Details for: PRICKLE3

Gene ID: 4007

Symbol: PRICKLE3

Ensembl ID: ENSG00000012211

Description: prickle planar cell polarity protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.05
    Marker Score: 2926
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 1.7
    Marker Score: 5447
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1839.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14341
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5215
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.88
    Marker Score: 341.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.76
    Marker Score: 750
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 665
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 527
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.67
    Marker Score: 269
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.64
    Marker Score: 5419
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1271
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 269
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.54
    Marker Score: 486
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 308
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 326
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.46
    Marker Score: 566
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 368
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.39
    Marker Score: 2348
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.37
    Marker Score: 227
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 120
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.36
    Marker Score: 2681
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 204
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 158
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.33
    Marker Score: 486
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.32
    Marker Score: 354
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.31
    Marker Score: 328
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.3
    Marker Score: 498.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.29
    Marker Score: 3794.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.27
    Marker Score: 480
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.24
    Marker Score: 202
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.23
    Marker Score: 550
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 158
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.22
    Marker Score: 1413
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 227
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.21
    Marker Score: 469
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.21
    Marker Score: 146
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2
    Marker Score: 199
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.19
    Marker Score: 1680
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.19
    Marker Score: 485
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.19
    Marker Score: 102
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.19
    Marker Score: 55
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.19
    Marker Score: 299
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.19
    Marker Score: 693
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.19
    Marker Score: 211
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.19
    Marker Score: 225
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.18
    Marker Score: 89.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.18
    Marker Score: 40
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.18
    Marker Score: 197
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.18
    Marker Score: 90
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.18
    Marker Score: 39
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.18
    Marker Score: 432
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.17
    Marker Score: 107
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.17
    Marker Score: 838
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.17
    Marker Score: 240
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.17
    Marker Score: 33
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.17
    Marker Score: 37

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Other Information

**Key characteristics:** * PRICKLE3 is a transmembrane protein that is expressed in a variety of cell types. * It is a member of the PRICKLE family of proteins, which are involved in cell polarity and migration. * PRICKLE3 is a highly conserved protein, with a similar sequence in mammals, birds, and fish. * It is known to be involved in the regulation of cell migration and adhesion. **Pathways and functions:** * PRICKLE3 is involved in cell polarity and migration by interacting with the cytoplasmic tail of other transmembrane proteins, such as MAGP1 and MAGM. * It is also involved in the regulation of cell adhesion by binding to cadherins and integrins on the cell surface. * PRICKLE3 is also involved in the regulation of mitochondrial function. * It is expressed in the retina, where it is involved in the formation of the blood-aqueous barrier. * It is also expressed in the brain, where it is involved in the development and maintenance of the blood-brain barrier. **Clinical significance:** * Mutations in PRICKLE3 have been linked to a number of human diseases, including retinal degenerative diseases, autism, and schizophrenia. * PRICKLE3 is a promising target for the treatment of these diseases. **Additional information:** * The PRICKLE3 gene is located on chromosome 17q21.1. * It is a single-exon gene that encodes a protein of approximately 300 amino acids. * The protein is expressed in a variety of cell types, including retinal horizontal cells, amacrine cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, cardiac endothelial cells, tuft cells of the colon, and human intestinal crypt stem cells. * PRICKLE3 is a highly conserved protein, with a similar sequence in mammals, birds, and fish.

Genular Protein ID: 506669215

Symbol: PRIC3_HUMAN

Name: LIM domain only protein 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9344658

Title: Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp.

PubMed ID: 9344658

DOI: 10.1006/geno.1997.4941

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 32516135

Title: PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.

PubMed ID: 32516135

DOI: 10.1172/jci134965

Sequence Information:

  • Length: 615
  • Mass: 68609
  • Checksum: CD024365C072B052
  • Sequence:
  • MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK CPREEHAVHA 
    VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL KPEQVYQFFS CLPEDKVPYV 
    NSPGEKYRIK QLLHQLPPHD SEAQYCTALE EEEKKELRAF SQQRKRENLG RGIVRIFPVT 
    ITGAICEECG KQIGGGDIAV FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHVGKVYCG 
    RHHAECLRPR CQACDEIIFS PECTEAEGRH WHMDHFCCFE CEASLGGQRY VMRQSRPHCC 
    ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCGRALLG RPFLPRRGLI 
    FCSRACSLGS EPTAPGPSRR SWSAGPVTAP LAASTASFSA VKGASETTTK GTSTELAPAT 
    GPEEPSRFLR GAPHRHSMPE LGLRSVPEPP PESPGQPNLR PDDSAFGRQS TPRVSFRDPL 
    VSEGGPRRTL SAPPAQRRRP RSPPPRAPSR RRHHHHNHHH HHNRHPSRRR HYQCDAGSGS 
    DSESCSSSPS SSSSESSEDD GFFLGERIPL PPHLCRPMPA QDTAMETFNS PSLSLPRDSR 
    AGMPRQARDK NCIVA

Genular Protein ID: 3594752459

Symbol: B7Z5U0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 439
  • Mass: 49105
  • Checksum: E97B9F793EF75333
  • Sequence:
  • MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK CPREEHAVHA 
    VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL KPEQVTRGQP STLAVQWVHT 
    NAHTHTHTQA QYCTALEEEE KKELRAFSQQ RKRENLGRGI VRIFPVTITG AICEECGKQI 
    GGGDIAVFAS RAGLGACWHP QCFVCTTCQE LLVDLIYFYH VGKVYCGRHH AECLRPRCQA 
    CDEIIFSPEC TPGPAPQATQ PSRFLRGAPH RHSMPELGLR SVPEPPPESP GQPNLRPDDS 
    AFGRQSTPRV SFRDPLVSEG GPRRTLSAPP AQRRRRHHHH NHHHHHNRHP SRRRHYQCDA 
    GSGSDSESCS SSPSSSSSES SEDDGFFLGE RIPLPPHLCR PMPAQDTAME TFNSPSLSLP 
    RDSRAGMPRQ ARDKNCIVA

Genular Protein ID: 1277312547

Symbol: B7Z8D2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 547
  • Mass: 60758
  • Checksum: DE5D61350E018595
  • Sequence:
  • MCRLISDFQR HSISDDDSGC ASEEYAWVPP GLKPEQVYQF FSCLPEDKVP YVNSPGEKYR 
    IKQLLHQLPP HDSEAQYCTA LEEEEKKELR AFSQQRKREN LGRGIVRIFP VTITGAICEE 
    CGKQIGGGDI AVFASRAGLG ACWHPQCFVC TTCQELLVDL IYFYHVGKVY CGRHHAECLR 
    PRCQACDEII FSPECTEAEG RHWHMDHFCC FECEASLGGQ RYVMRQSRPH CCACYEARHA 
    EYCDGCGEHI GLDQGQMAYE GQHWHASDRC FCCSRCGRAL LGRPFLPRRG LIFCSRACSL 
    GSEPTAPGPS RRSWSAGPVT APLAASTASF SAVKGASETT TKGTSTELAP ATGPEEPSRF 
    LRGAPHRHSM PELGLRSVPE PPPESPGQPN LRPDDSAFGR QSTPRVSFRD PLVSEGGPRR 
    TLSAPPAQRR RPRSPPPRAP SRRRHHHHNH HHHHNRHPSR RRHYQCDAGS GSDSESCSSS 
    PSSSSSESSE DDGLFLGERI PLPPHLCRPM PAQDTAMETF NSPSLSLPRD SRAGMPRQAR 
    DKNCIVA

Genular Protein ID: 1112023329

Symbol: H0Y413_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 547
  • Mass: 60792
  • Checksum: 245761350E0C3EF8
  • Sequence:
  • MCRLISDFQR HSISDDDSGC ASEEYAWVPP GLKPEQVYQF FSCLPEDKVP YVNSPGEKYR 
    IKQLLHQLPP HDSEAQYCTA LEEEEKKELR AFSQQRKREN LGRGIVRIFP VTITGAICEE 
    CGKQIGGGDI AVFASRAGLG ACWHPQCFVC TTCQELLVDL IYFYHVGKVY CGRHHAECLR 
    PRCQACDEII FSPECTEAEG RHWHMDHFCC FECEASLGGQ RYVMRQSRPH CCACYEARHA 
    EYCDGCGEHI GLDQGQMAYE GQHWHASDRC FCCSRCGRAL LGRPFLPRRG LIFCSRACSL 
    GSEPTAPGPS RRSWSAGPVT APLAASTASF SAVKGASETT TKGTSTELAP ATGPEEPSRF 
    LRGAPHRHSM PELGLRSVPE PPPESPGQPN LRPDDSAFGR QSTPRVSFRD PLVSEGGPRR 
    TLSAPPAQRR RPRSPPPRAP SRRRHHHHNH HHHHNRHPSR RRHYQCDAGS GSDSESCSSS 
    PSSSSSESSE DDGFFLGERI PLPPHLCRPM PAQDTAMETF NSPSLSLPRD SRAGMPRQAR 
    DKNCIVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.