Details for: LCN2

Gene ID: 3934

Symbol: LCN2

Ensembl ID: ENSG00000148346

Description: lipocalin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.22
    Marker Score: 9528
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 4.78
    Marker Score: 2065
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.3
    Marker Score: 1628
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.26
    Marker Score: 893
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.2
    Marker Score: 2180
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.05
    Marker Score: 2039
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.01
    Marker Score: 953
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.59
    Marker Score: 2044
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.57
    Marker Score: 3000.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.39
    Marker Score: 689
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.32
    Marker Score: 1083
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.32
    Marker Score: 80296
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.31
    Marker Score: 2062.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.25
    Marker Score: 5096
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.21
    Marker Score: 785
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.96
    Marker Score: 2059
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.9
    Marker Score: 16532
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.75
    Marker Score: 11169
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.74
    Marker Score: 443
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.74
    Marker Score: 23375
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.7
    Marker Score: 14688
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.68
    Marker Score: 4094
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.67
    Marker Score: 667
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6
    Marker Score: 14047
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.54
    Marker Score: 12056
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.52
    Marker Score: 2882
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5
    Marker Score: 2207
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.44
    Marker Score: 1202
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.43
    Marker Score: 6866
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.38
    Marker Score: 973
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.36
    Marker Score: 3104
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.32
    Marker Score: 2341
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.29
    Marker Score: 9613
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.28
    Marker Score: 481
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.17
    Marker Score: 3671
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.12
    Marker Score: 1793
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.08
    Marker Score: 5689
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.03
    Marker Score: 1024
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.03
    Marker Score: 1633
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.01
    Marker Score: 636
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.94
    Marker Score: 270
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.93
    Marker Score: 644
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.92
    Marker Score: 1189
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9
    Marker Score: 1710
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.88
    Marker Score: 213
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.88
    Marker Score: 1359
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 650
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.85
    Marker Score: 590
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.84
    Marker Score: 2001
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.82
    Marker Score: 790
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.81
    Marker Score: 2768
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.78
    Marker Score: 796
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3170.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.74
    Marker Score: 270
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.73
    Marker Score: 719
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.73
    Marker Score: 754
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.72
    Marker Score: 303
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.69
    Marker Score: 4530
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.69
    Marker Score: 979
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.68
    Marker Score: 352
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.66
    Marker Score: 134
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.64
    Marker Score: 321
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.64
    Marker Score: 327
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.6
    Marker Score: 381
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.56
    Marker Score: 328
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.56
    Marker Score: 140
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.56
    Marker Score: 140
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.56
    Marker Score: 161
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.52
    Marker Score: 1848
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.52
    Marker Score: 515
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5
    Marker Score: 194
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.49
    Marker Score: 2411
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.48
    Marker Score: 529
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.47
    Marker Score: 115214
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.46
    Marker Score: 218
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.46
    Marker Score: 125
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 963
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.46
    Marker Score: 289
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.45
    Marker Score: 102
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.44
    Marker Score: 203
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.44
    Marker Score: 219
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.44
    Marker Score: 294

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Other Information

**Key characteristics:** - The LCN2 gene is located on chromosome 14q32. - It is a large gene with a molecular weight of approximately 1600 amino acids. - It contains a single open reading frame that encodes a protein of 541 amino acids. - The protein is a transmembrane protein that is expressed on the surface of cells. - It is a member of the Lipocalin family of proteins. **Pathways and functions:** The LCN2 protein is a key regulator of innate immunity. It is expressed in high levels in secretory cells and other cells that are in close contact with the extracellular environment. This expression is thought to be important for the innate immune response to infection. The LCN2 protein binds to a variety of ligands, including enterobactin, which is a protein that is found on the surface of bacteria. This binding event triggers a signaling cascade that leads to the activation of immune cells. The LCN2 protein also binds to siderophores, which are molecules that are transported by siderophores. This binding event also triggers a signaling cascade that leads to the activation of immune cells. The LCN2 protein is a key regulator of the innate immune response to infection. Its expression and activity are regulated by a variety of factors, including cytokines and other immune signals. This regulation helps to ensure that the immune response is activated only when it is necessary. **Clinical significance:** Mutations in the LCN2 gene have been linked to a number of human diseases, including sepsis, tuberculosis, and inflammatory bowel disease. These diseases are characterized by a dysregulation of the innate immune response. It is thought that mutations in the LCN2 gene may contribute to these diseases by disrupting the normal regulation of the innate immune response.

Genular Protein ID: 3848438305

Symbol: NGAL_HUMAN

Name: Lipocalin-2

UniProtKB Accession Codes:

P80188 A6NII8 B4DWV4 B7ZAA2 P30150 Q5SYV9 Q5SYW0 Q6FGL5 Q92683

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 6 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 9 EMDB 1 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 56 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8060329

Title: Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils.

PubMed ID: 8060329

DOI: 10.1006/bbrc.1994.2096

PubMed ID: 9339356

Title: Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans.

PubMed ID: 9339356

DOI: 10.1006/geno.1997.4896

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7835423

Title: Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells.

PubMed ID: 7835423

DOI: 10.1016/0014-5793(94)01303-i

PubMed ID: 7683678

Title: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.

PubMed ID: 7683678

DOI: 10.1016/s0021-9258(18)82217-7

PubMed ID: 1281792

Title: A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase.

PubMed ID: 1281792

DOI: 10.1016/0014-5793(92)81511-j

PubMed ID: 8298140

Title: Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils.

PubMed ID: 8298140

PubMed ID: 12453413

Title: An iron delivery pathway mediated by a lipocalin.

PubMed ID: 12453413

DOI: 10.1016/s1097-2765(02)00710-4

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19229297

Title: Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.

PubMed ID: 19229297

DOI: 10.1038/emboj.2009.35

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 27780864

Title: Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine.

PubMed ID: 27780864

DOI: 10.1074/jbc.m116.759183

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30418175

Title: Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.

PubMed ID: 30418175

DOI: 10.1172/jci98595

PubMed ID: 10684642

Title: Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin.

PubMed ID: 10684642

DOI: 10.1021/bi992215v

PubMed ID: 10339412

Title: The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.

PubMed ID: 10339412

DOI: 10.1006/jmbi.1999.2755

PubMed ID: 12453412

Title: The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.

PubMed ID: 12453412

DOI: 10.1016/s1097-2765(02)00708-6

PubMed ID: 15642259

Title: Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration.

PubMed ID: 15642259

DOI: 10.1016/j.str.2004.10.009

PubMed ID: 20581821

Title: Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.

PubMed ID: 20581821

DOI: 10.1038/nchembio.402

PubMed ID: 21978368

Title: Immune interference in Mycobacterium tuberculosis intracellular iron acquisition through siderocalin recognition of carboxymycobactins.

PubMed ID: 21978368

DOI: 10.1021/cb200331g

Sequence Information:

  • Length: 198
  • Mass: 22588
  • Checksum: CD761805723FEF1E
  • Sequence:
    • MPLGLLWLGL ALLGALHAQA QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYVVGLAGNA 
ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY 
PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKSLG 
LPENHIVFPV PIDQCIDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.