Details for: ITIH1

Gene ID: 3697

Symbol: ITIH1

Ensembl ID: ENSG00000055957

Description: inter-alpha-trypsin inhibitor heavy chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 11.6302
    Cell Significance Index: 30.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 6.1045
    Cell Significance Index: -2.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2475
    Cell Significance Index: 446.0200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.9237
    Cell Significance Index: 7.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.6987
    Cell Significance Index: 28.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6640
    Cell Significance Index: 9.8000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6529
    Cell Significance Index: 3.7600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4318
    Cell Significance Index: 4.2600
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.3852
    Cell Significance Index: 2.9600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1941
    Cell Significance Index: 0.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1556
    Cell Significance Index: 2.2300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1473
    Cell Significance Index: 1.2600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1241
    Cell Significance Index: 0.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1017
    Cell Significance Index: 1.7100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0964
    Cell Significance Index: 1.1100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0788
    Cell Significance Index: 1.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0765
    Cell Significance Index: 2.0500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0431
    Cell Significance Index: 0.1500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0279
    Cell Significance Index: 0.2700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0155
    Cell Significance Index: 0.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0032
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0033
    Cell Significance Index: -0.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0041
    Cell Significance Index: -1.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0047
    Cell Significance Index: -2.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0050
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0071
    Cell Significance Index: -0.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0074
    Cell Significance Index: -1.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0076
    Cell Significance Index: -3.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0081
    Cell Significance Index: -0.2100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0098
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0106
    Cell Significance Index: -1.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0111
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0118
    Cell Significance Index: -2.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0127
    Cell Significance Index: -0.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0144
    Cell Significance Index: -2.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0148
    Cell Significance Index: -0.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0160
    Cell Significance Index: -0.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0183
    Cell Significance Index: -2.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0187
    Cell Significance Index: -2.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0187
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0209
    Cell Significance Index: -0.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0242
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0278
    Cell Significance Index: -2.8900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0283
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0344
    Cell Significance Index: -0.7200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0375
    Cell Significance Index: -0.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0379
    Cell Significance Index: -0.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0381
    Cell Significance Index: -2.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0386
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0395
    Cell Significance Index: -0.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0463
    Cell Significance Index: -2.9900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0467
    Cell Significance Index: -0.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0468
    Cell Significance Index: -2.4400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0490
    Cell Significance Index: -0.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0497
    Cell Significance Index: -2.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0530
    Cell Significance Index: -1.8600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0577
    Cell Significance Index: -0.6300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0626
    Cell Significance Index: -0.7100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0626
    Cell Significance Index: -0.6300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0635
    Cell Significance Index: -0.6400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0637
    Cell Significance Index: -0.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0639
    Cell Significance Index: -0.9700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0656
    Cell Significance Index: -0.9200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0658
    Cell Significance Index: -0.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0668
    Cell Significance Index: -0.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0691
    Cell Significance Index: -3.6300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0698
    Cell Significance Index: -0.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0702
    Cell Significance Index: -3.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0706
    Cell Significance Index: -2.3100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0715
    Cell Significance Index: -0.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0716
    Cell Significance Index: -0.4900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0719
    Cell Significance Index: -0.9400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0722
    Cell Significance Index: -0.6700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0732
    Cell Significance Index: -1.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0741
    Cell Significance Index: -2.3600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0750
    Cell Significance Index: -0.5400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0752
    Cell Significance Index: -0.8700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0765
    Cell Significance Index: -1.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0775
    Cell Significance Index: -1.9800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0783
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0808
    Cell Significance Index: -0.5000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0816
    Cell Significance Index: -1.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0825
    Cell Significance Index: -3.6500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0877
    Cell Significance Index: -0.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0891
    Cell Significance Index: -1.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0925
    Cell Significance Index: -2.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0938
    Cell Significance Index: -2.3400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0941
    Cell Significance Index: -0.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0951
    Cell Significance Index: -2.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0959
    Cell Significance Index: -2.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** ITIH1 consists of two heavy chains and one light chain, which are linked together by disulfide bonds. The heavy chains possess a unique structure that allows them to bind to multiple ligands. 2. **Expression:** ITIH1 is expressed in various cell types, including hepatocytes, plasma cells, granulocytes, and endothelial cells, suggesting its involvement in multiple cellular processes. 3. **Ligand binding:** ITIH1 binds to hyaluronic acid, collagen, and calcium ions, which are essential for its function and regulation. 4. **Serine-type endopeptidase inhibitor activity:** ITIH1 possesses serine-type endopeptidase inhibitor activity, which is crucial for regulating proteolytic processes. **Pathways and Functions:** 1. **Hyaluronic acid binding:** ITIH1 binds to hyaluronic acid, which is involved in cell migration, wound healing, and cancer metastasis. 2. **Collagen binding:** ITIH1 binds to collagen, which is essential for maintaining the structure and integrity of the extracellular matrix. 3. **Calcium ion binding:** ITIH1 binds to calcium ions, which play a crucial role in various cellular processes, including cell signaling and protein folding. 4. **Blood microparticle formation:** ITIH1 is involved in the formation of blood microparticles, which are small vesicles released from cells that play a role in intercellular communication. 5. **Extracellular exosome formation:** ITIH1 is also involved in the formation of extracellular exosomes, which are small vesicles released by cells that play a role in intercellular communication. **Clinical Significance:** 1. **Liver disease:** ITIH1 is significantly expressed in liver cells, suggesting its involvement in liver disease, including hepatitis and cirrhosis. 2. **Cancer:** ITIH1 has been implicated in cancer progression, including metastasis and angiogenesis. 3. **Inflammatory diseases:** ITIH1 has been shown to play a role in inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 4. **Wound healing:** ITIH1 is involved in wound healing, including cell migration and tissue repair. In conclusion, ITIH1 is a multifunctional protein that plays a crucial role in various physiological and pathological processes. Its involvement in liver disease, cancer, inflammatory diseases, and wound healing highlights its significance in human health and disease. Further research is necessary to fully elucidate the functions of ITIH1 and its role in human disease.

Genular Protein ID: 448896279

Symbol: ITIH1_HUMAN

Name: Inter-alpha-trypsin inhibitor heavy chain H1

UniProtKB Accession Codes:

P19827 A8K9N5 B2RAH9 B7Z558 B7Z8C0 F5H165 F5H7Y8 P78455 Q01746 Q562G1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 27 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1380832

Title: Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1.

PubMed ID: 1380832

DOI: 10.1016/0167-4781(92)90065-8

PubMed ID: 7505744

Title: Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene.

PubMed ID: 7505744

DOI: 10.1111/j.1432-1033.1993.tb18376.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1384548

Title: The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.

PubMed ID: 1384548

DOI: 10.1515/bchm3.1992.373.2.1009

PubMed ID: 2476436

Title: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.

PubMed ID: 2476436

DOI: 10.1016/s0021-9258(18)71575-5

PubMed ID: 2471637

Title: Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related.

PubMed ID: 2471637

DOI: 10.1111/j.1432-1033.1989.tb14762.x

PubMed ID: 7504674

Title: A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.

PubMed ID: 7504674

DOI: 10.1016/s0021-9258(19)74373-7

PubMed ID: 2446322

Title: Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.

PubMed ID: 2446322

DOI: 10.1073/pnas.84.23.8272

PubMed ID: 3663330

Title: cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins.

PubMed ID: 3663330

DOI: 10.1515/bchm3.1987.368.2.963

PubMed ID: 7513643

Title: Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.

PubMed ID: 7513643

DOI: 10.1111/j.1432-1033.1994.tb18803.x

PubMed ID: 7522574

Title: Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes.

PubMed ID: 7522574

DOI: 10.1016/0167-4781(94)90087-6

PubMed ID: 9677337

Title: Glycosylation pattern of human inter-alpha-inhibitor heavy chains.

PubMed ID: 9677337

DOI: 10.1042/bj3330749

PubMed ID: 9425062

Title: Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.

PubMed ID: 9425062

DOI: 10.1021/bi971137d

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26468290

Title: Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.

PubMed ID: 26468290

DOI: 10.1074/jbc.m115.669838

PubMed ID: 7535743

Title: Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism.

PubMed ID: 7535743

DOI: 10.1007/bf00208970

Sequence Information:

  • Length: 911
  • Mass: 101389
  • Checksum: 8FE715FF223FC917
  • Sequence:
    • MDGAMGPRGL LLCMYLVSLL ILQAMPALGS ATGRSKSSEK RQAVDTAVDG VFIRSLKVNC 
KVTSRFAHYV VTSQVVNTAN EAREVAFDLE IPKTAFISDF AVTADGNAFI GDIKDKVTAW 
KQYRKAAISG ENAGLVRASG RTMEQFTIHL TVNPQSKVTF QLTYEEVLKR NHMQYEIVIK 
VKPKQLVHHF EIDVDIFEPQ GISKLDAQAS FLPKELAAQT IKKSFSGKKG HVLFRPTVSQ 
QQSCPTCSTS LLNGHFKVTY DVSRDKICDL LVANNHFAHF FAPQNLTNMN KNVVFVIDIS 
GSMRGQKVKQ TKEALLKILG DMQPGDYFDL VLFGTRVQSW KGSLVQASEA NLQAAQDFVR 
GFSLDEATNL NGGLLRGIEI LNQVQESLPE LSNHASILIM LTDGDPTEGV TDRSQILKNV 
RNAIRGRFPL YNLGFGHNVD FNFLEVMSME NNGRAQRIYE DHDATQQLQG FYSQVAKPLL 
VDVDLQYPQD AVLALTQNHH KQYYEGSEIV VAGRIADNKQ SSFKADVQAH GEGQEFSITC 
LVDEEEMKKL LRERGHMLEN HVERLWAYLT IQELLAKRMK VDREERANLS SQALQMSLDY 
GFVTPLTSMS IRGMADQDGL KPTIDKPSED SPPLEMLGPR RTFVLSALQP SPTHSSSNTQ 
RLPDRVTGVD TDPHFIIHVP QKEDTLCFNI NEEPGVILSL VQDPNTGFSV NGQLIGNKAR 
SPGQHDGTYF GRLGIANPAT DFQLEVTPQN ITLNPGFGGP VFSWRDQAVL RQDGVVVTIN 
KKRNLVVSVD DGGTFEVVLH RVWKGSSVHQ DFLGFYVLDS HRMSARTHGL LGQFFHPIGF 
EVSDIHPGSD PTKPDATMVV RNRRLTVTRG LQKDYSKDPW HGAEVSCWFI HNNGAGLIDG 
AYTDYIVPDI F

Genular Protein ID: 4070735544

Symbol: B7Z8B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8B6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 623
  • Mass: 69527
  • Checksum: 60ED5DBCD93E45DA
  • Sequence:
    • MNKNVVFVID ISGSMRGQKV KQIKEALLKI LGDMQPGDYF DLVLFGTRVQ SWKGSLVQAS 
EANLQAAQDF VRGFSLDEAT NLNGGLLRGI EILNQVQESL PELSNHASIL IMLTDGDPTE 
GVTDRSQILK NVRNAIRGRF PLYNLGFGHN VDFNFLEVMS MENNGRAQRI YEDHDATQQL 
QGFYSQVAKP LLVDVDLQYP QDAVLALTQN HHKQYYEGSE IVVAGRIADN KQSSFKADVQ 
AHGEGQEFSI TCLVDEEEMK KLLRERGHML ENHVERLWAY LTIQELLAKR MKVDREVRAN 
LSSQALRMSL DYGFVTPLTS MSIRGMADQD GLKPTIDKPS EDSPPLEMLG PRRTFVLSAL 
QPSPTHSSSN TQRLPDRVTG VDTDPHFIIH VPQKEDTLCF NINEEPGVIL SLVQDPNTGF 
SVNGQLIGNK ARSPGQHDGT YFGRLGIANP ATDFQLEVTP QNITLNPGFG GPVFSWRDQA 
VLRQDGVVVT INKKRNLVVS VYDGGTFEVV LHRVWKGSSV HQDFLGFYVL DSHRMSARTH 
GLLGQFFHPI GFEVSDIHPG SDPTKPDATM VVRSRRLTVT RGLQKDYSKD PWHGAEVSCW 
FIHNNGAGLI DGAYTDYIVP DIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.