Details for: ITIH1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: liver dendritic cell (CL2000055)
Fold Change: 11.6302
Cell Significance Index: 30.6800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 6.1045
Cell Significance Index: -2.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2475
Cell Significance Index: 446.0200 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1.9237
Cell Significance Index: 7.2500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.6987
Cell Significance Index: 28.6200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.6640
Cell Significance Index: 9.8000 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.6529
Cell Significance Index: 3.7600 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.4318
Cell Significance Index: 4.2600 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.3852
Cell Significance Index: 2.9600 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.1941
Cell Significance Index: 0.5200 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.1556
Cell Significance Index: 2.2300 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.1473
Cell Significance Index: 1.2600 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.1241
Cell Significance Index: 0.9800 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.1017
Cell Significance Index: 1.7100 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.0964
Cell Significance Index: 1.1100 - Cell Name: helper T cell (CL0000912)
Fold Change: 0.0788
Cell Significance Index: 1.1200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0765
Cell Significance Index: 2.0500 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.0431
Cell Significance Index: 0.1500 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0279
Cell Significance Index: 0.2700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0155
Cell Significance Index: 0.1300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0036
Cell Significance Index: 0.0900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0012
Cell Significance Index: -2.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0024
Cell Significance Index: -1.3400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0031
Cell Significance Index: -2.3100 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0032
Cell Significance Index: -0.0500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0032
Cell Significance Index: -5.8400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0033
Cell Significance Index: -0.5700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0034
Cell Significance Index: -2.1500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0037
Cell Significance Index: -5.7100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0041
Cell Significance Index: -1.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0044
Cell Significance Index: -5.9200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0047
Cell Significance Index: -2.5500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0050
Cell Significance Index: -0.5100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0062
Cell Significance Index: -1.7700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0071
Cell Significance Index: -0.8200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0074
Cell Significance Index: -1.4800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0076
Cell Significance Index: -3.4400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0081
Cell Significance Index: -0.2100 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.0098
Cell Significance Index: -0.0900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0106
Cell Significance Index: -1.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0111
Cell Significance Index: -2.0000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0118
Cell Significance Index: -2.4900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0127
Cell Significance Index: -0.5900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0144
Cell Significance Index: -2.1000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0148
Cell Significance Index: -0.4100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0160
Cell Significance Index: -0.8100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0183
Cell Significance Index: -2.1600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0187
Cell Significance Index: -2.5700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0187
Cell Significance Index: -0.7700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0209
Cell Significance Index: -0.5700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0216
Cell Significance Index: -0.3100 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0242
Cell Significance Index: -0.2500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0278
Cell Significance Index: -2.8900 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: -0.0283
Cell Significance Index: -0.3000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0344
Cell Significance Index: -0.7200 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0375
Cell Significance Index: -0.5100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0379
Cell Significance Index: -0.7400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0381
Cell Significance Index: -2.5600 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0386
Cell Significance Index: -0.6200 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.0395
Cell Significance Index: -0.4100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0463
Cell Significance Index: -2.9900 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0467
Cell Significance Index: -0.3600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0468
Cell Significance Index: -2.4400 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.0490
Cell Significance Index: -0.4500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0497
Cell Significance Index: -2.3400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0530
Cell Significance Index: -1.8600 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0577
Cell Significance Index: -0.6300 - Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.0626
Cell Significance Index: -0.7100 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: -0.0626
Cell Significance Index: -0.6300 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0635
Cell Significance Index: -0.6400 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.0637
Cell Significance Index: -0.7600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0639
Cell Significance Index: -0.9700 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0656
Cell Significance Index: -0.9200 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0658
Cell Significance Index: -0.9100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0668
Cell Significance Index: -0.7600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0691
Cell Significance Index: -3.6300 - Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.0698
Cell Significance Index: -0.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0702
Cell Significance Index: -3.9400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0706
Cell Significance Index: -2.3100 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.0715
Cell Significance Index: -0.7400 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0716
Cell Significance Index: -0.4900 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0719
Cell Significance Index: -0.9400 - Cell Name: adventitial cell (CL0002503)
Fold Change: -0.0722
Cell Significance Index: -0.6700 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0732
Cell Significance Index: -1.4900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0741
Cell Significance Index: -2.3600 - Cell Name: mature T cell (CL0002419)
Fold Change: -0.0750
Cell Significance Index: -0.5400 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.0752
Cell Significance Index: -0.8700 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0765
Cell Significance Index: -1.2300 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0775
Cell Significance Index: -1.9800 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0783
Cell Significance Index: -0.8100 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0808
Cell Significance Index: -0.5000 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0816
Cell Significance Index: -1.1900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0825
Cell Significance Index: -3.6500 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0877
Cell Significance Index: -0.6300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0891
Cell Significance Index: -1.9500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0925
Cell Significance Index: -2.6400 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0938
Cell Significance Index: -2.3400 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0941
Cell Significance Index: -0.9100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0951
Cell Significance Index: -2.5400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0959
Cell Significance Index: -2.3000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 448896279
Symbol: ITIH1_HUMAN
Name: Inter-alpha-trypsin inhibitor heavy chain H1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1380832
Title: Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1.
PubMed ID: 1380832
PubMed ID: 7505744
Title: Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene.
PubMed ID: 7505744
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1384548
Title: The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.
PubMed ID: 1384548
PubMed ID: 2476436
Title: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.
PubMed ID: 2476436
PubMed ID: 2471637
Title: Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related.
PubMed ID: 2471637
PubMed ID: 7504674
Title: A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.
PubMed ID: 7504674
PubMed ID: 2446322
Title: Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.
PubMed ID: 2446322
PubMed ID: 3663330
Title: cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins.
PubMed ID: 3663330
PubMed ID: 7513643
Title: Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.
PubMed ID: 7513643
PubMed ID: 7522574
Title: Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes.
PubMed ID: 7522574
PubMed ID: 9677337
Title: Glycosylation pattern of human inter-alpha-inhibitor heavy chains.
PubMed ID: 9677337
DOI: 10.1042/bj3330749
PubMed ID: 9425062
Title: Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.
PubMed ID: 9425062
DOI: 10.1021/bi971137d
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26468290
Title: Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.
PubMed ID: 26468290
PubMed ID: 7535743
Title: Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism.
PubMed ID: 7535743
DOI: 10.1007/bf00208970
Sequence Information:
- Length: 911
- Mass: 101389
- Checksum: 8FE715FF223FC917
- Sequence:
MDGAMGPRGL LLCMYLVSLL ILQAMPALGS ATGRSKSSEK RQAVDTAVDG VFIRSLKVNC KVTSRFAHYV VTSQVVNTAN EAREVAFDLE IPKTAFISDF AVTADGNAFI GDIKDKVTAW KQYRKAAISG ENAGLVRASG RTMEQFTIHL TVNPQSKVTF QLTYEEVLKR NHMQYEIVIK VKPKQLVHHF EIDVDIFEPQ GISKLDAQAS FLPKELAAQT IKKSFSGKKG HVLFRPTVSQ QQSCPTCSTS LLNGHFKVTY DVSRDKICDL LVANNHFAHF FAPQNLTNMN KNVVFVIDIS GSMRGQKVKQ TKEALLKILG DMQPGDYFDL VLFGTRVQSW KGSLVQASEA NLQAAQDFVR GFSLDEATNL NGGLLRGIEI LNQVQESLPE LSNHASILIM LTDGDPTEGV TDRSQILKNV RNAIRGRFPL YNLGFGHNVD FNFLEVMSME NNGRAQRIYE DHDATQQLQG FYSQVAKPLL VDVDLQYPQD AVLALTQNHH KQYYEGSEIV VAGRIADNKQ SSFKADVQAH GEGQEFSITC LVDEEEMKKL LRERGHMLEN HVERLWAYLT IQELLAKRMK VDREERANLS SQALQMSLDY GFVTPLTSMS IRGMADQDGL KPTIDKPSED SPPLEMLGPR RTFVLSALQP SPTHSSSNTQ RLPDRVTGVD TDPHFIIHVP QKEDTLCFNI NEEPGVILSL VQDPNTGFSV NGQLIGNKAR SPGQHDGTYF GRLGIANPAT DFQLEVTPQN ITLNPGFGGP VFSWRDQAVL RQDGVVVTIN KKRNLVVSVD DGGTFEVVLH RVWKGSSVHQ DFLGFYVLDS HRMSARTHGL LGQFFHPIGF EVSDIHPGSD PTKPDATMVV RNRRLTVTRG LQKDYSKDPW HGAEVSCWFI HNNGAGLIDG AYTDYIVPDI F
Genular Protein ID: 4070735544
Symbol: B7Z8B6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 623
- Mass: 69527
- Checksum: 60ED5DBCD93E45DA
- Sequence:
MNKNVVFVID ISGSMRGQKV KQIKEALLKI LGDMQPGDYF DLVLFGTRVQ SWKGSLVQAS EANLQAAQDF VRGFSLDEAT NLNGGLLRGI EILNQVQESL PELSNHASIL IMLTDGDPTE GVTDRSQILK NVRNAIRGRF PLYNLGFGHN VDFNFLEVMS MENNGRAQRI YEDHDATQQL QGFYSQVAKP LLVDVDLQYP QDAVLALTQN HHKQYYEGSE IVVAGRIADN KQSSFKADVQ AHGEGQEFSI TCLVDEEEMK KLLRERGHML ENHVERLWAY LTIQELLAKR MKVDREVRAN LSSQALRMSL DYGFVTPLTS MSIRGMADQD GLKPTIDKPS EDSPPLEMLG PRRTFVLSAL QPSPTHSSSN TQRLPDRVTG VDTDPHFIIH VPQKEDTLCF NINEEPGVIL SLVQDPNTGF SVNGQLIGNK ARSPGQHDGT YFGRLGIANP ATDFQLEVTP QNITLNPGFG GPVFSWRDQA VLRQDGVVVT INKKRNLVVS VYDGGTFEVV LHRVWKGSSV HQDFLGFYVL DSHRMSARTH GLLGQFFHPI GFEVSDIHPG SDPTKPDATM VVRSRRLTVT RGLQKDYSKD PWHGAEVSCW FIHNNGAGLI DGAYTDYIVP DIF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.