Details for: IMPA2

Gene ID: 3613

Symbol: IMPA2

Ensembl ID: ENSG00000141401

Description: inositol monophosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.8167
    Cell Significance Index: -22.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.1108
    Cell Significance Index: -19.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.2187
    Cell Significance Index: -26.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.8350
    Cell Significance Index: -25.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.8810
    Cell Significance Index: -26.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.4411
    Cell Significance Index: -23.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2091
    Cell Significance Index: -24.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1555
    Cell Significance Index: -24.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0497
    Cell Significance Index: -15.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8244
    Cell Significance Index: -8.3700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.3411
    Cell Significance Index: 28.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.3249
    Cell Significance Index: 92.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.8948
    Cell Significance Index: 173.7900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.5150
    Cell Significance Index: 5.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.3506
    Cell Significance Index: 401.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0478
    Cell Significance Index: 27.9400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.7942
    Cell Significance Index: 6.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5768
    Cell Significance Index: 111.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5056
    Cell Significance Index: 665.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2200
    Cell Significance Index: 84.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0607
    Cell Significance Index: 22.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9456
    Cell Significance Index: 7.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9389
    Cell Significance Index: 25.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8705
    Cell Significance Index: 172.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8670
    Cell Significance Index: 39.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8621
    Cell Significance Index: 22.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8322
    Cell Significance Index: 94.9900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.7821
    Cell Significance Index: 12.6200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7500
    Cell Significance Index: 4.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6438
    Cell Significance Index: 63.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.6413
    Cell Significance Index: 50.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6262
    Cell Significance Index: 15.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4994
    Cell Significance Index: 90.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4801
    Cell Significance Index: 12.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4538
    Cell Significance Index: 6.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4221
    Cell Significance Index: 19.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3565
    Cell Significance Index: 194.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3295
    Cell Significance Index: 62.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2623
    Cell Significance Index: 13.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2572
    Cell Significance Index: 35.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2526
    Cell Significance Index: 19.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2473
    Cell Significance Index: 7.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2424
    Cell Significance Index: 39.4200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.2321
    Cell Significance Index: 1.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2250
    Cell Significance Index: 164.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1844
    Cell Significance Index: 22.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1789
    Cell Significance Index: 9.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0897
    Cell Significance Index: 1.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0874
    Cell Significance Index: 11.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0799
    Cell Significance Index: 147.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0480
    Cell Significance Index: 9.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0430
    Cell Significance Index: 0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0375
    Cell Significance Index: 28.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0221
    Cell Significance Index: 41.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0214
    Cell Significance Index: 1.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0205
    Cell Significance Index: 31.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0202
    Cell Significance Index: 18.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0146
    Cell Significance Index: 0.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0131
    Cell Significance Index: 9.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0130
    Cell Significance Index: -0.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0135
    Cell Significance Index: -1.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0135
    Cell Significance Index: -1.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0209
    Cell Significance Index: -7.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0345
    Cell Significance Index: -15.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0370
    Cell Significance Index: -4.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0374
    Cell Significance Index: -5.4300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0510
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0532
    Cell Significance Index: -11.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0579
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0629
    Cell Significance Index: -2.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0725
    Cell Significance Index: -20.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0812
    Cell Significance Index: -9.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1060
    Cell Significance Index: -12.3500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1300
    Cell Significance Index: -0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1393
    Cell Significance Index: -10.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1554
    Cell Significance Index: -5.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1620
    Cell Significance Index: -5.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1979
    Cell Significance Index: -5.8300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2111
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2127
    Cell Significance Index: -22.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2262
    Cell Significance Index: -4.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2332
    Cell Significance Index: -4.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2619
    Cell Significance Index: -2.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3174
    Cell Significance Index: -19.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3184
    Cell Significance Index: -21.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3196
    Cell Significance Index: -8.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3224
    Cell Significance Index: -5.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3331
    Cell Significance Index: -8.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3521
    Cell Significance Index: -7.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3536
    Cell Significance Index: -5.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3540
    Cell Significance Index: -6.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3608
    Cell Significance Index: -3.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3661
    Cell Significance Index: -22.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3753
    Cell Significance Index: -3.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IMPA2 is a monomeric enzyme that exhibits 4-phosphatase activity, specifically catalyzing the dephosphorylation of inositol monophosphates to inositol-1-phosphate. This enzyme is part of the inositol monophosphate pathway, which is a critical regulator of inositol signaling. IMPA2 is also characterized by its ability to interact with other proteins, including metal ions and other phosphatases, to modulate its activity and binding capabilities. **Pathways and Functions** IMPA2 is involved in several key pathways, including: 1. **Inositol biosynthetic process**: IMPA2 plays a crucial role in the biosynthesis of inositol, a key component of phospholipids and signaling molecules. 2. **Inositol metabolic process**: IMPA2 is involved in the regulation of inositol metabolism, including the conversion of inositol monophosphates to inositol-1-phosphate. 3. **Inositol monophosphate 1-phosphatase activity**: IMPA2 exhibits 1-phosphatase activity, which is essential for the regulation of inositol signaling pathways. 4. **Inositol monophosphate 3-phosphatase activity**: IMPA2 also exhibits 3-phosphatase activity, which is involved in the regulation of inositol signaling. 5. **Phosphate-containing compound metabolic process**: IMPA2 is involved in the regulation of phosphate-containing compounds, including inositol monophosphates. 6. **Synthesis of ip2, ip, and ins in the cytosol**: IMPA2 plays a crucial role in the synthesis of inositol-1,4,5-trisphosphate (ip3), inositol-1-phosphate (ip), and inositol (ins) in the cytosol. **Clinical Significance** IMPA2 has been implicated in various diseases, including: 1. **Renal disorders**: IMPA2 has been shown to play a crucial role in the regulation of inositol signaling in the kidney, and alterations in IMPA2 expression have been implicated in renal disorders, such as kidney failure and hypertension. 2. **Cancer**: IMPA2 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been implicated in cancer progression and metastasis. 3. **Neurological disorders**: IMPA2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, and has been shown to play a role in the regulation of inositol signaling pathways. In conclusion, IMPA2 is a critical enzyme involved in the regulation of inositol signaling pathways, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of IMPA2 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 1896091380

Symbol: IMPA2_HUMAN

Name: Inositol monophosphatase 2

UniProtKB Accession Codes:

O14732 B0YJ29 Q9UJT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9322233

Title: A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.

PubMed ID: 9322233

DOI: 10.1038/sj.mp.4000325

PubMed ID: 10822345

Title: A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.

PubMed ID: 10822345

DOI: 10.1038/sj.mp.4000681

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15504365

Title: Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter.

PubMed ID: 15504365

DOI: 10.1016/j.bbrc.2004.09.199

PubMed ID: 17068342

Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.

PubMed ID: 17068342

DOI: 10.1074/jbc.m604474200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17340635

Title: Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.

PubMed ID: 17340635

DOI: 10.1002/prot.21299

Sequence Information:

  • Length: 288
  • Mass: 31321
  • Checksum: 30D83FA339AC69B4
  • Sequence:
    • MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL 
VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI 
GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP 
ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR 
EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.