Details for: ITPR3

Gene ID: 3710

Symbol: ITPR3

Ensembl ID: ENSG00000096433

Description: inositol 1,4,5-trisphosphate receptor type 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.5081
    Cell Significance Index: -18.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.4352
    Cell Significance Index: -18.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.6486
    Cell Significance Index: -13.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.5863
    Cell Significance Index: -17.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3696
    Cell Significance Index: -18.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4123
    Cell Significance Index: -13.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5812
    Cell Significance Index: -17.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8428
    Cell Significance Index: -19.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4686
    Cell Significance Index: -9.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.7824
    Cell Significance Index: 80.1700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.5682
    Cell Significance Index: 5.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7932
    Cell Significance Index: 26.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7060
    Cell Significance Index: 36.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6603
    Cell Significance Index: 180.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6599
    Cell Significance Index: 99.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5651
    Cell Significance Index: 1413.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4118
    Cell Significance Index: 27.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2531
    Cell Significance Index: 56.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1312
    Cell Significance Index: 16.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0814
    Cell Significance Index: 54.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8992
    Cell Significance Index: 25.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7501
    Cell Significance Index: 51.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6205
    Cell Significance Index: 16.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4960
    Cell Significance Index: 17.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3972
    Cell Significance Index: 46.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3456
    Cell Significance Index: 4.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3348
    Cell Significance Index: 148.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3129
    Cell Significance Index: 170.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2516
    Cell Significance Index: 7.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2264
    Cell Significance Index: 4.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2245
    Cell Significance Index: 42.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1970
    Cell Significance Index: 10.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1606
    Cell Significance Index: 28.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1590
    Cell Significance Index: 15.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1540
    Cell Significance Index: 7.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1432
    Cell Significance Index: 16.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1353
    Cell Significance Index: 16.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1332
    Cell Significance Index: 6.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1309
    Cell Significance Index: 6.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1170
    Cell Significance Index: 13.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0717
    Cell Significance Index: 2.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0602
    Cell Significance Index: 4.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0536
    Cell Significance Index: 40.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0170
    Cell Significance Index: 2.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0127
    Cell Significance Index: 2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0124
    Cell Significance Index: 2.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0122
    Cell Significance Index: -1.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0193
    Cell Significance Index: -12.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0294
    Cell Significance Index: -10.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0298
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0343
    Cell Significance Index: -7.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0352
    Cell Significance Index: -15.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0454
    Cell Significance Index: -13.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0494
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0497
    Cell Significance Index: -5.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0579
    Cell Significance Index: -0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0581
    Cell Significance Index: -5.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0660
    Cell Significance Index: -8.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0788
    Cell Significance Index: -11.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0933
    Cell Significance Index: -6.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1112
    Cell Significance Index: -2.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1347
    Cell Significance Index: -8.2600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1475
    Cell Significance Index: -2.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1812
    Cell Significance Index: -18.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1927
    Cell Significance Index: -15.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2170
    Cell Significance Index: -1.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2307
    Cell Significance Index: -17.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2402
    Cell Significance Index: -15.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2496
    Cell Significance Index: -16.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2576
    Cell Significance Index: -3.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2581
    Cell Significance Index: -16.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2758
    Cell Significance Index: -16.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2941
    Cell Significance Index: -6.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3075
    Cell Significance Index: -9.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3350
    Cell Significance Index: -7.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3423
    Cell Significance Index: -19.2100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3483
    Cell Significance Index: -3.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3606
    Cell Significance Index: -9.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3630
    Cell Significance Index: -5.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3704
    Cell Significance Index: -5.3100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3815
    Cell Significance Index: -6.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3844
    Cell Significance Index: -20.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3873
    Cell Significance Index: -4.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3939
    Cell Significance Index: -14.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3981
    Cell Significance Index: -17.6100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3990
    Cell Significance Index: -3.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4139
    Cell Significance Index: -14.5000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4173
    Cell Significance Index: -5.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4178
    Cell Significance Index: -5.8600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4195
    Cell Significance Index: -3.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4288
    Cell Significance Index: -12.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Calcium Release Channel**: ITPR3 is a calcium-release channel that regulates the release of calcium ions from the endoplasmic reticulum, which is essential for various cellular functions, including muscle contraction, neurotransmission, and cell signaling. 2. **Inositol 1,4,5-trisphosphate (IP3) Binding**: ITPR3 binds to IP3, a second messenger molecule, which triggers the release of calcium ions from the endoplasmic reticulum. 3. **Regulation of Cytosolic Calcium Ion Concentration**: ITPR3 regulates the concentration of cytosolic calcium ions, which is essential for various cellular functions, including muscle contraction, neurotransmission, and cell signaling. 4. **Signaling Pathways**: ITPR3 is involved in various signaling pathways, including the calcium-mediated signaling pathway, the IP3 signaling pathway, and the G-protein coupled receptor signaling pathway. **Pathways and Functions** 1. **Adaptive Immune System**: ITPR3 is involved in the adaptive immune system, specifically in the regulation of B cell receptor signaling and the activation of immune cells. 2. **Anti-inflammatory Response**: ITPR3 is involved in the anti-inflammatory response, specifically in the regulation of Leishmania parasite infection. 3. **Ca2+ Pathway**: ITPR3 regulates the Ca2+ pathway, which is essential for various cellular functions, including muscle contraction, neurotransmission, and cell signaling. 4. **Calcium-Mediated Signaling**: ITPR3 is involved in calcium-mediated signaling, which is essential for various cellular functions, including muscle contraction, neurotransmission, and cell signaling. 5. **G-Protein Coupled Receptor Signaling**: ITPR3 is involved in G-protein coupled receptor signaling, which is essential for various cellular functions, including cell signaling and immune response. **Clinical Significance** 1. **Leishmania Infection**: Abnormalities in ITPR3 have been linked to Leishmania infection, which is a significant public health problem in many tropical and subtropical regions. 2. **Cardiac Conduction Disorders**: ITPR3 is involved in the regulation of cardiac conduction, and abnormalities in ITPR3 have been linked to cardiac conduction disorders. 3. **Taste Disorders**: ITPR3 is involved in the regulation of taste, and abnormalities in ITPR3 have been linked to taste disorders. 4. **Immune System Disorders**: ITPR3 is involved in the adaptive immune system, and abnormalities in ITPR3 have been linked to immune system disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, ITPR3 is a critical protein involved in various cellular processes, including calcium signaling, immune response, and cellular homeostasis. Abnormalities in ITPR3 have been linked to various diseases, including Leishmania infection, cardiac conduction disorders, and taste disorders. Further research is needed to fully understand the role of ITPR3 in human disease and to develop effective therapeutic strategies to treat ITPR3-related disorders.

Genular Protein ID: 2184404245

Symbol: ITPR3_HUMAN

Name: IP3 receptor isoform 3

UniProtKB Accession Codes:

Q14573 Q14649 Q5TAQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 30 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EMDB 46 Ensembl 2 GO 37 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 15 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8081734

Title: Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

PubMed ID: 8081734

PubMed ID: 8288584

Title: Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium.

PubMed ID: 8288584

DOI: 10.1016/s0021-9258(17)42246-0

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 12032348

Title: Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

PubMed ID: 12032348

DOI: 10.1073/pnas.102006299

PubMed ID: 18826956

Title: IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.

PubMed ID: 18826956

DOI: 10.1074/jbc.c800184200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19553469

Title: Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.

PubMed ID: 19553469

DOI: 10.1091/mbc.e09-05-0385

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23936024

Title: Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors.

PubMed ID: 23936024

DOI: 10.1371/journal.pone.0069473

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25996873

Title: TMEM203 is a novel regulator of intracellular calcium homeostasis and is required for spermatogenesis.

PubMed ID: 25996873

DOI: 10.1371/journal.pone.0127480

PubMed ID: 27995898

Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.

PubMed ID: 27995898

DOI: 10.7554/elife.19896

PubMed ID: 30013099

Title: Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3.

PubMed ID: 30013099

DOI: 10.1038/s41594-018-0089-6

PubMed ID: 35301323

Title: Structural basis for activation and gating of IP3 receptors.

PubMed ID: 35301323

DOI: 10.1038/s41467-022-29073-2

PubMed ID: 37898605

Title: Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor.

PubMed ID: 37898605

DOI: 10.1038/s41467-023-42707-3

PubMed ID: 24627108

Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.

PubMed ID: 24627108

DOI: 10.1007/s00415-014-7289-8

PubMed ID: 32949214

Title: Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease.

PubMed ID: 32949214

DOI: 10.1002/acn3.51190

Sequence Information:

  • Length: 2671
  • Mass: 304106
  • Checksum: 04D1957A53320EEE
  • Sequence:
    • MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 
PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 
VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 
DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 
VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 
NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGMGAQGR TGRRNAGEKI KYCLVAVPHG 
NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC 
PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 
FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQVFG ILKAPFREKG GEGPLVRLEE 
LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK 
NSDILIRTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA 
HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL 
MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY 
LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA 
MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS RKQSVFSAPS LSAGASAAEP LDRSKFEENE 
DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT 
ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLI HLTMHDYAPL VSGALQLLFK 
HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSGKGEEVE 
AGAAKDKKER PTDEEGFLHP PGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 
DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL HLFLTPGLLE 
AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM 
IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN 
VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL 
FENFTLDMAR VCSKREKRVA DPTLEKYVLS VVLDTINAFF SSPFSENSTS LQTHQTIVVQ 
LLQSTTRLLE CPWLQQQHKG SVEACIRTLA MVAKGRAILL PMDLDAHISS MLSSGASCAA 
AAQRNASSYK ATTRAFPRVT PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDV 
LHWPELLFLE GSEAYQRCES GGFLSKLIQH TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG 
DRGNQLRKML LQNYLQNRKS TSRGDLPDPI GTGLDPDWSA IAATQCRLDK EGATKLVCDL 
ITSTKNEKIF QESIGLAIHL LDGGNTEIQK SFHNLMMSDK KSERFFKVLH DRMKRAQQET 
KSTVAVNMND LGSQPHEDRE PVDPTTKGRV ASFSIPGSSS RYSLGPSLRR GHEVSERVQS 
SEMGTSVLIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDIMCGSTTG 
GLGLLGLYIN EDNVGLVIQT LETLTEYCQG PCHENQTCIV THESNGIDII TALILNDISP 
LCKYRMDLVL QLKDNASKLL LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEERE 
NSEVSPREVG HNIYILALQL SRHNKQLQHL LKPVKRIQEE EAEGISSMLS LNNKQLSQML 
KSSAPAQEEE EDPLAYYENH TSQIEIVRQD RSMEQIVFPV PGICQFLTEE TKHRLFTTTE 
QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS MPLIYWFSRR MTLWGSISFN LAVFINIIIA 
FFYPYMEGAS TGVLDSPLIS LLFWILICFS IAALFTKRYS IRPLIVALIL RSIYYLGIGP 
TLNILGALNL TNKIVFVVSF VGNRGTFIRG YKAMVMDMEF LYHVGYILTS VLGLFAHELF 
YSILLFDLIY REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD 
RLPNNHSTAS PLGMPHGAAA FVDTCSGDKM DCVSGLSVPE VLEEDRELDS TERACDTLLM 
CIVTVMNHGL RNGGGVGDIL RKPSKDESLF PARVVYDLLF FFIVIIIVLN LIFGVIIDTF 
ADLRSEKQKK EEILKTTCFI CGLERDKFDN KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK 
TDYTGPESYV AQMIKNKNLD WFPRMRAMSL VSNEGEGEQN EIRILQDKLN STMKLVSHLT 
AQLNELKEQM TEQRKRRQRL GFVDVQNCIS R

Genular Protein ID: 4213262244

Symbol: Q59ES2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59ES2

Database IDs:

ARBA 10 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 3 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 8 PharmGKB 1 RefSeq 1 Rhea 1 SAM 3 SUPFAM 2

Sequence Information:

  • Length: 2341
  • Mass: 267023
  • Checksum: 21E4BF7271409D83
  • Sequence:
    • KAAGMGAQGR TGRRNAGEKI KYCLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR 
HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS 
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK PNRERQKLMR 
EQNILKQVFG ILKAPFREKG GEGPLVRLEE LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN 
QEHIAKQFGM MQSQIGYDIL AEDTITALLH NNRKLLEKHI TKTEVETFVS LVRKNREPRF 
LDYLSDLCVS NHIAIPVTQE LICKCVLDPK NSDILIRTEL RPVKEMAQSH EYLSIEYSEE 
EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE 
ISQQLGVDLI FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA RLWTEIPTAI 
TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY LNNVVSEAVP FANEEKNKLT FEVVSLAHNL 
IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS 
RKQSVFSAPS LSAGASAAEP LDRSKFEENE DIVVMETKLK ILEILQFILN VRLDYRISYL 
LSVFKKEFVE VFPMQDSGAD GTASAFDSTT ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE 
GGRMFLRVLI HLTMHDYAPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS AQDVENYKVI 
KSELDRLRTM VEKSELWVDK KGSGKGEEVE AGAAKDKKER PTDEEGFLHP PGEKSSENYQ 
IVKGILERLN KMCGVGEQMR KKQQRLLKNM DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ 
FLQKFCAGNP GNQALLHKHL HLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHLL 
ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK 
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV THEDCITEVK 
MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAR VCSKREKRVA DPTLEKYVLS 
VVLDTINAFF SSPFSENSTS LQTHQTIVVQ LLQSTTRLLE CPWLQQQHKG SVEACIRTLA 
MVAKGRAILL PMDLDAHISS MLSSGASCAA AAQRNASSYK ATTRAFPRVT PTANQWDYKN 
IIEKLQDIIT ALEERLKPLV QAELSVLVDV LHWPELLFLE GSEAYQRCES GGFLSKLIQH 
TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG DRGNQLRKML LQNYLQNRKS TSRGDLPDPI 
GTGLDPDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF QESIGLAIHL LDGGNTEIQK 
SFHNLMMSDK KSERFFKVLH DRMKRAQQET KSTVAVNMND LGSQPHEDRE PVDPTTKGRV 
ASFSIPGSSS RYSLGPSLRR GHEVSERVQS SEMGTSVLIM QPILRFLQLL CENHNRDLQN 
FLRCQNNKTN YNLVCETLQF LDIMCGSTTG GLGLLGLYIN EDNVGLVIQT LETLTEYCQG 
PCHENQTCIV THESNGIDII TALILNDISP LCKYRMDLVL QLKDNASKLL LALMESRHDS 
ENAERILISL RPQELVDVIK KAYLQEEERE NSEVSPREVG HNIYILALQL SRHNKQLQHL 
LKPVKRIQEE EAEGISSMLS LNNKQLSQML KSSAPAQEEE EDPLAYYENH TSQIEIVRQD 
RSMEQIVFPV PGICQFLTEE TKHRLFTTTE QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS 
MPLIYWFSRR MTLWGSISFN LAVFINIIIA FFYPYMEGAS TGVLDSPLIS LLFWILICFS 
IAALFTKRYS IRPLIVALIL RSIYYLGIGP TLNILGALNL TNKIVFVVSF VGNRGTFIRG 
YKAMVMDMEF LYHVGYILTS VLGLFAHELF YSILLFDLIY REETLFNVIK SVTRNGRSIL 
LTALLALILV YLFSIVGFLF LKDDFILEVD RLPNNHSTAS PLGMPHGAAA FVDTCSGDKM 
DCVSGLSVPE VLEEDRELDS TERACDTLLM CIVTVMNHGL RNGGGVGDIL RKPSKDESLF 
PARVVYDLLF FFIVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN 
KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK TDYTGPESYV AQMIKNKNLD WFPRMRAMSL 
VSNEGEGEQN EIRILQDKLN STMKLVSHLT AQLNELKEQM TEQRKRRQRL GFVDVQNCIS 
R

Genular Protein ID: 2013760648

Symbol: A6H8K3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6H8K3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1049
  • Mass: 119214
  • Checksum: BF4224180E6C031A
  • Sequence:
    • MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 
PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 
VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 
DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 
VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 
NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGMGAQGR TGRRNAGEKI KYCLVAVPHG 
NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC 
PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 
FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQVFG ILKAPFREKG GEGPLVRLEE 
LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK 
NSDILIRTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA 
HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL 
MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY 
LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA 
MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS RKQSVFSAPS LSAGASAAEP LDRSKFEENE 
DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT 
ANMNLDRIGE QAEAMFGVGK TSSMLEVDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.