Details for: IVD
Gene ID: 3712
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IVD
Ensembl ID: ENSG00000128928
Description: isovaleryl-CoA dehydrogenase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 10.29rCSI 17.8%PRS 36.12
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CSI 9.1rCSI 18.28%PRS 35.23
-
CSI 8.61rCSI 12.73%PRS 50.22
-
CSI 6.2rCSI 8.44%PRS 38.61
-
CSI 5.87rCSI 9.01%PRS 52.21
-
CSI 5.14rCSI 6.04%PRS 48.8
-
CSI 5.13rCSI 8.26%PRS 36.07
-
CSI 4.94rCSI 30.88%PRS 37.82
-
CSI 4.78rCSI 6.78%PRS 42.19
-
CSI 4.67rCSI 10.67%PRS 44.59
-
CSI 4.62rCSI 11.68%PRS 53.48
-
CSI 4.49rCSI 7.53%PRS 29.76
-
CSI 3.9rCSI 10.28%PRS 52.85
-
CSI 3.67rCSI 9.32%PRS 41.18
-
CSI 3.63rCSI 3.74%PRS 62.94
-
CSI 3.29rCSI 2.73%PRS 43.7
-
CSI 3.06rCSI 2.85%PRS 44.91
-
CSI 2.97rCSI 7.75%PRS 44.28
-
CSI 2.94rCSI 2.05%PRS 53.81
-
CSI 2.94rCSI 6.9%PRS 54.19
-
CSI 2.92rCSI 5.12%PRS 37.72
-
CSI 2.89rCSI 2.39%PRS 46.12
-
CSI 2.87rCSI 1.93%PRS 55.58
-
CSI 2.87rCSI 2.18%PRS 56.49
-
CSI 2.85rCSI 3.89%PRS 47.78
-
CSI 2.83rCSI 2.73%PRS 45.71
-
CSI 2.69rCSI 7.2%PRS 38.24
-
CSI 2.68rCSI 3.41%PRS 50.54
-
CSI 2.67rCSI 2.37%PRS 44.11
-
CSI 2.64rCSI 1.99%PRS 48.66
-
CSI 2.56rCSI 9.9%PRS 63.13
-
CSI 2.49rCSI 2.6%PRS 47.94
-
CSI 2.42rCSI 1.79%PRS 38.79
-
CSI 2.4rCSI 1.68%PRS 46.95
-
CSI 2.38rCSI 2.34%PRS 47.54
-
CSI 2.36rCSI 2.94%PRS 28.25
-
CSI 2.32rCSI 1.54%PRS 48.96
-
CSI 2.29rCSI 2.46%PRS 43.15
-
CSI 2.26rCSI 3.66%PRS 43.67
-
CSI 2.26rCSI 2.04%PRS 41.87
-
CSI 2.24rCSI 5.38%PRS 63.26
-
CSI 2.21rCSI 5.31%PRS 60.54
-
CSI 2.2rCSI 1.7%PRS 45.65
-
CSI 2.18rCSI 1.91%PRS 50.1
-
CSI 2.17rCSI 3.33%PRS 61.33
-
CSI 2.15rCSI 3.2%PRS 47.64
-
CSI 2.14rCSI 7.69%PRS 28.65
-
CSI 2.11rCSI 2.65%PRS 54.91
-
CSI 2.11rCSI 1.62%PRS 44.05
-
CSI 2.08rCSI 2.17%PRS 45.8
-
CSI 2.06rCSI 6.07%PRS 49.09
-
CSI 2.05rCSI 7.66%PRS 38.37
-
CSI 2.01rCSI 2.21%PRS 49.03
-
CSI 2.01rCSI 1.59%PRS 33.18
-
CSI 2rCSI 2.08%PRS 50.97
-
CSI 1.97rCSI 6.39%PRS 47.88
-
CSI 1.97rCSI 1.71%PRS 48.89
-
CSI 1.97rCSI 9.04%PRS 63.78
-
CSI 1.94rCSI 1.53%PRS 51.6
-
CSI 1.94rCSI 4.73%PRS 41.23
-
CSI 1.93rCSI 2.49%PRS 30.66
-
CSI 1.88rCSI 1.74%PRS 46.05
-
CSI 1.87rCSI 4.27%PRS 38.71
-
CSI 1.86rCSI 44.43%PRS 29.22
-
CSI 1.85rCSI 1.78%PRS 36.03
-
CSI 1.84rCSI 2.63%PRS 47.83
-
CSI 1.84rCSI 2.46%PRS 53.57
-
CSI 1.84rCSI 1.61%PRS 34.58
-
CSI 1.83rCSI 1.48%PRS 45.76
-
CSI 1.81rCSI 43.56%PRS 30.09
-
CSI 1.75rCSI 2.71%PRS 55.02
-
CSI 1.73rCSI 3.15%PRS 38.92
-
CSI 1.69rCSI 4.41%PRS 53.35
-
CSI 1.68rCSI 1.68%PRS 39.52
-
CSI 1.66rCSI 3.52%PRS 59.99
-
CSI 1.58rCSI 2.51%PRS 38.35
-
CSI 1.57rCSI 2.77%PRS 43.52
-
CSI 1.57rCSI 2.42%PRS 42.97
-
CSI 1.53rCSI 3.87%PRS 35.92
-
CSI 1.51rCSI 2.83%PRS 35.17
-
CSI 1.5rCSI 1.93%PRS 43.16
-
CSI 1.47rCSI 1.76%PRS 29.7
-
CSI 1.45rCSI 1.9%PRS 58.18
-
CSI 1.45rCSI 3.74%PRS 41.43
-
CSI 1.44rCSI 1.17%PRS 45.8
-
CSI 1.41rCSI 1.47%PRS 42.32
-
CSI 1.4rCSI 2.24%PRS 39.16
-
CSI 1.4rCSI 2.25%PRS 31.83
-
CSI 1.39rCSI 2.28%PRS 36.09
-
CSI 1.39rCSI 2.45%PRS 28.78
-
CSI 1.35rCSI 2.99%PRS 42.54
-
CSI 1.34rCSI 2.41%PRS 43.59
-
CSI 1.27rCSI 1.85%PRS 48.22
-
CSI 1.26rCSI 4.03%PRS 42.19
-
CSI 1.25rCSI 4.87%PRS 54.12
-
CSI 1.11rCSI 1.52%PRS 41.42
-
CSI 1.11rCSI 3.56%PRS 52.64
-
CSI 1.1rCSI 3.58%PRS 47.16
-
CSI 1.09rCSI 1.57%PRS 58.5
-
CSI 1.06rCSI 2.37%PRS 30.49
-
CSI 0.1rCSI 3.1%PRS 67.9%
-
CSI 0.2rCSI 1.4%PRS 33.4%
-
CSI 0.2rCSI 1.4%PRS 31.1%
-
CSI 0.3rCSI 1.0%PRS 33.2%
-
CSI 0.3rCSI 2.8%PRS 33.0%
-
CSI 0.4rCSI 2.2%PRS 55.9%
-
CSI 0.4rCSI 1.5%PRS 30.7%
-
CSI 0.4rCSI 1.3%PRS 31.0%
-
CSI 0.4rCSI 2.1%PRS 69.0%
-
CSI 0.4rCSI 1.7%PRS 60.5%
-
CSI 0.6rCSI 1.3%PRS 28.9%
-
CSI 0.6rCSI 0.7%PRS 35.6%
-
CSI 0.6rCSI 1.8%PRS 47.6%
-
CSI 0.6rCSI 2.7%PRS 64.2%
-
CSI 0.7rCSI 3.4%PRS 56.1%
-
CSI 0.7rCSI 3.9%PRS 47.8%
-
CSI 0.7rCSI 1.6%PRS 33.8%
-
CSI 0.7rCSI 6.5%PRS 34.1%
-
CSI 0.7rCSI 4.2%PRS 31.9%
-
CSI 0.9rCSI 3.8%PRS 31.9%
-
CSI 0.9rCSI 1.0%PRS 52.8%
-
CSI 0.9rCSI 1.4%PRS 46.2%
-
CSI 0.9rCSI 3.8%PRS 38.8%
-
CSI 1.0rCSI 1.0%PRS 63.5%
-
CSI 1.0rCSI 1.5%PRS 36.7%
-
CSI 1.0rCSI 2.9%PRS 42.0%
-
CSI 1.1rCSI 2.4%PRS 30.5%
-
CSI 1.1rCSI 1.6%PRS 58.5%
-
CSI 1.1rCSI 3.6%PRS 47.2%
-
CSI 1.1rCSI 3.6%PRS 52.6%
-
CSI 1.1rCSI 1.5%PRS 41.4%
-
CSI 1.3rCSI 4.9%PRS 54.1%
-
CSI 1.3rCSI 4.0%PRS 42.2%
-
CSI 1.3rCSI 1.9%PRS 48.2%
-
CSI 1.3rCSI 2.4%PRS 43.6%
-
CSI 1.4rCSI 3.0%PRS 42.5%
-
CSI 1.4rCSI 2.5%PRS 28.8%
-
CSI 1.4rCSI 2.3%PRS 36.1%
-
CSI 1.4rCSI 2.3%PRS 31.8%
-
CSI 1.4rCSI 2.2%PRS 39.2%
-
CSI 1.4rCSI 1.5%PRS 42.3%
-
CSI 1.4rCSI 1.2%PRS 45.8%
-
CSI 1.5rCSI 3.7%PRS 41.4%
-
CSI 1.5rCSI 1.9%PRS 58.2%
-
CSI 1.5rCSI 1.8%PRS 29.7%
-
CSI 1.5rCSI 1.9%PRS 43.2%
-
CSI 1.5rCSI 2.8%PRS 35.2%
-
CSI 1.5rCSI 3.9%PRS 35.9%
-
CSI 1.6rCSI 2.4%PRS 43.0%
-
CSI 1.6rCSI 2.8%PRS 43.5%
-
CSI 1.6rCSI 2.5%PRS 38.4%
-
CSI 1.7rCSI 3.5%PRS 60.0%
-
CSI 1.7rCSI 1.7%PRS 39.5%
-
CSI 1.7rCSI 4.4%PRS 53.4%
-
CSI 1.7rCSI 3.2%PRS 38.9%
-
CSI 1.8rCSI 2.7%PRS 55.0%
-
CSI 1.8rCSI 43.6%PRS 30.1%
-
CSI 1.8rCSI 1.5%PRS 45.8%
-
CSI 1.8rCSI 1.6%PRS 34.6%
-
CSI 1.8rCSI 2.5%PRS 53.6%
-
CSI 1.8rCSI 2.6%PRS 47.8%
-
CSI 1.9rCSI 1.8%PRS 36.0%
-
CSI 1.9rCSI 44.4%PRS 29.2%
-
CSI 1.9rCSI 4.3%PRS 38.7%
-
CSI 1.9rCSI 1.7%PRS 46.1%
-
CSI 1.9rCSI 2.5%PRS 30.7%
-
CSI 1.9rCSI 4.7%PRS 41.2%
-
CSI 1.9rCSI 1.5%PRS 51.6%
-
CSI 2.0rCSI 9.0%PRS 63.8%
-
CSI 2.0rCSI 1.7%PRS 48.9%
-
CSI 2.0rCSI 6.4%PRS 47.9%
-
CSI 2.0rCSI 2.1%PRS 51.0%
-
CSI 2.0rCSI 1.6%PRS 33.2%
-
CSI 2.0rCSI 2.2%PRS 49.0%
-
CSI 2.1rCSI 7.7%PRS 38.4%
-
CSI 2.1rCSI 6.1%PRS 49.1%
-
CSI 2.1rCSI 2.2%PRS 45.8%
-
CSI 2.1rCSI 1.6%PRS 44.1%
-
CSI 2.1rCSI 2.7%PRS 54.9%
-
CSI 2.1rCSI 7.7%PRS 28.7%
-
CSI 2.2rCSI 3.2%PRS 47.6%
-
CSI 2.2rCSI 3.3%PRS 61.3%
-
CSI 2.2rCSI 1.9%PRS 50.1%
-
CSI 2.2rCSI 1.7%PRS 45.7%
-
CSI 2.2rCSI 5.3%PRS 60.5%
-
CSI 2.2rCSI 5.4%PRS 63.3%
-
CSI 2.3rCSI 2.0%PRS 41.9%
-
CSI 2.3rCSI 3.7%PRS 43.7%
-
CSI 2.3rCSI 2.5%PRS 43.2%
-
CSI 2.3rCSI 1.5%PRS 49.0%
-
CSI 2.4rCSI 2.9%PRS 28.3%
-
CSI 2.4rCSI 2.3%PRS 47.5%
-
CSI 2.4rCSI 1.7%PRS 47.0%
-
CSI 2.4rCSI 1.8%PRS 38.8%
-
CSI 2.5rCSI 2.6%PRS 47.9%
-
CSI 2.6rCSI 9.9%PRS 63.1%
-
CSI 2.6rCSI 2.0%PRS 48.7%
-
CSI 2.7rCSI 2.4%PRS 44.1%
-
CSI 2.7rCSI 3.4%PRS 50.5%
-
CSI 2.7rCSI 7.2%PRS 38.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4110251337
Symbol: IVD_HUMAN
Name: Butyryl-CoA dehydrogenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2318964
Title: Nucleotide sequence of messenger RNA encoding human isovaleryl-coenzyme A dehydrogenase and its expression in isovaleric acidemia fibroblasts.
PubMed ID: 2318964
DOI: 10.1172/jci114536
PubMed ID: 10677295
Title: Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene.
PubMed ID: 10677295
DOI: 10.1086/302751
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8468053
Title: Structural organization of the human isovaleryl-CoA dehydrogenase gene.
PubMed ID: 8468053
PubMed ID: 1310317
Title: The variant human isovaleryl-CoA dehydrogenase gene responsible for type II isovaleric acidemia determines an RNA splicing error, leading to the deletion of the entire second coding exon and the production of a truncated precursor protein that interacts poorly with mitochondrial import receptors.
PubMed ID: 1310317
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 7640268
Title: Identification of the active site catalytic residue in human isovaleryl-CoA dehydrogenase.
PubMed ID: 7640268
DOI: 10.1021/bi00032a007
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9214289
Title: Structure of human isovaleryl-CoA dehydrogenase at 2.6-A resolution: structural basis for substrate specificity.
PubMed ID: 9214289
DOI: 10.1021/bi970422u
PubMed ID: 2063866
Title: Molecular characterization of four different classes of mutations in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric acidemia.
PubMed ID: 2063866
PubMed ID: 9665741
Title: Characterization of molecular defects in isovaleryl-CoA dehydrogenase in patients with isovaleric acidemia.
PubMed ID: 9665741
DOI: 10.1021/bi973096r
PubMed ID: 22004070
Title: Phenotypic and mutation spectrums of Thai patients with isovaleric acidemia.
PubMed ID: 22004070
PubMed ID: 22350545
Title: Clinical variability of isovaleric acidemia in a genetically homogeneous population.
PubMed ID: 22350545
PubMed ID: 23587913
Title: Two novel isovaleryl-CoA dehydrogenase gene mutations in a Chinese infant.
PubMed ID: 23587913
PubMed ID: 28535199
Title: Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
PubMed ID: 28535199
DOI: 10.1093/hmg/ddx195
Sequence Information:
- Length: 426
- Mass: 46651
- Checksum: D744DA85752BF307
- Sequence:
MAEMATATRL LGWRVASWRL RPPLAGFVSQ RAHSLLPVDD AINGLSEEQR QLRQTMAKFL QEHLAPKAQE IDRSNEFKNL REFWKQLGNL GVLGITAPVQ YGGSGLGYLE HVLVMEEISR ASGAVGLSYG AHSNLCINQL VRNGNEAQKE KYLPKLISGE YIGALAMSEP NAGSDVVSMK LKAEKKGNHY ILNGNKFWIT NGPDADVLIV YAKTDLAAVP ASRGITAFIV EKGMPGFSTS KKLDKLGMRG SNTCELIFED CKIPAANILG HENKGVYVLM SGLDLERLVL AGGPLGLMQA VLDHTIPYLH VREAFGQKIG HFQLMQGKMA DMYTRLMACR QYVYNVAKAC DEGHCTAKDC AGVILYSAEC ATQVALDGIQ CFGGNGYIND FPMGRFLRDA KLYEIGAGTS EVRRLVIGRA FNADFH
Genular Protein ID: 329058693
Symbol: A0A0A0MT83_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 423
- Mass: 46319
- Checksum: 121AF14C7F1FA13D
- Sequence:
MATATRLLGW RVASWRLRPP LAGFVSQRAH SLLPVDDAIN GLSEEQRQLR QTMAKFLQEH LAPKAQEIDR SNEFKNLREF WKQLGNLGVL GITAPVQYGG SGLGYLEHVL VMEEISRASG AVGLSYGAHS NLCINQLVRN GNEAQKEKYL PKLISGEYIG ALAMSEPNAG SDVVSMKLKA EKKGNHYILN GNKFWITNGP DADVLIVYAK TDLAAVPASR GITAFIVEKG MPGFSTSKKL DKLGMRGSNT CELIFEDCKI PAANILGHEN KGVYVLMSGL DLERLVLAGG PLGLMQAVLD HTIPYLHVRE AFGQKIGHFQ LMQGKMADMY TRLMACRQYV YNVAKACDEG HCTAKDCAGV ILYSAECATQ VALDGIQCFG GNGYINDFPM GRFLRDAKLY EIGAGTSEVR RLVIGRAFNA DFH
Genular Protein ID: 4161770915
Symbol: A0A0S2Z4K7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 393
- Mass: 42724
- Checksum: 6C75C436286F2617
- Sequence:
MATATRLLGW RVASWRLRPP LAGFVSQRAH SLLPVDDAIN GLSEEQRQEF WKQLGNLGVL GITAPVQYGG SGLGYLEHVL VMEEISRASG AVGLSYGAHS NLCINQLVRN GNEAQKEKYL PKLISGEYIG ALAMSEPNAG SDVVSMKLKA EKKGNHYILN GNKFWITNGP DADVLIVYAK TDLAAVPASR GITAFIVEKG MPGFSTSKKL DKLGMRGSNT CELIFEDCKI PAANILGHEN KGVYVLMSGL DLERLVLAGG PLGLMQAVLD HTIPYLHVRE AFGQKIGHFQ LMQGKMADMY TRLMACRQYV YNVAKACDEG HCTAKDCAGV ILYSAECATQ VALDGIQCFG GNGYINDFPM GRFLRDAKLY EIGAGTSEVR RLVIGRAFNA DFH