Details for: IVD

Gene ID: 3712

Symbol: IVD

Ensembl ID: ENSG00000128928

Description: isovaleryl-CoA dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 170.4327
    Cell Significance Index: -26.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.5261
    Cell Significance Index: -23.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.3835
    Cell Significance Index: -25.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 56.2808
    Cell Significance Index: -28.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.0544
    Cell Significance Index: -25.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.9205
    Cell Significance Index: -28.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9147
    Cell Significance Index: -26.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3695
    Cell Significance Index: -22.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2896
    Cell Significance Index: -28.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4549
    Cell Significance Index: -9.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.0467
    Cell Significance Index: 400.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9035
    Cell Significance Index: 51.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6672
    Cell Significance Index: 100.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1263
    Cell Significance Index: 223.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1025
    Cell Significance Index: 179.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0267
    Cell Significance Index: 205.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7846
    Cell Significance Index: 141.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7487
    Cell Significance Index: 51.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7084
    Cell Significance Index: 87.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7055
    Cell Significance Index: 36.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6350
    Cell Significance Index: 87.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6331
    Cell Significance Index: 29.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6036
    Cell Significance Index: 544.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5579
    Cell Significance Index: 25.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5262
    Cell Significance Index: 363.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5224
    Cell Significance Index: 187.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4470
    Cell Significance Index: 19.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4430
    Cell Significance Index: 84.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3984
    Cell Significance Index: 25.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3951
    Cell Significance Index: 6.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3949
    Cell Significance Index: 10.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3889
    Cell Significance Index: 14.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3445
    Cell Significance Index: 188.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3304
    Cell Significance Index: 9.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2928
    Cell Significance Index: 16.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2658
    Cell Significance Index: 20.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2632
    Cell Significance Index: 6.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2300
    Cell Significance Index: 29.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1563
    Cell Significance Index: 3.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0719
    Cell Significance Index: 8.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0586
    Cell Significance Index: 10.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0426
    Cell Significance Index: 31.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0405
    Cell Significance Index: 62.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0390
    Cell Significance Index: 17.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0354
    Cell Significance Index: 65.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0344
    Cell Significance Index: 64.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0190
    Cell Significance Index: 12.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0101
    Cell Significance Index: 13.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0035
    Cell Significance Index: 2.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0115
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0135
    Cell Significance Index: -0.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0200
    Cell Significance Index: -2.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0201
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0240
    Cell Significance Index: -1.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0302
    Cell Significance Index: -2.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0309
    Cell Significance Index: -17.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0354
    Cell Significance Index: -0.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0547
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0555
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0725
    Cell Significance Index: -15.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0878
    Cell Significance Index: -25.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1011
    Cell Significance Index: -7.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1033
    Cell Significance Index: -12.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1110
    Cell Significance Index: -16.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1182
    Cell Significance Index: -13.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1241
    Cell Significance Index: -7.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1362
    Cell Significance Index: -10.7900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1497
    Cell Significance Index: -2.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1685
    Cell Significance Index: -2.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1816
    Cell Significance Index: -4.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1911
    Cell Significance Index: -4.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2228
    Cell Significance Index: -11.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2242
    Cell Significance Index: -4.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2389
    Cell Significance Index: -24.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2473
    Cell Significance Index: -7.9200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2960
    Cell Significance Index: -3.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3096
    Cell Significance Index: -7.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3172
    Cell Significance Index: -6.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3186
    Cell Significance Index: -5.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3480
    Cell Significance Index: -3.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3530
    Cell Significance Index: -21.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3566
    Cell Significance Index: -5.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3628
    Cell Significance Index: -7.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3655
    Cell Significance Index: -3.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3656
    Cell Significance Index: -10.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4227
    Cell Significance Index: -22.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4329
    Cell Significance Index: -12.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4387
    Cell Significance Index: -9.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4439
    Cell Significance Index: -6.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4484
    Cell Significance Index: -6.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4539
    Cell Significance Index: -12.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4737
    Cell Significance Index: -11.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5024
    Cell Significance Index: -11.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5110
    Cell Significance Index: -10.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5758
    Cell Significance Index: -6.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5806
    Cell Significance Index: -18.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IVD exhibits the following key characteristics: 1. **Mitochondrial localization**: IVD is a mitochondrial enzyme, which suggests its involvement in the oxidative metabolism of fatty acids and branched-chain amino acids. 2. **Isovaleryl-CoA specificity**: IVD has a high specificity for isovaleryl-CoA, which is a branched-chain amino acid derivative. 3. **Flavin adenine dinucleotide (FAD) binding**: IVD uses FAD as a cofactor, which is essential for its catalytic activity. 4. **Isovaleryl-CoA dehydrogenase activity**: IVD catalyzes the oxidative decarboxylation of isovaleryl-CoA to methylmalonyl-CoA. **Pathways and Functions** IVD is involved in the following metabolic pathways: 1. **Branched-chain amino acid catabolism**: IVD plays a crucial role in the catabolism of branched-chain amino acids (BCAAs), which are essential amino acids that cannot be synthesized by the human body. 2. **Fatty acid beta-oxidation**: IVD is also involved in the beta-oxidation of fatty acids, which is a process that generates energy for the cell. 3. **Metabolism of amino acids and derivatives**: IVD is part of the broader metabolic network that involves the breakdown and synthesis of amino acids and their derivatives. 4. **Mitochondrial matrix**: IVD is localized to the mitochondrial matrix, which is the site of oxidative phosphorylation and fatty acid oxidation. **Clinical Significance** IVD has implications for various diseases and disorders, including: 1. **Branched-chain ketoaciduria**: IVD deficiency can lead to branched-chain ketoaciduria, a metabolic disorder characterized by the accumulation of branched-chain amino acids and their derivatives. 2. **Fatty acid oxidation disorders**: IVD mutations can also contribute to fatty acid oxidation disorders, which are a group of metabolic disorders characterized by impaired fatty acid oxidation. 3. **Neurological disorders**: IVD expression in cortical neurons suggests its potential role in neurological disorders, such as epilepsy and Alzheimer's disease. 4. **Cancer**: IVD has been implicated in cancer development and progression, particularly in the context of fatty acid metabolism and energy production. In conclusion, IVD is a critical enzyme that plays a vital role in the catabolism of branched-chain amino acids and the metabolism of fatty acids. Its expression in various cell types and its involvement in different metabolic pathways make it an important target for understanding human disease and developing therapeutic strategies.

Genular Protein ID: 4110251337

Symbol: IVD_HUMAN

Name: Butyryl-CoA dehydrogenase

UniProtKB Accession Codes:

P26440 B2RCV5 B3KVI7 J3KR54 Q53XZ9 Q96AF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChEBI 27 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 15 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 12 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2318964

Title: Nucleotide sequence of messenger RNA encoding human isovaleryl-coenzyme A dehydrogenase and its expression in isovaleric acidemia fibroblasts.

PubMed ID: 2318964

DOI: 10.1172/jci114536

PubMed ID: 10677295

Title: Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene.

PubMed ID: 10677295

DOI: 10.1086/302751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8468053

Title: Structural organization of the human isovaleryl-CoA dehydrogenase gene.

PubMed ID: 8468053

DOI: 10.1006/geno.1993.1111

PubMed ID: 1310317

Title: The variant human isovaleryl-CoA dehydrogenase gene responsible for type II isovaleric acidemia determines an RNA splicing error, leading to the deletion of the entire second coding exon and the production of a truncated precursor protein that interacts poorly with mitochondrial import receptors.

PubMed ID: 1310317

DOI: 10.1016/s0021-9258(18)45906-6

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7640268

Title: Identification of the active site catalytic residue in human isovaleryl-CoA dehydrogenase.

PubMed ID: 7640268

DOI: 10.1021/bi00032a007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9214289

Title: Structure of human isovaleryl-CoA dehydrogenase at 2.6-A resolution: structural basis for substrate specificity.

PubMed ID: 9214289

DOI: 10.1021/bi970422u

PubMed ID: 2063866

Title: Molecular characterization of four different classes of mutations in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric acidemia.

PubMed ID: 2063866

PubMed ID: 9665741

Title: Characterization of molecular defects in isovaleryl-CoA dehydrogenase in patients with isovaleric acidemia.

PubMed ID: 9665741

DOI: 10.1021/bi973096r

PubMed ID: 22004070

Title: Phenotypic and mutation spectrums of Thai patients with isovaleric acidemia.

PubMed ID: 22004070

DOI: 10.1111/j.1442-200x.2011.03488.x

PubMed ID: 22350545

Title: Clinical variability of isovaleric acidemia in a genetically homogeneous population.

PubMed ID: 22350545

DOI: 10.1007/s10545-012-9457-2

PubMed ID: 23587913

Title: Two novel isovaleryl-CoA dehydrogenase gene mutations in a Chinese infant.

PubMed ID: 23587913

DOI: 10.1016/j.gene.2013.03.139

PubMed ID: 28535199

Title: Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.

PubMed ID: 28535199

DOI: 10.1093/hmg/ddx195

Sequence Information:

  • Length: 426
  • Mass: 46651
  • Checksum: D744DA85752BF307
  • Sequence:
    • MAEMATATRL LGWRVASWRL RPPLAGFVSQ RAHSLLPVDD AINGLSEEQR QLRQTMAKFL 
QEHLAPKAQE IDRSNEFKNL REFWKQLGNL GVLGITAPVQ YGGSGLGYLE HVLVMEEISR 
ASGAVGLSYG AHSNLCINQL VRNGNEAQKE KYLPKLISGE YIGALAMSEP NAGSDVVSMK 
LKAEKKGNHY ILNGNKFWIT NGPDADVLIV YAKTDLAAVP ASRGITAFIV EKGMPGFSTS 
KKLDKLGMRG SNTCELIFED CKIPAANILG HENKGVYVLM SGLDLERLVL AGGPLGLMQA 
VLDHTIPYLH VREAFGQKIG HFQLMQGKMA DMYTRLMACR QYVYNVAKAC DEGHCTAKDC 
AGVILYSAEC ATQVALDGIQ CFGGNGYIND FPMGRFLRDA KLYEIGAGTS EVRRLVIGRA 
FNADFH

Genular Protein ID: 329058693

Symbol: A0A0A0MT83_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MT83 A0A0S2Z422

Database IDs:

ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 27 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 2 GO 8 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PROSITE 2 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 12 RuleBase 1 SUPFAM 2 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 423
  • Mass: 46319
  • Checksum: 121AF14C7F1FA13D
  • Sequence:
    • MATATRLLGW RVASWRLRPP LAGFVSQRAH SLLPVDDAIN GLSEEQRQLR QTMAKFLQEH 
LAPKAQEIDR SNEFKNLREF WKQLGNLGVL GITAPVQYGG SGLGYLEHVL VMEEISRASG 
AVGLSYGAHS NLCINQLVRN GNEAQKEKYL PKLISGEYIG ALAMSEPNAG SDVVSMKLKA 
EKKGNHYILN GNKFWITNGP DADVLIVYAK TDLAAVPASR GITAFIVEKG MPGFSTSKKL 
DKLGMRGSNT CELIFEDCKI PAANILGHEN KGVYVLMSGL DLERLVLAGG PLGLMQAVLD 
HTIPYLHVRE AFGQKIGHFQ LMQGKMADMY TRLMACRQYV YNVAKACDEG HCTAKDCAGV 
ILYSAECATQ VALDGIQCFG GNGYINDFPM GRFLRDAKLY EIGAGTSEVR RLVIGRAFNA 
DFH

Genular Protein ID: 4161770915

Symbol: A0A0S2Z4K7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4K7

Database IDs:

ARBA 16 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 27 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 2 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PROSITE 2 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 12 RuleBase 1 SUPFAM 2 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 393
  • Mass: 42724
  • Checksum: 6C75C436286F2617
  • Sequence:
    • MATATRLLGW RVASWRLRPP LAGFVSQRAH SLLPVDDAIN GLSEEQRQEF WKQLGNLGVL 
GITAPVQYGG SGLGYLEHVL VMEEISRASG AVGLSYGAHS NLCINQLVRN GNEAQKEKYL 
PKLISGEYIG ALAMSEPNAG SDVVSMKLKA EKKGNHYILN GNKFWITNGP DADVLIVYAK 
TDLAAVPASR GITAFIVEKG MPGFSTSKKL DKLGMRGSNT CELIFEDCKI PAANILGHEN 
KGVYVLMSGL DLERLVLAGG PLGLMQAVLD HTIPYLHVRE AFGQKIGHFQ LMQGKMADMY 
TRLMACRQYV YNVAKACDEG HCTAKDCAGV ILYSAECATQ VALDGIQCFG GNGYINDFPM 
GRFLRDAKLY EIGAGTSEVR RLVIGRAFNA DFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.