Details for: LASP1

Gene ID: 3927

Symbol: LASP1

Ensembl ID: ENSG00000002834

Description: LIM and SH3 protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 247.7736
    Cell Significance Index: -38.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.5550
    Cell Significance Index: -37.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.4011
    Cell Significance Index: -41.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.8230
    Cell Significance Index: -37.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.0568
    Cell Significance Index: -42.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.9230
    Cell Significance Index: -42.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.1410
    Cell Significance Index: -43.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.0003
    Cell Significance Index: -38.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.3126
    Cell Significance Index: -39.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9388
    Cell Significance Index: -37.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1798
    Cell Significance Index: -40.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9367
    Cell Significance Index: -30.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1194
    Cell Significance Index: -17.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3871
    Cell Significance Index: 143.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1731
    Cell Significance Index: 190.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1330
    Cell Significance Index: 32.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0829
    Cell Significance Index: 27.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0645
    Cell Significance Index: 55.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0358
    Cell Significance Index: 22.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0289
    Cell Significance Index: 204.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9478
    Cell Significance Index: 42.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9029
    Cell Significance Index: 162.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8560
    Cell Significance Index: 171.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8542
    Cell Significance Index: 92.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7447
    Cell Significance Index: 91.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7418
    Cell Significance Index: 11.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5512
    Cell Significance Index: 28.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5253
    Cell Significance Index: 39.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5243
    Cell Significance Index: 286.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5067
    Cell Significance Index: 69.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4988
    Cell Significance Index: 58.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3913
    Cell Significance Index: 270.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3909
    Cell Significance Index: 27.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3909
    Cell Significance Index: 140.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3012
    Cell Significance Index: 2.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2708
    Cell Significance Index: 34.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2651
    Cell Significance Index: 17.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2599
    Cell Significance Index: 1.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2505
    Cell Significance Index: 4.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2476
    Cell Significance Index: 8.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2214
    Cell Significance Index: 21.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1672
    Cell Significance Index: 4.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1637
    Cell Significance Index: 72.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1523
    Cell Significance Index: 26.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1501
    Cell Significance Index: 4.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1182
    Cell Significance Index: 5.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1179
    Cell Significance Index: 2.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0981
    Cell Significance Index: 11.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0913
    Cell Significance Index: 4.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0841
    Cell Significance Index: 16.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0633
    Cell Significance Index: 1.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0608
    Cell Significance Index: 3.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0105
    Cell Significance Index: 19.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0015
    Cell Significance Index: -0.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0070
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0195
    Cell Significance Index: -26.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0261
    Cell Significance Index: -16.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0324
    Cell Significance Index: -20.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0363
    Cell Significance Index: -20.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0395
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0419
    Cell Significance Index: -30.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0673
    Cell Significance Index: -30.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0781
    Cell Significance Index: -7.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0863
    Cell Significance Index: -11.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1031
    Cell Significance Index: -21.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1043
    Cell Significance Index: -1.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1075
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1075
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1157
    Cell Significance Index: -13.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1204
    Cell Significance Index: -34.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1266
    Cell Significance Index: -18.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2096
    Cell Significance Index: -1.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2142
    Cell Significance Index: -5.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2171
    Cell Significance Index: -14.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2510
    Cell Significance Index: -13.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2511
    Cell Significance Index: -4.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2694
    Cell Significance Index: -31.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2893
    Cell Significance Index: -20.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3518
    Cell Significance Index: -27.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3751
    Cell Significance Index: -39.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3798
    Cell Significance Index: -12.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3957
    Cell Significance Index: -2.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3979
    Cell Significance Index: -17.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4276
    Cell Significance Index: -26.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4782
    Cell Significance Index: -37.8700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.4996
    Cell Significance Index: -5.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5255
    Cell Significance Index: -7.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5438
    Cell Significance Index: -14.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5563
    Cell Significance Index: -14.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5564
    Cell Significance Index: -21.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5798
    Cell Significance Index: -6.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5862
    Cell Significance Index: -20.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6033
    Cell Significance Index: -36.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6345
    Cell Significance Index: -16.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7274
    Cell Significance Index: -20.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LASP1 is a cytoskeletal protein that belongs to the LIM and SH3 protein family. It contains a unique combination of LIM and SH3 domains, which enable its interaction with a wide range of proteins, including actin-binding proteins, cadherins, and metal ion transporters. The gene is highly expressed in various tissues and cell types, including immune cells, epithelial cells, and neuronal cells. LASP1 has been implicated in several cellular processes, including: * Focal adhesion formation and maintenance * Actin filament dynamics and cytoskeleton organization * Metal ion transport and homeostasis * Cell migration and adhesion * Signaling pathways, including those involved in immune responses and neuronal function **Pathways and Functions:** LASP1's multifaceted nature allows it to interact with various signaling pathways and molecular complexes, influencing cellular behavior. Some of the key pathways and functions associated with LASP1 include: * **Focal adhesion formation and maintenance:** LASP1 interacts with focal adhesion proteins, such as paxillin and focal adhesion kinase (FAK), to regulate the assembly and disassembly of focal adhesions. * **Actin filament dynamics and cytoskeleton organization:** LASP1 interacts with actin-binding proteins, such as actin-associated protein 2 (AP-2), to regulate actin filament dynamics and cytoskeleton organization. * **Metal ion transport and homeostasis:** LASP1 interacts with metal ion transporters, such as ferroportin, to regulate metal ion transport and homeostasis. * **Cell migration and adhesion:** LASP1 regulates cell migration and adhesion by interacting with proteins involved in the regulation of cell shape and movement. * **Signaling pathways:** LASP1 interacts with signaling proteins, such as PI3K and MAPK, to regulate immune responses and neuronal function. **Clinical Significance:** LASP1's involvement in various cellular processes and signaling pathways makes it a potential therapeutic target for several diseases, including: * **Cancer:** LASP1's role in cell migration and adhesion makes it a potential target for cancer therapy. * **Neurological disorders:** LASP1's involvement in neuronal function and signaling pathways makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. * **Autoimmune diseases:** LASP1's role in immune responses and signaling pathways makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. * **Wound healing:** LASP1's involvement in cell migration and adhesion makes it a potential target for the treatment of wound healing disorders. In conclusion, LASP1 is a complex gene that plays a multifaceted role in maintaining cellular integrity, motility, and adhesion. Its involvement in various cellular processes and signaling pathways makes it a potential therapeutic target for several diseases. Further research is needed to fully elucidate the functional implications of LASP1 and its potential applications in human disease.

Genular Protein ID: 1725070699

Symbol: LASP1_HUMAN

Name: LIM and SH3 domain protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7490069

Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

PubMed ID: 7490069

DOI: 10.1006/geno.1995.1163

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7589475

Title: Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains.

PubMed ID: 7589475

DOI: 10.1016/0014-5793(95)01040-l

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19726686

Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.

PubMed ID: 19726686

DOI: 10.1074/jbc.m109.023259

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 261
  • Mass: 29717
  • Checksum: 3B89B988605B3639
  • Sequence:
  • MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 
    SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 
    KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA 
    QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM 
    YGTVERTGDT GMLPANYVEA I

Genular Protein ID: 1839427047

Symbol: B4DIC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 125
  • Mass: 14598
  • Checksum: 900F5D3C3D145534
  • Sequence:
  • MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 
    SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRS SLGFLWNEIP 
    PSPHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.