Details for: KCNK1

Gene ID: 3775

Symbol: KCNK1

Ensembl ID: ENSG00000135750

Description: potassium two pore domain channel subfamily K member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.2184
    Cell Significance Index: -43.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.5001
    Cell Significance Index: -42.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.3085
    Cell Significance Index: -35.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.9972
    Cell Significance Index: -43.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.7147
    Cell Significance Index: 63.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.2687
    Cell Significance Index: 219.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0163
    Cell Significance Index: 82.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3697
    Cell Significance Index: 475.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2853
    Cell Significance Index: 49.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8124
    Cell Significance Index: 68.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6962
    Cell Significance Index: 76.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4954
    Cell Significance Index: 43.0900
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.4181
    Cell Significance Index: 16.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2228
    Cell Significance Index: 63.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0999
    Cell Significance Index: 119.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0730
    Cell Significance Index: 585.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0544
    Cell Significance Index: 25.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.0074
    Cell Significance Index: 16.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8300
    Cell Significance Index: 36.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7846
    Cell Significance Index: 22.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6211
    Cell Significance Index: 42.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5979
    Cell Significance Index: 118.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5935
    Cell Significance Index: 45.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5851
    Cell Significance Index: 30.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5772
    Cell Significance Index: 399.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5374
    Cell Significance Index: 18.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5311
    Cell Significance Index: 52.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5293
    Cell Significance Index: 7.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4355
    Cell Significance Index: 12.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4073
    Cell Significance Index: 9.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3889
    Cell Significance Index: 351.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3846
    Cell Significance Index: 17.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3438
    Cell Significance Index: 123.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3097
    Cell Significance Index: 40.0100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2518
    Cell Significance Index: 4.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2418
    Cell Significance Index: 43.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2391
    Cell Significance Index: 45.5000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2264
    Cell Significance Index: 3.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1947
    Cell Significance Index: 5.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1765
    Cell Significance Index: 3.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1315
    Cell Significance Index: 18.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1268
    Cell Significance Index: 57.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1197
    Cell Significance Index: 14.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1026
    Cell Significance Index: 4.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0324
    Cell Significance Index: 14.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0293
    Cell Significance Index: 5.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0204
    Cell Significance Index: 1.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0154
    Cell Significance Index: -9.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0187
    Cell Significance Index: -0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0203
    Cell Significance Index: -38.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0263
    Cell Significance Index: -48.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0310
    Cell Significance Index: -47.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0316
    Cell Significance Index: -17.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0367
    Cell Significance Index: -49.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0390
    Cell Significance Index: -29.5200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0396
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0404
    Cell Significance Index: -25.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0469
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0804
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0929
    Cell Significance Index: -19.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1291
    Cell Significance Index: -37.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1379
    Cell Significance Index: -22.4300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1997
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2107
    Cell Significance Index: -24.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2453
    Cell Significance Index: -31.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2532
    Cell Significance Index: -36.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2744
    Cell Significance Index: -28.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2853
    Cell Significance Index: -32.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3778
    Cell Significance Index: -12.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3838
    Cell Significance Index: -45.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3977
    Cell Significance Index: -41.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4019
    Cell Significance Index: -12.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4472
    Cell Significance Index: -31.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4853
    Cell Significance Index: -29.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4884
    Cell Significance Index: -38.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5101
    Cell Significance Index: -25.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5397
    Cell Significance Index: -33.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5714
    Cell Significance Index: -23.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5833
    Cell Significance Index: -32.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6011
    Cell Significance Index: -19.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6375
    Cell Significance Index: -13.5300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6665
    Cell Significance Index: -9.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6838
    Cell Significance Index: -17.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6844
    Cell Significance Index: -35.6500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7134
    Cell Significance Index: -9.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7168
    Cell Significance Index: -14.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7333
    Cell Significance Index: -25.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7425
    Cell Significance Index: -46.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7574
    Cell Significance Index: -18.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7669
    Cell Significance Index: -20.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7764
    Cell Significance Index: -28.5000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.7779
    Cell Significance Index: -10.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7834
    Cell Significance Index: -16.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8939
    Cell Significance Index: -22.3500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.9420
    Cell Significance Index: -13.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0000
    Cell Significance Index: -34.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0907
    Cell Significance Index: -7.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0985
    Cell Significance Index: -21.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNK1 is a member of the two-pore domain potassium channel subfamily, characterized by its unique structure consisting of two pore domains. This channel exhibits inward rectification, allowing potassium ions to flow more easily in the direction opposite to the voltage gradient. KCNK1 is also known to be sensitive to nicotine, suggesting its involvement in nicotine-mediated signaling pathways. Its expression is highly regulated, with significant changes observed in various pathological conditions, underscoring its importance in maintaining cellular function. **Pathways and Functions:** KCNK1 is involved in several critical cellular processes, including: 1. **Regulation of Resting Membrane Potential:** KCNK1 helps maintain the resting membrane potential by allowing potassium ions to flow out of the cell, thereby reducing the membrane potential. 2. **Muscle Contraction:** KCNK1 is expressed in cardiac myocytes and plays a role in regulating muscle contraction by modulating the influx of potassium ions. 3. **Synaptic Transmission:** KCNK1 is involved in regulating synaptic transmission by modulating the flow of potassium ions across the synaptic membrane. 4. **Nicotine Signaling:** KCNK1 is sensitive to nicotine, suggesting its involvement in nicotine-mediated signaling pathways. 5. **Cellular Homeostasis:** KCNK1 helps maintain cellular homeostasis by regulating the flow of potassium ions across the plasma membrane. **Clinical Significance:** Dysregulation of KCNK1 has been implicated in various pathological conditions, including: 1. **Cardiac Arrhythmias:** KCNK1 dysfunction has been linked to cardiac arrhythmias, such as atrial fibrillation. 2. **Neurological Disorders:** KCNK1 has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 3. **Respiratory Diseases:** KCNK1 has been linked to respiratory diseases, such as chronic obstructive pulmonary disease (COPD). 4. **Cancer:** KCNK1 has been implicated in cancer development and progression, particularly in prostate cancer. In conclusion, KCNK1 is a critical gene involved in regulating membrane potential and cellular function. Its dysregulation has been implicated in various pathological conditions, highlighting the importance of understanding its role in maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms underlying KCNK1-mediated cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3688522068

Symbol: KCNK1_HUMAN

Name: Potassium channel subfamily K member 1

UniProtKB Accession Codes:

O00180 Q13307 Q5T5E8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605869

Title: TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.

PubMed ID: 8605869

DOI: 10.1002/j.1460-2075.1996.tb00437.x

PubMed ID: 9462864

Title: Sequence and function of the two P domain potassium channels: implications of an emerging superfamily.

PubMed ID: 9462864

DOI: 10.1007/s001090050186

PubMed ID: 9362344

Title: Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments.

PubMed ID: 9362344

DOI: 10.1152/ajprenal.1997.273.4.f663

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8978667

Title: Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.

PubMed ID: 8978667

DOI: 10.1002/j.1460-2075.1996.tb01031.x

PubMed ID: 11165377

Title: Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.

PubMed ID: 11165377

DOI: 10.1016/s0169-328x(00)00263-1

PubMed ID: 15820677

Title: Sumoylation silences the plasma membrane leak K+ channel K2P1.

PubMed ID: 15820677

DOI: 10.1016/j.cell.2005.01.019

PubMed ID: 17693262

Title: Does sumoylation control K2P1/TWIK1 background K+ channels?

PubMed ID: 17693262

DOI: 10.1016/j.cell.2007.06.012

PubMed ID: 17478540

Title: Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart.

PubMed ID: 17478540

DOI: 10.1113/jphysiol.2006.126714

PubMed ID: 19959478

Title: Potassium channel silencing by constitutive endocytosis and intracellular sequestration.

PubMed ID: 19959478

DOI: 10.1074/jbc.m109.078535

PubMed ID: 20498050

Title: One SUMO is sufficient to silence the dimeric potassium channel K2P1.

PubMed ID: 20498050

DOI: 10.1073/pnas.1004712107

PubMed ID: 21653227

Title: TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.

PubMed ID: 21653227

DOI: 10.1126/scisignal.2001726

PubMed ID: 21964404

Title: A role for two-pore K? channels in modulating Na? absorption and Cl? secretion in normal human bronchial epithelial cells.

PubMed ID: 21964404

DOI: 10.1152/ajplung.00102.2011

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22431633

Title: TWIK1, a unique background channel with variable ion selectivity.

PubMed ID: 22431633

DOI: 10.1073/pnas.1201132109

PubMed ID: 23169818

Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

PubMed ID: 23169818

DOI: 10.1126/scisignal.2003431

PubMed ID: 25530075

Title: The family of K2P channels: salient structural and functional properties.

PubMed ID: 25530075

DOI: 10.1113/jphysiol.2014.287268

PubMed ID: 25001086

Title: A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

PubMed ID: 25001086

DOI: 10.1038/ncomms5377

PubMed ID: 25339226

Title: Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.

PubMed ID: 25339226

DOI: 10.1007/s00424-014-1631-y

PubMed ID: 22282804

Title: Crystal structure of the human two-pore domain potassium channel K2P1.

PubMed ID: 22282804

DOI: 10.1126/science.1213274

Sequence Information:

  • Length: 336
  • Mass: 38143
  • Checksum: 2A41D9501323215D
  • Sequence:
    • MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED LLRQELRKLK 
RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW NWDFTSALFF ASTVLSTTGY 
GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT AVVQRITVHV TRRPVLYFHI RWGFSKQVVA 
IVHAVLLGFV TVSCFFFIPA AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK 
FRELYKIGIT CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS 
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.