Details for: ITPKA

Gene ID: 3706

Symbol: ITPKA

Ensembl ID: ENSG00000137825

Description: inositol-trisphosphate 3-kinase A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1779
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1547
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.89
    Marker Score: 1849
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.88
    Marker Score: 5617
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.72
    Marker Score: 714
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.71
    Marker Score: 306
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.69
    Marker Score: 3323
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.68
    Marker Score: 6493
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 451
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.67
    Marker Score: 1171
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2793
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.61
    Marker Score: 1734
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.61
    Marker Score: 5227
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.6
    Marker Score: 410
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.57
    Marker Score: 138
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.56
    Marker Score: 1758
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.54
    Marker Score: 33318
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8448
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 883.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 445
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 892
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.42
    Marker Score: 103
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.4
    Marker Score: 677
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 550
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.36
    Marker Score: 134
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.35
    Marker Score: 171
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.34
    Marker Score: 812
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.31
    Marker Score: 440
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.31
    Marker Score: 127.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3
    Marker Score: 3052
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 171
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 103
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.27
    Marker Score: 336
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.27
    Marker Score: 77
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.26
    Marker Score: 204
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.25
    Marker Score: 238
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.24
    Marker Score: 571
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.23
    Marker Score: 3152
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.23
    Marker Score: 107
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.19
    Marker Score: 240
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 63
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.18
    Marker Score: 181
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.18
    Marker Score: 201
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.18
    Marker Score: 3761
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.17
    Marker Score: 5819
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.17
    Marker Score: 385
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.14
    Marker Score: 47
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.13
    Marker Score: 275.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.13
    Marker Score: 177
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.13
    Marker Score: 361
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.12
    Marker Score: 2108
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.11
    Marker Score: 37

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Other Information

**Key characteristics** * ITPKA is a serine/threonine kinase that is involved in the regulation of the actin cytoskeleton. * It is a key regulator of dendritic spine morphogenesis, synaptic plasticity, and cellular responses to calcium ion. * ITPKA is also involved in the regulation of the inositol phosphate metabolic process, the regulation of the small GTPase-mediated signaling pathway, and the regulation of the calcium/calmodulin signaling pathway. **Pathways and functions** * ITPKA is a key regulator of the actin cytoskeleton. It is involved in the regulation of dendritic spine morphogenesis, synaptic plasticity, and cellular responses to calcium ion. * ITPKA is also involved in the regulation of the inositol phosphate metabolic process, the regulation of the small GTPase-mediated signaling pathway, and the regulation of the calcium/calmodulin signaling pathway. * ITPKA is a key regulator of synaptic plasticity. It is involved in the modulation of synaptic plasticity by regulating the formation and stabilization of dendritic spines. **Clinical significance** Mutations in the ITPKA gene have been linked to a number of human diseases, including autism, schizophrenia, and epilepsy. These mutations can lead to the formation of abnormal dendritic spines, which can disrupt synaptic plasticity and lead to neuronal dysfunction. **Conclusion** ITPKA is a key regulator of cellular processes that are important for maintaining homeostasis and preventing disease. Mutations in the ITPKA gene can lead to a number of human diseases, highlighting the importance of this protein in human health.

Genular Protein ID: 4242907163

Symbol: IP3KA_HUMAN

Name: Inositol 1,4,5-trisphosphate 3-kinase A

UniProtKB Accession Codes:

P23677 Q8TAN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847047

Title: Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinase.

PubMed ID: 1847047

DOI: 10.1016/0006-291x(91)91449-m

PubMed ID: 2175886

Title: Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence.

PubMed ID: 2175886

DOI: 10.1093/nar/18.23.7141

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12747803

Title: The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.

PubMed ID: 12747803

DOI: 10.1042/bj20021963

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15350214

Title: Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.

PubMed ID: 15350214

DOI: 10.1016/j.molcel.2004.08.004

Sequence Information:

  • Length: 461
  • Mass: 51009
  • Checksum: 18CA214A091F5B19
  • Sequence:
    • MTLPGGPTGM ARPGGARPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA AGEPRARGAK 
RRGGQVPNGL PRAPPAPVIP QLTVTAEEPD VPPTSPGPPE RERDCLPAAG SSHLQQPRRL 
STSSVSSTGS SSLLEDSEDD LLSDSESRSR GNVQLEAGED VGQKNHWQKI RTMVNLPVIS 
PFKKRYAWVQ LAGHTGSFKA AGTSGLILKR CSEPERYCLA RLMADALRGC VPAFHGVVER 
DGESYLQLQD LLDGFDGPCV LDCKMGVRTY LEEELTKARE RPKLRKDMYK KMLAVDPEAP 
TEEEHAQRAV TKPRYMQWRE GISSSTTLGF RIEGIKKADG SCSTDFKTTR SREQVLRVFE 
EFVQGDEEVL RRYLNRLQQI RDTLEVSEFF RRHEVIGSSL LFVHDHCHRA GVWLIDFGKT 
TPLPDGQILD HRRPWEEGNR EDGYLLGLDN LIGILASLAE R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.