Details for: LAIR2

Gene ID: 3904

Symbol: LAIR2

Ensembl ID: ENSG00000167618

Description: leukocyte associated immunoglobulin like receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.5658
    Cell Significance Index: -3.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.6305
    Cell Significance Index: -2.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 7.1447
    Cell Significance Index: 251.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.5912
    Cell Significance Index: 89.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.1000
    Cell Significance Index: 190.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8509
    Cell Significance Index: -3.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0970
    Cell Significance Index: 45.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.0069
    Cell Significance Index: 12.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3927
    Cell Significance Index: 44.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1747
    Cell Significance Index: 53.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9728
    Cell Significance Index: 15.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8819
    Cell Significance Index: 167.8300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7024
    Cell Significance Index: 3.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.6707
    Cell Significance Index: -2.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5998
    Cell Significance Index: 59.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4995
    Cell Significance Index: 451.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4463
    Cell Significance Index: 9.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4113
    Cell Significance Index: 12.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3290
    Cell Significance Index: 35.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3149
    Cell Significance Index: 51.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2324
    Cell Significance Index: 13.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1672
    Cell Significance Index: 11.5600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1598
    Cell Significance Index: 1.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1226
    Cell Significance Index: 3.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1005
    Cell Significance Index: 2.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0281
    Cell Significance Index: 1.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0045
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0060
    Cell Significance Index: -3.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0067
    Cell Significance Index: -3.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0079
    Cell Significance Index: -0.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0080
    Cell Significance Index: -2.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0088
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0095
    Cell Significance Index: -4.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0116
    Cell Significance Index: -0.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0128
    Cell Significance Index: -3.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0131
    Cell Significance Index: -2.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0160
    Cell Significance Index: -2.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0166
    Cell Significance Index: -2.1300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0187
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0209
    Cell Significance Index: -3.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0221
    Cell Significance Index: -0.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0231
    Cell Significance Index: -0.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0251
    Cell Significance Index: -1.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0254
    Cell Significance Index: -3.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0288
    Cell Significance Index: -4.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0306
    Cell Significance Index: -3.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0341
    Cell Significance Index: -4.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0344
    Cell Significance Index: -4.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0345
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0350
    Cell Significance Index: -4.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0352
    Cell Significance Index: -3.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0362
    Cell Significance Index: -3.7000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0416
    Cell Significance Index: -0.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0494
    Cell Significance Index: -3.7900
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.0508
    Cell Significance Index: -0.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0530
    Cell Significance Index: -3.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0572
    Cell Significance Index: -1.4700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0642
    Cell Significance Index: -0.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0667
    Cell Significance Index: -4.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0727
    Cell Significance Index: -2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0822
    Cell Significance Index: -4.6100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0824
    Cell Significance Index: -1.4000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0839
    Cell Significance Index: -0.9200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0848
    Cell Significance Index: -0.6100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0971
    Cell Significance Index: -1.4200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0977
    Cell Significance Index: -0.9800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0996
    Cell Significance Index: -1.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1037
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1053
    Cell Significance Index: -3.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1054
    Cell Significance Index: -4.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1070
    Cell Significance Index: -2.2400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1079
    Cell Significance Index: -0.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1100
    Cell Significance Index: -3.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1103
    Cell Significance Index: -4.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1146
    Cell Significance Index: -3.6500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1151
    Cell Significance Index: -2.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1156
    Cell Significance Index: -2.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1176
    Cell Significance Index: -3.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1225
    Cell Significance Index: -4.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1249
    Cell Significance Index: -1.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1324
    Cell Significance Index: -2.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1361
    Cell Significance Index: -1.9100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1405
    Cell Significance Index: -1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1429
    Cell Significance Index: -3.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1467
    Cell Significance Index: -3.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1471
    Cell Significance Index: -3.6700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1521
    Cell Significance Index: -1.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1562
    Cell Significance Index: -3.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1576
    Cell Significance Index: -2.7000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1621
    Cell Significance Index: -2.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1644
    Cell Significance Index: -5.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1661
    Cell Significance Index: -1.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LAIR2 is a type II transmembrane protein that belongs to the immunoglobulin superfamily. It consists of two immunoglobulin-like domains, which are responsible for ligand binding, and a cytoplasmic tail that interacts with signaling molecules. LAIR2 is expressed on a wide range of cell types, including immune cells, endothelial cells, and trophoblasts. Its expression is typically restricted to specific tissues and cell types, suggesting a specialized role in maintaining tissue-specific immune homeostasis. **Pathways and Functions** LAIR2 interacts with its ligands, ICAM-2 and ICAM-4, to regulate immune cell adhesion and migration. This interaction involves the binding of LAIR2 to the extracellular domains of ICAM-2 and ICAM-4, which triggers a conformational change in the receptor, leading to the activation of downstream signaling pathways. The primary signaling pathways involved in LAIR2-mediated immune responses include the PI3K/Akt and MAPK/ERK pathways, which regulate cell survival, proliferation, and differentiation. LAIR2 also plays a role in modulating the activity of immune cells, including T cells and dendritic cells. By interacting with ICAM-2 and ICAM-4, LAIR2 can regulate the adhesion and migration of immune cells to sites of inflammation, which is critical for the initiation and resolution of immune responses. Additionally, LAIR2 can influence the activation and proliferation of immune cells, which can impact the development of immune-related diseases. **Clinical Significance** Dysregulation of LAIR2 has been implicated in various diseases, including cancer and autoimmune disorders. For example, alterations in LAIR2 expression have been observed in certain types of cancer, including leukemia and lymphoma, where it is thought to contribute to immune evasion and tumor progression. Additionally, LAIR2 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it is thought to contribute to immune dysregulation and tissue damage. Furthermore, LAIR2 has been identified as a potential therapeutic target for the treatment of immune-related disorders. For example, inhibitors of LAIR2 have been shown to modulate immune responses and reduce inflammation in animal models of disease. Additionally, LAIR2 has been identified as a potential biomarker for disease diagnosis and prognosis, as its expression levels can be altered in response to disease-related changes in tissue homeostasis. In conclusion, LAIR2 is a complex protein receptor that plays a critical role in modulating immune responses and maintaining tissue homeostasis. Its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders, and its therapeutic potential has been identified as a promising area of research. Further studies are needed to fully elucidate the mechanisms by which LAIR2 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 4244475172

Symbol: LAIR2_HUMAN

Name: Leukocyte-associated immunoglobulin-like receptor 2

UniProtKB Accession Codes:

Q6ISS4 Q6PEZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 6 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9285412

Title: LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.

PubMed ID: 9285412

DOI: 10.1016/s1074-7613(00)80530-0

PubMed ID: 10229813

Title: Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.

PubMed ID: 10229813

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 152
  • Mass: 16280
  • Checksum: 8097688A9DB42EC8
  • Sequence:
    • MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL 
EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV 
KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.