Details for: TNPO1

Gene ID: 3842

Symbol: TNPO1

Ensembl ID: ENSG00000083312

Description: transportin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 463.5951
    Cell Significance Index: -72.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 277.7916
    Cell Significance Index: -70.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 158.4122
    Cell Significance Index: -74.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 146.3359
    Cell Significance Index: -59.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 135.8320
    Cell Significance Index: -69.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 111.6357
    Cell Significance Index: -74.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.6242
    Cell Significance Index: -59.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.8805
    Cell Significance Index: -73.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.2910
    Cell Significance Index: -70.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.0617
    Cell Significance Index: -64.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8872
    Cell Significance Index: -74.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.3197
    Cell Significance Index: -31.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.3147
    Cell Significance Index: 141.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.0233
    Cell Significance Index: 169.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6078
    Cell Significance Index: 523.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.1413
    Cell Significance Index: 143.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1079
    Cell Significance Index: 1903.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0125
    Cell Significance Index: 126.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.9431
    Cell Significance Index: 41.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8150
    Cell Significance Index: 360.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7209
    Cell Significance Index: 23.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.6799
    Cell Significance Index: 43.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4170
    Cell Significance Index: 508.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3286
    Cell Significance Index: 37.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2520
    Cell Significance Index: 55.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2149
    Cell Significance Index: 46.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2075
    Cell Significance Index: 74.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1741
    Cell Significance Index: 90.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1227
    Cell Significance Index: 67.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0868
    Cell Significance Index: 176.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0597
    Cell Significance Index: 732.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0491
    Cell Significance Index: 129.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0312
    Cell Significance Index: 185.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7885
    Cell Significance Index: 22.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6082
    Cell Significance Index: 60.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5852
    Cell Significance Index: 30.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5680
    Cell Significance Index: 39.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5293
    Cell Significance Index: 289.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5212
    Cell Significance Index: 330.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4994
    Cell Significance Index: 68.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4607
    Cell Significance Index: 9.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4496
    Cell Significance Index: 12.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4084
    Cell Significance Index: 769.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3652
    Cell Significance Index: 161.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3102
    Cell Significance Index: 7.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2873
    Cell Significance Index: 49.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2720
    Cell Significance Index: 34.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1861
    Cell Significance Index: 84.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1834
    Cell Significance Index: 8.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1261
    Cell Significance Index: 5.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1209
    Cell Significance Index: 23.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0973
    Cell Significance Index: 179.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0972
    Cell Significance Index: 149.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0819
    Cell Significance Index: 2.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0788
    Cell Significance Index: 1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0592
    Cell Significance Index: 80.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0225
    Cell Significance Index: 0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0058
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0372
    Cell Significance Index: -27.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0374
    Cell Significance Index: -27.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0764
    Cell Significance Index: -57.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0825
    Cell Significance Index: -3.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1023
    Cell Significance Index: -57.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1419
    Cell Significance Index: -14.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1667
    Cell Significance Index: -8.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1689
    Cell Significance Index: -35.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1740
    Cell Significance Index: -22.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1948
    Cell Significance Index: -10.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2069
    Cell Significance Index: -30.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2231
    Cell Significance Index: -26.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2278
    Cell Significance Index: -65.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2389
    Cell Significance Index: -15.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2586
    Cell Significance Index: -3.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2800
    Cell Significance Index: -5.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3255
    Cell Significance Index: -23.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3360
    Cell Significance Index: -38.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3914
    Cell Significance Index: -29.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4297
    Cell Significance Index: -11.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4401
    Cell Significance Index: -7.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4612
    Cell Significance Index: -52.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4817
    Cell Significance Index: -16.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4959
    Cell Significance Index: -51.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5213
    Cell Significance Index: -56.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5710
    Cell Significance Index: -3.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6650
    Cell Significance Index: -21.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6907
    Cell Significance Index: -14.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7463
    Cell Significance Index: -59.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8611
    Cell Significance Index: -21.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8895
    Cell Significance Index: -23.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9185
    Cell Significance Index: -56.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9199
    Cell Significance Index: -26.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0473
    Cell Significance Index: -34.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1052
    Cell Significance Index: -35.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.3086
    Cell Significance Index: -19.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3121
    Cell Significance Index: -32.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3413
    Cell Significance Index: -29.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3930
    Cell Significance Index: -41.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.4389
    Cell Significance Index: -13.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4765
    Cell Significance Index: -39.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNPO1 is a nuclear import receptor that recognizes specific nuclear localization signals (NLS) and facilitates the transport of proteins and RNAs into the nucleus. The gene encodes a 34-kDa protein, which is composed of two distinct domains: an N-terminal domain that binds to NLS and a C-terminal domain that interacts with the nuclear pore complex (NPC). TNPO1 is also involved in the regulation of mRNA stability by binding to and destabilizing AU-rich elements (AREs) in target mRNAs. **Pathways and Functions** TNPO1 is integral to various cellular pathways, including: 1. **Cell Cycle Regulation**: TNPO1 plays a critical role in the regulation of the cell cycle, particularly during the G1-S transition, by facilitating the import of key transcription factors and proteins into the nucleus. 2. **Intraflagellar Transport (IFT)**: TNPO1 is involved in the IFT pathway, which is essential for the assembly and maintenance of cilia in various cell types, including those involved in sensory perception and immune response. 3. **RNA Metabolism**: TNPO1 regulates mRNA stability by binding to and destabilizing AREs, which are commonly found in mRNAs involved in stress responses and inflammation. 4. **Protein Import into the Nucleus**: TNPO1 facilitates the nuclear import of proteins, including transcription factors, which are essential for gene expression and cellular regulation. **Clinical Significance** Dysregulation of TNPO1 has been implicated in various diseases and disorders, including: 1. **Cancer**: TNPO1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 2. **Neurological Disorders**: TNPO1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it may contribute to neuronal dysfunction and death. 3. **Immune System Disorders**: TNPO1 has been shown to play a role in immune system disorders, including autoimmune diseases and cancer immunotherapy resistance. 4. **Eye Diseases**: TNPO1 has been implicated in eye diseases, including age-related macular degeneration and cataracts, where it may contribute to cellular dysfunction and disease progression. In summary, TNPO1 is a crucial gene involved in the regulation of nuclear import and export, as well as the maintenance of nucleocytoplasmic transport pathways. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1354476764

Symbol: TNPO1_HUMAN

Name: Transportin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8808633

Title: A novel receptor-mediated nuclear protein import pathway.

PubMed ID: 8808633

DOI: 10.1016/s0092-8674(00)80173-7

PubMed ID: 9144189

Title: Karyopherin beta2 mediates nuclear import of a mRNA binding protein.

PubMed ID: 9144189

DOI: 10.1073/pnas.94.10.5055

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8986607

Title: Transportin: nuclear transport receptor of a novel nuclear protein import pathway.

PubMed ID: 8986607

DOI: 10.1006/excr.1996.0369

PubMed ID: 9351834

Title: The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.

PubMed ID: 9351834

DOI: 10.1093/emboj/16.21.6535

PubMed ID: 9428644

Title: RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.

PubMed ID: 9428644

DOI: 10.1016/s0014-5793(97)01467-1

PubMed ID: 9524220

Title: Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor.

PubMed ID: 9524220

DOI: 10.1016/s0167-4781(97)00223-6

PubMed ID: 9687515

Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

PubMed ID: 9687515

DOI: 10.1093/emboj/17.15.4491

PubMed ID: 11682607

Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

PubMed ID: 11682607

DOI: 10.1242/jcs.114.19.3479

PubMed ID: 16704975

Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.

PubMed ID: 16704975

DOI: 10.1074/jbc.m602189200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19124606

Title: RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

PubMed ID: 19124606

DOI: 10.1128/mcb.01519-08

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24753571

Title: A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.

PubMed ID: 24753571

DOI: 10.1073/pnas.1323698111

PubMed ID: 10353245

Title: Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.

PubMed ID: 10353245

DOI: 10.1038/20375

PubMed ID: 35446349

Title: Tumor suppressor BAP1 nuclear import is governed by transportin-1.

PubMed ID: 35446349

DOI: 10.1083/jcb.202201094

Sequence Information:

  • Length: 898
  • Mass: 102355
  • Checksum: 7B880D9E7CA6798F
  • Sequence:
  • MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ YPDFNNYLIF 
    VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK SECLNNIGDS SPLIRATVGI 
    LITTIASKGE LQNWPDLLPK LCSLLDSEDY NTCEGAFGAL QKICEDSAEI LDSDVLDRPL 
    NIMIPKFLQF FKHSSPKIRS HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR 
    KNVCRALVML LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV 
    LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS RTVAQQHDED 
    GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD ELLPHILPLL KELLFHHEWV 
    VKESGILVLG AIAEGCMQGM IPYLPELIPH LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ 
    PPDTYLKPLM TELLKRILDS NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK 
    YQHKNLLILY DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS 
    VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI VALDLLSGLA 
    EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG DLTKACFQHV KPCIADFMPI 
    LGTNLNPEFI SVCNNATWAI GEISIQMGIE MQPYIPMVLH QLVEIINRPN TPKTLLENTA 
    ITIGRLGYVC PQEVAPMLQQ FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF 
    IFFCDAVASW INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.