Details for: ING2

Gene ID: 3622

Symbol: ING2

Ensembl ID: ENSG00000168556

Description: inhibitor of growth family member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.94
    Marker Score: 4766
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.48
    Marker Score: 5490
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.22
    Marker Score: 875
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.15
    Marker Score: 2183.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.12
    Marker Score: 1209
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.11
    Marker Score: 753
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1
    Marker Score: 11067
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.09
    Marker Score: 6477
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16763
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Marker Score: 1576
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.03
    Marker Score: 6714
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.03
    Marker Score: 35688
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71709
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47933
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.96
    Marker Score: 304
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.95
    Marker Score: 1003
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.95
    Marker Score: 8222
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.94
    Marker Score: 995
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.94
    Marker Score: 1346
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.92
    Marker Score: 1154
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.92
    Marker Score: 2091.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.91
    Marker Score: 4370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5161
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 208
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.89
    Marker Score: 1364
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.88
    Marker Score: 1067
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.88
    Marker Score: 734
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.87
    Marker Score: 2054
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.87
    Marker Score: 275
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.87
    Marker Score: 272
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5235
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 278
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.86
    Marker Score: 248
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.86
    Marker Score: 807
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.85
    Marker Score: 1357
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.85
    Marker Score: 1616
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1662
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.79
    Marker Score: 1612
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.79
    Marker Score: 20241.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 474
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.78
    Marker Score: 627
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.78
    Marker Score: 369
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.78
    Marker Score: 529
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.77
    Marker Score: 812
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.77
    Marker Score: 382
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.75
    Marker Score: 4890
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.74
    Marker Score: 6399.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.73
    Marker Score: 404
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 461
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 539
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.71
    Marker Score: 2775
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.7
    Marker Score: 211
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.7
    Marker Score: 1892
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.68
    Marker Score: 284
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.67
    Marker Score: 2743
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.67
    Marker Score: 1408
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.66
    Marker Score: 801
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 438
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2777.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 603
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.65
    Marker Score: 1548
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.65
    Marker Score: 861
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.65
    Marker Score: 1757
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.64
    Marker Score: 332
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.64
    Marker Score: 4992
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.64
    Marker Score: 1999
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.62
    Marker Score: 305.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.62
    Marker Score: 796
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 294
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.61
    Marker Score: 1389
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.61
    Marker Score: 256
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.61
    Marker Score: 20692
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.61
    Marker Score: 606
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.61
    Marker Score: 1074
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6
    Marker Score: 539.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.6
    Marker Score: 346
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.6
    Marker Score: 274
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 599
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.59
    Marker Score: 1187
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.59
    Marker Score: 273
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.59
    Marker Score: 401
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.58
    Marker Score: 154
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.58
    Marker Score: 545
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.58
    Marker Score: 816
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 636
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.58
    Marker Score: 615
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.57
    Marker Score: 3479

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Other Information

## Summary ING2 is a protein that acts as an inhibitor of growth factor receptor 2 (IGF-R2). It is a key regulator of cell growth, proliferation, and differentiation. ING2 is expressed in a variety of cell types, including epithelial cells, thymic cells, cardiac cells, and cancer cells. ## Key characteristics * ING2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a serine/threonine kinase inhibitor. * It is expressed in high levels in many human tumors. * It is involved in the regulation of cell growth, proliferation, and differentiation. ## Pathways and functions ING2 is involved in a variety of cellular pathways, including: * **Chromatin binding:** ING2 can bind to DNA and regulate gene expression through the recruitment of coactivators and the inhibition of transcription factors. * **Dna binding:** ING2 can bind to DNA and regulate gene expression through the recruitment of coactivators and the inhibition of transcription factors. * **Gene expression (transcription):** ING2 can regulate gene expression by binding to DNA and promoting the transcription of target genes. * **Generic transcription pathway:** ING2 can also regulate gene expression by binding to DNA and promoting the transcription of target genes through the activation of the generic transcription pathway. * **Histone deacetylase regulator activity:** ING2 can inhibit the activity of histone deacetylases, which are enzymes that remove acetyl groups from histones. This can lead to the acetylation of histones and the activation of transcription factors, which can promote gene expression. * **Metabolic of proteins:** ING2 can also regulate the metabolism of proteins. It can bind to the protein kinase Akt and inhibit its activity, which can lead to the activation of protein kinases that are involved in cell growth and proliferation. * **Methylated histone binding:** ING2 can also bind to methylated histone proteins and prevent them from interacting with transcription factors, which can lead to the inhibition of gene expression. * **Phosphatidylinositol binding:** ING2 can bind to phosphatidylinositol 3-kinase (PI3K), a kinase that is involved in cell growth and proliferation. This binding can inhibit the activity of PI3K, which can lead to the inhibition of cell growth and proliferation. * **Pi5p regulates tp53 acetylation:** ING2 can also regulate the acetylation of p53, a tumor suppressor protein that is involved in cell growth and proliferation. ## Clinical significance ING2 is a promising target for cancer therapy. It is often overexpressed in cancer cells, and its inhibition can lead to cell death. Clinical trials of ING2 inhibitors are currently underway in an effort to develop new cancer drugs.

Genular Protein ID: 791069594

Symbol: ING2_HUMAN

Name: Inhibitor of growth protein 2

UniProtKB Accession Codes:

Q9H160 B6ZDS1 O95698

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10072587

Title: Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor.

PubMed ID: 10072587

DOI: 10.1159/000015188

PubMed ID: 11481424

Title: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

PubMed ID: 11481424

DOI: 10.1073/pnas.161151798

PubMed ID: 18951897

Title: A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.

PubMed ID: 18951897

DOI: 10.1016/j.febslet.2008.10.024

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11784859

Title: Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

PubMed ID: 11784859

DOI: 10.1128/mcb.22.3.835-848.2002

PubMed ID: 12859901

Title: The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.

PubMed ID: 12859901

DOI: 10.1016/s0092-8674(03)00480-x

PubMed ID: 16893883

Title: The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding.

PubMed ID: 16893883

DOI: 10.1074/jbc.m605624200

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 16728974

Title: ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

PubMed ID: 16728974

DOI: 10.1038/nature04835

PubMed ID: 20676127

Title: Sumoylation of ING2 regulates the transcription mediated by Sin3A.

PubMed ID: 20676127

DOI: 10.1038/onc.2010.325

Sequence Information:

  • Length: 280
  • Mass: 32808
  • Checksum: DC85A6ECAF7A5D81
  • Sequence:
    • MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 
HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE 
KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF 
SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

Genular Protein ID: 510926874

Symbol: B2RA15_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RA15

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 DNASU 1 EMBL 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 280
  • Mass: 32736
  • Checksum: DE87A6EEAD7A5D81
  • Sequence:
    • MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 
HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE 
KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGGMIGCDN EQCPIEWFHF 
SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.