Details for: ING2

Gene ID: 3622

Symbol: ING2

Ensembl ID: ENSG00000168556

Description: inhibitor of growth family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.3216
    Cell Significance Index: -17.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.8151
    Cell Significance Index: -19.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.6946
    Cell Significance Index: -18.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.6443
    Cell Significance Index: -22.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4453
    Cell Significance Index: -19.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1758
    Cell Significance Index: -22.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6674
    Cell Significance Index: -20.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9097
    Cell Significance Index: -23.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8511
    Cell Significance Index: -14.9000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.2451
    Cell Significance Index: 24.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5179
    Cell Significance Index: 174.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5803
    Cell Significance Index: 94.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3978
    Cell Significance Index: 37.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2432
    Cell Significance Index: 32.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1317
    Cell Significance Index: 123.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1170
    Cell Significance Index: 1008.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0222
    Cell Significance Index: 53.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9963
    Cell Significance Index: 28.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7850
    Cell Significance Index: 127.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7781
    Cell Significance Index: 35.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6891
    Cell Significance Index: 304.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6468
    Cell Significance Index: 79.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6230
    Cell Significance Index: 340.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5559
    Cell Significance Index: 15.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5286
    Cell Significance Index: 6.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5240
    Cell Significance Index: 24.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5073
    Cell Significance Index: 91.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5006
    Cell Significance Index: 10.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4546
    Cell Significance Index: 62.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4452
    Cell Significance Index: 15.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4329
    Cell Significance Index: 30.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3338
    Cell Significance Index: 56.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2876
    Cell Significance Index: 6.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2716
    Cell Significance Index: 17.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2651
    Cell Significance Index: 53.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2378
    Cell Significance Index: 6.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2074
    Cell Significance Index: 1.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1991
    Cell Significance Index: 1.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1966
    Cell Significance Index: 37.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1920
    Cell Significance Index: 10.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1790
    Cell Significance Index: 11.2800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1625
    Cell Significance Index: 2.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1554
    Cell Significance Index: 15.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1415
    Cell Significance Index: 18.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1329
    Cell Significance Index: 6.9200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1255
    Cell Significance Index: 0.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1219
    Cell Significance Index: 5.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1213
    Cell Significance Index: 3.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1206
    Cell Significance Index: 1.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1199
    Cell Significance Index: 14.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0991
    Cell Significance Index: 19.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0963
    Cell Significance Index: 12.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0734
    Cell Significance Index: 2.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0484
    Cell Significance Index: 1.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0479
    Cell Significance Index: 0.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0400
    Cell Significance Index: 29.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0270
    Cell Significance Index: 0.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0269
    Cell Significance Index: 0.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0164
    Cell Significance Index: 5.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0141
    Cell Significance Index: 0.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0130
    Cell Significance Index: 0.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0128
    Cell Significance Index: 0.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0012
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0061
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0086
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0122
    Cell Significance Index: -9.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0132
    Cell Significance Index: -24.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0146
    Cell Significance Index: -22.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0192
    Cell Significance Index: -1.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0194
    Cell Significance Index: -13.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0221
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0436
    Cell Significance Index: -19.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0450
    Cell Significance Index: -9.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0513
    Cell Significance Index: -4.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0533
    Cell Significance Index: -15.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0666
    Cell Significance Index: -7.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1054
    Cell Significance Index: -12.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1063
    Cell Significance Index: -1.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1274
    Cell Significance Index: -18.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1385
    Cell Significance Index: -3.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1410
    Cell Significance Index: -1.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1658
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1889
    Cell Significance Index: -21.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1944
    Cell Significance Index: -10.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2000
    Cell Significance Index: -8.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2217
    Cell Significance Index: -23.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2220
    Cell Significance Index: -13.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2235
    Cell Significance Index: -15.0300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2358
    Cell Significance Index: -1.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2438
    Cell Significance Index: -2.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2604
    Cell Significance Index: -19.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2621
    Cell Significance Index: -9.9300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3510
    Cell Significance Index: -4.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3752
    Cell Significance Index: -6.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ING2 is a member of the inhibitor of growth family, which includes four genes (ING1, ING2, ING3, and ING4). These genes are characterized by their ability to inhibit cell growth and promote differentiation. ING2 is specifically expressed in various cell types, including epithelial cells, stem cells, and muscle cells. It is also highly expressed in certain tissues, such as the testis, where it plays a crucial role in spermatogenesis. ING2 is a transcriptional regulator that interacts with various transcription factors and chromatin-modifying enzymes to control gene expression. It has been shown to bind to specific DNA sequences and histone modifications to regulate the expression of target genes. ING2 also interacts with other proteins, including sumoylation enzymes, to regulate protein stability and function. **Pathways and Functions** ING2 is involved in several signaling pathways that control cell behavior, including: 1. **DNA Damage Response**: ING2 plays a crucial role in the DNA damage response by interacting with p53, a tumor suppressor protein. ING2 inhibits p53 activity, which can lead to cell death or senescence. 2. **Transcriptional Regulation**: ING2 regulates gene expression by interacting with transcription factors and chromatin-modifying enzymes. It has been shown to bind to specific DNA sequences and histone modifications to control the expression of target genes. 3. **Apoptosis**: ING2 has been implicated in the regulation of apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins. 4. **Cell Cycle Regulation**: ING2 regulates cell cycle progression by interacting with cyclin-dependent kinases and other cell cycle regulators. 5. **Stem Cell Maintenance**: ING2 plays a crucial role in maintaining stem cell populations by regulating their self-renewal and differentiation. **Clinical Significance** Dysregulation of the ING2 gene has been associated with various diseases, including: 1. **Cancer**: ING2 is frequently mutated or deleted in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular Disorders**: ING2 has been implicated in the regulation of cardiovascular function and has been associated with cardiovascular diseases, including heart failure and atherosclerosis. 3. **Neurological Disorders**: ING2 has been implicated in the regulation of neuronal function and has been associated with neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Reproductive Disorders**: ING2 plays a crucial role in spermatogenesis and has been implicated in the regulation of reproductive function. In conclusion, the ING2 gene is a critical regulator of cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been associated with various diseases, including cancer, cardiovascular disorders, and neurological disorders. Further research is needed to fully understand the role of ING2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 791069594

Symbol: ING2_HUMAN

Name: Inhibitor of growth protein 2

UniProtKB Accession Codes:

Q9H160 B6ZDS1 O95698

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10072587

Title: Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor.

PubMed ID: 10072587

DOI: 10.1159/000015188

PubMed ID: 11481424

Title: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

PubMed ID: 11481424

DOI: 10.1073/pnas.161151798

PubMed ID: 18951897

Title: A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.

PubMed ID: 18951897

DOI: 10.1016/j.febslet.2008.10.024

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11784859

Title: Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

PubMed ID: 11784859

DOI: 10.1128/mcb.22.3.835-848.2002

PubMed ID: 12859901

Title: The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.

PubMed ID: 12859901

DOI: 10.1016/s0092-8674(03)00480-x

PubMed ID: 16893883

Title: The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding.

PubMed ID: 16893883

DOI: 10.1074/jbc.m605624200

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 16728974

Title: ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

PubMed ID: 16728974

DOI: 10.1038/nature04835

PubMed ID: 20676127

Title: Sumoylation of ING2 regulates the transcription mediated by Sin3A.

PubMed ID: 20676127

DOI: 10.1038/onc.2010.325

Sequence Information:

  • Length: 280
  • Mass: 32808
  • Checksum: DC85A6ECAF7A5D81
  • Sequence:
    • MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 
HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE 
KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF 
SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

Genular Protein ID: 510926874

Symbol: B2RA15_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RA15

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 280
  • Mass: 32736
  • Checksum: DE87A6EEAD7A5D81
  • Sequence:
    • MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 
HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE 
KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGGMIGCDN EQCPIEWFHF 
SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.