Details for: ITPKA

Gene ID: 3706

Symbol: ITPKA

Ensembl ID: ENSG00000137825

Description: inositol-trisphosphate 3-kinase A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.1888
    Cell Significance Index: -7.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.5834
    Cell Significance Index: -7.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9775
    Cell Significance Index: -7.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.7968
    Cell Significance Index: 80.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4646
    Cell Significance Index: 469.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3508
    Cell Significance Index: 50.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4588
    Cell Significance Index: 144.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4019
    Cell Significance Index: 228.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1162
    Cell Significance Index: 121.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1127
    Cell Significance Index: 1004.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9706
    Cell Significance Index: 194.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9490
    Cell Significance Index: 20.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9216
    Cell Significance Index: 20.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9052
    Cell Significance Index: 41.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8153
    Cell Significance Index: 21.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.8080
    Cell Significance Index: 10.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7194
    Cell Significance Index: 14.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5570
    Cell Significance Index: 7.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5419
    Cell Significance Index: 23.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5290
    Cell Significance Index: 36.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4706
    Cell Significance Index: 13.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4621
    Cell Significance Index: 17.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4305
    Cell Significance Index: 6.4500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.3576
    Cell Significance Index: 3.9200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2964
    Cell Significance Index: 4.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2963
    Cell Significance Index: 4.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2857
    Cell Significance Index: 56.7100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2528
    Cell Significance Index: 2.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2423
    Cell Significance Index: 8.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2224
    Cell Significance Index: 14.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2181
    Cell Significance Index: 14.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0866
    Cell Significance Index: 1.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0692
    Cell Significance Index: 1.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0460
    Cell Significance Index: 20.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0244
    Cell Significance Index: 0.7800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0116
    Cell Significance Index: 0.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0084
    Cell Significance Index: 3.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0024
    Cell Significance Index: 1.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0050
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0066
    Cell Significance Index: -3.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0107
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0124
    Cell Significance Index: -7.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0157
    Cell Significance Index: -0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0186
    Cell Significance Index: -2.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0201
    Cell Significance Index: -3.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0204
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0217
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0249
    Cell Significance Index: -4.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0266
    Cell Significance Index: -7.6400
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0324
    Cell Significance Index: -0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0407
    Cell Significance Index: -4.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0458
    Cell Significance Index: -9.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0491
    Cell Significance Index: -6.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0505
    Cell Significance Index: -5.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0524
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0561
    Cell Significance Index: -6.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0600
    Cell Significance Index: -3.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0617
    Cell Significance Index: -2.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0699
    Cell Significance Index: -9.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0722
    Cell Significance Index: -7.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0723
    Cell Significance Index: -5.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0781
    Cell Significance Index: -4.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0851
    Cell Significance Index: -6.0200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0912
    Cell Significance Index: -0.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0914
    Cell Significance Index: -4.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0941
    Cell Significance Index: -3.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0960
    Cell Significance Index: -7.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1104
    Cell Significance Index: -6.7900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1108
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1109
    Cell Significance Index: -1.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1113
    Cell Significance Index: -5.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1225
    Cell Significance Index: -6.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1228
    Cell Significance Index: -9.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1273
    Cell Significance Index: -2.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1364
    Cell Significance Index: -7.1600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1372
    Cell Significance Index: -1.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1459
    Cell Significance Index: -1.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1494
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1594
    Cell Significance Index: -4.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1611
    Cell Significance Index: -7.5700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1773
    Cell Significance Index: -1.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1852
    Cell Significance Index: -4.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1953
    Cell Significance Index: -4.7300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2050
    Cell Significance Index: -1.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2130
    Cell Significance Index: -3.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2176
    Cell Significance Index: -7.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2187
    Cell Significance Index: -5.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2187
    Cell Significance Index: -5.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Activity:** ITPKA is a unique enzyme that catalyzes the phosphorylation of inositol-1,4,5-trisphosphate (IP3) to inositol-1,4,5-trisphosphate-3-phosphate (IP4), generating a potent signaling molecule that regulates various cellular processes. 2. **Cellular Localization:** ITPKA is predominantly expressed in neurons, particularly in glutamatergic cortical neurons and GABAergic interneurons, as well as in intestinal epithelial cells and stem cells. 3. **Regulatory Mechanisms:** ITPKA is modulated by various regulatory mechanisms, including calcium ion-dependent phosphorylation, calmodulin binding, and interaction with small GTPases. **Pathways and Functions:** 1. **Dendritic Spine Morphogenesis:** ITPKA plays a crucial role in regulating the morphology of dendritic spines, which are critical for synaptic plasticity and learning. 2. **Synaptic Plasticity:** ITPKA is involved in the regulation of synaptic plasticity, a process essential for learning and memory. 3. **Immune Regulation:** ITPKA is expressed in immune cells, such as dendritic cells and T cells, where it regulates immune responses and inflammation. 4. **Intestinal Homeostasis:** ITPKA is expressed in intestinal epithelial cells and stem cells, where it maintains intestinal homeostasis and prevents inflammation. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in ITPKA expression and function have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Immune-Mediated Disorders:** ITPKA dysregulation has been implicated in immune-mediated disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Intestinal Disorders:** ITPKA expression and function are altered in intestinal disorders, including inflammatory bowel disease and colon cancer. 4. **Cancer:** ITPKA has been identified as a potential oncogene, with its expression and activity contributing to cancer progression and metastasis. In conclusion, ITPKA is a vital enzyme that plays a multifaceted role in various cellular processes, including immune regulation, synaptic plasticity, and cellular signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying ITPKA function and its clinical significance.

Genular Protein ID: 4242907163

Symbol: IP3KA_HUMAN

Name: Inositol 1,4,5-trisphosphate 3-kinase A

UniProtKB Accession Codes:

P23677 Q8TAN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847047

Title: Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinase.

PubMed ID: 1847047

DOI: 10.1016/0006-291x(91)91449-m

PubMed ID: 2175886

Title: Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence.

PubMed ID: 2175886

DOI: 10.1093/nar/18.23.7141

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12747803

Title: The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.

PubMed ID: 12747803

DOI: 10.1042/bj20021963

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15350214

Title: Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.

PubMed ID: 15350214

DOI: 10.1016/j.molcel.2004.08.004

Sequence Information:

  • Length: 461
  • Mass: 51009
  • Checksum: 18CA214A091F5B19
  • Sequence:
    • MTLPGGPTGM ARPGGARPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA AGEPRARGAK 
RRGGQVPNGL PRAPPAPVIP QLTVTAEEPD VPPTSPGPPE RERDCLPAAG SSHLQQPRRL 
STSSVSSTGS SSLLEDSEDD LLSDSESRSR GNVQLEAGED VGQKNHWQKI RTMVNLPVIS 
PFKKRYAWVQ LAGHTGSFKA AGTSGLILKR CSEPERYCLA RLMADALRGC VPAFHGVVER 
DGESYLQLQD LLDGFDGPCV LDCKMGVRTY LEEELTKARE RPKLRKDMYK KMLAVDPEAP 
TEEEHAQRAV TKPRYMQWRE GISSSTTLGF RIEGIKKADG SCSTDFKTTR SREQVLRVFE 
EFVQGDEEVL RRYLNRLQQI RDTLEVSEFF RRHEVIGSSL LFVHDHCHRA GVWLIDFGKT 
TPLPDGQILD HRRPWEEGNR EDGYLLGLDN LIGILASLAE R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.