Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 36.0619
Cell Significance Index: 309.8800 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 27.9051
Cell Significance Index: 82.9900 - Cell Name: thymocyte (CL0000893)
Fold Change: 7.4632
Cell Significance Index: 94.3000 - Cell Name: epidermal cell (CL0000362)
Fold Change: 3.2824
Cell Significance Index: 7.4000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.0796
Cell Significance Index: -6.7400 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.6962
Cell Significance Index: 219.1400 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.7608
Cell Significance Index: 5.0500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3530
Cell Significance Index: 9.8700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3400
Cell Significance Index: 15.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2988
Cell Significance Index: 22.2700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2359
Cell Significance Index: 104.2800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1942
Cell Significance Index: 2.6500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1694
Cell Significance Index: 8.8000 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.1252
Cell Significance Index: 0.7800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0616
Cell Significance Index: 0.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0589
Cell Significance Index: 7.2400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0393
Cell Significance Index: 21.4600 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.0035
Cell Significance Index: 0.0200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0004
Cell Significance Index: -0.0200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0016
Cell Significance Index: -0.0800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0036
Cell Significance Index: -0.6600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0054
Cell Significance Index: -0.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0056
Cell Significance Index: -4.2600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0060
Cell Significance Index: -11.3300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0062
Cell Significance Index: -11.4700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0072
Cell Significance Index: -11.1100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0088
Cell Significance Index: -11.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0140
Cell Significance Index: -10.3400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0194
Cell Significance Index: -10.9200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0290
Cell Significance Index: -13.1800 - Cell Name: eosinophil (CL0000771)
Fold Change: -0.0298
Cell Significance Index: -0.2600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0395
Cell Significance Index: -11.3800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0468
Cell Significance Index: -3.3100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0616
Cell Significance Index: -12.3600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0689
Cell Significance Index: -8.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0769
Cell Significance Index: -10.5600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0833
Cell Significance Index: -10.6800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0925
Cell Significance Index: -15.7900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1093
Cell Significance Index: -11.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1115
Cell Significance Index: -12.7700 - Cell Name: reticular cell (CL0000432)
Fold Change: -0.1475
Cell Significance Index: -0.9400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1503
Cell Significance Index: -4.0900 - Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1506
Cell Significance Index: -1.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1507
Cell Significance Index: -7.8500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1539
Cell Significance Index: -9.7000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1841
Cell Significance Index: -6.7600 - Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: -0.2071
Cell Significance Index: -1.4900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2095
Cell Significance Index: -6.0100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.2194
Cell Significance Index: -1.3500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2303
Cell Significance Index: -10.4400 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2370
Cell Significance Index: -5.9200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2375
Cell Significance Index: -13.3300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2406
Cell Significance Index: -11.2200 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: -0.2595
Cell Significance Index: -2.1200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2977
Cell Significance Index: -5.2600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3181
Cell Significance Index: -9.3700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.3315
Cell Significance Index: -6.6100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3336
Cell Significance Index: -11.6900 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.3518
Cell Significance Index: -4.5300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3569
Cell Significance Index: -9.5300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3691
Cell Significance Index: -12.9700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3760
Cell Significance Index: -12.3100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3785
Cell Significance Index: -9.6700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3831
Cell Significance Index: -12.2000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3963
Cell Significance Index: -10.6200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4038
Cell Significance Index: -10.0700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.4091
Cell Significance Index: -12.9400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4124
Cell Significance Index: -10.8500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4266
Cell Significance Index: -12.2900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4277
Cell Significance Index: -12.2100 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: -0.4300
Cell Significance Index: -1.9800 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.4574
Cell Significance Index: -3.4900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4649
Cell Significance Index: -10.1800 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.4838
Cell Significance Index: -5.8900 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.4849
Cell Significance Index: -6.8900 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5138
Cell Significance Index: -13.0900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.5163
Cell Significance Index: -7.3500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5230
Cell Significance Index: -13.0500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5279
Cell Significance Index: -11.0500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5415
Cell Significance Index: -12.5100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5492
Cell Significance Index: -13.4000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5562
Cell Significance Index: -10.2800 - Cell Name: lung secretory cell (CL1000272)
Fold Change: -0.5661
Cell Significance Index: -4.3100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5707
Cell Significance Index: -12.3300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5824
Cell Significance Index: -12.3600 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.5856
Cell Significance Index: -10.0600 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.5991
Cell Significance Index: -7.7400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6042
Cell Significance Index: -13.0900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6104
Cell Significance Index: -13.0000 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.6123
Cell Significance Index: -10.4000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.6133
Cell Significance Index: -12.7900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6171
Cell Significance Index: -12.3900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6281
Cell Significance Index: -13.0300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6295
Cell Significance Index: -10.5400 - Cell Name: basal cell (CL0000646)
Fold Change: -0.6361
Cell Significance Index: -7.5700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6478
Cell Significance Index: -12.8100 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.6549
Cell Significance Index: -10.3900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.6557
Cell Significance Index: -9.3900 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.6564
Cell Significance Index: -12.9200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6572
Cell Significance Index: -17.5800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1968005274
Symbol: K1C16_HUMAN
Name: Keratin, type I cytoskeletal 16
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2431270
Title: Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.
PubMed ID: 2431270
PubMed ID: 2451124
Title: A group of type I keratin genes on human chromosome 17: characterization and expression.
PubMed ID: 2451124
PubMed ID: 7487986
Title: cDNA cloning and bacterial expression of the human type I keratin 16.
PubMed ID: 7487986
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7539673
Title: Keratin 16 and keratin 17 mutations cause pachyonychia congenita.
PubMed ID: 7539673
DOI: 10.1038/ng0395-273
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 11840567
Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.
PubMed ID: 11840567
DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h
PubMed ID: 15731013
Title: Identification of trichoplein, a novel keratin filament-binding protein.
PubMed ID: 15731013
DOI: 10.1242/jcs.01667
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26758872
Title: Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
PubMed ID: 26758872
DOI: 10.1093/hmg/ddw001
PubMed ID: 8595410
Title: Novel mutations in keratin 16 gene underly focal nonepidermolytic palmoplantar keratoderma (NEPPK) in two families.
PubMed ID: 8595410
PubMed ID: 10606845
Title: Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1.
PubMed ID: 10606845
PubMed ID: 10521820
Title: Cloning of multiple keratin 16 genes facilitates prenatal diagnosis of pachyonychia congenita type 1.
PubMed ID: 10521820
DOI: 10.1002/(sici)1097-0223(199910)19:10<941::aid-pd663>3.3.co;2-n
PubMed ID: 10839714
Title: Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma.
PubMed ID: 10839714
PubMed ID: 10844556
Title: A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus.
PubMed ID: 10844556
PubMed ID: 11359398
Title: Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16.
PubMed ID: 11359398
PubMed ID: 11886499
Title: Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.
PubMed ID: 11886499
PubMed ID: 16250206
Title: The genetic basis of pachyonychia congenita.
PubMed ID: 16250206
PubMed ID: 17719747
Title: A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.
PubMed ID: 17719747
PubMed ID: 21326300
Title: A large mutational study in pachyonychia congenita.
PubMed ID: 21326300
DOI: 10.1038/jid.2011.20
PubMed ID: 21160496
Title: Genotype-phenotype correlations among pachyonychia congenita patients with K16 mutations.
PubMed ID: 21160496
DOI: 10.1038/jid.2010.373
PubMed ID: 22668561
Title: Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma.
PubMed ID: 22668561
PubMed ID: 24118415
Title: A new KRT16 mutation associated with a phenotype of pachyonychia congenita.
PubMed ID: 24118415
DOI: 10.1111/exd.12262
Sequence Information:
- Length: 473
- Mass: 51268
- Checksum: BA8CE9F4716A88A4
- Sequence:
MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL SVSSRFSSGG ACGLGGGYGG GFSSSSSFGS GFGGGYGGGL GAGFGGGLGA GFGGGFAGGD GLLVGSEKVT MQNLNDRLAS YLDKVRALEE ANADLEVKIR DWYQRQRPSE IKDYSPYFKT IEDLRNKIIA ATIENAQPIL QIDNARLAAD DFRTKYEHEL ALRQTVEADV NGLRRVLDEL TLARTDLEMQ IEGLKEELAY LRKNHEEEML ALRGQTGGDV NVEMDAAPGV DLSRILNEMR DQYEQMAEKN RRDAETWFLS KTEELNKEVA SNSELVQSSR SEVTELRRVL QGLEIELQSQ LSMKASLENS LEETKGRYCM QLSQIQGLIG SVEEQLAQLR CEMEQQSQEY QILLDVKTRL EQEIATYRRL LEGEDAHLSS QQASGQSYSS REVFTSSSSS SSRQTRPILK EQSSSSFSQG QSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.