI: 10.1074/jbc.m001095200

PubMed ID: 18243101

Title: Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

PubMed ID: 18243101

DOI: 10.1016/j.cell.2007.12.030

Sequence Information:

  • Length: 427
  • Mass: 48760
  • Checksum: 5983B3E8F554107B
  • Sequence:
    • MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS 
NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP 
PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG 
QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN 
DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP 
GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI 
IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE 
NLKKASQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.