Details for: KCNJ10

Gene ID: 3766

Symbol: KCNJ10

Ensembl ID: ENSG00000177807

Description: potassium inwardly rectifying channel subfamily J member 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.48
    Marker Score: 1928
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.19
    Marker Score: 2201
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.78
    Marker Score: 38043
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.57
    Marker Score: 1661
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.48
    Marker Score: 778
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.36
    Marker Score: 1875
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.28
    Marker Score: 3421
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.28
    Marker Score: 3053
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.26
    Marker Score: 831
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7487
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.12
    Marker Score: 1547.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.97
    Marker Score: 566
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.85
    Marker Score: 733
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1799
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.73
    Marker Score: 306
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 458
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 198
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.57
    Marker Score: 707
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8729
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.56
    Marker Score: 174
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1015
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1066
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.47
    Marker Score: 193
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.42
    Marker Score: 190
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.34
    Marker Score: 346
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.34
    Marker Score: 479
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 147
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.29
    Marker Score: 67
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 80
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.26
    Marker Score: 120
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.26
    Marker Score: 257
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 154
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.25
    Marker Score: 246
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 271
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.22
    Marker Score: 149
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.21
    Marker Score: 130
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.19
    Marker Score: 308
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 315
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.17
    Marker Score: 245
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.16
    Marker Score: 404
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.15
    Marker Score: 521
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 136
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 126
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.14
    Marker Score: 158
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 232
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 765
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 66
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 251
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.12
    Marker Score: 200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.12
    Marker Score: 143

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Other Information

**Key characteristics:** * The KCNJ10 gene is located on chromosome 19p13.1. * It is a single-exon gene that encodes a protein of 547 amino acids. * The protein is a transmembrane protein that is expressed on the surface of cells. * It is a member of the KCNJ family of potassium channels. * The protein is a ligand for the G protein-gated potassium channel opener Gabap. **Pathways and functions:** * The KCNJ10 protein is a key regulator of neuronal excitability. * It is activated by the G protein-gated potassium channel opener Gabap. * Activation of the KCNJ10 protein leads to the opening of potassium channels, which causes a decrease in membrane potential. * This inhibition of voltage-gated calcium channels is thought to be responsible for the inhibitory postsynaptic potential that is characteristic of many neurons. **Clinical significance:** * Mutations in the KCNJ10 gene have been linked to a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * These diseases are characterized by neuronal loss and dysfunction. * The KCNJ10 gene is a promising target for the treatment of these diseases. **Additional information:** * The KCNJ10 protein is a highly conserved protein. * It is expressed in a wide variety of cell types, suggesting that it is an important regulator of cellular function. * The KCNJ10 protein is a promising target for the development of new therapies for neurodegenerative diseases.

Genular Protein ID: 2785625837

Symbol: KCJ10_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 10

UniProtKB Accession Codes:

P78508 A3KME7 Q5VUT9 Q8N4I7 Q92808

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8995301

Title: Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).

PubMed ID: 8995301

DOI: 10.1074/jbc.272.1.586

PubMed ID: 10659995

Title: Co-expression of human Kir3 subunits can yield channels with different functional properties.

PubMed ID: 10659995

DOI: 10.1016/s0898-6568(99)00059-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24561201

Title: Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome.

PubMed ID: 24561201

DOI: 10.1016/j.febslet.2014.02.024

PubMed ID: 19420365

Title: Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.

PubMed ID: 19420365

DOI: 10.1056/nejmoa0810276

PubMed ID: 19289823

Title: Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10.

PubMed ID: 19289823

DOI: 10.1073/pnas.0901749106

PubMed ID: 22612257

Title: Targeted next generation sequencing as a diagnostic tool in epileptic disorders.

PubMed ID: 22612257

DOI: 10.1111/j.1528-1167.2012.03516.x

PubMed ID: 28887846

Title: Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism.

PubMed ID: 28887846

DOI: 10.1002/humu.23335

Sequence Information:

  • Length: 379
  • Mass: 42508
  • Checksum: D9DA013FF4003533
  • Sequence:
    • MTSVAKVYYS QTTQTESRPL MGPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI 
DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELD PPANHTPCVV QVHTLTGAFL 
FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR 
FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV 
DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES 
LREQAEKEGS ALSVRISNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.