Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 68.7709
Cell Significance Index: -28.3300 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 63.1026
Cell Significance Index: 542.2400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 13.1033
Cell Significance Index: 356.6600 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 10.8284
Cell Significance Index: 14.0100 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 8.7198
Cell Significance Index: 53.9700 - Cell Name: epidermal cell (CL0000362)
Fold Change: 7.9397
Cell Significance Index: 17.9000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 7.6061
Cell Significance Index: 395.1200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 7.6016
Cell Significance Index: 67.4800 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 4.7229
Cell Significance Index: 39.0600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.0587
Cell Significance Index: 1794.4600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 3.7776
Cell Significance Index: 120.9900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.5538
Cell Significance Index: 251.3400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.9982
Cell Significance Index: 368.6500 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 2.7022
Cell Significance Index: 11.6200 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.0134
Cell Significance Index: 14.4600 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.6691
Cell Significance Index: 215.6300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.3340
Cell Significance Index: 8.2100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.3173
Cell Significance Index: 98.1800 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.2453
Cell Significance Index: 9.2200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.2336
Cell Significance Index: 11.3600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2104
Cell Significance Index: 218.2100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1916
Cell Significance Index: 56.0100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4409
Cell Significance Index: 83.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4375
Cell Significance Index: 12.5400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4113
Cell Significance Index: 224.6200 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.3736
Cell Significance Index: 1.7200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.2105
Cell Significance Index: 9.1500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1892
Cell Significance Index: 170.8500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1529
Cell Significance Index: 15.1300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0984
Cell Significance Index: 16.0100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0716
Cell Significance Index: 54.1600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0364
Cell Significance Index: 22.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0056
Cell Significance Index: 1.1200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0009
Cell Significance Index: -0.0900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0057
Cell Significance Index: -10.4300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0060
Cell Significance Index: -11.2500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0078
Cell Significance Index: -12.0100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0096
Cell Significance Index: -6.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0106
Cell Significance Index: -7.8500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0192
Cell Significance Index: -10.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0202
Cell Significance Index: -0.7100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0223
Cell Significance Index: -30.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0240
Cell Significance Index: -0.6700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0246
Cell Significance Index: -0.2800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0264
Cell Significance Index: -0.3600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0293
Cell Significance Index: -21.4500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0344
Cell Significance Index: -5.8700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0377
Cell Significance Index: -1.7600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0558
Cell Significance Index: -25.3500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0594
Cell Significance Index: -1.7100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0599
Cell Significance Index: -21.4800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0607
Cell Significance Index: -1.5600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0614
Cell Significance Index: -7.0400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0691
Cell Significance Index: -14.5500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0729
Cell Significance Index: -10.0100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0770
Cell Significance Index: -1.3600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0856
Cell Significance Index: -10.9700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1135
Cell Significance Index: -6.9600 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.1177
Cell Significance Index: -1.7600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1302
Cell Significance Index: -25.8300 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.1336
Cell Significance Index: -0.8300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1345
Cell Significance Index: -6.1000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1412
Cell Significance Index: -3.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1490
Cell Significance Index: -21.6600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1565
Cell Significance Index: -10.8300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1693
Cell Significance Index: -19.7300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1721
Cell Significance Index: -19.6400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1759
Cell Significance Index: -3.8100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1770
Cell Significance Index: -10.6300 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.2136
Cell Significance Index: -1.6300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2150
Cell Significance Index: -4.4600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2210
Cell Significance Index: -22.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2213
Cell Significance Index: -13.9500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2424
Cell Significance Index: -25.2400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2431
Cell Significance Index: -28.6700 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2592
Cell Significance Index: -6.4800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2878
Cell Significance Index: -17.6900 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.3347
Cell Significance Index: -4.3100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3363
Cell Significance Index: -8.9800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3406
Cell Significance Index: -11.1500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3519
Cell Significance Index: -23.6700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3560
Cell Significance Index: -13.0700 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.3691
Cell Significance Index: -2.4500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3736
Cell Significance Index: -24.1000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4246
Cell Significance Index: -9.8100 - Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.4641
Cell Significance Index: -2.4300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4717
Cell Significance Index: -13.8900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4749
Cell Significance Index: -26.6500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5144
Cell Significance Index: -27.0100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5191
Cell Significance Index: -18.1900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5441
Cell Significance Index: -17.3300 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.5627
Cell Significance Index: -8.0100 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.5722
Cell Significance Index: -8.1300 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: -0.6114
Cell Significance Index: -5.2600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.6375
Cell Significance Index: -6.9300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6491
Cell Significance Index: -28.7100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6540
Cell Significance Index: -13.6900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6576
Cell Significance Index: -22.8500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7508
Cell Significance Index: -15.9900 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.7571
Cell Significance Index: -5.2500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2384205657
Symbol: K1C17_HUMAN
Name: Keratin, type I cytoskeletal 17
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1281771
Title: Characterization of the human gene encoding cytokeratin 17 and its expression pattern.
PubMed ID: 1281771
PubMed ID: 1372562
Title: Interferon-gamma regulates expression of a novel keratin class I gene.
PubMed ID: 1372562
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7539673
Title: Keratin 16 and keratin 17 mutations cause pachyonychia congenita.
PubMed ID: 7539673
DOI: 10.1038/ng0395-273
PubMed ID: 2481679
Title: Patterns of expression of keratin 17 in human epithelia: dependency on cell position.
PubMed ID: 2481679
DOI: 10.1242/jcs.93.3.419
PubMed ID: 10651700
Title: Keratin expression in the normal nail unit: markers of regional differentiation.
PubMed ID: 10651700
PubMed ID: 10844551
Title: Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype.
PubMed ID: 10844551
PubMed ID: 15795121
Title: HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.
PubMed ID: 15795121
PubMed ID: 15608502
Title: Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects.
PubMed ID: 15608502
DOI: 10.1159/000081685
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16713453
Title: Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis.
PubMed ID: 16713453
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22006917
Title: Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion.
PubMed ID: 22006917
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 9008238
Title: Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex.
PubMed ID: 9008238
PubMed ID: 9767294
Title: Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2.
PubMed ID: 9767294
PubMed ID: 10571744
Title: Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2.
PubMed ID: 10571744
PubMed ID: 11348474
Title: Novel keratin 17 mutations in pachyonychia congenita type 2.
PubMed ID: 11348474
PubMed ID: 11886499
Title: Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.
PubMed ID: 11886499
PubMed ID: 11874497
Title: A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2.
PubMed ID: 11874497
PubMed ID: 15102078
Title: A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2.
PubMed ID: 15102078
PubMed ID: 15795125
Title: Identification of a recurrent mutation in keratin 17 in a Japanese family with pachyonychia congenita type 2.
PubMed ID: 15795125
PubMed ID: 16250206
Title: The genetic basis of pachyonychia congenita.
PubMed ID: 16250206
PubMed ID: 16620218
Title: Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity.
PubMed ID: 16620218
PubMed ID: 17719747
Title: A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.
PubMed ID: 17719747
PubMed ID: 18547302
Title: A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb.
PubMed ID: 18547302
PubMed ID: 19470054
Title: Novel missense mutation of keratin in Chinese family with steatocystoma multiplex.
PubMed ID: 19470054
PubMed ID: 21326300
Title: A large mutational study in pachyonychia congenita.
PubMed ID: 21326300
DOI: 10.1038/jid.2011.20
PubMed ID: 23278621
Title: A novel mutation of keratin 17 gene in a pedigree with pachyonychia congenita type 2.
PubMed ID: 23278621
PubMed ID: 23855588
Title: Novel mutation (p.L91P, c.272T>C) of keratin 17 in a case with pachyonychia congenita type 2.
PubMed ID: 23855588
PubMed ID: 34686882
Title: Formation of keto-type ceramides in palmoplantar keratoderma based on biallelic KDSR mutations in patients.
PubMed ID: 34686882
DOI: 10.1093/hmg/ddab309
Sequence Information:
- Length: 432
- Mass: 48106
- Checksum: 35B429243F47EB5C
- Sequence:
MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS TLGGSSYSSC YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY QRQAPGPARD YSQYYRTIEE LQNKILTATV DNANILLQID NARLAADDFR TKFETEQALR LSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK EPVTTRQVRT IVEEVQDGKV ISSREQVHQT TR
Genular Protein ID: 2823457695
Symbol: Q14666_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2442723
Title: Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.
PubMed ID: 2442723
Sequence Information:
- Length: 266
- Mass: 30838
- Checksum: 0F39A8D9AC5A01BE
- Sequence:
DEFRTKFETD QALRLSVEAD INGLRRVLDE LTLARADLEM QIENLKEELA YLKKNHEEEM NALRGQVGGE INVEMDAAPG VDLSRILNEM RDQYEKMAEK NRKDAEDWFF SKTEELNREV ATNSELVQSG KSEISELRRT MQALEIELQS QLSMKASLEG NLAETENRYC VQLSQIQGLI GSVEEQLAQL RCEMEQQNQE YKILLDVKTR LEQEIATYRR LLEGEDAHLT QYKKEPVTTR QVRTIVEEVQ DGKVISSREQ VHQTTR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.