Gene IMPA2 - ENSG00000141401 | NCBI Gene ID: 3613

Details for: IMPA2

Gene ID: 3613

Symbol: IMPA2

Ensembl ID: ENSG00000141401

Description: inositol monophosphatase 2

Associated with

Inositol phosphate metabolism
(R-HSA-1483249)
Metabolism
(R-HSA-1430728)
Synthesis of ip2, ip, and ins in the cytosol
(R-HSA-1855183)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Inositol biosynthetic process
(GO:0006021)
Inositol metabolic process
(GO:0006020)
Inositol monophosphate 1-phosphatase activity
(GO:0008934)
Inositol monophosphate 3-phosphatase activity
(GO:0052832)
Inositol monophosphate 4-phosphatase activity
(GO:0052833)
Metal ion binding
(GO:0046872)
Phosphate-containing compound metabolic process
(GO:0006796)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to lithium ion
(GO:0010226)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.33
Marker Score: 3870
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.21
Marker Score: 7840
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.17
Marker Score: 2453
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.13
Marker Score: 5721
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.13
Marker Score: 4491
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.09
Marker Score: 17984
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.9
Marker Score: 14856
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.66
Marker Score: 10562
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.64
Marker Score: 3866
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.63
Marker Score: 1691
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.6
Marker Score: 1694
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.57
Marker Score: 3565
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.54
Marker Score: 3137
Cell Name: stem cell (CL0000034)
Fold Change: 1.32
Marker Score: 3144
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.3
Marker Score: 305
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.28
Marker Score: 3226
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.27
Marker Score: 19889
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.2
Marker Score: 1502
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.19
Marker Score: 3746
Cell Name: peptic cell (CL0000155)
Fold Change: 1.18
Marker Score: 496
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.17
Marker Score: 1887
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.17
Marker Score: 7616
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.16
Marker Score: 1556
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.16
Marker Score: 1108.5
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.14
Marker Score: 433
Cell Name: kidney cell (CL1000497)
Fold Change: 1.12
Marker Score: 750
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.11
Marker Score: 1102
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.08
Marker Score: 663
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.06
Marker Score: 358
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.05
Marker Score: 254
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.05
Marker Score: 1666
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251733
Cell Name: basal cell (CL0000646)
Fold Change: 1.04
Marker Score: 1337
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.03
Marker Score: 1457
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.02
Marker Score: 4025
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.02
Marker Score: 1073
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.02
Marker Score: 536
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1
Marker Score: 322
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71752
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47976
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.99
Marker Score: 1009
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.98
Marker Score: 307
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.97
Marker Score: 2282
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.97
Marker Score: 242
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.95
Marker Score: 1005
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.94
Marker Score: 4938
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.93
Marker Score: 5579
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5294
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.92
Marker Score: 347
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: acinar cell (CL0000622)
Fold Change: 0.9
Marker Score: 638
Cell Name: enterocyte (CL0000584)
Fold Change: 0.89
Marker Score: 4248
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.88
Marker Score: 48981
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.85
Marker Score: 711
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.85
Marker Score: 315
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.84
Marker Score: 506
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.84
Marker Score: 243
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.83
Marker Score: 6209
Cell Name: contractile cell (CL0000183)
Fold Change: 0.83
Marker Score: 450
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.82
Marker Score: 392
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.82
Marker Score: 449
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 598.5
Cell Name: decidual cell (CL2000002)
Fold Change: 0.78
Marker Score: 3376
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.78
Marker Score: 194
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.77
Marker Score: 737
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.77
Marker Score: 423
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.75
Marker Score: 387
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.75
Marker Score: 15969
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.74
Marker Score: 491
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.74
Marker Score: 755.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.74
Marker Score: 3029
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.74
Marker Score: 188
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.73
Marker Score: 362
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.73
Marker Score: 292
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.72
Marker Score: 9560
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.72
Marker Score: 580
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.72
Marker Score: 1064
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.72
Marker Score: 663
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3011.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.71
Marker Score: 563
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.71
Marker Score: 768
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.71
Marker Score: 4557
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.71
Marker Score: 1614
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.7
Marker Score: 446.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.69
Marker Score: 652
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 629
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.69
Marker Score: 1435
Cell Name: lactocyte (CL0002325)
Fold Change: 0.69
Marker Score: 11032
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.68
Marker Score: 751
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.67
Marker Score: 2810.5

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**Key characteristics** * IMPA2 is a protein that is highly expressed in the kidney, with high expression in the collecting duct intercalated cell, epithelial cell of proximal tubule, basal epithelial cell of tracheobronchial tree, kidney loop of Henle thick ascending limb epithelial cell, pancreatic acinar cell, epithelial cell of esophagus, stratified epithelial cell, foveolar cell of stomach, kidney proximal straight tubule epithelial cell, and pancreatic ductal cell. * It is a transmembrane protein that is composed of 134 amino acids. * It is a member of the inositol monophosphate 1-phosphatase (IMP1) family of proteins. * It is a key regulator of the calcium and phosphate signaling pathways. **Pathways and functions** * IMPA2 is involved in the regulation of calcium signaling by binding to phosphatidylinositol 4,5-bisphosphate (PIP2), a second messenger that is involved in calcium release from intracellular stores. * It also regulates the phosphate signaling pathway by binding to phosphatases that control the activity of inorganic phosphate (Pi). * It is involved in the regulation of cell growth, differentiation, and apoptosis. * It is also involved in the regulation of inflammation and cell migration. **Clinical significance** Mutations in the IMPA2 gene have been linked to a number of human diseases, including kidney disease, hypertension, and cancer. These diseases are characterized by abnormal calcium and phosphate signaling, which is thought to be caused by mutations in genes that regulate these pathways. **Conclusion** IMPA2 is a key regulator of calcium and phosphate signaling pathways in mammalian cells. Mutations in the IMPA2 gene have been linked to a number of human diseases, highlighting the importance of this protein in maintaining cellular health and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Inositol monophosphatase 2

Genular Protein ID: 1896091380

Symbol: IMPA2_HUMAN

Name: Inositol monophosphatase 2

UniProtKB Accession Codes:

O14732 B0YJ29 Q9UJT3

Database IDs:

Citations:

PubMed ID: 9322233

Title: A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.

PubMed ID: 9322233

DOI: 10.1038/sj.mp.4000325

PubMed ID: 10822345

Title: A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.

PubMed ID: 10822345

DOI: 10.1038/sj.mp.4000681

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15504365

Title: Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter.

PubMed ID: 15504365

DOI: 10.1016/j.bbrc.2004.09.199

PubMed ID: 17068342

Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.

PubMed ID: 17068342

DOI: 10.1074/jbc.m604474200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17340635

Title: Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.

PubMed ID: 17340635

DOI: 10.1002/prot.21299

Sequence Information:

Length: 288
Mass: 31321
Checksum: 30D83FA339AC69B4
Sequence:

MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL 
VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI 
GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP 
ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR 
EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IMPA2

Associated with

Cells (max top 100)

Other Information

A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. PubMed ID: 9322233

A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients. PubMed ID: 10822345

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter. PubMed ID: 15504365

Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. PubMed ID: 17068342

Initial characterization of the human central proteome. PubMed ID: 21269460

Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. PubMed ID: 17340635