Details for: TNPO1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 463.5951
Cell Significance Index: -72.1100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 277.7916
Cell Significance Index: -70.4600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 158.4122
Cell Significance Index: -74.7900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 146.3359
Cell Significance Index: -59.4500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 135.8320
Cell Significance Index: -69.8700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 111.6357
Cell Significance Index: -74.9100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 62.6242
Cell Significance Index: -59.7900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 59.8805
Cell Significance Index: -73.8300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 26.2910
Cell Significance Index: -70.4300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.0617
Cell Significance Index: -64.6900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.8872
Cell Significance Index: -74.5300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.3197
Cell Significance Index: -31.3400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 5.3147
Cell Significance Index: 141.9100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.0233
Cell Significance Index: 169.6500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6078
Cell Significance Index: 523.1300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.1413
Cell Significance Index: 143.9800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.1079
Cell Significance Index: 1903.2400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.0125
Cell Significance Index: 126.8400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.9431
Cell Significance Index: 41.5400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8150
Cell Significance Index: 360.1900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.7209
Cell Significance Index: 23.4800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.6799
Cell Significance Index: 43.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4170
Cell Significance Index: 508.2700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3286
Cell Significance Index: 37.1300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.2520
Cell Significance Index: 55.3800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.2149
Cell Significance Index: 46.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2075
Cell Significance Index: 74.2200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1741
Cell Significance Index: 90.1000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1227
Cell Significance Index: 67.4000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0868
Cell Significance Index: 176.7600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.0597
Cell Significance Index: 732.9600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0491
Cell Significance Index: 129.0000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0312
Cell Significance Index: 185.9000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.7885
Cell Significance Index: 22.5000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6082
Cell Significance Index: 60.1600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5852
Cell Significance Index: 30.4800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5680
Cell Significance Index: 39.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5293
Cell Significance Index: 289.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5212
Cell Significance Index: 330.9900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4994
Cell Significance Index: 68.5800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4607
Cell Significance Index: 9.9800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4496
Cell Significance Index: 12.9600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4084
Cell Significance Index: 769.0300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3652
Cell Significance Index: 161.4800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3102
Cell Significance Index: 7.4400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2873
Cell Significance Index: 49.0500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2720
Cell Significance Index: 34.8700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1861
Cell Significance Index: 84.4700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1834
Cell Significance Index: 8.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1261
Cell Significance Index: 5.9300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1209
Cell Significance Index: 23.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0973
Cell Significance Index: 179.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0972
Cell Significance Index: 149.5900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0819
Cell Significance Index: 2.2300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0788
Cell Significance Index: 1.3500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0592
Cell Significance Index: 80.4500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0225
Cell Significance Index: 0.7900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0058
Cell Significance Index: -0.6800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0186
Cell Significance Index: -11.6200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0372
Cell Significance Index: -27.5700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0374
Cell Significance Index: -27.4100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0764
Cell Significance Index: -57.8100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0825
Cell Significance Index: -3.7400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1023
Cell Significance Index: -57.7000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1419
Cell Significance Index: -14.5000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1667
Cell Significance Index: -8.7500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1689
Cell Significance Index: -35.5800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1740
Cell Significance Index: -22.4900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1948
Cell Significance Index: -10.1200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2069
Cell Significance Index: -30.0700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2231
Cell Significance Index: -26.0000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2278
Cell Significance Index: -65.5600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2389
Cell Significance Index: -15.4200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2586
Cell Significance Index: -3.0800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2800
Cell Significance Index: -5.4600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3255
Cell Significance Index: -23.0200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3360
Cell Significance Index: -38.5000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3914
Cell Significance Index: -29.1700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4297
Cell Significance Index: -11.3000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4401
Cell Significance Index: -7.3700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4612
Cell Significance Index: -52.6400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4817
Cell Significance Index: -16.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4959
Cell Significance Index: -51.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.5213
Cell Significance Index: -56.7000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5710
Cell Significance Index: -3.4500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6650
Cell Significance Index: -21.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6907
Cell Significance Index: -14.7100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7463
Cell Significance Index: -59.1100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.8611
Cell Significance Index: -21.0100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8895
Cell Significance Index: -23.8400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9185
Cell Significance Index: -56.3100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9199
Cell Significance Index: -26.3700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0473
Cell Significance Index: -34.2900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1052
Cell Significance Index: -35.2000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.3086
Cell Significance Index: -19.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.3121
Cell Significance Index: -32.8000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.3413
Cell Significance Index: -29.3700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3930
Cell Significance Index: -41.0300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.4389
Cell Significance Index: -13.2500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4765
Cell Significance Index: -39.5000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1354476764
Symbol: TNPO1_HUMAN
Name: Transportin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8808633
Title: A novel receptor-mediated nuclear protein import pathway.
PubMed ID: 8808633
PubMed ID: 9144189
Title: Karyopherin beta2 mediates nuclear import of a mRNA binding protein.
PubMed ID: 9144189
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8986607
Title: Transportin: nuclear transport receptor of a novel nuclear protein import pathway.
PubMed ID: 8986607
PubMed ID: 9351834
Title: The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.
PubMed ID: 9351834
PubMed ID: 9428644
Title: RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.
PubMed ID: 9428644
PubMed ID: 9524220
Title: Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor.
PubMed ID: 9524220
PubMed ID: 9687515
Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.
PubMed ID: 9687515
PubMed ID: 11682607
Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.
PubMed ID: 11682607
PubMed ID: 16704975
Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.
PubMed ID: 16704975
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19386897
Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.
PubMed ID: 19386897
DOI: 10.1242/jcs.041749
PubMed ID: 19124606
Title: RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.
PubMed ID: 19124606
DOI: 10.1128/mcb.01519-08
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 24753571
Title: A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.
PubMed ID: 24753571
PubMed ID: 10353245
Title: Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
PubMed ID: 10353245
DOI: 10.1038/20375
PubMed ID: 35446349
Title: Tumor suppressor BAP1 nuclear import is governed by transportin-1.
PubMed ID: 35446349
Sequence Information:
- Length: 898
- Mass: 102355
- Checksum: 7B880D9E7CA6798F
- Sequence:
MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ YPDFNNYLIF VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK SECLNNIGDS SPLIRATVGI LITTIASKGE LQNWPDLLPK LCSLLDSEDY NTCEGAFGAL QKICEDSAEI LDSDVLDRPL NIMIPKFLQF FKHSSPKIRS HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR KNVCRALVML LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS RTVAQQHDED GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD ELLPHILPLL KELLFHHEWV VKESGILVLG AIAEGCMQGM IPYLPELIPH LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ PPDTYLKPLM TELLKRILDS NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK YQHKNLLILY DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI VALDLLSGLA EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG DLTKACFQHV KPCIADFMPI LGTNLNPEFI SVCNNATWAI GEISIQMGIE MQPYIPMVLH QLVEIINRPN TPKTLLENTA ITIGRLGYVC PQEVAPMLQQ FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF IFFCDAVASW INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.