Details for: KCNJ10

Gene ID: 3766

Symbol: KCNJ10

Ensembl ID: ENSG00000177807

Description: potassium inwardly rectifying channel subfamily J member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.8293
    Cell Significance Index: 25.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7491
    Cell Significance Index: 16.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4843
    Cell Significance Index: 15.5100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3453
    Cell Significance Index: 10.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3424
    Cell Significance Index: 5.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2865
    Cell Significance Index: 54.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2605
    Cell Significance Index: 51.6900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.2088
    Cell Significance Index: 2.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1025
    Cell Significance Index: 92.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1020
    Cell Significance Index: 5.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0918
    Cell Significance Index: 67.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0894
    Cell Significance Index: 5.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0836
    Cell Significance Index: 8.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0687
    Cell Significance Index: 93.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0678
    Cell Significance Index: 7.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0438
    Cell Significance Index: 7.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0208
    Cell Significance Index: 0.7300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0182
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0135
    Cell Significance Index: 0.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0113
    Cell Significance Index: 0.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0068
    Cell Significance Index: 2.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0053
    Cell Significance Index: 0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0012
    Cell Significance Index: 0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -5.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0097
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0129
    Cell Significance Index: -0.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0145
    Cell Significance Index: -7.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0243
    Cell Significance Index: -4.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0260
    Cell Significance Index: -0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0279
    Cell Significance Index: -4.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0418
    Cell Significance Index: -0.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0457
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0490
    Cell Significance Index: -8.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0493
    Cell Significance Index: -6.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0529
    Cell Significance Index: -4.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0545
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0558
    Cell Significance Index: -11.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0588
    Cell Significance Index: -6.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0593
    Cell Significance Index: -6.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0605
    Cell Significance Index: -8.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0702
    Cell Significance Index: -1.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0711
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0731
    Cell Significance Index: -8.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0752
    Cell Significance Index: -7.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0792
    Cell Significance Index: -10.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0917
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0930
    Cell Significance Index: -7.1400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1043
    Cell Significance Index: -0.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1097
    Cell Significance Index: -5.1200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1140
    Cell Significance Index: -1.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1246
    Cell Significance Index: -6.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1290
    Cell Significance Index: -6.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1443
    Cell Significance Index: -6.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1532
    Cell Significance Index: -3.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1537
    Cell Significance Index: -6.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1593
    Cell Significance Index: -3.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1596
    Cell Significance Index: -8.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1718
    Cell Significance Index: -4.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1734
    Cell Significance Index: -7.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1823
    Cell Significance Index: -9.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1844
    Cell Significance Index: -5.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1930
    Cell Significance Index: -6.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1931
    Cell Significance Index: -6.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1994
    Cell Significance Index: -7.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2057
    Cell Significance Index: -5.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2080
    Cell Significance Index: -6.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2132
    Cell Significance Index: -6.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2194
    Cell Significance Index: -2.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2284
    Cell Significance Index: -5.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2293
    Cell Significance Index: -3.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2407
    Cell Significance Index: -3.4200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2448
    Cell Significance Index: -1.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2489
    Cell Significance Index: -5.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2568
    Cell Significance Index: -7.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2721
    Cell Significance Index: -6.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2726
    Cell Significance Index: -6.8000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2732
    Cell Significance Index: -4.6700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2739
    Cell Significance Index: -1.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2744
    Cell Significance Index: -7.3400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2752
    Cell Significance Index: -5.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2792
    Cell Significance Index: -7.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2813
    Cell Significance Index: -7.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2864
    Cell Significance Index: -7.5300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.2903
    Cell Significance Index: -3.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2978
    Cell Significance Index: -6.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2983
    Cell Significance Index: -7.6000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3012
    Cell Significance Index: -7.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3032
    Cell Significance Index: -6.5500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3057
    Cell Significance Index: -3.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3091
    Cell Significance Index: -6.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3107
    Cell Significance Index: -7.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The KCNJ10 gene is a member of the inwardly rectifying potassium channel subfamily J. It encodes for a small, C-terminal-inwardly-rectifying (Kir) subunit that forms heteromeric potassium channels with other KCNJ subunits. The KCNJ10 channel has a high sensitivity to ATP, which activates the channel and regulates its activity. The KCNJ10 channel is also sensitive to intracellular calcium and G-protein coupled receptor activation, further modulating its activity. **Pathways and Functions** The KCNJ10 channel is involved in several cellular pathways, including: 1. **Potassium ion homeostasis**: The KCNJ10 channel regulates the flow of potassium ions across cell membranes, maintaining the resting membrane potential and influencing cell excitability. 2. **Neurotransmission**: The KCNJ10 channel modulates synaptic transmission by regulating the release of neurotransmitters, such as GABA and glutamate, and the activity of voltage-gated calcium channels. 3. **Synaptic plasticity**: The KCNJ10 channel is involved in long-term neuronal synaptic plasticity, influencing the strength and duration of synaptic connections. 4. **G-protein coupled receptor activation**: The KCNJ10 channel is activated by G-protein coupled receptors, such as GABA_B receptors, modulating its activity and influencing cellular responses. 5. **Ciliary base function**: The KCNJ10 channel is involved in the assembly and function of cilia, including non-motile cilia, which are essential for sensory perception and cellular signaling. **Clinical Significance** Dysregulation of the KCNJ10 channel has been implicated in various neurological and psychiatric disorders, including: 1. **Migraine**: Abnormal KCNJ10 channel activity has been linked to migraine pathophysiology, with altered potassium channel function contributing to migraine headache. 2. **Epilepsy**: KCNJ10 channel dysfunction has been implicated in epilepsy, with altered potassium channel activity contributing to seizure susceptibility. 3. **Neurodevelopmental disorders**: KCNJ10 channel dysregulation has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Neuropathy**: KCNJ10 channel dysfunction has been implicated in peripheral neuropathy, with altered potassium channel activity contributing to nerve damage and dysfunction. In conclusion, the KCNJ10 gene plays a crucial role in maintaining ion homeostasis, regulating neurotransmission, and influencing synaptic plasticity. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of understanding KCNJ10 channel function and its role in human disease.

Genular Protein ID: 2785625837

Symbol: KCJ10_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 10

UniProtKB Accession Codes:

P78508 A3KME7 Q5VUT9 Q8N4I7 Q92808

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8995301

Title: Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).

PubMed ID: 8995301

DOI: 10.1074/jbc.272.1.586

PubMed ID: 10659995

Title: Co-expression of human Kir3 subunits can yield channels with different functional properties.

PubMed ID: 10659995

DOI: 10.1016/s0898-6568(99)00059-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24561201

Title: Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome.

PubMed ID: 24561201

DOI: 10.1016/j.febslet.2014.02.024

PubMed ID: 19420365

Title: Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.

PubMed ID: 19420365

DOI: 10.1056/nejmoa0810276

PubMed ID: 19289823

Title: Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10.

PubMed ID: 19289823

DOI: 10.1073/pnas.0901749106

PubMed ID: 22612257

Title: Targeted next generation sequencing as a diagnostic tool in epileptic disorders.

PubMed ID: 22612257

DOI: 10.1111/j.1528-1167.2012.03516.x

PubMed ID: 28887846

Title: Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism.

PubMed ID: 28887846

DOI: 10.1002/humu.23335

Sequence Information:

  • Length: 379
  • Mass: 42508
  • Checksum: D9DA013FF4003533
  • Sequence:
    • MTSVAKVYYS QTTQTESRPL MGPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI 
DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELD PPANHTPCVV QVHTLTGAFL 
FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR 
FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV 
DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES 
LREQAEKEGS ALSVRISNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.