Details for: IREB2

Gene ID: 3658

Symbol: IREB2

Ensembl ID: ENSG00000136381

Description: iron responsive element binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.7035
    Cell Significance Index: -41.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.1568
    Cell Significance Index: -41.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.1903
    Cell Significance Index: -46.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.8804
    Cell Significance Index: -44.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.0191
    Cell Significance Index: -44.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2756
    Cell Significance Index: -43.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.1566
    Cell Significance Index: -40.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5229
    Cell Significance Index: -45.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5084
    Cell Significance Index: -20.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5721
    Cell Significance Index: 418.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7849
    Cell Significance Index: 358.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5406
    Cell Significance Index: 167.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5210
    Cell Significance Index: 301.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5131
    Cell Significance Index: 84.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0103
    Cell Significance Index: 27.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9589
    Cell Significance Index: 343.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9104
    Cell Significance Index: 24.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8331
    Cell Significance Index: 16.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8205
    Cell Significance Index: 22.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7106
    Cell Significance Index: 54.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6031
    Cell Significance Index: 38.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5913
    Cell Significance Index: 322.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5849
    Cell Significance Index: 7.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5800
    Cell Significance Index: 104.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5715
    Cell Significance Index: 35.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5529
    Cell Significance Index: 15.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5510
    Cell Significance Index: 75.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5500
    Cell Significance Index: 24.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5043
    Cell Significance Index: 348.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4602
    Cell Significance Index: 56.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4435
    Cell Significance Index: 29.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4136
    Cell Significance Index: 28.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3889
    Cell Significance Index: 17.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3599
    Cell Significance Index: 13.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2805
    Cell Significance Index: 27.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2618
    Cell Significance Index: 115.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2042
    Cell Significance Index: 4.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2027
    Cell Significance Index: 5.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1801
    Cell Significance Index: 34.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1737
    Cell Significance Index: 326.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1591
    Cell Significance Index: 18.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1368
    Cell Significance Index: 3.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0887
    Cell Significance Index: 1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0862
    Cell Significance Index: 3.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0821
    Cell Significance Index: 2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0788
    Cell Significance Index: 13.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0759
    Cell Significance Index: 48.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0473
    Cell Significance Index: 0.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0461
    Cell Significance Index: 41.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0425
    Cell Significance Index: 5.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0410
    Cell Significance Index: 63.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0392
    Cell Significance Index: 72.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0310
    Cell Significance Index: 14.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0052
    Cell Significance Index: 0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0018
    Cell Significance Index: 2.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0158
    Cell Significance Index: -9.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0268
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0277
    Cell Significance Index: -20.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0452
    Cell Significance Index: -34.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0493
    Cell Significance Index: -2.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0623
    Cell Significance Index: -35.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0756
    Cell Significance Index: -4.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0923
    Cell Significance Index: -9.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1208
    Cell Significance Index: -25.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1375
    Cell Significance Index: -39.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1494
    Cell Significance Index: -21.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1501
    Cell Significance Index: -17.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1594
    Cell Significance Index: -20.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2171
    Cell Significance Index: -24.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2259
    Cell Significance Index: -3.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2346
    Cell Significance Index: -16.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2493
    Cell Significance Index: -18.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2634
    Cell Significance Index: -3.1400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2704
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2851
    Cell Significance Index: -7.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2979
    Cell Significance Index: -8.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3489
    Cell Significance Index: -36.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3601
    Cell Significance Index: -41.1000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4139
    Cell Significance Index: -3.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4597
    Cell Significance Index: -9.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4618
    Cell Significance Index: -2.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4694
    Cell Significance Index: -6.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4937
    Cell Significance Index: -39.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5269
    Cell Significance Index: -10.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5353
    Cell Significance Index: -18.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5409
    Cell Significance Index: -15.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5601
    Cell Significance Index: -17.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6168
    Cell Significance Index: -13.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6523
    Cell Significance Index: -4.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6563
    Cell Significance Index: -9.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6892
    Cell Significance Index: -11.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6959
    Cell Significance Index: -36.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7001
    Cell Significance Index: -12.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7056
    Cell Significance Index: -18.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7147
    Cell Significance Index: -36.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7193
    Cell Significance Index: -17.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7421
    Cell Significance Index: -16.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7434
    Cell Significance Index: -45.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IREB2 is a transcription factor that binds to iron-responsive elements (IREs) in the 3' untranslated region (UTR) of target mRNAs. This binding event triggers the stabilization of these mRNAs, leading to increased protein synthesis and transcription. IREB2 is a member of the basic leucine zipper (bZIP) family of transcription factors, which are known for their ability to regulate gene expression in response to various stimuli, including changes in iron levels. **Pathways and Functions** IREB2 is involved in several key pathways that regulate iron homeostasis: 1. **Intracellular Iron Ion Homeostasis**: IREB2 plays a critical role in maintaining the balance of intracellular iron levels by regulating the expression of genes involved in iron uptake, storage, and utilization. 2. **Iron Uptake and Transport**: IREB2 binds to IREs in the 3' UTR of target mRNAs, leading to increased expression of genes involved in iron uptake and transport, such as DMT1 and ferroportin. 3. **Mitochondrial Iron Homeostasis**: IREB2 regulates the expression of genes involved in mitochondrial iron metabolism, including mitochondrial iron uptake and storage proteins. 4. **Erythrocyte Homeostasis**: IREB2 plays a crucial role in maintaining the balance of iron levels in erythrocytes, which is essential for the proper functioning of these cells. **Clinical Significance** Dysregulation of IREB2 has been implicated in various diseases, including: 1. **Iron Deficiency Anemia**: IREB2 mutations have been associated with iron deficiency anemia, a condition characterized by low iron levels and impaired erythropoiesis. 2. **Thalassemia**: IREB2 mutations have also been linked to thalassemia, a group of genetic disorders characterized by impaired hemoglobin synthesis and iron overload. 3. **Neurodegenerative Diseases**: IREB2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where iron dysregulation plays a critical role. In conclusion, IREB2 is a crucial transcription factor involved in regulating iron homeostasis in the body. Its dysregulation has been implicated in various diseases, highlighting the importance of maintaining proper iron levels for optimal cellular function. Further research is necessary to fully understand the mechanisms by which IREB2 regulates iron homeostasis and to develop therapeutic strategies for the treatment of iron-related diseases.

Genular Protein ID: 291285507

Symbol: IREB2_HUMAN

Name: Iron-responsive element-binding protein 2

UniProtKB Accession Codes:

P48200 A0A0A6YY96 A8KAC7 E1CJT9 H0YKU0 Q13095 Q1HE21 Q59FQ7 Q8WVK6 Q9UF17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7983023

Title: Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

PubMed ID: 7983023

DOI: 10.1016/s0021-9258(18)47367-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2172968

Title: Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein.

PubMed ID: 2172968

DOI: 10.1073/pnas.87.20.7958

PubMed ID: 7622457

Title: Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels.

PubMed ID: 7622457

DOI: 10.1074/jbc.270.28.16529

PubMed ID: 12629548

Title: Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

PubMed ID: 12629548

DOI: 10.1038/ncb952

PubMed ID: 19762596

Title: Control of iron homeostasis by an iron-regulated ubiquitin ligase.

PubMed ID: 19762596

DOI: 10.1126/science.1176333

PubMed ID: 19762597

Title: An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis.

PubMed ID: 19762597

DOI: 10.1126/science.1176326

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23891004

Title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

PubMed ID: 23891004

DOI: 10.1016/j.cmet.2013.06.015

PubMed ID: 30915432

Title: Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome.

PubMed ID: 30915432

DOI: 10.1093/brain/awz072

Sequence Information:

  • Length: 963
  • Mass: 105059
  • Checksum: 051228C6CE5362FD
  • Sequence:
    • MDAPKAGYAF EYLIETLNDS SHKKFFDVSK LGTKYDVLPY SIRVLLEAAV RNCDGFLMKK 
EDVMNILDWK TKQSNVEVPF FPARVLLQDF TGIPAMVDFA AMREAVKTLG GDPEKVHPAC 
PTDLTVDHSL QIDFSKCAIQ NAPNPGGGDL QKAGKLSPLK VQPKKLPCRG QTTCRGSCDS 
GELGRNSGTF SSQIENTPIL CPFHLQPVPE PETVLKNQEV EFGRNRERLQ FFKWSSRVFK 
NVAVIPPGTG MAHQINLEYL SRVVFEEKDL LFPDSVVGTD SHITMVNGLG ILGWGVGGIE 
TEAVMLGLPV SLTLPEVVGC ELTGSSNPFV TSIDVVLGIT KHLRQVGVAG KFVEFFGSGV 
SQLSIVDRTT IANMCPEYGA ILSFFPVDNV TLKHLEHTGF SKAKLESMET YLKAVKLFRN 
DQNSSGEPEY SQVIQINLNS IVPSVSGPKR PQDRVAVTDM KSDFQACLNE KVGFKGFQIA 
AEKQKDIVSI HYEGSEYKLS HGSVVIAAVI SCTNNCNPSV MLAAGLLAKK AVEAGLRVKP 
YIRTSLSPGS GMVTHYLSSS GVLPYLSKLG FEIVGYGCSI CVGNTAPLSD AVLNAVKQGD 
LVTCGILSGN KNFEGRLCDC VRANYLASPP LVVAYAIAGT VNIDFQTEPL GTDPTGKNIY 
LHDIWPSREE VHRVEEEHVI LSMFKALKDK IEMGNKRWNS LEAPDSVLFP WDLKSTYIRC 
PSFFDKLTKE PIALQAIENA HVLLYLGDSV TTDHISPAGS IARNSAAAKY LTNRGLTPRE 
FNSYGARRGN DAVMTRGTFA NIKLFNKFIG KPAPKTIHFP SGQTLDVFEA AELYQKEGIP 
LIILAGKKYG SGNSRDWAAK GPYLLGVKAV LAESYEKIHK DHLIGIGIAP LQFLPGENAD 
SLGLSGRETF SLTFPEELSP GITLNIQTST GKVFSVIASF EDDVEITLYK HGGLLNFVAR 
KFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.