Details for: ITPR1

Gene ID: 3708

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ITPR1

Ensembl ID: ENSG00000150995

Description: inositol 1,4,5-trisphosphate receptor type 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • sst GABAergic cortical interneuron CL4023017
    CSI 43.89
    rCSI 56.58%
    PRS 39.25
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 40.59
    rCSI 50.5%
    PRS 36.34
  • choroid plexus epithelial cell CL0000706
    CSI 38.53
    rCSI 63.09%
    PRS 45.3
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 31.59
    rCSI 68.52%
    PRS 44.18
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 28.79
    rCSI 69.98%
    PRS 36.85
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 27.41
    rCSI 48.41%
    PRS 37.13
  • VIP GABAergic cortical interneuron CL4023016
    CSI 25.51
    rCSI 30.47%
    PRS 37.94
  • myoepithelial cell CL0000185
    CSI 24.15
    rCSI 61.1%
    PRS 64.02
  • L6b glutamatergic cortical neuron CL4023038
    CSI 21.55
    rCSI 67.33%
    PRS 39.56
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 21.1
    rCSI 50.47%
    PRS 43.47
  • sncg GABAergic cortical interneuron CL4023015
    CSI 19.69
    rCSI 31.66%
    PRS 40.23
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 19.19
    rCSI 69.04%
    PRS 36.73
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 18.88
    rCSI 62.04%
    PRS 43.09
  • melanocyte CL0000148
    CSI 18.78
    rCSI 13.91%
    PRS 48.31
  • mononuclear phagocyte CL0000113
    CSI 14.18
    rCSI 31.2%
    PRS 59.51
  • basophil CL0000767
    CSI 13.39
    rCSI 28.33%
    PRS 74.3
  • enteroendocrine cell CL0000164
    CSI 13.24
    rCSI 18.08%
    PRS 57.75
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 12.49
    rCSI 8.78%
    PRS 74.85
  • retinal pigment epithelial cell CL0002586
    CSI 12.34
    rCSI 24.51%
    PRS 53.64
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 11.51
    rCSI 67.74%
    PRS 39.5
  • neuron CL0000540
    CSI 11.34
    rCSI 30.19%
    PRS 45.5
  • naive B cell CL0000788
    CSI 11.3
    rCSI 9.69%
    PRS 63.31
  • pulmonary artery endothelial cell CL1001568
    CSI 10.82
    rCSI 14.73%
    PRS 67.7
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 10.64
    rCSI 12.85%
    PRS 64.04
  • glutamatergic neuron CL0000679
    CSI 10.56
    rCSI 21.7%
    PRS 46.92
  • amacrine cell CL0000561
    CSI 10.37
    rCSI 30.05%
    PRS 45.76
  • plasmablast CL0000980
    CSI 10.32
    rCSI 8.12%
    PRS 62.35
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 10.31
    rCSI 38.96%
    PRS 38.94
  • kidney connecting tubule epithelial cell CL1000768
    CSI 10.06
    rCSI 25.51%
    PRS 45.31
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 9.72
    rCSI 30.39%
    PRS 41.97
  • renal interstitial pericyte CL1001318
    CSI 9.4
    rCSI 25.92%
    PRS 51.43
  • alveolar macrophage CL0000583
    CSI 9.21
    rCSI 15.18%
    PRS 60.9
  • T follicular helper cell CL0002038
    CSI 9.2
    rCSI 6.89%
    PRS 70.83
  • interneuron CL0000099
    CSI 9.12
    rCSI 18.32%
    PRS 44.82
  • hepatic stellate cell CL0000632
    CSI 8.97
    rCSI 33.62%
    PRS 47.82
  • alpha-beta T cell CL0000789
    CSI 8.93
    rCSI 10.46%
    PRS 72.06
  • group 3 innate lymphoid cell CL0001071
    CSI 8.83
    rCSI 6.64%
    PRS 60.45
  • fibroblast of lung CL0002553
    CSI 8.79
    rCSI 8.18%
    PRS 55.52
  • intermediate monocyte CL0002393
    CSI 8.59
    rCSI 12.97%
    PRS 58.84
  • pro-B cell CL0000826
    CSI 8.5
    rCSI 7.04%
    PRS 57.36
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 8.42
    rCSI 7.67%
    PRS 69.98
  • Kupffer cell CL0000091
    CSI 8.37
    rCSI 19.13%
    PRS 55.12
  • Schwann cell CL0002573
    CSI 8.04
    rCSI 22.84%
    PRS 53.83
  • mucosal invariant T cell CL0000940
    CSI 7.61
    rCSI 6.14%
    PRS 65.48
  • lung secretory cell CL1000272
    CSI 7.56
    rCSI 18.71%
    PRS 53.67
  • lung pericyte CL0009089
    CSI 7.45
    rCSI 19.67%
    PRS 64.21
  • vascular associated smooth muscle cell CL0000359
    CSI 7.17
    rCSI 23.25%
    PRS 57.02
  • blood vessel endothelial cell CL0000071
    CSI 7.15
    rCSI 14.83%
    PRS 52.83
  • perivascular cell CL4033054
    CSI 7.14
    rCSI 9.76%
    PRS 61.21
  • neural cell CL0002319
    CSI 7.07
    rCSI 26.69%
    PRS 43.47
  • cardiac neuron CL0010022
    CSI 6.93
    rCSI 22.17%
    PRS 52.8
  • stromal cell of ovary CL0002132
    CSI 6.8
    rCSI 18.69%
    PRS 69.17
  • adipocyte CL0000136
    CSI 6.65
    rCSI 8.54%
    PRS 48.94
  • lung macrophage CL1001603
    CSI 6.58
    rCSI 14.71%
    PRS 63.06
  • medium spiny neuron CL1001474
    CSI 6.55
    rCSI 56.4%
    PRS 42.93
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 6.45
    rCSI 9.14%
    PRS 51.97
  • B cell CL0000236
    CSI 6.4
    rCSI 8.57%
    PRS 77.78
  • dendritic cell, human CL0001056
    CSI 6.36
    rCSI 9.77%
    PRS 64.1
  • mural cell CL0008034
    CSI 5.97
    rCSI 20.22%
    PRS 47.52
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.76
    rCSI 6.31%
    PRS 59.41
  • interstitial cell of Cajal CL0002088
    CSI 5.75
    rCSI 7.32%
    PRS 61.9
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 5.63
    rCSI 4.28%
    PRS 68.29
  • vascular leptomeningeal cell CL4023051
    CSI 5.63
    rCSI 9.86%
    PRS 47.79
  • blood vessel smooth muscle cell CL0019018
    CSI 5.56
    rCSI 45.23%
    PRS 48.67
  • unswitched memory B cell CL0000970
    CSI 5.43
    rCSI 4.57%
    PRS 73.4
  • fraction A pre-pro B cell CL0002045
    CSI 5.41
    rCSI 6.2%
    PRS 76.14
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 5.3
    rCSI 12.09%
    PRS 52.66
  • inhibitory interneuron CL0000498
    CSI 5.14
    rCSI 11.88%
    PRS 45.33
  • ependymal cell CL0000065
    CSI 5.06
    rCSI 10.26%
    PRS 35.92
  • retinal blood vessel endothelial cell CL0002585
    CSI 4.95
    rCSI 7.91%
    PRS 59.56
  • myeloid dendritic cell CL0000782
    CSI 4.88
    rCSI 7.07%
    PRS 71.64
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 4.78
    rCSI 2.82%
    PRS 72.5
  • central nervous system macrophage CL0000878
    CSI 4.72
    rCSI 15.65%
    PRS 58.6
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.63
    rCSI 10.38%
    PRS 38.86
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.57
    rCSI 11.81%
    PRS 50.79
  • chondrocyte CL0000138
    CSI 4.5
    rCSI 7.16%
    PRS 48.04
  • granulocyte CL0000094
    CSI 4.48
    rCSI 6.85%
    PRS 64.8
  • basal cell CL0000646
    CSI 4.44
    rCSI 5.94%
    PRS 56.35
  • early lymphoid progenitor CL0000936
    CSI 4.38
    rCSI 3.85%
    PRS 60.87
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.33
    rCSI 11.29%
    PRS 54.93
  • cerebral cortex endothelial cell CL1001602
    CSI 4.3
    rCSI 7.44%
    PRS 45.74
  • renal alpha-intercalated cell CL0005011
    CSI 4.11
    rCSI 5.5%
    PRS 64.7
  • cerebral cortex neuron CL0010012
    CSI 4.05
    rCSI 16.52%
    PRS 50.99
  • CD14-positive monocyte CL0001054
    CSI 3.98
    rCSI 4.95%
    PRS 66.3
  • mesangial cell CL0000650
    CSI 3.86
    rCSI 15.74%
    PRS 66.7
  • endocardial cell CL0002350
    CSI 3.84
    rCSI 18.38%
    PRS 54.67
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 3.82
    rCSI 7.62%
    PRS 73.81
  • fibroblast of cardiac tissue CL0002548
    CSI 3.82
    rCSI 18.3%
    PRS 55.12
  • common lymphoid progenitor CL0000051
    CSI 3.82
    rCSI 5.1%
    PRS 77.84
  • smooth muscle cell CL0000192
    CSI 3.76
    rCSI 8.97%
    PRS 63
  • parietal epithelial cell CL1000452
    CSI 3.74
    rCSI 10.01%
    PRS 47.1
  • immature B cell CL0000816
    CSI 3.74
    rCSI 2.78%
    PRS 69.43
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.73
    rCSI 7.1%
    PRS 71.27
  • naive T cell CL0000898
    CSI 3.71
    rCSI 2.58%
    PRS 70.2
  • epithelial cell of proximal tubule CL0002306
    CSI 3.68
    rCSI 9%
    PRS 49.55
  • mature T cell CL0002419
    CSI 3.62
    rCSI 2.82%
    PRS 73.51
  • endothelial cell of vascular tree CL0002139
    CSI 3.57
    rCSI 19.52%
    PRS 55.35
  • glycinergic amacrine cell CL4030028
    CSI 3.49
    rCSI 9.1%
    PRS 53.67
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.43
    rCSI 2.31%
    PRS 68.11
  • cardiac endothelial cell CL0010008
    CSI 3.4
    rCSI 13.72%
    PRS 54.13
  • respiratory goblet cell CL0002370
    CSI 0.2
    rCSI 2.3%
    PRS 72.3%
  • pancreatic stellate cell CL0002410
    CSI 0.4
    rCSI 2.4%
    PRS 65.4%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.4
    rCSI 2.9%
    PRS 70.2%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.5
    rCSI 3.2%
    PRS 47.5%
  • ON parasol ganglion cell CL4033052
    CSI 0.5
    rCSI 7.3%
    PRS 47.2%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.5
    rCSI 2.8%
    PRS 78.0%
  • endothelial cell of placenta CL0009092
    CSI 0.6
    rCSI 2.8%
    PRS 67.1%
  • central nervous system neuron CL2000029
    CSI 0.6
    rCSI 4.6%
    PRS 42.6%
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 0.8
    rCSI 5.8%
    PRS 66.0%
  • mesenchymal cell CL0008019
    CSI 0.9
    rCSI 2.2%
    PRS 50.4%
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.9
    rCSI 13.2%
    PRS 74.8%
  • mucus secreting cell CL0000319
    CSI 0.9
    rCSI 1.4%
    PRS 66.6%
  • colon macrophage CL0009038
    CSI 0.9
    rCSI 4.3%
    PRS 75.4%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.2
    rCSI 2.1%
    PRS 71.6%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.2
    rCSI 1.1%
    PRS 52.4%
  • stromal cell CL0000499
    CSI 1.4
    rCSI 3.9%
    PRS 53.1%
  • tissue-resident macrophage CL0000864
    CSI 1.5
    rCSI 7.1%
    PRS 72.3%
  • basket cell CL0000118
    CSI 1.6
    rCSI 9.7%
    PRS 38.7%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.6
    rCSI 5.0%
    PRS 54.1%
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 1.7
    rCSI 4.3%
    PRS 82.9%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.7
    rCSI 2.7%
    PRS 57.2%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 1.7
    rCSI 3.2%
    PRS 75.4%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 1.7
    rCSI 12.3%
    PRS 47.4%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 1.8
    rCSI 7.0%
    PRS 76.2%
  • epicardial adipocyte CL1000309
    CSI 2.0
    rCSI 6.4%
    PRS 56.6%
  • common dendritic progenitor CL0001029
    CSI 2.0
    rCSI 2.5%
    PRS 66.0%
  • pancreatic D cell CL0000173
    CSI 2.0
    rCSI 1.9%
    PRS 58.1%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.0
    rCSI 1.7%
    PRS 60.4%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 2.0
    rCSI 3.5%
    PRS 64.0%
  • renal principal cell CL0005009
    CSI 2.0
    rCSI 5.2%
    PRS 59.5%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.0
    rCSI 1.5%
    PRS 55.4%
  • enteroendocrine cell of small intestine CL0009006
    CSI 2.0
    rCSI 4.4%
    PRS 69.0%
  • conjunctival epithelial cell CL1000432
    CSI 2.2
    rCSI 3.4%
    PRS 56.2%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.2
    rCSI 4.1%
    PRS 48.0%
  • elicited macrophage CL0000861
    CSI 2.3
    rCSI 2.1%
    PRS 64.0%
  • late pro-B cell CL0002048
    CSI 2.3
    rCSI 5.8%
    PRS 82.3%
  • mesothelial cell CL0000077
    CSI 2.3
    rCSI 9.0%
    PRS 32.1%
  • GABAergic neuron CL0000617
    CSI 2.3
    rCSI 7.8%
    PRS 41.6%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.4
    rCSI 1.8%
    PRS 57.0%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 2.4
    rCSI 20.3%
    PRS 53.6%
  • contractile cell CL0000183
    CSI 2.4
    rCSI 7.1%
    PRS 53.7%
  • promyelocyte CL0000836
    CSI 2.4
    rCSI 3.5%
    PRS 65.3%
  • pancreatic A cell CL0000171
    CSI 2.4
    rCSI 2.5%
    PRS 59.0%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 2.5
    rCSI 6.0%
    PRS 74.0%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.6
    rCSI 4.0%
    PRS 63.6%
  • dopaminergic neuron CL0000700
    CSI 2.6
    rCSI 14.6%
    PRS 41.1%
  • serotonergic neuron CL0000850
    CSI 2.6
    rCSI 11.6%
    PRS 40.1%
  • kidney collecting duct intercalated cell CL1001432
    CSI 2.6
    rCSI 18.6%
    PRS 56.5%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 2.6
    rCSI 7.6%
    PRS 57.4%
  • innate lymphoid cell CL0001065
    CSI 2.7
    rCSI 5.5%
    PRS 58.5%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 2.7
    rCSI 7.7%
    PRS 75.1%
  • lung ciliated cell CL1000271
    CSI 2.7
    rCSI 3.1%
    PRS 45.5%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.7
    rCSI 65.6%
    PRS 38.3%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.8
    rCSI 65.8%
    PRS 37.4%
  • renal beta-intercalated cell CL0002201
    CSI 2.8
    rCSI 6.6%
    PRS 56.8%
  • cardiac muscle cell CL0000746
    CSI 2.8
    rCSI 4.1%
    PRS 45.8%
  • enteric smooth muscle cell CL0002504
    CSI 2.9
    rCSI 4.1%
    PRS 58.1%
  • mature B cell CL0000785
    CSI 2.9
    rCSI 2.5%
    PRS 66.2%
  • T-helper 17 cell CL0000899
    CSI 2.9
    rCSI 2.3%
    PRS 77.6%
  • podocyte CL0000653
    CSI 2.9
    rCSI 13.0%
    PRS 54.7%
  • retinal ganglion cell CL0000740
    CSI 2.9
    rCSI 6.5%
    PRS 42.4%
  • GABAergic amacrine cell CL4030027
    CSI 3.0
    rCSI 10.2%
    PRS 45.1%
  • enteroglial cell CL4040002
    CSI 3.0
    rCSI 15.6%
    PRS 61.8%
  • bronchus fibroblast of lung CL2000093
    CSI 3.0
    rCSI 2.5%
    PRS 56.0%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 3.1
    rCSI 5.1%
    PRS 38.1%
  • common myeloid progenitor CL0000049
    CSI 3.1
    rCSI 2.5%
    PRS 56.9%
  • class switched memory B cell CL0000972
    CSI 3.2
    rCSI 2.4%
    PRS 73.2%
  • hematopoietic stem cell CL0000037
    CSI 3.2
    rCSI 2.1%
    PRS 59.1%
  • helper T cell CL0000912
    CSI 3.2
    rCSI 4.6%
    PRS 62.0%
  • epithelial cell CL0000066
    CSI 3.3
    rCSI 5.1%
    PRS 53.3%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 3.3
    rCSI 34.9%
    PRS 54.6%
  • adventitial cell CL0002503
    CSI 3.4
    rCSI 8.1%
    PRS 64.6%
  • cardiac endothelial cell CL0010008
    CSI 3.4
    rCSI 13.7%
    PRS 54.1%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.4
    rCSI 2.3%
    PRS 68.1%
  • glycinergic amacrine cell CL4030028
    CSI 3.5
    rCSI 9.1%
    PRS 53.7%
  • endothelial cell of vascular tree CL0002139
    CSI 3.6
    rCSI 19.5%
    PRS 55.4%
  • mature T cell CL0002419
    CSI 3.6
    rCSI 2.8%
    PRS 73.5%
  • epithelial cell of proximal tubule CL0002306
    CSI 3.7
    rCSI 9.0%
    PRS 49.6%
  • naive T cell CL0000898
    CSI 3.7
    rCSI 2.6%
    PRS 70.2%
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.7
    rCSI 7.1%
    PRS 71.3%
  • immature B cell CL0000816
    CSI 3.7
    rCSI 2.8%
    PRS 69.4%
  • parietal epithelial cell CL1000452
    CSI 3.7
    rCSI 10.0%
    PRS 47.1%
  • smooth muscle cell CL0000192
    CSI 3.8
    rCSI 9.0%
    PRS 63.0%
  • common lymphoid progenitor CL0000051
    CSI 3.8
    rCSI 5.1%
    PRS 77.8%
  • fibroblast of cardiac tissue CL0002548
    CSI 3.8
    rCSI 18.3%
    PRS 55.1%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 3.8
    rCSI 7.6%
    PRS 73.8%
  • endocardial cell CL0002350
    CSI 3.8
    rCSI 18.4%
    PRS 54.7%
  • mesangial cell CL0000650
    CSI 3.9
    rCSI 15.7%
    PRS 66.7%
  • CD14-positive monocyte CL0001054
    CSI 4.0
    rCSI 5.0%
    PRS 66.3%
  • cerebral cortex neuron CL0010012
    CSI 4.1
    rCSI 16.5%
    PRS 51.0%
  • renal alpha-intercalated cell CL0005011
    CSI 4.1
    rCSI 5.5%
    PRS 64.7%
  • cerebral cortex endothelial cell CL1001602
    CSI 4.3
    rCSI 7.4%
    PRS 45.7%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.3
    rCSI 11.3%
    PRS 54.9%
  • early lymphoid progenitor CL0000936
    CSI 4.4
    rCSI 3.9%
    PRS 60.9%
  • basal cell CL0000646
    CSI 4.4
    rCSI 5.9%
    PRS 56.4%
  • granulocyte CL0000094
    CSI 4.5
    rCSI 6.9%
    PRS 64.8%
  • chondrocyte CL0000138
    CSI 4.5
    rCSI 7.2%
    PRS 48.0%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.6
    rCSI 11.8%
    PRS 50.8%
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.6
    rCSI 10.4%
    PRS 38.9%
  • central nervous system macrophage CL0000878
    CSI 4.7
    rCSI 15.7%
    PRS 58.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Inositol 1,4,5-trisphosphate receptor type 1, encoded by the [ITPR1](/details-gene/3708) gene, is a ligand-gated ion channel that mediates the release of calcium (Ca2+) from intracellular stores, primarily the endoplasmic reticulum. This function is central to intracellular calcium signaling, a ubiquitous and critical process for cellular function. **Overall**, expression data reveals that [ITPR1](/details-gene/3708) is a highly significant gene in the central nervous system, showing prominent expression in diverse neuronal subtypes, including [sst GABAergic cortical interneurons](/details-cell/CL4023017) and [pvalb GABAergic cortical interneurons](/details-cell/CL4023018), as well as in specialized secretory cells like [choroid plexus epithelial cells](/details-cell/CL0000706). Mutations in [ITPR1](/details-gene/3708) are associated with several neurological disorders, most notably spinocerebellar ataxia ([147265](https://omim.org/entry/147265)), underscoring its critical role in neuronal function and motor control. ## Cellular Roles and Expression Landscape The expression profile of [ITPR1](/details-gene/3708) highlights its fundamental role in cells that rely on precise and rapid calcium signaling. **Overall**, the gene exhibits its highest significance in the brain, where it is a defining component of multiple neuronal populations. It is particularly prominent in inhibitory interneurons, such as [sst GABAergic cortical interneurons](/details-cell/CL4023017) (CSI: 43.89) and [pvalb GABAergic cortical interneurons](/details-cell/CL4023018) (CSI: 40.59), suggesting a crucial role in regulating cortical network activity and maintaining excitatory/inhibitory balance. Its high significance extends to various glutamatergic neuron populations, including [L2/3 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4030059) (CSI: 31.59), indicating a broad involvement in excitatory neurotransmission and synaptic plasticity. Beyond neurons, [ITPR1](/details-gene/3708) is a key marker for [choroid plexus epithelial cells](/details-cell/CL0000706) (CSI: 38.53), which are responsible for producing cerebrospinal fluid. This suggests a vital function in regulating ion and fluid transport across this critical brain barrier. Other notable cell types include [myoepithelial cells](/details-cell/CL0000185) and [melanocytes](/details-cell/CL0000148), pointing to its involvement in contraction and pigmentation processes, respectively. Its moderate significance in [mononuclear phagocytes](/details-cell/CL0000113) is consistent with its established role in immune cell activation and signaling. ## Pathways and Molecular Function The molecular function of [ITPR1](/details-gene/3708) is centered on its activity as an [inositol 1,4,5-trisphosphate-gated calcium channel](/details-ontology/GO:0005220), located primarily on the [endoplasmic reticulum membrane](/details-ontology/GO:0005789). Upon binding its ligand, inositol 1,4,5-trisphosphate (IP3), it facilitates the [release of sequestered calcium ion into the cytosol](/details-ontology/GO:0051209), a key step in numerous signaling cascades. This activity is integral to a vast array of biological processes. In neurons, it is essential for [regulation of postsynaptic cytosolic calcium ion concentration](/details-ontology/GO:0099566), which underpins synaptic transmission and plasticity. This role connects it to major signaling pathways, including [GPCR downstream signalling](/details-pathway/R-HSA-388396) and the broader [Ca2+ pathway](/details-pathway/R-HSA-4086398). The gene product forms homotetramers ([GO:0051289](https://www.ebi.ac.uk/QuickGO/term/GO:0051289)) and its activity is modulated by various factors, including ATP, calcium itself, and interacting proteins ([Link](https://doi.org/10.1073/pnas.102006299), [Link](https://doi.org/10.1038/sj.emboj.7600037)). Consistent with its expression in immune cells, [ITPR1](/details-gene/3708) participates in the [innate immune system](/details-pathway/R-HSA-168249) and [adaptive immune system](/details-pathway/R-HSA-1280218) pathways. Specifically, it is involved in signaling downstream of the [B cell receptor (BCR)](/details-pathway/R-HSA-983705) and [Fc epsilon receptor (FCERI)](/details-pathway/R-HSA-2454202), where IP3-mediated calcium release is a critical step for lymphocyte activation and effector function. Its role also extends to [platelet activation, signaling and aggregation](/details-pathway/R-HSA-76002), highlighting its importance in hemostasis. ## Research Directions The central role of [ITPR1](/details-gene/3708) in calcium homeostasis, combined with its high expression in specific neuronal subtypes, positions it as a critical factor in both normal physiology and neurological disease. Deletions and mutations in [ITPR1](/details-gene/3708) are known to cause spinocerebellar ataxia 15 ([147265](https://omim.org/entry/147265)) and ataxia 29 ([117360](https://omim.org/entry/117360)), directly linking its dysfunction to motor deficits ([Link](https://doi.org/10.1371/journal.pgen.0030108)). ### Proposed Hypotheses: 1. **Subtype-Specific Neuronal Vulnerability:** Given its exceptionally high CSI in specific cortical interneurons ([sst GABAergic cortical interneuron](/details-cell/CL4023017), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018)) and cerebellar neurons, it is hypothesized that subtle, cell-type-specific alterations in [ITPR1](/details-gene/3708) expression or function are a primary driver of network imbalance in ataxias and potentially other circuitopathies like epilepsy. Different neuronal subtypes may have unique dependencies on ITPR1-mediated calcium signaling, rendering them differentially vulnerable to its dysregulation. 2. **Role in Cerebrospinal Fluid (CSF) Homeostasis:** The high significance of [ITPR1](/details-gene/3708) in [choroid plexus epithelial cells](/details-cell/CL0000706) suggests a critical role in CSF production and ion balance. It is hypothesized that [ITPR1](/details-gene/3708) dysfunction in these cells could lead to altered CSF composition or pressure, contributing to the pathology of neurodegenerative or neuroinflammatory conditions by disrupting the brain's parenchymal environment. ### Experimental Approach: To test the hypothesis of **subtype-specific neuronal vulnerability**, a powerful approach would be to use a murine model with conditional knockout of *Itpr1*. By crossing *Itpr1*-floxed mice with mouse lines expressing Cre recombinase under the control of subtype-specific promoters (e.g., Pvalb-Cre or Sst-Cre), one could selectively delete the gene in distinct interneuron populations. Subsequent analysis using *in vivo* two-photon calcium imaging and *ex vivo* patch-clamp electrophysiology would allow for a precise assessment of how the loss of [ITPR1](/details-gene/3708) affects cellular excitability, synaptic integration, and local circuit function. Behavioral assays focused on motor coordination (e.g., rotarod test) and seizure susceptibility would directly link these cellular deficits to disease-relevant phenotypes. ### Therapeutic Potential: As an ion channel, [ITPR1](/details-gene/3708) is a theoretically druggable target. However, its widespread and critical role in many cell types presents a major challenge for systemic therapies, which would likely cause significant off-target toxicity. The therapeutic goal for associated ataxias would be to restore, rather than simply inhibit or activate, proper calcium signaling. This suggests that future therapeutic strategies should focus on developing highly specific modulators or pursuing cell-type-targeted delivery systems, such as adeno-associated viruses (AAVs) engineered to deliver functional copies of [ITPR1](/details-gene/3708) or regulatory elements specifically to affected neuronal populations in the cerebellum and cortex.

Genular Protein ID: 3339447163

Symbol: ITPR1_HUMAN

Name: IP3 receptor isoform 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7945203

Title: Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.

PubMed ID: 7945203

DOI: 10.1042/bj3020781

PubMed ID: 7852357

Title: The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.

PubMed ID: 7852357

DOI: 10.1074/jbc.270.6.2833

PubMed ID: 7500840

Title: Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant.

PubMed ID: 7500840

DOI: 10.1016/0169-328x(95)00089-b

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8648241

Title: Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.

PubMed ID: 8648241

DOI: 10.1080/095530096145544

PubMed ID: 10620513

Title: Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.

PubMed ID: 10620513

DOI: 10.1042/bj3450357

PubMed ID: 12032348

Title: Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

PubMed ID: 12032348

DOI: 10.1073/pnas.102006299

PubMed ID: 14685260

Title: Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

PubMed ID: 14685260

DOI: 10.1038/sj.emboj.7600037

PubMed ID: 15652484

Title: Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44.

PubMed ID: 15652484

DOI: 10.1016/j.cell.2004.11.048

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16793548

Title: IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.

PubMed ID: 16793548

DOI: 10.1016/j.molcel.2006.05.017

PubMed ID: 16990611

Title: IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.

PubMed ID: 16990611

DOI: 10.1182/blood-2005-10-026294

PubMed ID: 17590087

Title: Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.

PubMed ID: 17590087

DOI: 10.1371/journal.pgen.0030108

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19220705

Title: An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.

PubMed ID: 19220705

DOI: 10.1111/j.1471-4159.2009.05979.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23650607

Title: Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes.

PubMed ID: 23650607

DOI: 10.1016/j.fob.2012.08.005

PubMed ID: 23884412

Title: The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.

PubMed ID: 23884412

DOI: 10.1074/jbc.m113.496570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27995898

Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.

PubMed ID: 27995898

DOI: 10.7554/elife.19896

PubMed ID: 18579805

Title: Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families.

PubMed ID: 18579805

DOI: 10.1212/01.wnl.0000311277.71046.a0

PubMed ID: 22986007

Title: Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia.

PubMed ID: 22986007

DOI: 10.1186/1750-1172-7-67

PubMed ID: 26770814

Title: ITPR1 gene p.Val1553Met mutation in Russian family with mild Spinocerebellar ataxia.

PubMed ID: 26770814

DOI: 10.1186/s40673-016-0040-8

PubMed ID: 27108797

Title: Recessive and dominant de novo ITPR1 mutations cause Gillespie syndrome.

PubMed ID: 27108797

DOI: 10.1016/j.ajhg.2016.03.004

PubMed ID: 27108798

Title: A restricted repertoire of de novo mutations in ITPR1 cause Gillespie syndrome with evidence for dominant-negative effect.

PubMed ID: 27108798

DOI: 10.1016/j.ajhg.2016.03.018

PubMed ID: 30197081

Title: Mutations in disordered regions can cause disease by creating dileucine motifs.

PubMed ID: 30197081

DOI: 10.1016/j.cell.2018.08.019

Sequence Information:

  • Length: 2758
  • Mass: 313929
  • Checksum: D29B072252B0D8E7
  • Sequence:
  • MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 
    CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 
    IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 
    KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 
    RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
    SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 
    GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 
    SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 
    VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 
    LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 
    NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 
    NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA 
    KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA 
    SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF 
    VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 
    VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 
    PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQTSE 
    TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH 
    DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE 
    LWVYKGQGPD ETMDGASGEN EHKKTEEGNN KPQKHESTSS YNYRVVKEIL IRLSKLCVQE 
    SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 
    NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK 
    FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP 
    LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY 
    VDTEVEMKEI YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF 
    SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI 
    PVDLDSQVNN LFLKSHSIVQ KTAMNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL 
    EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL 
    CIKVLQTLRE MMTKDRGYGE KLISIDELDN AELPPAPDSE NATEELEPSP PLRQLEDHKR 
    GEALRQVLVN RYYGNVRPSG RRESLTSFGN GPLSAGGPGK PGGGGGGSGS SSMSRGEMSL 
    AEVQCHLDKE GASNLVIDLI MNASSDRVFH ESILLAIALL EGGNTTIQHS FFCRLTEDKK 
    SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL GNKKKDDEVD RDAPSRKKAK EPTTQITEEV 
    RDQLLEASAA TRKAFTTFRR EADPDDHYQP GEGTQATADK AKDDLEMSAV ITIMQPILRF 
    LQLLCENHNR DLQNFLRCQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL 
    INQTLESLTE YCQGPCHENQ NCIATHESNG IDIITALILN DINPLGKKRM DLVLELKNNA 
    SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYMQG EVEFEDGENG EDGAASPRNV 
    GHNIYILAHQ LARHNKELQS MLKPGGQVDG DEALEFYAKH TAQIEIVRLD RTMEQIVFPV 
    PSICEFLTKE SKLRIYYTTE RDEQGSKIND FFLRSEDLFN EMNWQKKLRA QPVLYWCARN 
    MSFWSSISFN LAVLMNLLVA FFYPFKGVRG GTLEPHWSGL LWTAMLISLA IVIALPKPHG 
    IRALIASTIL RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF VGNCGTFTRG YRAMVLDVEF 
    LYHLLYLVIC AMGLFVHEFF YSLLLFDLVY REETLLNVIK SVTRNGRSII LTAVLALILV 
    YLFSIVGYLF FKDDFILEVD RLPNETAVPE TGESLASEFL FSDVCRVESG ENCSSPAPRE 
    ELVPAEETEQ DKEHTCETLL MCIVTVLSHG LRSGGGVGDV LRKPSKEEPL FAARVIYDLL 
    FFFMVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVTFEEHI 
    KEEHNMWHYL CFIVLVKVKD STEYTGPESY VAEMIKERNL DWFPRMRAMS LVSSDSEGEQ 
    NELRNLQEKL ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR IGLLGHPPHM NVNPQQPA

Genular Protein ID: 3268817532

Symbol: B4DER3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1101
  • Mass: 126200
  • Checksum: 18B3D9F51ABE1DBA
  • Sequence:
  • MKWSDNKDDI LKGGDVVRLF HAEQEKFLTC DEHRKKQHVF LRTTGRQSAT SATSSKALWE 
    VEVVQHDPCR GGAGYWNSLF RFKHLATGHY LAAEVDPDFE EECLEFQPSV DPDHDASRSR 
    LRNAQEKMVY SLVSVPEGND ISSIFELDPT TLRGGDSLVP RNSYVRLRHL CTNTWVHSTN 
    IPIDKEEEKP VMLKIGTSPV KEDKEAFAIV PVSPAEVRDL DFANDASKVL GSIAGKLEKG 
    TITQNERRSV TKLLEDLVYF VTGGTNSGQD VLEVVFSKPN RERQKLMREQ NILKQIFKLL 
    QAPFTDCGDG PMLRLEELGD QRHAPFRHIC RLCYRVLRHS QQDYRKNQEY IAKQFGFMQK 
    QIGYDVLAED TITALLHNNR KLLEKHITAA EIDTFVSLVR KNREPRFLDY LSDLCVSMNK 
    SIPVTQELIC KAVLNPTNAD ILIETKLVLS RFEFEGVSST GENALEAGED EEEVWLFWRD 
    SNKEIRSKSV RELAQDAKEG QKGDRDVLSY YRYQLNLFAR MCLDRQYLAI NEISGQLDVD 
    LILRCMSDEN LPYDLRASFC RLMLHMHVDR DPQEQVTPVK YARLWSEIPS EIAIDDYDSS 
    GASKDEIKER FAQTMEFVEE YLRDVVCQRF PFSDKEKNKL TFEVVNLARN LIYFGFYNFS 
    DLLRLTKILL AILDCVHVTT IFPISKMAKG EENKGSNVMR SIHGVGELMT QVVLRGGGFL 
    PMTPMAAAPE GNVKQAEPEK EDIMVMDTKL KIIEILQFIL NVRLDYRISC LLCIFKREFD 
    ESNSQTSETS SGNSSQEGPS NVPGALDFEH IEEQAEGIFG GSEENTPLDL DDHGGRTFLR 
    VLLHLTMHDY PPLVSGALQL LFRHFSQRQE VLQAFKQVQL LVTSQDVDNY KQIKQDLDQL 
    RSIVEKSELW VYKGQGPDET MDGASGENEH KKTEEGNNKP QKHESTSSYN YRVVKEILIR 
    LSKLCVQESA SVRKSRKQQQ RLLRNMGAHA VVLELLQIPY EKAEDTKMQE IMRLAHEFLQ 
    NFCAGNQQNQ ALLHKHINLF LNPGILEAVT MQHIFMNNFQ LCSEINERVV QHFVHCIETH 
    GRNVQYIKFL QTIVKAEGKF I

Genular Protein ID: 919174250

Symbol: Q59H91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1207
  • Mass: 136431
  • Checksum: DC3C375E249C5DE6
  • Sequence:
  • CSQEPGHCHS RGPGQPSQQP LSQVPQHCAE TAMNWRLSAR NAARRDSVLA ASRDYRNIIE 
    RLQDIVSALE DRLRPLVQAE LSVLVDVLHR PELLFPENTD ARRKCESGGF ICKLIKHTKQ 
    LLEENEEKLC IKVLQTLREM MTKDRGYGEK LISIDELDNA ELPPAPDSEN ATEELEPSPP 
    LRQLEDHKRG EALRQVLVNR YYGNVRPSGR RESLTSFGNG PLSAGGPGKP GGGGGGSGSS 
    SMSRGEMSLA EVQCHLDKEG ASNLVIDLIM NASSDRVFHE SILLAIALLE GGNTTIQHSF 
    FCRLTEDKKS EKFFKVFYDR MKVAQQEIKA TVTVNTSDLG NKKKDDEVDR DAPSRKKAKE 
    PTTQITEEVR DQLLEASAAT RKAFTTFRRE ADPDDHYQPG EGTQATADKA KDDLEMSAVI 
    TIMQPILRFL QLLCENHNRD LQNFLRCQNN KTNYNLVCET LQFLDCICGS TTGGLGLLGL 
    YINEKNVALI NQTLESLTEY CQGPCHENQN CIATHESNGI DIITALILND INPLGKKRMD 
    LVLELKNNAS KLLLAIMESR HDSENAERIL YNMRPKELVE VIKKAYMQGE VEFEDGENGE 
    DGAASPRNVG HNIYILAHQL ARHNKELQSM LKPGGQVDGD EALEFYAKHT AQIEIVRLDR 
    TMEQIVFPVP SICEFLTKES KLRIYYTTER DEQGSKINDF FLRSEDLFNE MNWQKKLRAQ 
    PVLYWCARNM SFWSSISFNL AVLMNLLVAF FYPFKGVRGG TLEPHWSGLL WTAMLISLAI 
    VIALPKPHGI RALIASTILR LIFSVGLQPT LFLLGAFNVC NKIIFLMSFV GNCGTFTRGY 
    RAMVLDVEFL YHLLYLVICA MGLFVHEFFY SLLLFDLVYR EETLLNVIKS VTRDGRSIIL 
    TAVLALILVY LFSIVGYLFF KDDFILEVDR LPNETAVPET GESLASEFLF SDVCRVESGE 
    NCSSPAPREE LVPAEETEQD KEHTCETLLM CIVTVLSHGL RSGGGVGDVL RKPSKEEPLF 
    AARVIYDLLF FFMVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN 
    KTVTFEEHIK EEHNMWHYLC FIVLVKVKDS TEYTGPESYV AEMIKERNLD WFPRMRAMSL 
    VSSDSEGEQN ELRNLQEKLE STMKLVTNLS GQLSELKDQM TEQRKQKQRI GLLGHPPHMN 
    VNPQQPA

Genular Protein ID: 665033943

Symbol: B4DGH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 466
  • Mass: 53098
  • Checksum: 2A534078CB05AAFB
  • Sequence:
  • MHEFYFSNKL FVSTCQAPGT LEPHWSGLLW TAMLISLAIV IALPKPHGIR ALIASTILRL 
    IFSVGLQPTL FLLGAFNVCN KIIFLMSFVG NCGTFTRGYR AMVLDVEFLY HLLYLVICAM 
    GLFVHEFFYS LLLFDLVYRE ETLLNVIKSV TRNGRSIILT AVLALILVYL FSIVGYLFFK 
    DDFILEVDRL PNETAVPETG ESLASEFLFS DVCRVESGEN CSSPAPREEL VPAEETEQDK 
    EHTCETLLMC IVTVLSHGLR SGGGVGDVLR KPSKEEPLFA ARVIYDLLFF FMVIIIVLNL 
    IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVTFEEHIKE EHNMWHYLCF 
    IVLVKVKDST EYTGPESYVA EMIKERNLDW FPRMRAMSLV SSDSEGEQNE LRNLQEKLES 
    TMKLVTNLSG QLSELKDQMT EQRKQKQRIG LLGHPPHMNV NPQQPA