Details for: ITGB8

Gene ID: 3696

Symbol: ITGB8

Ensembl ID: ENSG00000105855

Description: integrin subunit beta 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.84
    Marker Score: 4789
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.67
    Marker Score: 92641
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.58
    Marker Score: 2286
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.56
    Marker Score: 54582
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.52
    Marker Score: 1715.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.4
    Marker Score: 2074
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.3
    Marker Score: 2336
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.3
    Marker Score: 1730
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.2
    Marker Score: 1528
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.12
    Marker Score: 771
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.07
    Marker Score: 4944
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.05
    Marker Score: 7281
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.92
    Marker Score: 1575
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.8
    Marker Score: 4527
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.76
    Marker Score: 6817
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7
    Marker Score: 3871
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.7
    Marker Score: 5832
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.65
    Marker Score: 1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.64
    Marker Score: 2031
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.63
    Marker Score: 851
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.59
    Marker Score: 1225
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.58
    Marker Score: 1662
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.57
    Marker Score: 13478
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.57
    Marker Score: 3018
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.55
    Marker Score: 7624
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.49
    Marker Score: 16780
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.47
    Marker Score: 1278
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.46
    Marker Score: 3576
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.45
    Marker Score: 1508
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.43
    Marker Score: 530
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.41
    Marker Score: 942
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.39
    Marker Score: 648.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.35
    Marker Score: 1456
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.32
    Marker Score: 5123
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.32
    Marker Score: 627
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.3
    Marker Score: 9979
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.29
    Marker Score: 482
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.27
    Marker Score: 11023
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.26
    Marker Score: 3365
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.25
    Marker Score: 822
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.19
    Marker Score: 378
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.18
    Marker Score: 379
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.15
    Marker Score: 3273
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.14
    Marker Score: 2168
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.14
    Marker Score: 328
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.13
    Marker Score: 2007
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1459
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 707
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.09
    Marker Score: 1991
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251761
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71780
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1
    Marker Score: 559
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48005
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.99
    Marker Score: 2331
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.99
    Marker Score: 480
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.99
    Marker Score: 4263
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.96
    Marker Score: 277
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1928
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.95
    Marker Score: 12712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1534
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.93
    Marker Score: 449
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.92
    Marker Score: 6875
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.92
    Marker Score: 1115
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.92
    Marker Score: 1288
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.91
    Marker Score: 1341
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.9
    Marker Score: 1278
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.9
    Marker Score: 462
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.89
    Marker Score: 318
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.89
    Marker Score: 460
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.88
    Marker Score: 841
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.87
    Marker Score: 176
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 644
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.84
    Marker Score: 1129
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.83
    Marker Score: 943
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.82
    Marker Score: 909
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.82
    Marker Score: 20922
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.81
    Marker Score: 497
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.8
    Marker Score: 935.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1491
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.76
    Marker Score: 425
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3179
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.76
    Marker Score: 441
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.75
    Marker Score: 306
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.75
    Marker Score: 667.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.75
    Marker Score: 368
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.74
    Marker Score: 192
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.74
    Marker Score: 493

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Other Information

**Key characteristics:** * ITGB8 is a type I transmembrane protein that is expressed in a variety of cell types. * It is a highly conserved protein, with a similar sequence in mammals, birds, and reptiles. * ITGB8 is a transmembrane protein that is involved in cell-matrix adhesion, cell adhesion, and the formation of elastic fibers. * ITGB8 is also involved in the regulation of the immune response and the signaling pathway of transforming growth factor beta receptor (TGFB). **Pathways and functions:** * ITGB8 is involved in cell-matrix adhesion by binding to extracellular matrix proteins. * ITGB8 is also involved in cell adhesion to other cells. * ITGB8 is involved in the formation of elastic fibers, which are important for cell migration and tissue remodeling. * ITGB8 is also involved in the regulation of the immune response. * ITGB8 is a key regulator of the TGF-beta signaling pathway. * TGF-beta is a growth factor that is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. * TGF-beta signaling is activated by the binding of TGF-beta to its receptor, TGFR. * Activation of TGFR by TGF-beta triggers a signaling cascade that leads to the activation of Smad proteins. * Smad proteins are a family of intracellular proteins that regulate a variety of cellular processes, including cell growth, differentiation, and migration. **Clinical significance:** ITGB8 is a promising target for cancer immunotherapy. Antibodies against ITGB8 have been shown to be effective in blocking the growth of tumor cells in vitro and in animal models of cancer. This suggests that ITGB8 is a valuable target for the treatment of cancer.

Genular Protein ID: 1550847920

Symbol: ITB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

P26012 A4D133 B4DHD4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 6 EPD 1 Ensembl 2 GO 25 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 8 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1918072

Title: Cloning and expression of a divergent integrin subunit beta 8.

PubMed ID: 1918072

DOI: 10.1016/s0021-9258(18)55042-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 31792290

Title: General structural features that regulate integrin affinity revealed by atypical alphaVbeta8.

PubMed ID: 31792290

DOI: 10.1038/s41467-019-13248-5

Sequence Information:

  • Length: 769
  • Mass: 85632
  • Checksum: F7E3994F92B12A65
  • Sequence:
    • MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA 
LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP 
GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 
SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 
VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 
VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 
TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 
NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK 
CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK 
VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 
CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS 
CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ WNSNKIKSSS 
DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF

Genular Protein ID: 44285263

Symbol: Q9BUG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BUG9

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 2

Citations:

PubMed ID: 9847074

Title: Toward a complete human genome sequence.

PubMed ID: 9847074

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 439
  • Mass: 48419
  • Checksum: 3F94379926729566
  • Sequence:
    • MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA 
LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP 
GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 
SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 
VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 
VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 
TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 
NVTSNDEVCG CAFFPFKIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.