Details for: VWA5A

Gene ID: 4013

Symbol: VWA5A

Ensembl ID: ENSG00000110002

Description: von Willebrand factor A domain containing 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.5273
    Cell Significance Index: -13.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.9467
    Cell Significance Index: -12.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.2252
    Cell Significance Index: -14.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.4395
    Cell Significance Index: -11.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.5374
    Cell Significance Index: -11.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2534
    Cell Significance Index: -13.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8099
    Cell Significance Index: -12.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5403
    Cell Significance Index: -13.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.1060
    Cell Significance Index: -9.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5614
    Cell Significance Index: 93.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3638
    Cell Significance Index: 148.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.2720
    Cell Significance Index: 20.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1240
    Cell Significance Index: 58.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7341
    Cell Significance Index: 50.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6926
    Cell Significance Index: 80.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6786
    Cell Significance Index: 67.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6029
    Cell Significance Index: 544.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5962
    Cell Significance Index: 213.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4741
    Cell Significance Index: 21.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4394
    Cell Significance Index: 11.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4276
    Cell Significance Index: 12.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3983
    Cell Significance Index: 8.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3535
    Cell Significance Index: 57.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3183
    Cell Significance Index: 60.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3098
    Cell Significance Index: 20.8300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3090
    Cell Significance Index: 2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3043
    Cell Significance Index: 54.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2403
    Cell Significance Index: 17.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2147
    Cell Significance Index: 8.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1927
    Cell Significance Index: 24.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1492
    Cell Significance Index: 6.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1420
    Cell Significance Index: 6.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1386
    Cell Significance Index: 4.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1322
    Cell Significance Index: 16.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1277
    Cell Significance Index: 56.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1229
    Cell Significance Index: 1.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1198
    Cell Significance Index: 14.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1099
    Cell Significance Index: 2.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0934
    Cell Significance Index: 4.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0862
    Cell Significance Index: 14.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0706
    Cell Significance Index: 2.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0631
    Cell Significance Index: 7.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0583
    Cell Significance Index: 8.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0564
    Cell Significance Index: 1.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0372
    Cell Significance Index: 1.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0270
    Cell Significance Index: 1.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0182
    Cell Significance Index: 9.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0145
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0135
    Cell Significance Index: 25.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0037
    Cell Significance Index: 2.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0027
    Cell Significance Index: 1.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0043
    Cell Significance Index: -3.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0081
    Cell Significance Index: -5.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0188
    Cell Significance Index: -8.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0198
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0231
    Cell Significance Index: -4.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0234
    Cell Significance Index: -3.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0372
    Cell Significance Index: -10.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0378
    Cell Significance Index: -0.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0413
    Cell Significance Index: -8.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0426
    Cell Significance Index: -4.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0447
    Cell Significance Index: -0.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0508
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0546
    Cell Significance Index: -6.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0673
    Cell Significance Index: -1.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0695
    Cell Significance Index: -0.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0705
    Cell Significance Index: -1.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0841
    Cell Significance Index: -5.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0869
    Cell Significance Index: -2.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0895
    Cell Significance Index: -1.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1142
    Cell Significance Index: -1.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1178
    Cell Significance Index: -13.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1256
    Cell Significance Index: -13.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1304
    Cell Significance Index: -2.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1412
    Cell Significance Index: -10.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1443
    Cell Significance Index: -1.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1485
    Cell Significance Index: -11.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1891
    Cell Significance Index: -2.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1893
    Cell Significance Index: -10.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1934
    Cell Significance Index: -11.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2010
    Cell Significance Index: -10.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2022
    Cell Significance Index: -6.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2050
    Cell Significance Index: -5.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2058
    Cell Significance Index: -4.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2061
    Cell Significance Index: -12.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2147
    Cell Significance Index: -13.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2167
    Cell Significance Index: -4.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2264
    Cell Significance Index: -5.4300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2423
    Cell Significance Index: -1.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2492
    Cell Significance Index: -6.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2514
    Cell Significance Index: -3.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2515
    Cell Significance Index: -5.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2516
    Cell Significance Index: -6.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The VWA5A gene exhibits a unique expression profile, with notable expression in basophils, which are crucial players in allergic reactions and immune responses. Its presence in enteroendocrine cells, neurons, and epithelial cells underscores its potential role in regulating various physiological processes. The gene's involvement in protein binding and nucleoplasmic pathways suggests that it may interact with other proteins to modulate cellular activities. Notably, the VWA5A gene shares homology with the von Willebrand factor A domain-containing protein 5A (VMA5A_HUMAN), highlighting its evolutionary conserved nature. **Pathways and Functions:** The VWA5A gene is intricately involved in protein binding and nucleoplasmic pathways, which are essential for regulating cellular functions. The protein binding capabilities of VWA5A suggest that it may interact with other proteins to modulate signaling pathways, cellular adhesion, and immune responses. Specifically, its expression in basophils implies that it may play a role in allergic reactions and immune responses. The gene's presence in neurons and epithelial cells highlights its potential involvement in regulating neural and epithelial functions. **Clinical Significance:** The VWA5A gene's involvement in protein binding and nucleoplasmic pathways has significant implications for our understanding of various diseases. For instance, its expression in basophils may contribute to the pathogenesis of allergic reactions and immune disorders. Furthermore, its presence in neurons and epithelial cells suggests that it may play a role in regulating neural and epithelial functions, which could have implications for neurological and gastrointestinal disorders. The identification of the VWA5A gene's clinical significance will require further research and investigation into its role in human diseases. In conclusion, the VWA5A gene is a multifaceted molecule with significant implications for our understanding of immunology and disease. Further research into its pathways and functions will provide valuable insights into its clinical significance and potential therapeutic applications. As an expert immunologist, I emphasize the importance of continued investigation into the VWA5A gene's role in human diseases and its potential as a therapeutic target.

Genular Protein ID: 3325036405

Symbol: VMA5A_HUMAN

Name: von Willebrand factor A domain-containing protein 5A

UniProtKB Accession Codes:

O00534 Q6UN19 Q6UN20 Q9BVF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14504409

Title: The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

PubMed ID: 14504409

DOI: 10.1073/pnas.1934602100

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9417908

Title: Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23.

PubMed ID: 9417908

DOI: 10.1006/geno.1997.5036

Sequence Information:

  • Length: 786
  • Mass: 86489
  • Checksum: 4CCD27B4B6DD9BD0
  • Sequence:
    • MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF FVFPMDEDSA 
VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL EGDSSSRDVF SCNVGNLQPG 
SKAAVTLKYV QELPLEADGA LRFVLPAVLN PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL 
SMVATIDSQH GIEKVQSNCP LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP 
SVVLEMGMPN MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD 
TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM EEALGRVKLM 
QADLGGTEIL APLQNIYRGP SIPGHPLQLF VFTDGEVTDT FSVIKEVRIN RQKHRCFSFG 
IGEGTSTSLI KGIARASGGT SEFITGKDRM QSKALRTLKR SLQPVVEDVS LSWHLPPGLS 
AKMLSPEQTV IFRGQRLISY AQLTGRMPAA ETTGEVCLKY TLQGKTFEDK VTFPLQPKPD 
VNLTIHRLAA KSLLQTKDMG LRETPASDKK DALNLSLESG VISSFTAFIA INKELNKPVQ 
GPLAHRDVPR PILLGASAPL KIKCQSGFRK ALHSDRPPSA SQPRGELMCY KAKTFQMDDY 
SLCGLISHKD QHSPGFGENH LVQLIYHQNA NGSWDLNEDL AKILGMSLEE IMAAQPAELV 
DSSGWATILA VIWLHSNGKD LKCEWELLER KAVAWMRAHA GSTMPSVVKA AITFLKSSVD 
PAIFAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.