Details for: IMPA2

Gene ID: 3613

Symbol: IMPA2

Ensembl ID: ENSG00000141401

Description: inositol monophosphatase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.33
    Marker Score: 3,870
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.21
    Marker Score: 7,840
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.17
    Marker Score: 2,453
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.13
    Marker Score: 5,721
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.13
    Marker Score: 4,491
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.09
    Marker Score: 17,984
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.9
    Marker Score: 14,856
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.66
    Marker Score: 10,562
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.64
    Marker Score: 3,866
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.63
    Marker Score: 1,691
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.6
    Marker Score: 1,694
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.57
    Marker Score: 3,565
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3,137
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.32
    Marker Score: 3,144
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.3
    Marker Score: 305
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.28
    Marker Score: 3,226
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,889
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.2
    Marker Score: 1,502
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.19
    Marker Score: 3,746
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.18
    Marker Score: 496
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.17
    Marker Score: 1,887
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.17
    Marker Score: 7,616
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.16
    Marker Score: 1,556
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.16
    Marker Score: 1,109
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.14
    Marker Score: 433
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.12
    Marker Score: 750
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.11
    Marker Score: 1,102
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.08
    Marker Score: 663
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.06
    Marker Score: 358
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.05
    Marker Score: 254
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.05
    Marker Score: 1,666
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,733
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.04
    Marker Score: 1,337
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.03
    Marker Score: 1,457
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.02
    Marker Score: 4,025
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.02
    Marker Score: 1,073
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.02
    Marker Score: 536
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1
    Marker Score: 322
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,752
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,976
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.99
    Marker Score: 1,009
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 307
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.97
    Marker Score: 2,282
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.97
    Marker Score: 242
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.95
    Marker Score: 1,005
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.94
    Marker Score: 4,938
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.93
    Marker Score: 5,579
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,294
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.92
    Marker Score: 347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.9
    Marker Score: 638
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.89
    Marker Score: 4,248
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.88
    Marker Score: 48,981
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.85
    Marker Score: 711
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.85
    Marker Score: 315
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 506
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.84
    Marker Score: 243
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.83
    Marker Score: 6,209
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.83
    Marker Score: 450
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 392
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.82
    Marker Score: 449
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.78
    Marker Score: 3,376
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.78
    Marker Score: 194
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.77
    Marker Score: 737
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.77
    Marker Score: 423
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.75
    Marker Score: 15,969
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 491
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.74
    Marker Score: 756
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.74
    Marker Score: 3,029
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.74
    Marker Score: 188
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.73
    Marker Score: 362
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.72
    Marker Score: 9,560
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.72
    Marker Score: 580
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.72
    Marker Score: 1,064
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 663
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,012
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.71
    Marker Score: 563
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.71
    Marker Score: 768
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.71
    Marker Score: 4,557
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.71
    Marker Score: 1,614
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7
    Marker Score: 447
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.69
    Marker Score: 652
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.69
    Marker Score: 1,435
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.69
    Marker Score: 11,032
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.68
    Marker Score: 751
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.67
    Marker Score: 2,811

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IMPA2 is a monomeric enzyme that exhibits 4-phosphatase activity, specifically catalyzing the dephosphorylation of inositol monophosphates to inositol-1-phosphate. This enzyme is part of the inositol monophosphate pathway, which is a critical regulator of inositol signaling. IMPA2 is also characterized by its ability to interact with other proteins, including metal ions and other phosphatases, to modulate its activity and binding capabilities. **Pathways and Functions** IMPA2 is involved in several key pathways, including: 1. **Inositol biosynthetic process**: IMPA2 plays a crucial role in the biosynthesis of inositol, a key component of phospholipids and signaling molecules. 2. **Inositol metabolic process**: IMPA2 is involved in the regulation of inositol metabolism, including the conversion of inositol monophosphates to inositol-1-phosphate. 3. **Inositol monophosphate 1-phosphatase activity**: IMPA2 exhibits 1-phosphatase activity, which is essential for the regulation of inositol signaling pathways. 4. **Inositol monophosphate 3-phosphatase activity**: IMPA2 also exhibits 3-phosphatase activity, which is involved in the regulation of inositol signaling. 5. **Phosphate-containing compound metabolic process**: IMPA2 is involved in the regulation of phosphate-containing compounds, including inositol monophosphates. 6. **Synthesis of ip2, ip, and ins in the cytosol**: IMPA2 plays a crucial role in the synthesis of inositol-1,4,5-trisphosphate (ip3), inositol-1-phosphate (ip), and inositol (ins) in the cytosol. **Clinical Significance** IMPA2 has been implicated in various diseases, including: 1. **Renal disorders**: IMPA2 has been shown to play a crucial role in the regulation of inositol signaling in the kidney, and alterations in IMPA2 expression have been implicated in renal disorders, such as kidney failure and hypertension. 2. **Cancer**: IMPA2 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been implicated in cancer progression and metastasis. 3. **Neurological disorders**: IMPA2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, and has been shown to play a role in the regulation of inositol signaling pathways. In conclusion, IMPA2 is a critical enzyme involved in the regulation of inositol signaling pathways, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of IMPA2 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 1896091380

Symbol: IMPA2_HUMAN

Name: Inositol monophosphatase 2

UniProtKB Accession Codes:

O14732 B0YJ29 Q9UJT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9322233

Title: A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.

PubMed ID: 9322233

DOI: 10.1038/sj.mp.4000325

PubMed ID: 10822345

Title: A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.

PubMed ID: 10822345

DOI: 10.1038/sj.mp.4000681

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15504365

Title: Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter.

PubMed ID: 15504365

DOI: 10.1016/j.bbrc.2004.09.199

PubMed ID: 17068342

Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.

PubMed ID: 17068342

DOI: 10.1074/jbc.m604474200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17340635

Title: Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.

PubMed ID: 17340635

DOI: 10.1002/prot.21299

Sequence Information:

  • Length: 288
  • Mass: 31321
  • Checksum: 30D83FA339AC69B4
  • Sequence:
    • MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL 
VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI 
GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP 
ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR 
EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.