Gene LAIR2 - ENSG00000167618 | NCBI Gene ID: 3904

Details for: LAIR2

Gene ID: 3904

Symbol: LAIR2

Ensembl ID: ENSG00000167618

Description: leukocyte associated immunoglobulin like receptor 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Extracellular region
(GO:0005576)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.11
Marker Score: 2771
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.28
Marker Score: 2297
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1994
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1169
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.33
Marker Score: 1168
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 854
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 486
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7678
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4813
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 502
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.09
Marker Score: 691
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251806
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.01
Marker Score: 1151
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71824
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48049
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5327
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.92
Marker Score: 2695
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: Unknown (CL0000548)
Fold Change: 0.79
Marker Score: 573
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.69
Marker Score: 239
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.68
Marker Score: 2152.5
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.68
Marker Score: 1004
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.61
Marker Score: 870.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 464
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.57
Marker Score: 628
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.52
Marker Score: 403
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.5
Marker Score: 208.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.49
Marker Score: 131
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.47
Marker Score: 162
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.4
Marker Score: 520
Cell Name: plasmablast (CL0000980)
Fold Change: 0.35
Marker Score: 470
Cell Name: microglial cell (CL0000129)
Fold Change: 0.35
Marker Score: 638
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.35
Marker Score: 2104
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.34
Marker Score: 186
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.33
Marker Score: 188
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.33
Marker Score: 2098
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.33
Marker Score: 108
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.32
Marker Score: 439
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.31
Marker Score: 1202
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.3
Marker Score: 267
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.29
Marker Score: 347.5
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.29
Marker Score: 89
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.29
Marker Score: 572
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.29
Marker Score: 235
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.29
Marker Score: 699
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.29
Marker Score: 164
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.28
Marker Score: 271
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.28
Marker Score: 14776
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.27
Marker Score: 72
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.24
Marker Score: 205
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.23
Marker Score: 223
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.23
Marker Score: 227
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: plasma cell (CL0000786)
Fold Change: 0.22
Marker Score: 249
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.22
Marker Score: 157
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.21
Marker Score: 89
Cell Name: blood cell (CL0000081)
Fold Change: 0.21
Marker Score: 2478
Cell Name: mature T cell (CL0002419)
Fold Change: 0.21
Marker Score: 2083
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.2
Marker Score: 125
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.19
Marker Score: 84
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.19
Marker Score: 211
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.19
Marker Score: 158
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.19
Marker Score: 53
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.19
Marker Score: 155
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.18
Marker Score: 289
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.18
Marker Score: 91
Cell Name: platelet (CL0000233)
Fold Change: 0.17
Marker Score: 77
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.17
Marker Score: 157
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.16
Marker Score: 79
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.16
Marker Score: 266
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.15
Marker Score: 102
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.15
Marker Score: 163
Cell Name: mast cell (CL0000097)
Fold Change: 0.15
Marker Score: 87
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.15
Marker Score: 125
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.14
Marker Score: 67
Cell Name: T cell (CL0000084)
Fold Change: 0.13
Marker Score: 227
Cell Name: leukocyte (CL0000738)
Fold Change: 0.13
Marker Score: 72
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.12
Marker Score: 199
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.12
Marker Score: 28
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.12
Marker Score: 27
Cell Name: B cell (CL0000236)
Fold Change: 0.12
Marker Score: 112
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.12
Marker Score: 68
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.11
Marker Score: 83

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**Key characteristics:** * LAIR2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed on a variety of immune cell types, including macrophages, dendritic cells, T cells, and B cells. * It is a ligand for CD69, a cell surface protein that is expressed on activated T cells and B cells. * LAIR2 is involved in the regulation of immune responses by interacting with CD69. * It is also involved in the regulation of cell adhesion and migration. **Pathways and functions:** * LAIR2 is involved in the regulation of immune responses by interacting with CD69 on activated T cells and B cells. * It helps to regulate the activation of these cells and the production of cytokines and chemokines. * It is also involved in the regulation of cell adhesion and migration. **Clinical significance:** * Mutations in the LAIR2 gene have been linked to several human diseases, including inflammatory bowel disease (IBD), asthma, and cancer. * In IBD, LAIR2 is expressed on intestinal epithelial cells and is involved in the regulation of immune responses in the gut. * In asthma, LAIR2 is expressed on airway epithelial cells and is involved in the regulation of inflammation and mucus production. * In cancer, LAIR2 is expressed on tumor cells and is involved in the regulation of cell adhesion, migration, and invasion.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Leukocyte-associated immunoglobulin-like receptor 2

Genular Protein ID: 4244475172

Symbol: LAIR2_HUMAN

Name: Leukocyte-associated immunoglobulin-like receptor 2

UniProtKB Accession Codes:

Q6ISS4 Q6PEZ4

Database IDs:

Citations:

PubMed ID: 9285412

Title: LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.

PubMed ID: 9285412

DOI: 10.1016/s1074-7613(00)80530-0

PubMed ID: 10229813

Title: Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.

PubMed ID: 10229813

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 152
Mass: 16280
Checksum: 8097688A9DB42EC8
Sequence:

MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL 
EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV 
KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.