Details for: IMPA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 143.8167
Cell Significance Index: -22.3700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 76.1108
Cell Significance Index: -19.3100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 55.2187
Cell Significance Index: -26.0700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 48.8350
Cell Significance Index: -25.1200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 38.8810
Cell Significance Index: -26.0900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.4411
Cell Significance Index: -23.9700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.2091
Cell Significance Index: -24.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.1555
Cell Significance Index: -24.2900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.0497
Cell Significance Index: -15.5100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.8244
Cell Significance Index: -8.3700 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 3.3411
Cell Significance Index: 28.7100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.3249
Cell Significance Index: 92.9200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.8948
Cell Significance Index: 173.7900 - Cell Name: epidermal cell (CL0000362)
Fold Change: 2.5150
Cell Significance Index: 5.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.3506
Cell Significance Index: 401.3700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.0478
Cell Significance Index: 27.9400 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.7942
Cell Significance Index: 6.8700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.5768
Cell Significance Index: 111.5200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5056
Cell Significance Index: 665.6500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.2200
Cell Significance Index: 84.3700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0607
Cell Significance Index: 22.9800 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.9456
Cell Significance Index: 7.5500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9389
Cell Significance Index: 25.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8705
Cell Significance Index: 172.7500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8670
Cell Significance Index: 39.3000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.8621
Cell Significance Index: 22.1600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.8322
Cell Significance Index: 94.9900 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.7821
Cell Significance Index: 12.6200 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.7500
Cell Significance Index: 4.6600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6438
Cell Significance Index: 63.6900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.6413
Cell Significance Index: 50.7900 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.6262
Cell Significance Index: 15.2800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4994
Cell Significance Index: 90.0200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4801
Cell Significance Index: 12.0000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.4538
Cell Significance Index: 6.8000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4221
Cell Significance Index: 19.6800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3565
Cell Significance Index: 194.7200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3295
Cell Significance Index: 62.7000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2623
Cell Significance Index: 13.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2572
Cell Significance Index: 35.3200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2526
Cell Significance Index: 19.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2473
Cell Significance Index: 7.9200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2424
Cell Significance Index: 39.4200 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.2321
Cell Significance Index: 1.5400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2250
Cell Significance Index: 164.9700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1844
Cell Significance Index: 22.6700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1789
Cell Significance Index: 9.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0897
Cell Significance Index: 1.9100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0874
Cell Significance Index: 11.3000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0799
Cell Significance Index: 147.3800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0480
Cell Significance Index: 9.6200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0430
Cell Significance Index: 0.7200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0375
Cell Significance Index: 28.3600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0221
Cell Significance Index: 41.5600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0214
Cell Significance Index: 1.2000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0205
Cell Significance Index: 31.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0202
Cell Significance Index: 18.2200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0146
Cell Significance Index: 0.9400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0131
Cell Significance Index: 9.0300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0037
Cell Significance Index: -0.0400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0068
Cell Significance Index: -4.2200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0076
Cell Significance Index: -5.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0077
Cell Significance Index: -4.8700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0130
Cell Significance Index: -0.3800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0135
Cell Significance Index: -1.3800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0135
Cell Significance Index: -1.7300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0151
Cell Significance Index: -20.5900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0209
Cell Significance Index: -7.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0274
Cell Significance Index: -15.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0345
Cell Significance Index: -15.6800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0370
Cell Significance Index: -4.2400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0374
Cell Significance Index: -5.4300 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0510
Cell Significance Index: -0.3900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0532
Cell Significance Index: -11.2000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0579
Cell Significance Index: -1.4800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0629
Cell Significance Index: -2.9600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0725
Cell Significance Index: -20.8600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0812
Cell Significance Index: -9.5800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1060
Cell Significance Index: -12.3500 - Cell Name: early promyelocyte (CL0002154)
Fold Change: -0.1300
Cell Significance Index: -0.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1393
Cell Significance Index: -10.3800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1554
Cell Significance Index: -5.4600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1620
Cell Significance Index: -5.6300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1979
Cell Significance Index: -5.8300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2111
Cell Significance Index: -1.4300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2127
Cell Significance Index: -22.1500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2262
Cell Significance Index: -4.8400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2332
Cell Significance Index: -4.3100 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2619
Cell Significance Index: -2.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3174
Cell Significance Index: -19.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3184
Cell Significance Index: -21.4100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3196
Cell Significance Index: -8.7000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3224
Cell Significance Index: -5.4300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3331
Cell Significance Index: -8.9100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3521
Cell Significance Index: -7.3700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3536
Cell Significance Index: -5.4700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3540
Cell Significance Index: -6.9100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3608
Cell Significance Index: -3.7400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3661
Cell Significance Index: -22.5000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3753
Cell Significance Index: -3.0600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1896091380
Symbol: IMPA2_HUMAN
Name: Inositol monophosphatase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9322233
Title: A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.
PubMed ID: 9322233
PubMed ID: 10822345
Title: A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.
PubMed ID: 10822345
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15504365
Title: Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter.
PubMed ID: 15504365
PubMed ID: 17068342
Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.
PubMed ID: 17068342
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 17340635
Title: Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.
PubMed ID: 17340635
DOI: 10.1002/prot.21299
Sequence Information:
- Length: 288
- Mass: 31321
- Checksum: 30D83FA339AC69B4
- Sequence:
MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.