ITPR1 | ENSG00000150995 | NCBI 3708

Details for: ITPR1

Gene ID: 3708

Symbol: ITPR1

Ensembl ID: ENSG00000150995

Description: inositol 1,4,5-trisphosphate receptor type 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca2+ pathway
(R-HSA-4086398)
Cardiac conduction
(R-HSA-5576891)
Cgmp effects
(R-HSA-418457)
Clec7a (dectin-1) induces nfat activation
(R-HSA-5607763)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Effects of pip2 hydrolysis
(R-HSA-114508)
Elevation of cytosolic ca2+ levels
(R-HSA-139853)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion homeostasis
(R-HSA-5578775)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Muscle contraction
(R-HSA-397014)
Nitric oxide stimulates guanylate cyclase
(R-HSA-392154)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet calcium homeostasis
(R-HSA-418360)
Platelet homeostasis
(R-HSA-418346)
Plc beta mediated events
(R-HSA-112043)
Regulation of insulin secretion
(R-HSA-422356)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Calcineurin complex
(GO:0005955)
Calcium-mediated signaling
(GO:0019722)
Calcium-release channel activity
(GO:0015278)
Calcium channel inhibitor activity
(GO:0019855)
Calcium ion binding
(GO:0005509)
Calcium ion transmembrane transporter activity
(GO:0015085)
Calcium ion transport
(GO:0006816)
Cell morphogenesis
(GO:0000902)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum calcium ion homeostasis
(GO:0032469)
Endoplasmic reticulum membrane
(GO:0005789)
Epithelial fluid transport
(GO:0042045)
Inositol 1,4,5 trisphosphate binding
(GO:0070679)
Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
(GO:0005220)
Inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
(GO:0098695)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Membrane
(GO:0016020)
Negative regulation of calcium-mediated signaling
(GO:0050849)
Nuclear inner membrane
(GO:0005637)
Nucleolus
(GO:0005730)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol binding
(GO:0035091)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Plasma membrane
(GO:0005886)
Platelet dense granule membrane
(GO:0031088)
Platelet dense tubular network
(GO:0031094)
Platelet dense tubular network membrane
(GO:0031095)
Positive regulation of insulin secretion
(GO:0032024)
Post-embryonic development
(GO:0009791)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of autophagy
(GO:0010506)
Regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099566)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to hypoxia
(GO:0001666)
Sarcoplasmic reticulum
(GO:0016529)
Schaffer collateral - ca1 synapse
(GO:0098685)
Secretory granule membrane
(GO:0030667)
Signal transduction
(GO:0007165)
Transport vesicle membrane
(GO:0030658)
Voluntary musculoskeletal movement
(GO:0050882)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: Purkinje cell (CL0000121)
Fold Change: 7.07