Details for: IREB2

Gene ID: 3658

Symbol: IREB2

Ensembl ID: ENSG00000136381

Description: iron responsive element binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.47
    Marker Score: 10304.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.22
    Marker Score: 1291
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.71
    Marker Score: 25540
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.67
    Marker Score: 6992
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.63
    Marker Score: 100236
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.59
    Marker Score: 60499.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.58
    Marker Score: 33768.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.57
    Marker Score: 58001
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.56
    Marker Score: 14804
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.55
    Marker Score: 2978
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.53
    Marker Score: 13135
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.53
    Marker Score: 27112
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.52
    Marker Score: 5862
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15586.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29798
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.49
    Marker Score: 14059
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.48
    Marker Score: 1701
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.48
    Marker Score: 11324
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.46
    Marker Score: 1295
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.46
    Marker Score: 6040.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.38
    Marker Score: 2130
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.31
    Marker Score: 5339
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.3
    Marker Score: 2848
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.28
    Marker Score: 5901.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.24
    Marker Score: 1220
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1307
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.21
    Marker Score: 354
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.2
    Marker Score: 502
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.17
    Marker Score: 584
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.17
    Marker Score: 568
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.16
    Marker Score: 1281
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.1
    Marker Score: 662
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.09
    Marker Score: 610
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.09
    Marker Score: 1175
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16886
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.07
    Marker Score: 10868
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.06
    Marker Score: 36702
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.06
    Marker Score: 1498
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.05
    Marker Score: 1356
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.05
    Marker Score: 1262
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.04
    Marker Score: 652
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.04
    Marker Score: 711
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.04
    Marker Score: 367
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.03
    Marker Score: 445
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 654
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.02
    Marker Score: 10292
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 938
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3777
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.02
    Marker Score: 971.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.01
    Marker Score: 703
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.01
    Marker Score: 409
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.01
    Marker Score: 874
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1
    Marker Score: 683
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71615
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.99
    Marker Score: 594
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.99
    Marker Score: 1126
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47840
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.99
    Marker Score: 4131.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.99
    Marker Score: 369
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.99
    Marker Score: 1228
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.98
    Marker Score: 1045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30378
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.97
    Marker Score: 360
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.97
    Marker Score: 660
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.97
    Marker Score: 835
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.96
    Marker Score: 902
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.96
    Marker Score: 332
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.96
    Marker Score: 21404.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.95
    Marker Score: 1364
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.95
    Marker Score: 959
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.94
    Marker Score: 225
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.94
    Marker Score: 239
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2386
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.94
    Marker Score: 973
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.93
    Marker Score: 1317
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.92
    Marker Score: 1036
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.91
    Marker Score: 300
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.91
    Marker Score: 249
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.91
    Marker Score: 476
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.91
    Marker Score: 316
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.91
    Marker Score: 917
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.91
    Marker Score: 1224
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.91
    Marker Score: 1334
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.91
    Marker Score: 1096
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9
    Marker Score: 3555
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.9
    Marker Score: 368
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.9
    Marker Score: 614
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 207
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5131
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1455
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2677
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.89
    Marker Score: 469
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.88
    Marker Score: 5239
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.88
    Marker Score: 279
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.88
    Marker Score: 356
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.88
    Marker Score: 307
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.87
    Marker Score: 874
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293

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Other Information

**Key characteristics:** * IREB2 is a protein of the immunoglobulin superfamily. * It is expressed in high levels in neurons and other cell types that are involved in iron metabolism. * IREB2 contains a conserved iron-responsive element (IREB) that is responsible for its regulation. * IREB2 is a key regulator of iron uptake, storage, and transport. * It is also involved in the regulation of cellular differentiation and proliferation. **Pathways and functions:** * IREB2 is involved in the regulation of iron uptake by binding to the ferritin complex on the surface of red blood cells. * It also binds to the transferrin receptor on the surface of endothelial cells, which is responsible for the uptake of iron from the blood. * IREB2 is involved in the regulation of cellular respiration. * It is also involved in the regulation of calcium homeostasis. * IREB2 is a key regulator of erythropoiesis. **Clinical significance:** * Mutations in the IREB2 gene have been linked to a number of human diseases, including hemochromatosis, siderocytosis, and iron-deficiency anemia. * IREB2 is a potential target for the treatment of these diseases. **Additional notes:** * IREB2 is a highly conserved protein that is found in organisms from yeast to humans. * It is a key regulator of the expression of other genes involved in iron metabolism. * IREB2 is a promising target for the treatment of a variety of diseases that are caused by iron deficiency or excess.

Genular Protein ID: 291285507

Symbol: IREB2_HUMAN

Name: Iron-responsive element-binding protein 2

UniProtKB Accession Codes:

P48200 A0A0A6YY96 A8KAC7 E1CJT9 H0YKU0 Q13095 Q1HE21 Q59FQ7 Q8WVK6 Q9UF17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7983023

Title: Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

PubMed ID: 7983023

DOI: 10.1016/s0021-9258(18)47367-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2172968

Title: Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein.

PubMed ID: 2172968

DOI: 10.1073/pnas.87.20.7958

PubMed ID: 7622457

Title: Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels.

PubMed ID: 7622457

DOI: 10.1074/jbc.270.28.16529

PubMed ID: 12629548

Title: Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

PubMed ID: 12629548

DOI: 10.1038/ncb952

PubMed ID: 19762596

Title: Control of iron homeostasis by an iron-regulated ubiquitin ligase.

PubMed ID: 19762596

DOI: 10.1126/science.1176333

PubMed ID: 19762597

Title: An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis.

PubMed ID: 19762597

DOI: 10.1126/science.1176326

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23891004

Title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

PubMed ID: 23891004

DOI: 10.1016/j.cmet.2013.06.015

PubMed ID: 30915432

Title: Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome.

PubMed ID: 30915432

DOI: 10.1093/brain/awz072

Sequence Information:

  • Length: 963
  • Mass: 105059
  • Checksum: 051228C6CE5362FD
  • Sequence:
    • MDAPKAGYAF EYLIETLNDS SHKKFFDVSK LGTKYDVLPY SIRVLLEAAV RNCDGFLMKK 
EDVMNILDWK TKQSNVEVPF FPARVLLQDF TGIPAMVDFA AMREAVKTLG GDPEKVHPAC 
PTDLTVDHSL QIDFSKCAIQ NAPNPGGGDL QKAGKLSPLK VQPKKLPCRG QTTCRGSCDS 
GELGRNSGTF SSQIENTPIL CPFHLQPVPE PETVLKNQEV EFGRNRERLQ FFKWSSRVFK 
NVAVIPPGTG MAHQINLEYL SRVVFEEKDL LFPDSVVGTD SHITMVNGLG ILGWGVGGIE 
TEAVMLGLPV SLTLPEVVGC ELTGSSNPFV TSIDVVLGIT KHLRQVGVAG KFVEFFGSGV 
SQLSIVDRTT IANMCPEYGA ILSFFPVDNV TLKHLEHTGF SKAKLESMET YLKAVKLFRN 
DQNSSGEPEY SQVIQINLNS IVPSVSGPKR PQDRVAVTDM KSDFQACLNE KVGFKGFQIA 
AEKQKDIVSI HYEGSEYKLS HGSVVIAAVI SCTNNCNPSV MLAAGLLAKK AVEAGLRVKP 
YIRTSLSPGS GMVTHYLSSS GVLPYLSKLG FEIVGYGCSI CVGNTAPLSD AVLNAVKQGD 
LVTCGILSGN KNFEGRLCDC VRANYLASPP LVVAYAIAGT VNIDFQTEPL GTDPTGKNIY 
LHDIWPSREE VHRVEEEHVI LSMFKALKDK IEMGNKRWNS LEAPDSVLFP WDLKSTYIRC 
PSFFDKLTKE PIALQAIENA HVLLYLGDSV TTDHISPAGS IARNSAAAKY LTNRGLTPRE 
FNSYGARRGN DAVMTRGTFA NIKLFNKFIG KPAPKTIHFP SGQTLDVFEA AELYQKEGIP 
LIILAGKKYG SGNSRDWAAK GPYLLGVKAV LAESYEKIHK DHLIGIGIAP LQFLPGENAD 
SLGLSGRETF SLTFPEELSP GITLNIQTST GKVFSVIASF EDDVEITLYK HGGLLNFVAR 
KFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.