Details for: KIR3DL2

Gene ID: 3812

Symbol: KIR3DL2

Ensembl ID: ENSG00000240403

Description: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3175
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.16
    Marker Score: 609
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.09
    Marker Score: 587
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2495
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.9
    Marker Score: 1323
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 686
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1399
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 440
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.62
    Marker Score: 1814
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 495
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.55
    Marker Score: 178
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.51
    Marker Score: 1604
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.45
    Marker Score: 1255
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.36
    Marker Score: 206
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.31
    Marker Score: 229
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.31
    Marker Score: 302
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.27
    Marker Score: 651
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.26
    Marker Score: 215
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.26
    Marker Score: 131
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.24
    Marker Score: 306
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.23
    Marker Score: 155
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 202
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.19
    Marker Score: 149
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.17
    Marker Score: 118.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.16
    Marker Score: 54
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 184
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 140
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.14
    Marker Score: 1606
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.13
    Marker Score: 110
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 114
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.12
    Marker Score: 130
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.11
    Marker Score: 148
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.1
    Marker Score: 86
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.1
    Marker Score: 281
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.1
    Marker Score: 84
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 162
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 559
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 141
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 190
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.08
    Marker Score: 144
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 87.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 117
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 119
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 123
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.05
    Marker Score: 21

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Other Information

**Key characteristics:** - KIR3DL2 is a type I transmembrane receptor that is expressed in high levels on the surface of activated T cells and NK cells. - It is a member of the killer cell immunoglobulin like receptor (KIR) family, which are expressed on cytotoxic lymphocytes. - KIR3DL2 is a homophilic receptor that binds to the KIR3D1 molecule. - It has a long cytoplasmic tail that is rich in cysteine residues, which are involved in protein-protein interactions. **Pathways and functions:** - KIR3DL2 is expressed on the surface of immune cells and is involved in the regulation of immune responses. - It is expressed on activated T cells and NK cells, where it binds to KIR3D1 on activated CD8+ T cells and NK cells. - KIR3DL2 signaling is required for the regulation of T cell responses, including cytotoxicity, cytokine production, and migration. - KIR3DL2 also plays a role in the regulation of NK cell responses, including cytotoxicity, cytokine production, and migration. **Clinical significance:** - KIR3DL2 is a potential therapeutic target for cancer immunotherapy. - Inhibition of KIR3DL2 signaling has been shown to be effective in promoting the activation of T cells and NK cells, resulting in tumor regression. - KIR3DL2 is also a potential target for autoimmune diseases, where it could be used to suppress autoreactive T cells.

Genular Protein ID: 1081583369

Symbol: KI3L2_HUMAN

Name: CD158 antigen-like family member K

UniProtKB Accession Codes:

P43630 Q13238 Q14947 Q14948 Q92684 Q95366 Q95367 Q95368

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 Ensembl 20 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7716543

Title: Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.

PubMed ID: 7716543

DOI: 10.1126/science.7716543

PubMed ID: 8777725

Title: Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer.

PubMed ID: 8777725

DOI: 10.1016/1074-7613(95)90069-1

PubMed ID: 8760804

Title: The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

PubMed ID: 8760804

DOI: 10.1084/jem.184.2.505

PubMed ID: 8662091

Title: Alternatively spliced forms of human killer inhibitory receptors.

PubMed ID: 8662091

DOI: 10.1007/bf02602590

PubMed ID: 24018270

Title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

PubMed ID: 24018270

DOI: 10.4049/jimmunol.1300081

PubMed ID: 26928464

Title: Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

PubMed ID: 26928464

DOI: 10.1038/nm.4052

PubMed ID: 28636952

Title: Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.

PubMed ID: 28636952

DOI: 10.1016/j.immuni.2017.06.002

PubMed ID: 9430221

Title: Human diversity in killer cell inhibitory receptor genes.

PubMed ID: 9430221

DOI: 10.1016/s1074-7613(00)80394-5

Sequence Information:

  • Length: 455
  • Mass: 50230
  • Checksum: DB4BA6BB6B3C2945
  • Sequence:
    • MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML 
YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN 
HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF 
SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV 
TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL 
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL 
YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT 
PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF

Genular Protein ID: 906370089

Symbol: Q8NHK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NHK6 A0A0C4ZNW6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 10 Ensembl 4 GO 1 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 4 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 11207248

Title: Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.

PubMed ID: 11207248

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 455
  • Mass: 50211
  • Checksum: B60046AFD478D7AF
  • Sequence:
    • MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML 
YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN 
HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF 
SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV 
TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFHAL 
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL 
YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT 
PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF

Genular Protein ID: 1173352897

Symbol: Q8NHI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NHI6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 11859120

Title: Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype.

PubMed ID: 11859120

Sequence Information:

  • Length: 432
  • Mass: 47776
  • Checksum: 94ADE5F474591D4E
  • Sequence:
    • GGQDKPFLSA RPSTVVPRGG HVALQCHYRR GFNNFMLYKE DRSHVPIFHG RIFQESFIMG 
PVTPAHAGTY RCRGSRPHSL TGWSAPSNPL VIMVTGNHRK PSLLAHPGPL LKSGETVILQ 
CWSDVMFEHF FLHREGISED PSRLVGQIHD GVSKANFSIG PLMPVLAGTY RCYGSVPHSP 
YQLSAPSDPL DIVITGLYEK PSLSAQPGPT VQAGENVTLS CSSWSSYDIY HLSREGEAHE 
RRLRAVPKVN RTFQADFPLG PATHGGTYRC FGSFRALPCV WSNSSDPLLV SVTGNPSSSW 
PSPTEPSSKS GICRHLHVLI GTSVVIFLFI LLLFFLLYRW CSNKKNAAVM DQEPAGDRTV 
NRQDSDEQDP QEVMYAQLDH CVFIQRKISR PSQRPKTPLT DTSVYTELPN AEPRSKVVSC 
PRAPQSGLEG VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.