Details for: ITPKB

Gene ID: 3707

Symbol: ITPKB

Ensembl ID: ENSG00000143772

Description: inositol-trisphosphate 3-kinase B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 140.3450
    Cell Significance Index: -21.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.2521
    Cell Significance Index: -21.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.6723
    Cell Significance Index: -21.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1109
    Cell Significance Index: -22.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8002
    Cell Significance Index: -19.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6786
    Cell Significance Index: -20.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4590
    Cell Significance Index: -22.9100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 5.8426
    Cell Significance Index: 81.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7196
    Cell Significance Index: -22.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.1003
    Cell Significance Index: 44.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.3916
    Cell Significance Index: 1085.4700
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.6198
    Cell Significance Index: 18.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1039
    Cell Significance Index: 114.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7928
    Cell Significance Index: 1492.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.7878
    Cell Significance Index: 4.7600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.7859
    Cell Significance Index: 7.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4783
    Cell Significance Index: 47.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4206
    Cell Significance Index: 379.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3890
    Cell Significance Index: 45.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3389
    Cell Significance Index: 5.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3041
    Cell Significance Index: 2.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2840
    Cell Significance Index: 17.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2758
    Cell Significance Index: 30.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2641
    Cell Significance Index: 42.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2367
    Cell Significance Index: 150.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2362
    Cell Significance Index: 5.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2026
    Cell Significance Index: 3.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1506
    Cell Significance Index: 7.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1331
    Cell Significance Index: 23.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0917
    Cell Significance Index: 17.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0912
    Cell Significance Index: 2.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0847
    Cell Significance Index: 37.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0729
    Cell Significance Index: 14.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0514
    Cell Significance Index: 35.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0265
    Cell Significance Index: 14.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0042
    Cell Significance Index: 1.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0130
    Cell Significance Index: -1.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0168
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0247
    Cell Significance Index: -3.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0266
    Cell Significance Index: -20.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0274
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0332
    Cell Significance Index: -24.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0378
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0387
    Cell Significance Index: -24.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0439
    Cell Significance Index: -24.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0496
    Cell Significance Index: -6.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0548
    Cell Significance Index: -7.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0650
    Cell Significance Index: -12.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0672
    Cell Significance Index: -4.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0701
    Cell Significance Index: -20.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0710
    Cell Significance Index: -3.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0776
    Cell Significance Index: -2.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0848
    Cell Significance Index: -5.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0957
    Cell Significance Index: -12.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0982
    Cell Significance Index: -16.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1178
    Cell Significance Index: -24.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1200
    Cell Significance Index: -13.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1363
    Cell Significance Index: -13.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1406
    Cell Significance Index: -4.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1579
    Cell Significance Index: -7.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1769
    Cell Significance Index: -20.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1779
    Cell Significance Index: -13.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1801
    Cell Significance Index: -11.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2011
    Cell Significance Index: -10.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2165
    Cell Significance Index: -6.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2186
    Cell Significance Index: -3.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2321
    Cell Significance Index: -17.3000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2324
    Cell Significance Index: -2.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2331
    Cell Significance Index: -18.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2388
    Cell Significance Index: -16.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2420
    Cell Significance Index: -16.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2720
    Cell Significance Index: -14.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2837
    Cell Significance Index: -15.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2862
    Cell Significance Index: -17.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2888
    Cell Significance Index: -3.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3272
    Cell Significance Index: -10.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3671
    Cell Significance Index: -23.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4155
    Cell Significance Index: -11.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4222
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4293
    Cell Significance Index: -18.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4416
    Cell Significance Index: -23.1900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4915
    Cell Significance Index: -5.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5094
    Cell Significance Index: -19.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5293
    Cell Significance Index: -19.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5422
    Cell Significance Index: -8.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5530
    Cell Significance Index: -14.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5605
    Cell Significance Index: -9.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5830
    Cell Significance Index: -20.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5831
    Cell Significance Index: -19.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5836
    Cell Significance Index: -17.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5909
    Cell Significance Index: -15.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6072
    Cell Significance Index: -21.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6467
    Cell Significance Index: -17.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6605
    Cell Significance Index: -13.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6675
    Cell Significance Index: -21.2600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.6701
    Cell Significance Index: -10.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzyme Function**: ITPKB is a 3-kinase enzyme that phosphorylates inositol trisphosphate (IP3) and inositol tetrakisphosphate (IP4), generating inositol hexakisphosphate (IP6) and inositol pentakisphosphate (IP5). 2. **Cellular Localization**: ITPKB is found in the cytosol and endoplasmic reticulum of various cell types, including immune cells, neural cells, and epithelial cells. 3. **Subcellular Domains**: ITPKB contains two distinct domains: an N-terminal domain with kinase activity and a C-terminal domain with phosphoinositide-binding activity. 4. **Regulatory Mechanisms**: ITPKB is regulated by various mechanisms, including calcium-dependent activation, protein-protein interactions, and post-translational modifications. **Pathways and Functions** 1. **Phosphoinositide Signaling Pathway**: ITPKB plays a crucial role in the phosphoinositide signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 2. **Calcium Signaling**: ITPKB is activated by calcium ions, which are essential for various cellular processes, including muscle contraction, neurotransmission, and immune response. 3. **Cell Proliferation and Differentiation**: ITPKB regulates cell proliferation and differentiation by modulating the activity of downstream signaling pathways, including the MAPK cascade and the PI3K/AKT pathway. 4. **Immune Response**: ITPKB is involved in the regulation of immune responses, including the negative regulation of neutrophil apoptosis and the positive regulation of alpha-beta T cell differentiation. 5. **Neurological Functions**: ITPKB is expressed in neural cells and plays a role in the regulation of neuronal function, including synaptic plasticity and neuronal survival. **Clinical Significance** 1. **Cancer**: Alterations in ITPKB expression and activity have been associated with various types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Neurological Disorders**: ITPKB is involved in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune-Mediated Diseases**: ITPKB is involved in the regulation of immune responses, and alterations in its expression and activity have been associated with immune-mediated diseases, including rheumatoid arthritis and lupus. 4. **Cardiovascular Diseases**: ITPKB is involved in the regulation of cardiovascular functions, including blood pressure regulation and cardiac contractility, and alterations in its expression and activity have been associated with cardiovascular diseases. In conclusion, ITPKB is a critical enzyme in the phosphoinositide signaling pathway, which plays a significant role in various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, immune-mediated diseases, and cardiovascular diseases. Further research is needed to fully understand the mechanisms of ITPKB and its clinical significance.

Genular Protein ID: 1245149731

Symbol: IP3KB_HUMAN

Name: Inositol 1,4,5-trisphosphate 3-kinase B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11846419

Title: Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B.

PubMed ID: 11846419

DOI: 10.1006/bbrc.2002.6456

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1654894

Title: Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme.

PubMed ID: 1654894

DOI: 10.1042/bj2780883

PubMed ID: 12747803

Title: The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.

PubMed ID: 12747803

DOI: 10.1042/bj20021963

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23060452

Title: Headpiece domain of dematin regulates calcium mobilization and signaling in platelets.

PubMed ID: 23060452

DOI: 10.1074/jbc.m112.364679

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 946
  • Mass: 102376
  • Checksum: 2CCBCBE7AEF26848
  • Sequence:
  • MAVYCYALNS LVIMNSANEM KSGGGPGPSG SETPPPPRRA VLSPGSVFSP GRGASFLFPP 
    AESLSPEEPR SPGGWRSGRR RLNSSSGSGS GSSGSSVSSP SWAGRLRGDR QQVVAAGTLS 
    PPGPEEAKRK LRILQRELQN VQVNQKVGMF EAHIQAQSSA IQAPRSPRLG RARSPSPCPF 
    RSSSQPPGRV LVQGARSEER RTKSWGEQCP ETSGTDSGRK GGPSLCSSQV KKGMPPLPGR 
    AAPTGSEAQG PSAFVRMEKG IPASPRCGSP TAMEIDKRGS PTPGTRSCLA PSLGLFGASL 
    TMATEVAARV TSTGPHRPQD LALTEPSGRA RELEDLQPPE ALVERQGQFL GSETSPAPER 
    GGPRDGEPPG KMGKGYLPCG MPGSGEPEVG KRPEETTVSV QSAESSDSLS WSRLPRALAS 
    VGPEEARSGA PVGGGRWQLS DRVEGGSPTL GLLGGSPSAQ PGTGNVEAGI PSGRMLEPLP 
    CWDAAKDLKE PQCPPGDRVG VQPGNSRVWQ GTMEKAGLAW TRGTGVQSEG TWESQRQDSD 
    ALPSPELLPQ DPDKPFLRKA CSPSNIPAVI ITDMGTQEDG ALEETQGSPR GNLPLRKLSS 
    SSASSTGFSS SYEDSEEDIS SDPERTLDPN SAFLHTLDQQ KPRVSKSWRK IKNMVHWSPF 
    VMSFKKKYPW IQLAGHAGSF KAAANGRILK KHCESEQRCL DRLMVDVLRP FVPAYHGDVV 
    KDGERYNQMD DLLADFDSPC VMDCKMGIRT YLEEELTKAR KKPSLRKDMY QKMIEVDPEA 
    PTEEEKAQRA VTKPRYMQWR ETISSTATLG FRIEGIKKED GTVNRDFKKT KTREQVTEAF 
    REFTKGNHNI LIAYRDRLKA IRTTLEVSPF FKCHEVIGSS LLFIHDKKEQ AKVWMIDFGK 
    TTPLPEGQTL QHDVPWQEGN REDGYLSGLN NLVDILTEMS QDAPLA

Genular Protein ID: 949580081

Symbol: B2R9J0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 472
  • Mass: 53500
  • Checksum: 576E47E46AAC1A29
  • Sequence:
  • MLEPLPCWDA AKDLKEPQCP PGDRVGVQPG NSRVWQGTME KAGLAWTRGT GVQSEGTWES 
    QRQDSDALPS PELLPQDQDK PFLRKACSPS NIPAVIITDM GTQEDGALEE TQGSPRGNLP 
    LRKLSSSSAS STGFSSSYED SEEDISSDPE RTLDPNSAFL HTLDQQKPRV SKSWRKIKNM 
    VHWSPFVMSF KKKYPWIQLA GHAGSFKAAA NGRILKKHCE SEQRCLDRLM VDVLRPFVPA 
    YHGDVVKDGE RYNQMDDLLA DFDSPCVMDC KMGIRTYLEE ELTKARRKPS LRKDMYQKMI 
    EVDPEAPTEE EKAQRAVTKP RYMQWRETIS STATLGFRIE GIKKEDGTVN RDFKKTKTRE 
    QVTEAFREFT KGNHNILIAY RDRLKAIRTT LEVSPFFKCH EVIGSSLLFI HDKKEQAKVW 
    MIDFGKTTPL PEGQTLQHDV PWQEGNREDG YLSGLNNLVD ILTEMSQDAP LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.