Details for: LASP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 247.7736
Cell Significance Index: -38.5400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 148.5550
Cell Significance Index: -37.6800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 100.4011
Cell Significance Index: -41.3600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 92.8230
Cell Significance Index: -37.7100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 91.0568
Cell Significance Index: -42.9900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 81.9230
Cell Significance Index: -42.1400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 64.1410
Cell Significance Index: -43.0400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 40.0003
Cell Significance Index: -38.1900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.3126
Cell Significance Index: -39.8400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.9388
Cell Significance Index: -37.3400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.1798
Cell Significance Index: -40.1700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.9367
Cell Significance Index: -30.5200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.1194
Cell Significance Index: -17.7700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.3871
Cell Significance Index: 143.3100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1731
Cell Significance Index: 190.8000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1330
Cell Significance Index: 32.6500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.0829
Cell Significance Index: 27.0700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0645
Cell Significance Index: 55.4500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0358
Cell Significance Index: 22.4400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0289
Cell Significance Index: 204.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9478
Cell Significance Index: 42.9600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9029
Cell Significance Index: 162.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8560
Cell Significance Index: 171.7100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8542
Cell Significance Index: 92.9200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7447
Cell Significance Index: 91.5700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.7418
Cell Significance Index: 11.1200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5512
Cell Significance Index: 28.6400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5253
Cell Significance Index: 39.1500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5243
Cell Significance Index: 286.3500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5067
Cell Significance Index: 69.5800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4988
Cell Significance Index: 58.8200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3913
Cell Significance Index: 270.6100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3909
Cell Significance Index: 27.0400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3909
Cell Significance Index: 140.2200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.3012
Cell Significance Index: 2.5300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2708
Cell Significance Index: 34.7200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2651
Cell Significance Index: 17.1100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2599
Cell Significance Index: 1.5700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2505
Cell Significance Index: 4.6300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2476
Cell Significance Index: 8.7000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2214
Cell Significance Index: 21.9000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1672
Cell Significance Index: 4.5500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1637
Cell Significance Index: 72.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1523
Cell Significance Index: 26.0000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1501
Cell Significance Index: 4.2000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1182
Cell Significance Index: 5.5100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1179
Cell Significance Index: 2.5100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0981
Cell Significance Index: 11.2000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0913
Cell Significance Index: 4.2900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0841
Cell Significance Index: 16.0000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0633
Cell Significance Index: 1.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0608
Cell Significance Index: 3.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0105
Cell Significance Index: 19.8400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0056
Cell Significance Index: 0.1500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0015
Cell Significance Index: -0.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0070
Cell Significance Index: -0.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0079
Cell Significance Index: -14.4900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0092
Cell Significance Index: -14.1300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0195
Cell Significance Index: -26.5800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0211
Cell Significance Index: -15.6400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0219
Cell Significance Index: -16.5600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0261
Cell Significance Index: -16.2800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0324
Cell Significance Index: -20.6000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0363
Cell Significance Index: -20.4600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0395
Cell Significance Index: -0.7700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0419
Cell Significance Index: -30.7500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0673
Cell Significance Index: -30.5500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0781
Cell Significance Index: -7.9800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0863
Cell Significance Index: -11.1500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1031
Cell Significance Index: -21.7200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1043
Cell Significance Index: -1.7500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1075
Cell Significance Index: -0.9900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1075
Cell Significance Index: -2.2500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1157
Cell Significance Index: -13.2600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1204
Cell Significance Index: -34.6300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1266
Cell Significance Index: -18.4000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2096
Cell Significance Index: -1.4200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2142
Cell Significance Index: -5.7400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2171
Cell Significance Index: -14.6000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2510
Cell Significance Index: -13.1800 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2511
Cell Significance Index: -4.2200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2694
Cell Significance Index: -31.3900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2893
Cell Significance Index: -20.4600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3518
Cell Significance Index: -27.0000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3751
Cell Significance Index: -39.0600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3798
Cell Significance Index: -12.1700 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.3957
Cell Significance Index: -2.4400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3979
Cell Significance Index: -17.6000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4276
Cell Significance Index: -26.9500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4782
Cell Significance Index: -37.8700 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.4996
Cell Significance Index: -5.0400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5255
Cell Significance Index: -7.1700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5438
Cell Significance Index: -14.5200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5563
Cell Significance Index: -14.8800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5564
Cell Significance Index: -21.0700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.5798
Cell Significance Index: -6.0000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5862
Cell Significance Index: -20.3700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6033
Cell Significance Index: -36.9900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6345
Cell Significance Index: -16.2100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7274
Cell Significance Index: -20.8500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1725070699
Symbol: LASP1_HUMAN
Name: LIM and SH3 domain protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7490069
Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
PubMed ID: 7490069
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 7589475
Title: Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains.
PubMed ID: 7589475
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19726686
Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
PubMed ID: 19726686
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 261
- Mass: 29717
- Checksum: 3B89B988605B3639
- Sequence:
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM YGTVERTGDT GMLPANYVEA I
Genular Protein ID: 1839427047
Symbol: B4DIC4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 125
- Mass: 14598
- Checksum: 900F5D3C3D145534
- Sequence:
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRS SLGFLWNEIP PSPHL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.