Details for: INPP5D

Gene ID: 3635

Symbol: INPP5D

Ensembl ID: ENSG00000168918

Description: inositol polyphosphate-5-phosphatase D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.64
    Marker Score: 1316
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.13
    Marker Score: 1556
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.07
    Marker Score: 1238
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.97
    Marker Score: 3590
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.92
    Marker Score: 1893
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.7
    Marker Score: 733
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.65
    Marker Score: 995
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.64
    Marker Score: 4875.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.62
    Marker Score: 1228
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.6
    Marker Score: 565
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.6
    Marker Score: 786.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.56
    Marker Score: 951
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.49
    Marker Score: 533
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167881
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.45
    Marker Score: 2524
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.44
    Marker Score: 80627
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.42
    Marker Score: 5503.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.4
    Marker Score: 452
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.36
    Marker Score: 4288
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.35
    Marker Score: 424
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.35
    Marker Score: 13641
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.34
    Marker Score: 1005.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.33
    Marker Score: 3743
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.32
    Marker Score: 15356
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.32
    Marker Score: 1175
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.3
    Marker Score: 468
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.3
    Marker Score: 2721
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.27
    Marker Score: 2476
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.26
    Marker Score: 3668
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.25
    Marker Score: 1172
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.25
    Marker Score: 3109.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.23
    Marker Score: 3399
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.22
    Marker Score: 12038
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.17
    Marker Score: 477
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.16
    Marker Score: 841.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.16
    Marker Score: 844
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.15
    Marker Score: 2786
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.15
    Marker Score: 379
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.14
    Marker Score: 1072
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.13
    Marker Score: 1564
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.13
    Marker Score: 351
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.12
    Marker Score: 1204
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.09
    Marker Score: 4454
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.07
    Marker Score: 255
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.07
    Marker Score: 729
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.06
    Marker Score: 1064
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 637
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.06
    Marker Score: 1067
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.03
    Marker Score: 2801
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.02
    Marker Score: 2318
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.01
    Marker Score: 505
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71688
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47911
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.98
    Marker Score: 2540
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.98
    Marker Score: 1155
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.97
    Marker Score: 820
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.97
    Marker Score: 1046.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.96
    Marker Score: 337
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.96
    Marker Score: 290
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.94
    Marker Score: 49856.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.94
    Marker Score: 598
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.93
    Marker Score: 639
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.92
    Marker Score: 865
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.91
    Marker Score: 688
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.9
    Marker Score: 228
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.89
    Marker Score: 862
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.89
    Marker Score: 1312
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.89
    Marker Score: 205
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.89
    Marker Score: 306
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.88
    Marker Score: 643
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.88
    Marker Score: 220
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.88
    Marker Score: 428
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.86
    Marker Score: 451
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.86
    Marker Score: 278
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.85
    Marker Score: 698
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.85
    Marker Score: 416
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4846
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.85
    Marker Score: 941
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.84
    Marker Score: 933
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.84
    Marker Score: 712
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.83
    Marker Score: 267
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.82
    Marker Score: 454
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.81
    Marker Score: 591
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.81
    Marker Score: 1052
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.81
    Marker Score: 771
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.81
    Marker Score: 335
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.8
    Marker Score: 395
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.79
    Marker Score: 1556
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.79
    Marker Score: 523
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.79
    Marker Score: 5047.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.79
    Marker Score: 692
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.79
    Marker Score: 272

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Other Information

**Key characteristics:** * INPP5D is a protein that is involved in the regulation of the adaptive immune system. * It is expressed in a variety of cell types, including mature microglial cells, central nervous system macrophages, cerebral cortex endothelial cells, microglial cells, IgG-negative class switched memory B cells, CD8-positive, alpha-beta cytokine secreting effector T cell, IgG memory B cell, tonsil germinal center B cell, memory B cell, and transitional stage B cell. * It is a key regulator of the adaptive immune system, as it plays a role in controlling the activation and differentiation of immune cells. **Pathways and functions:** * INPP5D is involved in the regulation of the adaptive immune system through multiple pathways, including adaptive immune system, cell surface interactions at the vascular wall, cytokine signaling in immune system, Downstream tcr signaling, Hemostasis, Immune system, Inositol phosphate metabolism, Interleukin-2 family signaling, Interleukin-3, interleukin-5 and gm-csf signaling, Interleukin receptor shc signaling, Metabolism, Metabolism of lipids, Pecam1 interactions, Phospholipid metabolism, Pi metabolism, Signaling by csf1 (m-csf) in myeloid cells, Signaling by interleukins, Synthesis of ip3 and ip4 in the cytosol, Synthesis of pips at the plasma membrane. **Clinical significance:** * Mutations in INPP5D have been linked to a number of human diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. * In one study, mutations in INPP5D were found to be associated with the development of rheumatoid arthritis in patients with a family history of the disease. * Another study found that mutations in INPP5D were associated with the development of psoriasis in patients with a family history of the disease. * These studies suggest that INPP5D is a key gene in the development of inflammatory diseases, and that targeting INPP5D could be a potential therapeutic strategy for these diseases.

Genular Protein ID: 728261054

Symbol: SHIP1_HUMAN

Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

UniProtKB Accession Codes:

Q92835 O00145 Q13544 Q13545 Q6P5A4 Q92656 Q9UE80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 ELM 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 98 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 6 RefSeq 2 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8769125

Title: Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.

PubMed ID: 8769125

DOI: 10.1006/bbrc.1996.1161

PubMed ID: 8874179

Title: Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.

PubMed ID: 8874179

PubMed ID: 8723348

Title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.

PubMed ID: 8723348

DOI: 10.1016/s0960-9822(02)00511-0

PubMed ID: 9058707

Title: The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood.

PubMed ID: 9058707

PubMed ID: 9108392

Title: Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.

PubMed ID: 9108392

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10229804

Title: CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.

PubMed ID: 10229804

PubMed ID: 10822173

Title: The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.

PubMed ID: 10822173

DOI: 10.1016/s0898-6568(00)00073-5

PubMed ID: 10764818

Title: The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.

PubMed ID: 10764818

DOI: 10.1074/jbc.m910119199

PubMed ID: 12421919

Title: Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.

PubMed ID: 12421919

DOI: 10.4049/jimmunol.169.10.5441

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16682172

Title: The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils.

PubMed ID: 16682172

DOI: 10.1016/j.cellsig.2006.03.012

PubMed ID: 19843936

Title: FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.

PubMed ID: 19843936

DOI: 10.4049/jimmunol.0901982

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20933011

Title: FCRL6 receptor: expression and associated proteins.

PubMed ID: 20933011

DOI: 10.1016/j.imlet.2010.09.023

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12529653

Title: Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia.

PubMed ID: 12529653

DOI: 10.1038/sj.leu.2402725

Sequence Information:

  • Length: 1189
  • Mass: 133292
  • Checksum: 7958E91A64A4B68B
  • Sequence:
    • MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV YTYRILPNED 
DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP VPLEEEDTGD DPEEDTVESV 
VSPPELPPRN IPLTASSCEA KEVPFSNENP RATETSRPSL SETLFQRLQS MDTSGLPEEH 
LKAIQDYLST QLAQDSEFVK TGSSSLPHLK KLTTLLCKEL YGEVIRTLPS LESLQRLFDQ 
QLSPGLRPRP QVPGEANPIN MVSKLSQLTS LLSSIEDKVK ALLHEGPESP HRPSLIPPVT 
FEVKAESLGI PQKMQLKVDV ESGKLIIKKS KDGSEDKFYS HKKILQLIKS QKFLNKLVIL 
VETEKEKILR KEYVFADSKK REGFCQLLQQ MKNKHSEQPE PDMITIFIGT WNMGNAPPPK 
KITSWFLSKG QGKTRDDSAD YIPHDIYVIG TQEDPLSEKE WLEILKHSLQ EITSVTFKTV 
AIHTLWNIRI VVLAKPEHEN RISHICTDNV KTGIANTLGN KGAVGVSFMF NGTSLGFVNS 
HLTSGSEKKL RRNQNYMNIL RFLALGDKKL SPFNITHRFT HLFWFGDLNY RVDLPTWEAE 
TIIQKIKQQQ YADLLSHDQL LTERREQKVF LHFEEEEITF APTYRFERLT RDKYAYTKQK 
ATGMKYNLPS WCDRVLWKSY PLVHVVCQSY GSTSDIMTSD HSPVFATFEA GVTSQFVSKN 
GPGTVDSQGQ IEFLRCYATL KTKSQTKFYL EFHSSCLESF VKSQEGENEE GSEGELVVKF 
GETLPKLKPI ISDPEYLLDQ HILISIKSSD SDESYGEGCI ALRLEATETQ LPIYTPLTHH 
GELTGHFQGE IKLQTSQGKT REKLYDFVKT ERDESSGPKT LKSLTSHDPM KQWEVTSRAP 
PCSGSSITEI INPNYMGVGP FGPPMPLHVK QTLSPDQQPT AWSYDQPPKD SPLGPCRGES 
PPTPPGQPPI SPKKFLPSTA NRGLPPRTQE SRPSDLGKNA GDTLPQEDLP LTKPEMFENP 
LYGSLSSFPK PAPRKDQESP KMPRKEPPPC PEPGILSPSI VLTKAQEADR GEGPGKQVPA 
PRLRSFTCSS SAEGRAAGGD KSQGKPKTPV SSQAPVPAKR PIKPSRSEIN QQTPPTPTPR 
PPLPVKSPAV LHLQHSKGRD YRDNTELPHH GKHRPEEGPP GPLGRTAMQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.