Details for: AFF3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 7.51
Marker Score: 39,398 - Cell Name: granule cell (CL0000120)
Fold Change: 7
Marker Score: 52,781 - Cell Name: stellate neuron (CL0000122)
Fold Change: 6.81
Marker Score: 36,557 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 6.11
Marker Score: 20,502 - Cell Name: macroglial cell (CL0000126)
Fold Change: 5.65
Marker Score: 12,992 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.35
Marker Score: 147,028 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 3.88
Marker Score: 2,251 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.78
Marker Score: 8,306 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 3.76
Marker Score: 1,809 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.4
Marker Score: 6,549 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 3.4
Marker Score: 4,083 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.28
Marker Score: 15,181 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 3.23
Marker Score: 1,812 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 3.1
Marker Score: 983 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.88
Marker Score: 8,214 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.82
Marker Score: 4,728 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.77
Marker Score: 2,730 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.73
Marker Score: 40,837 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.71
Marker Score: 53,990 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.63
Marker Score: 20,189 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.61
Marker Score: 10,800 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.6
Marker Score: 98,927 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.6
Marker Score: 999 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.59
Marker Score: 758 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.55
Marker Score: 3,174 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.51
Marker Score: 4,747 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.47
Marker Score: 2,840 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.44
Marker Score: 5,125 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.44
Marker Score: 5,841 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.37
Marker Score: 87,545 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.37
Marker Score: 9,906 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.36
Marker Score: 990 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.33
Marker Score: 9,008 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.26
Marker Score: 3,185 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.16
Marker Score: 7,683 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.15
Marker Score: 20,192 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.1
Marker Score: 5,707 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.08
Marker Score: 127,638 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.04
Marker Score: 1,009 - Cell Name: immature B cell (CL0000816)
Fold Change: 2.01
Marker Score: 1,330 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.01
Marker Score: 20,715 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2
Marker Score: 1,601 - Cell Name: neuron (CL0000540)
Fold Change: 1.97
Marker Score: 8,040 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.93
Marker Score: 1,155 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,295 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.91
Marker Score: 30,669 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.87
Marker Score: 16,099 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.87
Marker Score: 662 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.83
Marker Score: 499 - Cell Name: centroblast (CL0009112)
Fold Change: 1.79
Marker Score: 882 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.77
Marker Score: 1,684 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.73
Marker Score: 546 - Cell Name: naive B cell (CL0000788)
Fold Change: 1.69
Marker Score: 1,511 - Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.69
Marker Score: 432 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.66
Marker Score: 1,959 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.65
Marker Score: 995 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.64
Marker Score: 2,525 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.62
Marker Score: 493 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.6
Marker Score: 369 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.59
Marker Score: 1,499 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1,146 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.54
Marker Score: 2,680 - Cell Name: thymocyte (CL0000893)
Fold Change: 1.53
Marker Score: 1,599 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.52
Marker Score: 1,877 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.52
Marker Score: 1,631 - Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.5
Marker Score: 339 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,587 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.46
Marker Score: 5,629 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.45
Marker Score: 383 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.43
Marker Score: 835 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.4
Marker Score: 2,483 - Cell Name: fat cell (CL0000136)
Fold Change: 1.4
Marker Score: 781 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.37
Marker Score: 30,702 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.37
Marker Score: 5,702 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.36
Marker Score: 794 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.34
Marker Score: 915 - Cell Name: follicular B cell (CL0000843)
Fold Change: 1.34
Marker Score: 1,449 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.33
Marker Score: 8,644 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.32
Marker Score: 20,724 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.32
Marker Score: 1,924 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.32
Marker Score: 869 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.3
Marker Score: 1,528 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.3
Marker Score: 1,750 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.27
Marker Score: 743 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.26
Marker Score: 321 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.24
Marker Score: 837 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.22
Marker Score: 663 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.22
Marker Score: 1,467 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.21
Marker Score: 1,470 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.2
Marker Score: 1,205 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.19
Marker Score: 3,535 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.17
Marker Score: 4,859 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.16
Marker Score: 587 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.16
Marker Score: 3,793 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,768 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.14
Marker Score: 683 - Cell Name: germ cell (CL0000586)
Fold Change: 1.13
Marker Score: 1,983 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.12
Marker Score: 850 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.1
Marker Score: 1,594 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.08
Marker Score: 6,472
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3318184585
Symbol: AFF3_HUMAN
Name: AF4/FMR2 family member 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8555498
Title: LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
PubMed ID: 8555498
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 28397838
Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.
PubMed ID: 28397838
DOI: 10.1038/mp.2017.60
PubMed ID: 31388108
Title: De novo AFF3 variant in a patient with mesomelic dysplasia with foot malformation.
PubMed ID: 31388108
PubMed ID: 33961779
Title: Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.
PubMed ID: 33961779
Sequence Information:
- Length: 1226
- Mass: 133503
- Checksum: BD2D90358609E156
- Sequence:
MDSFDLALLQ EWDLESLCVY EPDRNALRRK ERERRNQETQ QDDGTFNSSY SLFSEPYKTN KGDELSNRIQ NTLGNYDEMK DFLTDRSNQS HLVGVPKPGV PQTPVNKIDE HFVADSRAQN QPSSICSTTT STPAAVPVQQ SKRGTMGWQK AGHPPSDGQQ RATQQGSLRT LLGDGVGRQQ PRAKQVCNVE VGLQTQERPP AMAAKHSSSG HCVQNFPPSL ASKPSLVQQK PTAYVRPMDG QDQAPDESPK LKSSSETSVH CTSYRGVPAS KPEPARAKAK LSKFSIPKQG EESRSGETNS CVEEIIREMT WLPPLSAIQA PGKVEPTKFP FPNKDSQLVS SGHNNPKKGD AEPESPDNGT SNTSMLEDDL KLSSDEEENE QQAAQRTALR ALSDSAVVQQ PNCRTSVPSS KGSSSSSSSG SSSSSSDSES SSGSDSETES SSSESEGSKP PHFSSPEAEP ASSNKWQLDK WLNKVNPHKP PILIQNESHG SESNQYYNPV KEDVQDCGKV PDVCQPSLRE KEIKSTCKEE QRPRTANKAP GSKGVKQKSP PAAVAVAVSA AAPPPAVPCA PAENAPAPAR RSAGKKPTRR TERTSAGDGA NCHRPEEPAA ADALGTSVVV PPEPTKTRPC GNNRASHRKE LRSSVTCEKR RTRGLSRIVP KSKEFIETES SSSSSSSDSD LESEQEEYPL SKAQTVAASA SSGNDQRLKE AAANGGSGPR APVGSINART TSDIAKELEE QFYTLVPFGR NELLSPLKDS DEIRSLWVKI DLTLLSRIPE HLPQEPGVLS APATKDSESA PPSHTSDTPA EKALPKSKRK RKCDNEDDYR EIKKSQGEKD SSSRLATSTS NTLSANHCNM NINSVAIPIN KNEKMLRSPI SPLSDASKHK YTSEDLTSSS RPNGNSLFTS ASSSKKPKAD SQLQPHGGDL TKAAHNNSEN IPLHKSRPQT KPWSPGSNGH RDCKRQKLVF DDMPRSADYF MQEAKRMKHK ADAMVEKFGK ALNYAEAALS FIECGNAMEQ GPMESKSPYT MYSETVELIR YAMRLKTHSG PNATPEDKQL AALCYRCLAL LYWRMFRLKR DHAVKYSKAL IDYFKNSSKA AQAPSPWGAS GKSTGTPSPM SPNPSPASSV GSQGSLSNAS ALSPSTIVSI PQRIHQMAAN HVSITNSILH SYDYWEMADN LAKENREFFN DLDLLMGPVT LHSSMEHLVQ YSQQGLHWLR NSAHLS
Genular Protein ID: 3301587497
Symbol: Q8NAP7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 781
- Mass: 84197
- Checksum: 4D9EA69FB89D0C01
- Sequence:
MDSFDLALLQ EWDLESLWGE DILNQRNDSL VVEFQSSASR CRSVYEPDRN ALRRKERERR NQETQQDDGT FNSSYSLFSE PYKTNKGDEL SNRIQNTLGN YDEMKDFLTD RSNQSHLVGV PKPGVPQTPV NKIDEHFVAD SRAQNQPSSI CSTTTSTPAA VPVQQSKRGT MGWQKAGHPP SDGQQRATQQ GSLRTLLGDG VGRQQPRAKQ VCNVEVGLQT QERPPAMAAK HSSSGHCVQN FPPSLASKPS LVQQKPTAYV RPMDGQDQAP DESPKLKSSS ETSVHCTSYR GVPASKPEPA RAKAKLSKFS IPKQGEESRS GETNSCVEEI IREMTWLPPL SAIQAPGKVE PTKFPFPNKD SQLVSSGHNN PKKGDAEPES PDNGTSNTSM LEDDLKLSSD EEENEQQAAQ RTALRALSDS AVVQQPNCRT SVPSSKGSSS SSSSGSSSSS SDSESSSGSD SETESSSSES EGSKPPHFSS PEAEPASSNK WQLDKWLNKV NPHKPPILIQ NESHGSESNQ YYNPVKEDVQ DCGKVPDVCQ PSLREKEIKS TCKEEQRPRT ANKAPGSKGV KQKSPPAAVA VAVSAAAPPP AVPCAPAENA PAPARRSAGK KPTRRTERTS AGDGANCHRP EEPAAADALG TSVVVPPEPT KTRPCGNNRA SHRKELRSSV TCEKRRTRGL SRIVPKSKEF IETESSSSSS SSDSDLESEQ EEYPLSKAQT VAASASSGND QRLKEAAANG GSGPRAPVGS INARTTSDIA KELEEQFYTL VPLAGTNFSP L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.