Gene KRT17 - ENSG00000128422 | NCBI Gene ID: 3872

Details for: KRT17

Gene ID: 3872

Symbol: KRT17

Ensembl ID: ENSG00000128422

Description: keratin 17

Associated with

Developmental biology
(R-HSA-1266738)
Formation of the cornified envelope
(R-HSA-6809371)
Cornified envelope
(GO:0001533)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Epithelial cell differentiation
(GO:0030855)
Hair follicle morphogenesis
(GO:0031069)
Intermediate filament cytoskeleton
(GO:0045111)
Intermediate filament organization
(GO:0045109)
Keratin filament
(GO:0045095)
Keratinization
(GO:0031424)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of hair follicle development
(GO:0051798)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Structural molecule activity
(GO:0005198)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.89
Marker Score: 19131.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.53
Marker Score: 8630
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.48
Marker Score: 2743
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.81
Marker Score: 4610
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.68
Marker Score: 954
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.66
Marker Score: 2360
Cell Name: malignant cell (CL0001064)
Fold Change: 2.53
Marker Score: 34002
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.3
Marker Score: 3388
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.29
Marker Score: 17064
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.28
Marker Score: 8458
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.17
Marker Score: 820
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.12
Marker Score: 3763
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.09
Marker Score: 2198
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.95
Marker Score: 1737
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.72
Marker Score: 13460
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1155
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.55
Marker Score: 765
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.54
Marker Score: 1051
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.43
Marker Score: 1197
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.42
Marker Score: 354
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.41
Marker Score: 354
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.39
Marker Score: 355
Cell Name: granulocyte (CL0000094)
Fold Change: 1.37
Marker Score: 616
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.33
Marker Score: 515
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.29
Marker Score: 311
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.23
Marker Score: 2509.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.17
Marker Score: 2220
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.13
Marker Score: 9777
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.13
Marker Score: 4344
Cell Name: basal cell (CL0000646)
Fold Change: 1.12
Marker Score: 1444
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.11
Marker Score: 376
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.08
Marker Score: 448
Cell Name: club cell (CL0000158)
Fold Change: 1.04
Marker Score: 1217.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71796
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48020
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: secretory cell (CL0000151)
Fold Change: 0.98
Marker Score: 1787
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.94
Marker Score: 14694
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5300
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2733
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.91
Marker Score: 2132
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.89
Marker Score: 757
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5278.5
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.83
Marker Score: 774
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.82
Marker Score: 7140
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 611
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 315
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.78
Marker Score: 455
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.78
Marker Score: 469
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.77
Marker Score: 691
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 701
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.74
Marker Score: 494
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.71
Marker Score: 24223
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.7
Marker Score: 328.5
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.7
Marker Score: 201
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.69
Marker Score: 357
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2896
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.68
Marker Score: 1149
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.66
Marker Score: 5633
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.64
Marker Score: 446
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.61
Marker Score: 846
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.6
Marker Score: 398
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.58
Marker Score: 920
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.57
Marker Score: 158
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.56
Marker Score: 179
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.56
Marker Score: 311
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 360
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.55
Marker Score: 112
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.49
Marker Score: 97
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.49
Marker Score: 236
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.49
Marker Score: 16889
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.48
Marker Score: 657
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 274
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.46
Marker Score: 1044
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.46
Marker Score: 191
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.45
Marker Score: 5090
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.45
Marker Score: 166
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.44
Marker Score: 204
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.44
Marker Score: 117
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.42
Marker Score: 269
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.42
Marker Score: 466
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.42
Marker Score: 107
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.41
Marker Score: 348.5
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.41
Marker Score: 279
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.41
Marker Score: 182
Cell Name: leukocyte (CL0000738)
Fold Change: 0.41
Marker Score: 233
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 389.5
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.4
Marker Score: 789
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.39
Marker Score: 163
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.37
Marker Score: 250
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 367

Hover over a box to see details here...

**Key characteristics:** * KRT17 is a transmembrane protein with a molecular weight of approximately 190 kDa. * It is a member of the keratin family of structural proteins. * It is expressed in a variety of cell types, including epithelial cells, hair follicle cells, and myoepithelial cells. * It is involved in the formation of the cornified envelope, which is a protective barrier that surrounds the cell. * It is also involved in the regulation of hair follicle development and maintenance. **Pathways and functions:** * KRT17 is involved in the formation of the cornified envelope. * It is a key intermediate in the assembly of the cornified envelope. * It is also involved in the maintenance of the cornified envelope. * It is involved in the regulation of hair follicle development and maintenance. **Clinical significance:** Mutations in KRT17 have been linked to a number of human diseases, including skin cancer, psoriasis, and ichthyosis. These diseases are characterized by abnormalities in the skin, including the formation of tumors, the loss of skin integrity, and abnormal hair growth. **Conclusion:** KRT17 is a key protein involved in the formation and maintenance of the cornified envelope, which is a protective barrier that surrounds the cell. It is also involved in the regulation of hair follicle development and maintenance. Mutations in KRT17 have been linked to a number of human diseases, highlighting its importance in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Keratin, type I cytoskeletal 17
Q14666_HUMAN

Genular Protein ID: 2384205657

Symbol: K1C17_HUMAN

Name: Keratin, type I cytoskeletal 17

UniProtKB Accession Codes:

Q04695 A5Z1M9 A5Z1N0 A5Z1N1 A5Z1N2 A6NDV6 A6NKQ2 Q6IP98 Q8N1P6

Database IDs:

Citations:

PubMed ID: 1281771

Title: Characterization of the human gene encoding cytokeratin 17 and its expression pattern.

PubMed ID: 1281771

PubMed ID: 1372562

Title: Interferon-gamma regulates expression of a novel keratin class I gene.

PubMed ID: 1372562

DOI: 10.1002/eji.1830220415

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7539673

Title: Keratin 16 and keratin 17 mutations cause pachyonychia congenita.

PubMed ID: 7539673

DOI: 10.1038/ng0395-273

PubMed ID: 2481679

Title: Patterns of expression of keratin 17 in human epithelia: dependency on cell position.

PubMed ID: 2481679

DOI: 10.1242/jcs.93.3.419

PubMed ID: 10651700

Title: Keratin expression in the normal nail unit: markers of regional differentiation.

PubMed ID: 10651700

DOI: 10.1046/j.1365-2133.2000.03246.x

PubMed ID: 10844551

Title: Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype.

PubMed ID: 10844551

DOI: 10.1046/j.1523-1747.2000.00986.x

PubMed ID: 15795121

Title: HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.

PubMed ID: 15795121

DOI: 10.1016/j.jdermsci.2005.01.001

PubMed ID: 15608502

Title: Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects.

PubMed ID: 15608502

DOI: 10.1159/000081685

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16713453

Title: Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis.

PubMed ID: 16713453

DOI: 10.1016/j.jaad.2006.02.033

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22006917

Title: Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion.

PubMed ID: 22006917

DOI: 10.1074/jbc.m111.302042

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9008238

Title: Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex.

PubMed ID: 9008238

DOI: 10.1111/1523-1747.ep12335315

PubMed ID: 9767294

Title: Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2.

PubMed ID: 9767294

DOI: 10.1046/j.1365-2133.1998.02413.x

PubMed ID: 10571744

Title: Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2.

PubMed ID: 10571744

DOI: 10.1046/j.1523-1747.1999.00762.x

PubMed ID: 11348474

Title: Novel keratin 17 mutations in pachyonychia congenita type 2.

PubMed ID: 11348474

DOI: 10.1046/j.1523-1747.2001.01335.x

PubMed ID: 11886499

Title: Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.

PubMed ID: 11886499

DOI: 10.1046/j.0022-202x.2001.01565.x

PubMed ID: 11874497

Title: A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2.

PubMed ID: 11874497

DOI: 10.1046/j.0022-202x.2001.01701.x

PubMed ID: 15102078

Title: A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2.

PubMed ID: 15102078

DOI: 10.1111/j.0022-202x.2004.22408.x

PubMed ID: 15795125

Title: Identification of a recurrent mutation in keratin 17 in a Japanese family with pachyonychia congenita type 2.

PubMed ID: 15795125

DOI: 10.1016/j.jdermsci.2004.12.022

PubMed ID: 16250206

Title: The genetic basis of pachyonychia congenita.

PubMed ID: 16250206

DOI: 10.1111/j.1087-0024.2005.10204.x

PubMed ID: 16620218

Title: Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity.

PubMed ID: 16620218

DOI: 10.1111/j.1346-8138.2006.00037.x

PubMed ID: 17719747

Title: A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.

PubMed ID: 17719747

DOI: 10.1016/j.jdermsci.2007.07.003

PubMed ID: 18547302

Title: A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb.

PubMed ID: 18547302

DOI: 10.1111/j.1365-2133.2008.08684.x

PubMed ID: 19470054

Title: Novel missense mutation of keratin in Chinese family with steatocystoma multiplex.

PubMed ID: 19470054

DOI: 10.1111/j.1468-3083.2009.03180.x

PubMed ID: 21326300

Title: A large mutational study in pachyonychia congenita.

PubMed ID: 21326300

DOI: 10.1038/jid.2011.20

PubMed ID: 23278621

Title: A novel mutation of keratin 17 gene in a pedigree with pachyonychia congenita type 2.

PubMed ID: 23278621

DOI: 10.1111/j.1365-4632.2010.04667.x

PubMed ID: 23855588

Title: Novel mutation (p.L91P, c.272T>C) of keratin 17 in a case with pachyonychia congenita type 2.

PubMed ID: 23855588

DOI: 10.1111/1346-8138.12212

Sequence Information:

Length: 432
Mass: 48106
Checksum: 35B429243F47EB5C
Sequence:

MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS TLGGSSYSSC 
YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY 
QRQAPGPARD YSQYYRTIEE LQNKILTATV DNANILLQID NARLAADDFR TKFETEQALR 
LSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE 
MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI 
SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM 
EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK EPVTTRQVRT IVEEVQDGKV 
ISSREQVHQT TR

Genular Protein ID: 2823457695

Symbol: Q14666_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14666

Database IDs:

Citations:

PubMed ID: 2442723

Title: Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.

PubMed ID: 2442723

DOI: 10.1093/nar/15.15.5945

Sequence Information:

Length: 266
Mass: 30838
Checksum: 0F39A8D9AC5A01BE
Sequence:

DEFRTKFETD QALRLSVEAD INGLRRVLDE LTLARADLEM QIENLKEELA YLKKNHEEEM 
NALRGQVGGE INVEMDAAPG VDLSRILNEM RDQYEKMAEK NRKDAEDWFF SKTEELNREV 
ATNSELVQSG KSEISELRRT MQALEIELQS QLSMKASLEG NLAETENRYC VQLSQIQGLI 
GSVEEQLAQL RCEMEQQNQE YKILLDVKTR LEQEIATYRR LLEGEDAHLT QYKKEPVTTR 
QVRTIVEEVQ DGKVISSREQ VHQTTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KRT17

Associated with

Cells (max top 100)

Other Information

Characterization of the human gene encoding cytokeratin 17 and its expression pattern. PubMed ID: 1281771

Interferon-gamma regulates expression of a novel keratin class I gene. PubMed ID: 1372562

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Keratin 16 and keratin 17 mutations cause pachyonychia congenita. PubMed ID: 7539673

Patterns of expression of keratin 17 in human epithelia: dependency on cell position. PubMed ID: 2481679

Keratin expression in the normal nail unit: markers of regional differentiation. PubMed ID: 10651700

Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype. PubMed ID: 10844551

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis. PubMed ID: 15795121

Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects. PubMed ID: 15608502

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis. PubMed ID: 16713453

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. PubMed ID: 22006917

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex. PubMed ID: 9008238

Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2. PubMed ID: 9767294

Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2. PubMed ID: 10571744

Novel keratin 17 mutations in pachyonychia congenita type 2. PubMed ID: 11348474

Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. PubMed ID: 11886499

A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2. PubMed ID: 11874497

A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2. PubMed ID: 15102078

Identification of a recurrent mutation in keratin 17 in a Japanese family with pachyonychia congenita type 2. PubMed ID: 15795125

The genetic basis of pachyonychia congenita. PubMed ID: 16250206

Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity. PubMed ID: 16620218

A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita. PubMed ID: 17719747

A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb. PubMed ID: 18547302

Novel missense mutation of keratin in Chinese family with steatocystoma multiplex. PubMed ID: 19470054

A large mutational study in pachyonychia congenita. PubMed ID: 21326300

A novel mutation of keratin 17 gene in a pedigree with pachyonychia congenita type 2. PubMed ID: 23278621

Novel mutation (p.L91P, c.272T&gt;C) of keratin 17 in a case with pachyonychia congenita type 2. PubMed ID: 23855588

Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes. PubMed ID: 2442723