Details for: INPP5B

Gene ID: 3633

Symbol: INPP5B

Ensembl ID: ENSG00000204084

Description: inositol polyphosphate-5-phosphatase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.78
    Marker Score: 3917
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.75
    Marker Score: 64644
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.71
    Marker Score: 7172
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.7
    Marker Score: 25475.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.69
    Marker Score: 103718
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.68
    Marker Score: 703
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.65
    Marker Score: 4123
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.63
    Marker Score: 34849
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6291
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.61
    Marker Score: 15263.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.59
    Marker Score: 503
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.56
    Marker Score: 16100.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.55
    Marker Score: 58772
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.54
    Marker Score: 13200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.52
    Marker Score: 11683
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.52
    Marker Score: 6312
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.5
    Marker Score: 1721
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.47
    Marker Score: 856
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.39
    Marker Score: 27738
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.39
    Marker Score: 4934
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.37
    Marker Score: 5569
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.35
    Marker Score: 368
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.26
    Marker Score: 2421
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.22
    Marker Score: 1883
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.17
    Marker Score: 684
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.13
    Marker Score: 2655
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.12
    Marker Score: 25046.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17232
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.06
    Marker Score: 561
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.02
    Marker Score: 568
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1
    Marker Score: 1344
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71746.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47971
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.99
    Marker Score: 1201
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.94
    Marker Score: 727
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.93
    Marker Score: 298
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.91
    Marker Score: 865
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.9
    Marker Score: 1125
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.88
    Marker Score: 475
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 4998
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.84
    Marker Score: 13480
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.83
    Marker Score: 7796
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.83
    Marker Score: 545
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1341
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.78
    Marker Score: 229
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.78
    Marker Score: 1359
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.77
    Marker Score: 669
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.76
    Marker Score: 422
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.76
    Marker Score: 3272
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 234
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.75
    Marker Score: 448
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3121
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.74
    Marker Score: 366
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.74
    Marker Score: 4733.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.73
    Marker Score: 13025
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.73
    Marker Score: 354
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4358
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.71
    Marker Score: 259
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.7
    Marker Score: 321
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.7
    Marker Score: 418
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.69
    Marker Score: 250
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.68
    Marker Score: 253
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.68
    Marker Score: 446
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.68
    Marker Score: 1136
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.68
    Marker Score: 2399
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.67
    Marker Score: 177
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.67
    Marker Score: 170.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 611
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.66
    Marker Score: 938
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.65
    Marker Score: 703
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.64
    Marker Score: 3459
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 400
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 287
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.6
    Marker Score: 338
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.58
    Marker Score: 1711
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.57
    Marker Score: 1639
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.57
    Marker Score: 832
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.57
    Marker Score: 602
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.56
    Marker Score: 192
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.56
    Marker Score: 678
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.54
    Marker Score: 205
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 139
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.53
    Marker Score: 525
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.52
    Marker Score: 136
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.52
    Marker Score: 195
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.52
    Marker Score: 210
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.52
    Marker Score: 2392
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.51
    Marker Score: 162

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Other Information

**Key characteristics:** * Induces the phosphorylation of IP3 and IP4 by removing the phosphate group from the 5' end of these inositol 1,4,5-trisphosphate molecules. * Regulates the activity of various signaling pathways, including the MAPK pathway, the PI3K/AKT pathway, and the mTOR pathway. * Is highly expressed in ciliary muscle cells, where it is involved in regulating the motility of these cells. * Also expressed in other cell types, including neurons, astrocytes, and endothelial cells. **Pathways and functions:** * **Endoplasmic reticulum-golgi intermediate compartment (ERGIC):** INPP5B is involved in the regulation of protein trafficking between the ER and the Golgi apparatus. It is a key regulator of the secretory pathway, ensuring that proteins are properly sorted and delivered to their correct destinations. * **Flagellated sperm motility:** INPP5B is essential for the motility of sperm cells. It is involved in the regulation of the exocytosis of sperm-specific proteins, which is crucial for the proper functioning of sperm cells. * **Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity:** INPP5B is a key enzyme in the inositol 1,3,4,5-tetrakisphosphate (IP4) signaling pathway. IP4 is a second messenger that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and migration. * **Inositol phosphate metabolism:** INPP5B is involved in the regulation of inositol phosphate metabolism. It is a key enzyme in the production of IP3 and IP4, which are crucial signaling molecules. **Clinical significance:** INPP5B gene mutations have been linked to several human diseases, including developmental disorders, neurological disorders, and metabolic diseases. Mutations in INPP5B have been shown to cause a variety of neurological symptoms, including intellectual disability, seizures, and movement disorders. These findings suggest that INPP5B is a critical gene for human health. **Additional information:** * In humans, the INPP5B gene is located on chromosome 17q21.1. * The encoded protein is a protein of approximately 130 kDa. * INPP5B is a well-characterized protein that has been extensively studied in research.

Genular Protein ID: 1950503692

Symbol: I5P2_HUMAN

Name: Type II inositol 1,4,5-trisphosphate 5-phosphatase

UniProtKB Accession Codes:

P32019 C9J6U5 Q5VSG9 Q5VSH0 Q5VSH1 Q658Q5 Q6P6D4 Q6PD53 Q86YE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7721860

Title: Properties of type II inositol polyphosphate 5-phosphatase.

PubMed ID: 7721860

DOI: 10.1074/jbc.270.16.9370

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 1718960

Title: Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.

PubMed ID: 1718960

DOI: 10.1016/s0021-9258(18)54920-6

PubMed ID: 17956944

Title: Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway.

PubMed ID: 17956944

DOI: 10.1242/jcs.014423

PubMed ID: 20133602

Title: Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.

PubMed ID: 20133602

DOI: 10.1073/pnas.0914658107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21233288

Title: The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.

PubMed ID: 21233288

DOI: 10.1091/mbc.e10-08-0730

PubMed ID: 25869668

Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

PubMed ID: 25869668

DOI: 10.1083/jcb.201409064

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

Sequence Information:

  • Length: 993
  • Mass: 112852
  • Checksum: ABD3581CC6CD29D6
  • Sequence:
    • MDQSVAIQET LAEGEYCVIA VQGVLCEGDS RQSRLLGLVR YRLEHGGQEH ALFLYTHRRM 
AITGDDVSLD QIVPVSRDFT LEEVSPDGEL YILGSDVTVQ LDTAELSLVF QLPFGSQTRM 
FLHEVARACP GFDSATRDPE FLWLSRYRCA ELELEMPTPR GCNSALVTWP GYATIGGGRY 
PSRKKRWGLE EARPQGAGSV LFWGGAMEKT GFRLMERAHG GGFVWGRSAR DGRRDEELEE 
AGREMSAAAG SRERNTAGGS NFDGLRPNGK GVPMDQSSRG QDKPESLQPR QNKSKSEITD 
MVRSSTITVS DKAHILSMQK FGLRDTIVKS HLLQKEEDYT YIQNFRFFAG TYNVNGQSPK 
ECLRLWLSNG IQAPDVYCVG FQELDLSKEA FFFHDTPKEE EWFKAVSEGL HPDAKYAKVK 
LIRLVGIMLL LYVKQEHAAY ISEVEAETVG TGIMGRMGNK GGVAIRFQFH NTSICVVNSH 
LAAHIEEYER RNQDYKDICS RMQFCQPDPS LPPLTISNHD VILWLGDLNY RIEELDVEKV 
KKLIEEKDFQ MLYAYDQLKI QVAAKTVFEG FTEGELTFQP TYKYDTGSDD WDTSEKCRAP 
AWCDRILWKG KNITQLSYQS HMALKTSDHK PVSSVFDIGV RVVNDELYRK TLEEIVRSLD 
KMENANIPSV SLSKREFCFQ NVKYMQLKVE SFTIHNGQVP CHFEFINKPD EESYCKQWLN 
ANPSRGFLLP DSDVEIDLEL FVNKMTATKL NSGEDKIEDI LVLHLDRGKD YFLSVSGNYL 
PSCFGSPIHT LCYMREPILD LPLETISELT LMPVWTGDDG SQLDSPMEIP KELWMMVDYL 
YRNAVQQEDL FQQPGLRSEF EHIRDCLDTG MIDNLSASNH SVAEALLLFL ESLPEPVICY 
STYHNCLECS GNYTASKQVI STLPIFHKNV FHYLMAFLRE LLKNSAKNHL DENILASIFG 
SLLLRNPAGH QKLDMTEKKK AQEFIHQFLC NPL

Genular Protein ID: 667642376

Symbol: B3KMW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMW4

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 3 GenomeRNAi 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 749
  • Mass: 85642
  • Checksum: 083F0027A2664F7D
  • Sequence:
    • MSAAASSRER NTAGGSNFDG LRPNGKGVPM DQSSRGQDKP ESLQPRQNKS KSEITDMVRS 
STITVSDKAH ILSMQKFGLR DTIVKSHLLQ KEEDYTYIQN FRFFAGTYNV NGQSPKECLR 
LWLSNGIQAP DVYCVGFQEL DLSKEAFFFH DTPKEEEWFK AVSEGLHPDA KYAKVKLIRL 
VGIMLLLYVK QEHAAYISEV EAETVGTGIM GRMGNKGGVA IRFQFHNTSI CVVNSHLAAH 
IEEYERRNQD YKDICSRMQF CQPDPSLPPL TISNHDVILW LGDLNYRIEE LDVEKVKKLI 
EEKDFQMLYA YDQLKIQVAA KTVFEGFTEG ELTFQPTYKY DTGSDDWDTS EKCRAPAWCD 
RILWKGKNIT QLSYQSHMAL KTSDHKPVSS VFDIGVRVVN DELYRKTLEE IVRSLDKMEN 
ANIPSVSLSK REFCFQNVKY MQLKVESFTI HNGQVPCHFE FINKPDEESY CKQWLNANPS 
RGFLLPDSDV EIDLELFVNK TTATKLNSGE DKIEDILVLH LDRGKDYFLS VSGNYLPSCF 
GSPIHTLCYM REPILDLPLE TISELTLMPV WTGDDGSQLD SPMEIPKELW MMVDYLYRNA 
VQQEDLFQQP GLRSEFEHIR DCLDTGMIDN LSASNHSVAE ALLLFLESLP EPVICYSTYH 
NCLECSGNYT ASKQVISTLP IFHKNVFHYL MAFLRELLKN SAKNHLHENI LASIFGSLLL 
RNPAGHQKLD MTEKKKAQEF IHQFLCNPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.