Details for: LASP1

Gene ID: 3927

Symbol: LASP1

Ensembl ID: ENSG00000002834

Description: LIM and SH3 protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.53
    Marker Score: 6996.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.18
    Marker Score: 13883
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.03
    Marker Score: 9758.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.84
    Marker Score: 2220
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.76
    Marker Score: 5513
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.72
    Marker Score: 2649
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.53
    Marker Score: 5017
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3470
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.47
    Marker Score: 1003
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.46
    Marker Score: 6096
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.4
    Marker Score: 1338
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.38
    Marker Score: 3133
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.37
    Marker Score: 1254
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.34
    Marker Score: 13851
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.34
    Marker Score: 1969
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.34
    Marker Score: 1154.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.32
    Marker Score: 496
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.31
    Marker Score: 73406.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.31
    Marker Score: 371
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.31
    Marker Score: 921
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.27
    Marker Score: 5302.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.26
    Marker Score: 11075
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.26
    Marker Score: 627
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.25
    Marker Score: 32058
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.23
    Marker Score: 822
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.23
    Marker Score: 14254
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.22
    Marker Score: 4322.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.21
    Marker Score: 2872
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.21
    Marker Score: 288.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.2
    Marker Score: 660.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.2
    Marker Score: 417
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.18
    Marker Score: 559.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1219.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.16
    Marker Score: 1638
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.15
    Marker Score: 3348
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1756
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.12
    Marker Score: 9655
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.12
    Marker Score: 2786
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.11
    Marker Score: 453
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.11
    Marker Score: 809
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.11
    Marker Score: 1270
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68005.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.11
    Marker Score: 4261
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.1
    Marker Score: 1037
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.1
    Marker Score: 10445
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.1
    Marker Score: 354
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.1
    Marker Score: 40487
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.09
    Marker Score: 1090.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.09
    Marker Score: 469
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.09
    Marker Score: 268.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.07
    Marker Score: 1256
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.07
    Marker Score: 245.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.06
    Marker Score: 333
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.06
    Marker Score: 400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.06
    Marker Score: 263
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.06
    Marker Score: 10490.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.06
    Marker Score: 280.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.06
    Marker Score: 270.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.06
    Marker Score: 335
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.05
    Marker Score: 2054
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1134
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.05
    Marker Score: 4362.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.05
    Marker Score: 718
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9113
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.05
    Marker Score: 254
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.03
    Marker Score: 534
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.03
    Marker Score: 520
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.03
    Marker Score: 4435
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.03
    Marker Score: 225
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.03
    Marker Score: 291.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.02
    Marker Score: 1077
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.02
    Marker Score: 4162
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.02
    Marker Score: 3225
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 679
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.02
    Marker Score: 216.5
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 1.02
    Marker Score: 284.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.01
    Marker Score: 2558
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.01
    Marker Score: 1090
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.01
    Marker Score: 375.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.01
    Marker Score: 1022
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1
    Marker Score: 231
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1
    Marker Score: 433.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1
    Marker Score: 1748
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1
    Marker Score: 538
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1
    Marker Score: 997
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1
    Marker Score: 550
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1
    Marker Score: 9385
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1
    Marker Score: 222.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71551
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.99
    Marker Score: 2947
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47773.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.99
    Marker Score: 596
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.99
    Marker Score: 253
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.99
    Marker Score: 303.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.99
    Marker Score: 342
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.99
    Marker Score: 602
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.99
    Marker Score: 244
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.99
    Marker Score: 277
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.98
    Marker Score: 6290
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.98
    Marker Score: 880

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Other Information

## Summary The gene LASP1 encodes for a protein called LIM and SH3 domain protein 1. It is a transmembrane protein that is expressed in a variety of cell types, including decidual natural killer cells, human, foveolar cells of the stomach, enterocytes, myeloid leukocytes, colon epithelial cells, enterocytes of the colon, hepatocytes, kidney proximal straight tubule epithelial cells, squamous epithelial cells, and GABAergic neurons. ## Key characteristics * The protein is a transmembrane protein with a LIM and SH3 domain. * It is expressed in a variety of cell types. * It is involved in the regulation of cell adhesion, migration, and signaling. ## Pathways and functions * The protein is involved in the regulation of cell adhesion by binding to cadherins. * It is also involved in the regulation of cell migration by binding to the cytoskeleton. * It is involved in the regulation of cell signaling by binding to various signaling molecules. ## Clinical significance Mutations in the LASP1 gene have been linked to a number of human diseases, including breast cancer, colon cancer, and kidney cancer. These mutations can lead to the loss of function of the protein, which can result in the development of cancer.

Genular Protein ID: 1725070699

Symbol: LASP1_HUMAN

Name: LIM and SH3 domain protein 1

UniProtKB Accession Codes:

Q14847 B4DGQ0 Q96ED2 Q96IG0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490069

Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

PubMed ID: 7490069

DOI: 10.1006/geno.1995.1163

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7589475

Title: Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains.

PubMed ID: 7589475

DOI: 10.1016/0014-5793(95)01040-l

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19726686

Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.

PubMed ID: 19726686

DOI: 10.1074/jbc.m109.023259

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 261
  • Mass: 29717
  • Checksum: 3B89B988605B3639
  • Sequence:
    • MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 
KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA 
QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM 
YGTVERTGDT GMLPANYVEA I

Genular Protein ID: 1839427047

Symbol: B4DIC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIC4

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 125
  • Mass: 14598
  • Checksum: 900F5D3C3D145534
  • Sequence:
    • MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRS SLGFLWNEIP 
PSPHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.