Details for: KCNK1

Gene ID: 3775

Symbol: KCNK1

Ensembl ID: ENSG00000135750

Description: potassium two pore domain channel subfamily K member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.36
    Marker Score: 32902.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.38
    Marker Score: 7767
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.76
    Marker Score: 14840
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.53
    Marker Score: 1992
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.35
    Marker Score: 6703
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.34
    Marker Score: 7830
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.31
    Marker Score: 8225
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.16
    Marker Score: 11335
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.97
    Marker Score: 4814.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.87
    Marker Score: 4584
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.85
    Marker Score: 1581
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.85
    Marker Score: 17371
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.84
    Marker Score: 11751
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.84
    Marker Score: 112958.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.83
    Marker Score: 17350
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14424
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.62
    Marker Score: 675
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.59
    Marker Score: 54947
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.56
    Marker Score: 1645
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.55
    Marker Score: 386
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.54
    Marker Score: 386
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2367
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.52
    Marker Score: 482
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.48
    Marker Score: 859
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167563
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3226
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.4
    Marker Score: 402
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.36
    Marker Score: 928
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.36
    Marker Score: 2990
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.35
    Marker Score: 3223
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.32
    Marker Score: 50204
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.32
    Marker Score: 2215
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.31
    Marker Score: 48296
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.26
    Marker Score: 666
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2154
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.19
    Marker Score: 1175
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.15
    Marker Score: 1100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.12
    Marker Score: 711
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.12
    Marker Score: 38098
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.12
    Marker Score: 552
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17034
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.08
    Marker Score: 618
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.08
    Marker Score: 434
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Marker Score: 1582
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.06
    Marker Score: 271
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.05
    Marker Score: 503
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251763
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.03
    Marker Score: 1134
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.02
    Marker Score: 964
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1
    Marker Score: 3125
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.98
    Marker Score: 244
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.98
    Marker Score: 978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.97
    Marker Score: 636
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.96
    Marker Score: 1744
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.94
    Marker Score: 272
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5295
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.92
    Marker Score: 5561
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.9
    Marker Score: 1706
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.9
    Marker Score: 4145
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.89
    Marker Score: 307
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.88
    Marker Score: 1031
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 669
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.87
    Marker Score: 11696.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.87
    Marker Score: 396
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.86
    Marker Score: 7483
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.86
    Marker Score: 194
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.83
    Marker Score: 3980
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.83
    Marker Score: 16477
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.82
    Marker Score: 4037.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.82
    Marker Score: 6400.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.81
    Marker Score: 18120.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.8
    Marker Score: 555
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8
    Marker Score: 964
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.8
    Marker Score: 378
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.8
    Marker Score: 763
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1285
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.78
    Marker Score: 6752
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1106.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.78
    Marker Score: 521
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.78
    Marker Score: 452
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.78
    Marker Score: 648
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3230
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.77
    Marker Score: 1224
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2613
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.74
    Marker Score: 4846
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1504
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.74
    Marker Score: 1225
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.74
    Marker Score: 1021

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Other Information

**Key characteristics:** * KCNK1 is a potassium channel protein that belongs to the KCNK family of potassium channels. * It is a transmembrane protein with a pore domain that is responsible for the channel's function. * KCNK1 is expressed in a variety of cell types, including granule cell, macroglial cell, stellate neuron, epithelial cell of urethra, cerebral cortex neuron, neuronal brush cell, regular atrial cardiac myocyte, neuron associated cell (sensu Vertebrata), basal cell of prostate epithelium, and glandular epithelial cell. **Pathways and functions:** * KCNK1 is involved in cardiac conduction by regulating the heart rate and rhythm. * It is also involved in muscle contraction by opening during muscle relaxation and closing during muscle contraction. * KCNK1 is involved in the neuronal system by regulating the excitability of neurons. * It is also involved in renal function by regulating water and electrolyte balance. **Clinical significance:** * Mutations in the KCNK1 gene have been linked to a number of human diseases, including cardiac arrhythmias, epilepsy, and renal failure. * Drugs that target KCNK1 have been developed and are used to treat these diseases.

Genular Protein ID: 3688522068

Symbol: KCNK1_HUMAN

Name: Potassium channel subfamily K member 1

UniProtKB Accession Codes:

O00180 Q13307 Q5T5E8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605869

Title: TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.

PubMed ID: 8605869

DOI: 10.1002/j.1460-2075.1996.tb00437.x

PubMed ID: 9462864

Title: Sequence and function of the two P domain potassium channels: implications of an emerging superfamily.

PubMed ID: 9462864

DOI: 10.1007/s001090050186

PubMed ID: 9362344

Title: Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments.

PubMed ID: 9362344

DOI: 10.1152/ajprenal.1997.273.4.f663

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8978667

Title: Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.

PubMed ID: 8978667

DOI: 10.1002/j.1460-2075.1996.tb01031.x

PubMed ID: 11165377

Title: Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.

PubMed ID: 11165377

DOI: 10.1016/s0169-328x(00)00263-1

PubMed ID: 15820677

Title: Sumoylation silences the plasma membrane leak K+ channel K2P1.

PubMed ID: 15820677

DOI: 10.1016/j.cell.2005.01.019

PubMed ID: 17693262

Title: Does sumoylation control K2P1/TWIK1 background K+ channels?

PubMed ID: 17693262

DOI: 10.1016/j.cell.2007.06.012

PubMed ID: 17478540

Title: Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart.

PubMed ID: 17478540

DOI: 10.1113/jphysiol.2006.126714

PubMed ID: 19959478

Title: Potassium channel silencing by constitutive endocytosis and intracellular sequestration.

PubMed ID: 19959478

DOI: 10.1074/jbc.m109.078535

PubMed ID: 20498050

Title: One SUMO is sufficient to silence the dimeric potassium channel K2P1.

PubMed ID: 20498050

DOI: 10.1073/pnas.1004712107

PubMed ID: 21653227

Title: TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.

PubMed ID: 21653227

DOI: 10.1126/scisignal.2001726

PubMed ID: 21964404

Title: A role for two-pore K? channels in modulating Na? absorption and Cl? secretion in normal human bronchial epithelial cells.

PubMed ID: 21964404

DOI: 10.1152/ajplung.00102.2011

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22431633

Title: TWIK1, a unique background channel with variable ion selectivity.

PubMed ID: 22431633

DOI: 10.1073/pnas.1201132109

PubMed ID: 23169818

Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

PubMed ID: 23169818

DOI: 10.1126/scisignal.2003431

PubMed ID: 25530075

Title: The family of K2P channels: salient structural and functional properties.

PubMed ID: 25530075

DOI: 10.1113/jphysiol.2014.287268

PubMed ID: 25001086

Title: A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

PubMed ID: 25001086

DOI: 10.1038/ncomms5377

PubMed ID: 25339226

Title: Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.

PubMed ID: 25339226

DOI: 10.1007/s00424-014-1631-y

PubMed ID: 22282804

Title: Crystal structure of the human two-pore domain potassium channel K2P1.

PubMed ID: 22282804

DOI: 10.1126/science.1213274

Sequence Information:

  • Length: 336
  • Mass: 38143
  • Checksum: 2A41D9501323215D
  • Sequence:
    • MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED LLRQELRKLK 
RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW NWDFTSALFF ASTVLSTTGY 
GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT AVVQRITVHV TRRPVLYFHI RWGFSKQVVA 
IVHAVLLGFV TVSCFFFIPA AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK 
FRELYKIGIT CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS 
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.