Details for: INPP5B

Gene ID: 3633

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: INPP5B

Ensembl ID: ENSG00000204084

Description: inositol polyphosphate-5-phosphatase B

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • erythroblast CL0000765
    CSI 15.29
    rCSI 40.58%
    PRS 76.73
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 12.38
    rCSI 14.95%
    PRS 75.37
  • sst GABAergic cortical interneuron CL4023017
    CSI 10.83
    rCSI 13.96%
    PRS 49.13
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 8.76
    rCSI 7.98%
    PRS 80.68
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 6.62
    rCSI 16.09%
    PRS 46.29
  • mesothelial cell CL0000077
    CSI 6.28
    rCSI 24.54%
    PRS 43.31
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 6.05
    rCSI 21.78%
    PRS 46.1
  • intestinal tuft cell CL0019032
    CSI 5.93
    rCSI 9.06%
    PRS 70.63
  • stromal cell CL0000499
    CSI 5.82
    rCSI 16.36%
    PRS 62.96
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 5.54
    rCSI 9.29%
    PRS 47.89
  • group 3 innate lymphoid cell CL0001071
    CSI 4.64
    rCSI 3.48%
    PRS 72.37
  • choroid plexus epithelial cell CL0000706
    CSI 4.61
    rCSI 7.56%
    PRS 55.55
  • vascular leptomeningeal cell CL4023051
    CSI 4.5
    rCSI 7.88%
    PRS 58.76
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.46
    rCSI 7.88%
    PRS 46.95
  • mononuclear phagocyte CL0000113
    CSI 4.37
    rCSI 9.62%
    PRS 70.5
  • retina horizontal cell CL0000745
    CSI 4.29
    rCSI 6.54%
    PRS 62.95
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 4.17
    rCSI 24.55%
    PRS 49.02
  • alveolar macrophage CL0000583
    CSI 4.15
    rCSI 6.84%
    PRS 71.74
  • cardiac endothelial cell CL0010008
    CSI 4.07
    rCSI 16.43%
    PRS 65.54
  • cerebral cortex endothelial cell CL1001602
    CSI 3.79
    rCSI 6.56%
    PRS 56.8
  • ependymal cell CL0000065
    CSI 3.75
    rCSI 7.61%
    PRS 45.16
  • hepatic stellate cell CL0000632
    CSI 3.73
    rCSI 13.97%
    PRS 58.35
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.53
    rCSI 4.39%
    PRS 45.96
  • inhibitory interneuron CL0000498
    CSI 3.39
    rCSI 7.82%
    PRS 54.93
  • chondrocyte CL0000138
    CSI 3.38
    rCSI 5.38%
    PRS 59.13
  • melanocyte CL0000148
    CSI 3.38
    rCSI 2.5%
    PRS 59.26
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 3.35
    rCSI 7.63%
    PRS 62.25
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.21
    rCSI 8.29%
    PRS 61.43
  • L6b glutamatergic cortical neuron CL4023038
    CSI 3.04
    rCSI 9.5%
    PRS 49.56
  • renal beta-intercalated cell CL0002201
    CSI 3.03
    rCSI 7.23%
    PRS 66.89
  • lung neuroendocrine cell CL1000223
    CSI 3.03
    rCSI 4.49%
    PRS 71.72
  • Mueller cell CL0000636
    CSI 2.93
    rCSI 6.68%
    PRS 58.09
  • retinal bipolar neuron CL0000748
    CSI 2.74
    rCSI 5.14%
    PRS 54.53
  • retinal ganglion cell CL0000740
    CSI 2.72
    rCSI 6.01%
    PRS 52.46
  • naive B cell CL0000788
    CSI 2.69
    rCSI 2.31%
    PRS 74.41
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.68
    rCSI 6.97%
    PRS 66.29
  • periportal region hepatocyte CL0019026
    CSI 2.67
    rCSI 10.39%
    PRS 69.74
  • pancreatic D cell CL0000173
    CSI 2.63
    rCSI 2.58%
    PRS 69.23
  • lung interstitial macrophage CL4033043
    CSI 2.62
    rCSI 5.88%
    PRS 82.52
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.58
    rCSI 3.65%
    PRS 62.82
  • sncg GABAergic cortical interneuron CL4023015
    CSI 2.56
    rCSI 4.11%
    PRS 49.85
  • Kupffer cell CL0000091
    CSI 2.47
    rCSI 5.65%
    PRS 66.66
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.37
    rCSI 1.65%
    PRS 69.51
  • interneuron CL0000099
    CSI 2.35
    rCSI 4.72%
    PRS 55.6
  • fibroblast of lung CL0002553
    CSI 2.31
    rCSI 2.15%
    PRS 67.23
  • fibroblast of cardiac tissue CL0002548
    CSI 2.28
    rCSI 10.9%
    PRS 66.44
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.26
    rCSI 5.07%
    PRS 48.5
  • cardiac neuron CL0010022
    CSI 2.17
    rCSI 6.93%
    PRS 63.6
  • contractile cell CL0000183
    CSI 2.16
    rCSI 6.37%
    PRS 65.01
  • pulmonary alveolar type 1 cell CL0002062
    CSI 2.12
    rCSI 12.25%
    PRS 64.5
  • cerebellar granule cell CL0001031
    CSI 2.12
    rCSI 3.11%
    PRS 59.64
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.11
    rCSI 2.51%
    PRS 47.66
  • adipocyte CL0000136
    CSI 2.09
    rCSI 2.68%
    PRS 58.48
  • common lymphoid progenitor CL0000051
    CSI 2.02
    rCSI 2.7%
    PRS 85.57
  • parietal epithelial cell CL1000452
    CSI 2.01
    rCSI 5.37%
    PRS 57.26
  • hepatocyte CL0000182
    CSI 1.99
    rCSI 3.56%
    PRS 65.91
  • blood vessel endothelial cell CL0000071
    CSI 1.98
    rCSI 4.11%
    PRS 63.5
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.91
    rCSI 1.73%
    PRS 63.66
  • ON midget ganglion cell CL4033046
    CSI 1.83
    rCSI 37.21%
    PRS 56.91
  • cardiac muscle cell CL0000746
    CSI 1.76
    rCSI 2.53%
    PRS 56.06
  • suprabasal keratinocyte CL4033013
    CSI 1.74
    rCSI 2.83%
    PRS 34.91
  • pulmonary alveolar type 2 cell CL0002063
    CSI 1.68
    rCSI 2.61%
    PRS 73.15
  • lung pericyte CL0009089
    CSI 1.67
    rCSI 4.41%
    PRS 75.09
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.64
    rCSI 6.19%
    PRS 48.47
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.62
    rCSI 2.94%
    PRS 57.92
  • alveolar adventitial fibroblast CL4028006
    CSI 1.62
    rCSI 2.55%
    PRS 69.05
  • epithelial cell of proximal tubule CL0002306
    CSI 1.6
    rCSI 3.9%
    PRS 59.43
  • renal principal cell CL0005009
    CSI 1.55
    rCSI 4.03%
    PRS 69.49
  • lung secretory cell CL1000272
    CSI 1.43
    rCSI 3.53%
    PRS 65.08
  • OFF midget ganglion cell CL4033047
    CSI 1.42
    rCSI 28.9%
    PRS 58.39
  • renal interstitial pericyte CL1001318
    CSI 1.41
    rCSI 3.89%
    PRS 61.64
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.38
    rCSI 4.33%
    PRS 52.02
  • basal cell of epidermis CL0002187
    CSI 1.38
    rCSI 2.45%
    PRS 38.89
  • regular atrial cardiac myocyte CL0002129
    CSI 1.27
    rCSI 4.09%
    PRS 64.2
  • tuft cell of colon CL0009041
    CSI 1.24
    rCSI 2.88%
    PRS 76.32
  • blood vessel smooth muscle cell CL0019018
    CSI 1.18
    rCSI 9.61%
    PRS 59.88
  • ON parasol ganglion cell CL4033052
    CSI 1.13
    rCSI 15.99%
    PRS 57.37
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.05
    rCSI 1.27%
    PRS 51.62
  • dopaminergic neuron CL0000700
    CSI 1.01
    rCSI 5.68%
    PRS 51.57
  • melanocyte of skin CL1000458
    CSI 1
    rCSI 1.37%
    PRS 35.71
  • lung ciliated cell CL1000271
    CSI 1
    rCSI 1.16%
    PRS 57.06
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.96
    rCSI 2.45%
    PRS 55.96
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 0.93
    rCSI 2.23%
    PRS 53.56
  • extravillous trophoblast CL0008036
    CSI 0.89
    rCSI 1.1%
    PRS 63.36
  • helper T cell CL0000912
    CSI 0.87
    rCSI 1.23%
    PRS 70.1
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.86
    rCSI 2.83%
    PRS 53.19
  • GABAergic amacrine cell CL4030027
    CSI 0.81
    rCSI 2.76%
    PRS 54.85
  • glial cell CL0000125
    CSI 0.75
    rCSI 2.86%
    PRS 57.11
  • amacrine cell CL0000561
    CSI 0.71
    rCSI 2.06%
    PRS 56
  • central nervous system neuron CL2000029
    CSI 0.65
    rCSI 4.79%
    PRS 53.03
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.37
    rCSI 2.33%
    PRS 58.17
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.34
    rCSI 3.6%
    PRS 64.3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Analyzed for its expression specificity (CSI Z-Score), [INPP5B](/details-gene/3633) is characterized by a broad and ubiquitous expression pattern rather than serving as a defining marker for any specific cell type. The data consistently show a lack of statistical significance for cell-type specificity (CSI Z-Score: 0.00, p-values > 0.19) across diverse cell lineages. This expression profile is consistent with its fundamental role as an inositol polyphosphate-5-phosphatase, an enzyme central to the universally important '[Inositol phosphate metabolism](/details-pathway/R-HSA-1483249)' pathway, suggesting a housekeeping or foundational function in cellular signaling and maintenance. ## Cellular Roles and Expression Landscape The expression profile of [INPP5B](/details-gene/3633) is notable for its lack of cell-type specificity. In the **Overall** context, analysis based on the CSI (Z-SCORE) reveals that the gene is not a statistically significant specific marker for any of the top-ranked cell types. This includes cells from hematopoietic, neural, and epithelial lineages, such as [erythroblast](/details-cell/CL0000765) (p-value: 0.192), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (p-value: 0.409), [mesothelial cell](/details-cell/CL0000077) (p-value: 0.388), and [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (p-value: 0.506). In all these cases, the CSI (Z-SCORE) is 0.00, indicating that the expression level of [INPP5B](/details-gene/3633) does not significantly deviate from the average across different cell types. This suggests that its function is not confined to a specialized cellular identity but is rather a component of the basic machinery of many cells. This interpretation is supported by its consistent expression across a wide array of cell types, from [choroid plexus epithelial cell](/details-cell/CL0000706) to [mononuclear phagocyte](/details-cell/CL0000113). The gene's broad expression pattern points towards a role in fundamental cellular processes rather than in defining a unique cellular phenotype. ## Pathways and Molecular Function The ubiquitous expression of [INPP5B](/details-gene/3633) is strongly supported by its established molecular function. It encodes a Type II inositol 1,4,5-trisphosphate 5-phosphatase, a key enzyme in phosphoinositide signaling. Its functional annotations are dominated by its role in '[Inositol phosphate metabolism](/details-pathway/R-HSA-1483249)' ([GO:0043647](https://www.ebi.ac.uk/QuickGO/term/GO:0043647)), a pathway crucial for second messenger signaling, membrane trafficking, and cytoskeletal regulation in virtually all eukaryotic cells. Specifically, it exhibits '[inositol-1,4,5-trisphosphate 5-phosphatase activity](/details-ontology/GO:0052658)' and '[phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity](/details-ontology/GO:0004439)', which are critical for terminating signals mediated by IP3 and PIP2. The gene product is localized to multiple fundamental cellular compartments, including the '[cytoplasm](/details-ontology/GO:0005737)', '[Golgi apparatus](/details-ontology/GO:0005794)', and '[plasma membrane](/details-ontology/GO:0005886)'. Research indicates it is specifically targeted to the early secretory pathway (PubMed: [17956944](https://pubmed.ncbi.nlm.nih.gov/17956944)), linking it to protein processing and membrane logistics. Its involvement in processes such as '[in utero embryonic development](/details-ontology/GO:0001701)' and '[spermatogenesis](/details-ontology/GO:0007283)' further highlights its importance in complex, multi-cellular functions that rely on basic cellular integrity and signaling. ## Research Directions The observed lack of cell-type specific expression under basal conditions suggests that [INPP5B](/details-gene/3633) likely functions as a housekeeping gene. However, this broad expression pattern does not preclude a more dynamic or context-dependent role in disease. Future research should focus on whether its expression or activity becomes cell-type specific under pathological conditions, such as metabolic stress, neuroinflammation, or cancer, where phosphoinositide signaling is frequently dysregulated. ### Testable Hypotheses 1. **Context-Dependent Specificity:** The ubiquitous expression of [INPP5B](/details-gene/3633) at the transcript level masks a cell-type-specific functional requirement that only becomes apparent under cellular stress. It is hypothesized that upon specific stimuli (e.g., growth factor signaling or osmotic stress), certain cell types will exhibit a greater dependency on [INPP5B](/details-gene/3633) activity for survival or function compared to others. * **Experimental Approach:** Utilize a panel of cell lines (e.g., neuronal, immune, epithelial) and employ CRISPR-based interference (CRISPRi) to inducibly knock down [INPP5B](/details-gene/3633). Treat these cells with various stressors and assess cell-type-specific vulnerabilities through viability assays and functional readouts (e.g., calcium signaling, membrane trafficking). 2. **Functional Redundancy and Compensation:** The lack of a strong specificity signal for [INPP5B](/details-gene/3633) may be due to functional redundancy with other inositol 5-phosphatases (e.g., OCRL1, INPP5E). We hypothesize that in specific cell types, other family members are the dominant regulators of the PI(4,5)P2 pool, while [INPP5B](/details-gene/3633) plays a secondary or compensatory role. * **Experimental Approach:** Perform systematic single-cell RNA sequencing combined with targeted knockout or knockdown of different 5-phosphatase family members in a complex tissue model, such as organoids or primary co-cultures. Analyze the transcriptomic and phosphoinositide profiles to determine how the loss of [INPP5B](/details-gene/3633) is compensated for in different cell populations. 3. **Regulation via Subcellular Localization:** The functional specificity of [INPP5B](/details-gene/3633) is not primarily regulated at the transcriptional level but through post-translational modifications that dictate its dynamic relocalization to specific subcellular compartments in response to cellular signals. * **Experimental Approach:** Engineer cell lines to express a fluorescently-tagged [INPP5B](/details-gene/3633) (e.g., mEGFP-INPP5B). Using high-resolution live-cell imaging and total internal reflection fluorescence (TIRF) microscopy, track the protein's movement between compartments like the Golgi, plasma membrane, and endosomes in different cell types following stimulation with relevant agonists (e.g., growth factors, neurotransmitters). ### Therapeutic Potential Given its ubiquitous expression, systemically targeting [INPP5B](/details-gene/3633) presents a significant challenge due to the high risk of on-target, off-tissue toxicity. Therapeutic strategies would likely require highly targeted delivery systems (e.g., antibody-drug conjugates or lipid nanoparticles) directed to a specific cell type where [INPP5B](/details-gene/3633) dysregulation is a key driver of disease. Its known interaction with OCRL1 (the protein deficient in Lowe syndrome, OMIM: [147264](https://omim.org/entry/147264)) suggests that modulating [INPP5B](/details-gene/3633) could have therapeutic potential in disorders of endocytic trafficking and renal function, but a deeper understanding of its cell-specific roles is a prerequisite.

Genular Protein ID: 1950503692

Symbol: I5P2_HUMAN

Name: Type II inositol 1,4,5-trisphosphate 5-phosphatase

UniProtKB Accession Codes:

P32019 C9J6U5 Q5VSG9 Q5VSH0 Q5VSH1 Q658Q5 Q6P6D4 Q6PD53 Q86YE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7721860

Title: Properties of type II inositol polyphosphate 5-phosphatase.

PubMed ID: 7721860

DOI: 10.1074/jbc.270.16.9370

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 1718960

Title: Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.

PubMed ID: 1718960

DOI: 10.1016/s0021-9258(18)54920-6

PubMed ID: 17956944

Title: Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway.

PubMed ID: 17956944

DOI: 10.1242/jcs.014423

PubMed ID: 20133602

Title: Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.

PubMed ID: 20133602

DOI: 10.1073/pnas.0914658107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21233288

Title: The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.

PubMed ID: 21233288

DOI: 10.1091/mbc.e10-08-0730

PubMed ID: 25869668

Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

PubMed ID: 25869668

DOI: 10.1083/jcb.201409064

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

Sequence Information:

  • Length: 993
  • Mass: 112852
  • Checksum: ABD3581CC6CD29D6
  • Sequence:
    • MDQSVAIQET LAEGEYCVIA VQGVLCEGDS RQSRLLGLVR YRLEHGGQEH ALFLYTHRRM 
AITGDDVSLD QIVPVSRDFT LEEVSPDGEL YILGSDVTVQ LDTAELSLVF QLPFGSQTRM 
FLHEVARACP GFDSATRDPE FLWLSRYRCA ELELEMPTPR GCNSALVTWP GYATIGGGRY 
PSRKKRWGLE EARPQGAGSV LFWGGAMEKT GFRLMERAHG GGFVWGRSAR DGRRDEELEE 
AGREMSAAAG SRERNTAGGS NFDGLRPNGK GVPMDQSSRG QDKPESLQPR QNKSKSEITD 
MVRSSTITVS DKAHILSMQK FGLRDTIVKS HLLQKEEDYT YIQNFRFFAG TYNVNGQSPK 
ECLRLWLSNG IQAPDVYCVG FQELDLSKEA FFFHDTPKEE EWFKAVSEGL HPDAKYAKVK 
LIRLVGIMLL LYVKQEHAAY ISEVEAETVG TGIMGRMGNK GGVAIRFQFH NTSICVVNSH 
LAAHIEEYER RNQDYKDICS RMQFCQPDPS LPPLTISNHD VILWLGDLNY RIEELDVEKV 
KKLIEEKDFQ MLYAYDQLKI QVAAKTVFEG FTEGELTFQP TYKYDTGSDD WDTSEKCRAP 
AWCDRILWKG KNITQLSYQS HMALKTSDHK PVSSVFDIGV RVVNDELYRK TLEEIVRSLD 
KMENANIPSV SLSKREFCFQ NVKYMQLKVE SFTIHNGQVP CHFEFINKPD EESYCKQWLN 
ANPSRGFLLP DSDVEIDLEL FVNKMTATKL NSGEDKIEDI LVLHLDRGKD YFLSVSGNYL 
PSCFGSPIHT LCYMREPILD LPLETISELT LMPVWTGDDG SQLDSPMEIP KELWMMVDYL 
YRNAVQQEDL FQQPGLRSEF EHIRDCLDTG MIDNLSASNH SVAEALLLFL ESLPEPVICY 
STYHNCLECS GNYTASKQVI STLPIFHKNV FHYLMAFLRE LLKNSAKNHL DENILASIFG 
SLLLRNPAGH QKLDMTEKKK AQEFIHQFLC NPL

Genular Protein ID: 667642376

Symbol: B3KMW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMW4

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 749
  • Mass: 85642
  • Checksum: 083F0027A2664F7D
  • Sequence:
    • MSAAASSRER NTAGGSNFDG LRPNGKGVPM DQSSRGQDKP ESLQPRQNKS KSEITDMVRS 
STITVSDKAH ILSMQKFGLR DTIVKSHLLQ KEEDYTYIQN FRFFAGTYNV NGQSPKECLR 
LWLSNGIQAP DVYCVGFQEL DLSKEAFFFH DTPKEEEWFK AVSEGLHPDA KYAKVKLIRL 
VGIMLLLYVK QEHAAYISEV EAETVGTGIM GRMGNKGGVA IRFQFHNTSI CVVNSHLAAH 
IEEYERRNQD YKDICSRMQF CQPDPSLPPL TISNHDVILW LGDLNYRIEE LDVEKVKKLI 
EEKDFQMLYA YDQLKIQVAA KTVFEGFTEG ELTFQPTYKY DTGSDDWDTS EKCRAPAWCD 
RILWKGKNIT QLSYQSHMAL KTSDHKPVSS VFDIGVRVVN DELYRKTLEE IVRSLDKMEN 
ANIPSVSLSK REFCFQNVKY MQLKVESFTI HNGQVPCHFE FINKPDEESY CKQWLNANPS 
RGFLLPDSDV EIDLELFVNK TTATKLNSGE DKIEDILVLH LDRGKDYFLS VSGNYLPSCF 
GSPIHTLCYM REPILDLPLE TISELTLMPV WTGDDGSQLD SPMEIPKELW MMVDYLYRNA 
VQQEDLFQQP GLRSEFEHIR DCLDTGMIDN LSASNHSVAE ALLLFLESLP EPVICYSTYH 
NCLECSGNYT ASKQVISTLP IFHKNVFHYL MAFLRELLKN SAKNHLHENI LASIFGSLLL 
RNPAGHQKLD MTEKKKAQEF IHQFLCNPL