Details for: ITPKB

Gene ID: 3707

Symbol: ITPKB

Ensembl ID: ENSG00000143772

Description: inositol-trisphosphate 3-kinase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.7
    Marker Score: 2437
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.26
    Marker Score: 7151.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.08
    Marker Score: 65798
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.74
    Marker Score: 865
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.39
    Marker Score: 10008
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.11
    Marker Score: 1825
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.74
    Marker Score: 544
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.53
    Marker Score: 766
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168407.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.42
    Marker Score: 1509
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.41
    Marker Score: 455
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.35
    Marker Score: 812
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.32
    Marker Score: 387
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.32
    Marker Score: 3163
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.24
    Marker Score: 740
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.17
    Marker Score: 2380
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17599
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.09
    Marker Score: 544
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.04
    Marker Score: 315
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.02
    Marker Score: 957
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71715
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47940
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.94
    Marker Score: 887
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5652
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.94
    Marker Score: 290
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.93
    Marker Score: 2128
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.93
    Marker Score: 1066
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.92
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.88
    Marker Score: 955
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.88
    Marker Score: 510
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.87
    Marker Score: 937
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5246
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.85
    Marker Score: 1231
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.84
    Marker Score: 801
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.82
    Marker Score: 457
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.81
    Marker Score: 209
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.8
    Marker Score: 273
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1210
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.72
    Marker Score: 38046
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.72
    Marker Score: 251
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.72
    Marker Score: 2008
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2963
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.71
    Marker Score: 535
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.71
    Marker Score: 632
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.7
    Marker Score: 732
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.69
    Marker Score: 2053
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.68
    Marker Score: 966
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.68
    Marker Score: 172
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.67
    Marker Score: 332
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.66
    Marker Score: 286
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 603
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.66
    Marker Score: 633
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.63
    Marker Score: 24106
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.63
    Marker Score: 137
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.62
    Marker Score: 477
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.62
    Marker Score: 557
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.62
    Marker Score: 350
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.61
    Marker Score: 508
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.61
    Marker Score: 1629
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.6
    Marker Score: 389
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.6
    Marker Score: 649
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.6
    Marker Score: 267
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.6
    Marker Score: 216
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.6
    Marker Score: 550.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.6
    Marker Score: 644
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.6
    Marker Score: 649
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.59
    Marker Score: 163
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.59
    Marker Score: 213
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.59
    Marker Score: 1049
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.58
    Marker Score: 394
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.58
    Marker Score: 698
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.57
    Marker Score: 279
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.57
    Marker Score: 128
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.57
    Marker Score: 112
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.57
    Marker Score: 133
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.57
    Marker Score: 1096
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.57
    Marker Score: 736
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.56
    Marker Score: 2350.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.55
    Marker Score: 300
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.55
    Marker Score: 1303
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.55
    Marker Score: 224
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 363
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.55
    Marker Score: 1292
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.55
    Marker Score: 135
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.54
    Marker Score: 549
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.54
    Marker Score: 760

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Other Information

**Key characteristics:** - ITPKB is a serine/threonine kinase - It is a multi-domain protein with a catalytic domain and a regulatory domain - It is a key regulator of the MAPK pathway, which is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis **Pathways and functions:** - ITPKB is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. - It is a key regulator of the MAPK pathway, which is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. - ITPKB is also involved in the regulation of the transcription factor NF-κB, which is a key regulator of inflammation. **Clinical significance:** - Mutations in ITPKB have been linked to a number of human diseases, including cerebral palsy, epilepsy, and cancer. - ITPKB inhibitors are being investigated as a treatment for these diseases. **Additional notes:** - ITPKB is a highly conserved protein, with a similar protein found in other mammals. - ITPKB is a relatively new protein, with the first human gene encoding ITPKB being identified in 1999.

Genular Protein ID: 1245149731

Symbol: IP3KB_HUMAN

Name: Inositol 1,4,5-trisphosphate 3-kinase B

UniProtKB Accession Codes:

P27987 Q5VWL9 Q5VWM0 Q96BZ2 Q96JS1 Q9UH47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EPD 1 Ensembl 3 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11846419

Title: Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B.

PubMed ID: 11846419

DOI: 10.1006/bbrc.2002.6456

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1654894

Title: Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme.

PubMed ID: 1654894

DOI: 10.1042/bj2780883

PubMed ID: 12747803

Title: The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.

PubMed ID: 12747803

DOI: 10.1042/bj20021963

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23060452

Title: Headpiece domain of dematin regulates calcium mobilization and signaling in platelets.

PubMed ID: 23060452

DOI: 10.1074/jbc.m112.364679

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 946
  • Mass: 102376
  • Checksum: 2CCBCBE7AEF26848
  • Sequence:
    • MAVYCYALNS LVIMNSANEM KSGGGPGPSG SETPPPPRRA VLSPGSVFSP GRGASFLFPP 
AESLSPEEPR SPGGWRSGRR RLNSSSGSGS GSSGSSVSSP SWAGRLRGDR QQVVAAGTLS 
PPGPEEAKRK LRILQRELQN VQVNQKVGMF EAHIQAQSSA IQAPRSPRLG RARSPSPCPF 
RSSSQPPGRV LVQGARSEER RTKSWGEQCP ETSGTDSGRK GGPSLCSSQV KKGMPPLPGR 
AAPTGSEAQG PSAFVRMEKG IPASPRCGSP TAMEIDKRGS PTPGTRSCLA PSLGLFGASL 
TMATEVAARV TSTGPHRPQD LALTEPSGRA RELEDLQPPE ALVERQGQFL GSETSPAPER 
GGPRDGEPPG KMGKGYLPCG MPGSGEPEVG KRPEETTVSV QSAESSDSLS WSRLPRALAS 
VGPEEARSGA PVGGGRWQLS DRVEGGSPTL GLLGGSPSAQ PGTGNVEAGI PSGRMLEPLP 
CWDAAKDLKE PQCPPGDRVG VQPGNSRVWQ GTMEKAGLAW TRGTGVQSEG TWESQRQDSD 
ALPSPELLPQ DPDKPFLRKA CSPSNIPAVI ITDMGTQEDG ALEETQGSPR GNLPLRKLSS 
SSASSTGFSS SYEDSEEDIS SDPERTLDPN SAFLHTLDQQ KPRVSKSWRK IKNMVHWSPF 
VMSFKKKYPW IQLAGHAGSF KAAANGRILK KHCESEQRCL DRLMVDVLRP FVPAYHGDVV 
KDGERYNQMD DLLADFDSPC VMDCKMGIRT YLEEELTKAR KKPSLRKDMY QKMIEVDPEA 
PTEEEKAQRA VTKPRYMQWR ETISSTATLG FRIEGIKKED GTVNRDFKKT KTREQVTEAF 
REFTKGNHNI LIAYRDRLKA IRTTLEVSPF FKCHEVIGSS LLFIHDKKEQ AKVWMIDFGK 
TTPLPEGQTL QHDVPWQEGN REDGYLSGLN NLVDILTEMS QDAPLA

Genular Protein ID: 949580081

Symbol: B2R9J0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R9J0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 472
  • Mass: 53500
  • Checksum: 576E47E46AAC1A29
  • Sequence:
    • MLEPLPCWDA AKDLKEPQCP PGDRVGVQPG NSRVWQGTME KAGLAWTRGT GVQSEGTWES 
QRQDSDALPS PELLPQDQDK PFLRKACSPS NIPAVIITDM GTQEDGALEE TQGSPRGNLP 
LRKLSSSSAS STGFSSSYED SEEDISSDPE RTLDPNSAFL HTLDQQKPRV SKSWRKIKNM 
VHWSPFVMSF KKKYPWIQLA GHAGSFKAAA NGRILKKHCE SEQRCLDRLM VDVLRPFVPA 
YHGDVVKDGE RYNQMDDLLA DFDSPCVMDC KMGIRTYLEE ELTKARRKPS LRKDMYQKMI 
EVDPEAPTEE EKAQRAVTKP RYMQWRETIS STATLGFRIE GIKKEDGTVN RDFKKTKTRE 
QVTEAFREFT KGNHNILIAY RDRLKAIRTT LEVSPFFKCH EVIGSSLLFI HDKKEQAKVW 
MIDFGKTTPL PEGQTLQHDV PWQEGNREDG YLSGLNNLVD ILTEMSQDAP LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.