Details for: TNPO1

Gene ID: 3842

Symbol: TNPO1

Ensembl ID: ENSG00000083312

Description: transportin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.41
    Marker Score: 10086
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.35
    Marker Score: 687
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.31
    Marker Score: 1206.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.29
    Marker Score: 5035.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.26
    Marker Score: 1318
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.23
    Marker Score: 1296
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.19
    Marker Score: 3076
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.06
    Marker Score: 78195
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.01
    Marker Score: 600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2
    Marker Score: 5707
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2
    Marker Score: 18802
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.95
    Marker Score: 38742
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.93
    Marker Score: 118595
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.93
    Marker Score: 10115
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.92
    Marker Score: 6447
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.91
    Marker Score: 946
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.88
    Marker Score: 3611.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17482
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.84
    Marker Score: 2115
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15324
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.76
    Marker Score: 6823
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.75
    Marker Score: 1874
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.75
    Marker Score: 26176.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.75
    Marker Score: 13419.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.75
    Marker Score: 31057
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.72
    Marker Score: 962
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.72
    Marker Score: 17717
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.71
    Marker Score: 1001
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.7
    Marker Score: 62740
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7
    Marker Score: 57341
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.7
    Marker Score: 1905
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.67
    Marker Score: 529
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.66
    Marker Score: 2003.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.66
    Marker Score: 1744
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.66
    Marker Score: 989
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.65
    Marker Score: 1356
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.65
    Marker Score: 35114
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6664.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.61
    Marker Score: 1735
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.59
    Marker Score: 2132
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.58
    Marker Score: 1682
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.58
    Marker Score: 938
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.58
    Marker Score: 757
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.56
    Marker Score: 655
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.56
    Marker Score: 1891
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.56
    Marker Score: 607
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.56
    Marker Score: 1720
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.55
    Marker Score: 6409
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.54
    Marker Score: 488
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.54
    Marker Score: 1333
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2364
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.51
    Marker Score: 733
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.51
    Marker Score: 1705
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5
    Marker Score: 5882
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.47
    Marker Score: 2120
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.46
    Marker Score: 1393
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.45
    Marker Score: 417.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.45
    Marker Score: 535
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.44
    Marker Score: 332
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.44
    Marker Score: 2419
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.44
    Marker Score: 3440
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.42
    Marker Score: 7620
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.41
    Marker Score: 31555
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.4
    Marker Score: 1754.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.39
    Marker Score: 473
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.39
    Marker Score: 5786
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.38
    Marker Score: 1067
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.38
    Marker Score: 1777
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.38
    Marker Score: 529
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.35
    Marker Score: 2827
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.34
    Marker Score: 1893
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.33
    Marker Score: 745
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.31
    Marker Score: 1406
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.31
    Marker Score: 652
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.31
    Marker Score: 1134
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.31
    Marker Score: 3733
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.31
    Marker Score: 530
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.31
    Marker Score: 2222
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.31
    Marker Score: 323
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.3
    Marker Score: 1195.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.3
    Marker Score: 374
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.3
    Marker Score: 6003
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.29
    Marker Score: 1367
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.28
    Marker Score: 1887.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.28
    Marker Score: 2945
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.28
    Marker Score: 326
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.28
    Marker Score: 1579
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.27
    Marker Score: 9551
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.26
    Marker Score: 473
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.26
    Marker Score: 345
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.26
    Marker Score: 1355
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.26
    Marker Score: 300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.25
    Marker Score: 790.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.25
    Marker Score: 7975
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.24
    Marker Score: 1261
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.24
    Marker Score: 1097
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.23
    Marker Score: 2802.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.23
    Marker Score: 647
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.23
    Marker Score: 12340.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.22
    Marker Score: 1095

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Other Information

**Key characteristics:** * TNPO1 is a large protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including epithelial cells, neurons, and stem cells. * The protein is localized to the nuclear envelope, the nuclear pore complex, and the cytoplasm. * It is involved in the transport of mRNA from the nucleus to the cytoplasm and back. * It also plays a role in the reassembly of the nuclear envelope after mitosis. **Pathways and functions:** * The TNPO1 protein is involved in the cell cycle, where it is responsible for the transport of mRNA between the nucleus and the cytoplasm. * It is also involved in the mitotic and postmitotic nuclear transport of mRNA, as well as in the reassembly of the nuclear envelope. * The protein is also involved in the regulation of mRNA stability by binding to AU-rich elements and destabilizing mRNA. * It is also involved in the control of protein import into the nucleus, where it binds to small GTPases and facilitates their interaction with mRNA. **Clinical significance:** * Mutations in the TNPO1 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * One of the most common mutations is a gain-of-function mutation, which leads to the overexpression of the TNPO1 protein. * This can result in the accumulation of unstable mRNA in the nucleus, which can lead to the development of cancer. * TNPO1 mutations are also associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. * Therefore, TNPO1 is a promising target for the development of new therapies for cancer and neurodegenerative disorders.

Genular Protein ID: 1354476764

Symbol: TNPO1_HUMAN

Name: Transportin-1

UniProtKB Accession Codes:

Q92973 B4DVC6 Q92957 Q92975

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 EMDB 1 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 21 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8808633

Title: A novel receptor-mediated nuclear protein import pathway.

PubMed ID: 8808633

DOI: 10.1016/s0092-8674(00)80173-7

PubMed ID: 9144189

Title: Karyopherin beta2 mediates nuclear import of a mRNA binding protein.

PubMed ID: 9144189

DOI: 10.1073/pnas.94.10.5055

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8986607

Title: Transportin: nuclear transport receptor of a novel nuclear protein import pathway.

PubMed ID: 8986607

DOI: 10.1006/excr.1996.0369

PubMed ID: 9351834

Title: The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.

PubMed ID: 9351834

DOI: 10.1093/emboj/16.21.6535

PubMed ID: 9428644

Title: RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.

PubMed ID: 9428644

DOI: 10.1016/s0014-5793(97)01467-1

PubMed ID: 9524220

Title: Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor.

PubMed ID: 9524220

DOI: 10.1016/s0167-4781(97)00223-6

PubMed ID: 9687515

Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

PubMed ID: 9687515

DOI: 10.1093/emboj/17.15.4491

PubMed ID: 11682607

Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

PubMed ID: 11682607

DOI: 10.1242/jcs.114.19.3479

PubMed ID: 16704975

Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.

PubMed ID: 16704975

DOI: 10.1074/jbc.m602189200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19124606

Title: RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

PubMed ID: 19124606

DOI: 10.1128/mcb.01519-08

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24753571

Title: A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.

PubMed ID: 24753571

DOI: 10.1073/pnas.1323698111

PubMed ID: 10353245

Title: Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.

PubMed ID: 10353245

DOI: 10.1038/20375

Sequence Information:

  • Length: 898
  • Mass: 102355
  • Checksum: 7B880D9E7CA6798F
  • Sequence:
    • MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ YPDFNNYLIF 
VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK SECLNNIGDS SPLIRATVGI 
LITTIASKGE LQNWPDLLPK LCSLLDSEDY NTCEGAFGAL QKICEDSAEI LDSDVLDRPL 
NIMIPKFLQF FKHSSPKIRS HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR 
KNVCRALVML LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV 
LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS RTVAQQHDED 
GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD ELLPHILPLL KELLFHHEWV 
VKESGILVLG AIAEGCMQGM IPYLPELIPH LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ 
PPDTYLKPLM TELLKRILDS NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK 
YQHKNLLILY DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS 
VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI VALDLLSGLA 
EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG DLTKACFQHV KPCIADFMPI 
LGTNLNPEFI SVCNNATWAI GEISIQMGIE MQPYIPMVLH QLVEIINRPN TPKTLLENTA 
ITIGRLGYVC PQEVAPMLQQ FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF 
IFFCDAVASW INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.