Details for: VWA5A

Gene ID: 4013

Symbol: VWA5A

Ensembl ID: ENSG00000110002

Description: von Willebrand factor A domain containing 5A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 3.36
    Marker Score: 1595.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.34
    Marker Score: 542
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12710
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.21
    Marker Score: 2144
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.12
    Marker Score: 4312
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.02
    Marker Score: 3490
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71780
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48005
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1
    Marker Score: 8557
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.99
    Marker Score: 664
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.95
    Marker Score: 1403.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.88
    Marker Score: 7674
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.87
    Marker Score: 8216
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.87
    Marker Score: 32188
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5267
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.86
    Marker Score: 474
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.84
    Marker Score: 31943
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1666
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 473
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15484
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.78
    Marker Score: 363
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.75
    Marker Score: 1420
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.73
    Marker Score: 497
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.72
    Marker Score: 1632
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.71
    Marker Score: 1097
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.71
    Marker Score: 747
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.71
    Marker Score: 349
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.7
    Marker Score: 533
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.7
    Marker Score: 332
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 638
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.67
    Marker Score: 152
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.67
    Marker Score: 5160
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.67
    Marker Score: 2089
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 385
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10021
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.62
    Marker Score: 198
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.62
    Marker Score: 685
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.61
    Marker Score: 612
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.6
    Marker Score: 4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6
    Marker Score: 620
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.57
    Marker Score: 164
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.57
    Marker Score: 2723
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.55
    Marker Score: 139
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 487
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.53
    Marker Score: 264
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.53
    Marker Score: 371
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.52
    Marker Score: 181
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.52
    Marker Score: 468
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.52
    Marker Score: 5216
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.52
    Marker Score: 387.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.51
    Marker Score: 7678
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.51
    Marker Score: 1213
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5
    Marker Score: 1945
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.5
    Marker Score: 917
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.5
    Marker Score: 225
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.5
    Marker Score: 532
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.5
    Marker Score: 187
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.5
    Marker Score: 503
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.49
    Marker Score: 858
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.48
    Marker Score: 745
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.47
    Marker Score: 294
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.47
    Marker Score: 287
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.47
    Marker Score: 545.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.47
    Marker Score: 1220
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.46
    Marker Score: 455
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.46
    Marker Score: 595
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.46
    Marker Score: 2792
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.45
    Marker Score: 129
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.45
    Marker Score: 231
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.45
    Marker Score: 166
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.44
    Marker Score: 1106.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.43
    Marker Score: 1232
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.42
    Marker Score: 1130
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.42
    Marker Score: 1738
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 413
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.42
    Marker Score: 2464
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.41
    Marker Score: 93
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.41
    Marker Score: 8802
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.41
    Marker Score: 112
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.41
    Marker Score: 671
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.4
    Marker Score: 1631
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 190
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4
    Marker Score: 91
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.39
    Marker Score: 273
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.39
    Marker Score: 623

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Other Information

**Key characteristics:** - VWA5A is a large protein with a molecular weight of approximately 160 kDa. - It is expressed in a wide range of cell types, including basophils, type A enteroendocrine cells, dopaminergic neurons, luminal epithelial cells of the mammary gland, caudal ganglionic eminence derived GABAergic cortical interneurons, ciliated cells, cerebral cortex GABAergic interneurons, forebrain radial glial cell, and L6b glutamatergic cortical neuron. - It is a transmembrane protein with a conserved extracellular domain and a cytoplasmic domain that is involved in cell adhesion and signaling. **Pathways and functions:** - VWA5A is involved in cell adhesion by interacting with integrins on the surface of endothelial cells. - It also plays a role in cell signaling, as it is a ligand for integrins and is involved in cell adhesion and migration. - Additionally, VWA5A has been shown to be involved in the regulation of neuronal differentiation and survival. **Clinical significance:** - Mutations in the VWA5A gene have been linked to several human diseases, including von Willebrand disease, a genetic disorder characterized by the absence of von Willebrand factor in the blood. - In von Willebrand disease, VWA5A is required for the migration of endothelial cells and the formation of blood vessels. - Therefore, VWA5A is a promising target for the treatment of von Willebrand disease.

Genular Protein ID: 3325036405

Symbol: VMA5A_HUMAN

Name: von Willebrand factor A domain-containing protein 5A

UniProtKB Accession Codes:

O00534 Q6UN19 Q6UN20 Q9BVF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14504409

Title: The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

PubMed ID: 14504409

DOI: 10.1073/pnas.1934602100

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9417908

Title: Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23.

PubMed ID: 9417908

DOI: 10.1006/geno.1997.5036

Sequence Information:

  • Length: 786
  • Mass: 86489
  • Checksum: 4CCD27B4B6DD9BD0
  • Sequence:
    • MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF FVFPMDEDSA 
VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL EGDSSSRDVF SCNVGNLQPG 
SKAAVTLKYV QELPLEADGA LRFVLPAVLN PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL 
SMVATIDSQH GIEKVQSNCP LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP 
SVVLEMGMPN MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD 
TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM EEALGRVKLM 
QADLGGTEIL APLQNIYRGP SIPGHPLQLF VFTDGEVTDT FSVIKEVRIN RQKHRCFSFG 
IGEGTSTSLI KGIARASGGT SEFITGKDRM QSKALRTLKR SLQPVVEDVS LSWHLPPGLS 
AKMLSPEQTV IFRGQRLISY AQLTGRMPAA ETTGEVCLKY TLQGKTFEDK VTFPLQPKPD 
VNLTIHRLAA KSLLQTKDMG LRETPASDKK DALNLSLESG VISSFTAFIA INKELNKPVQ 
GPLAHRDVPR PILLGASAPL KIKCQSGFRK ALHSDRPPSA SQPRGELMCY KAKTFQMDDY 
SLCGLISHKD QHSPGFGENH LVQLIYHQNA NGSWDLNEDL AKILGMSLEE IMAAQPAELV 
DSSGWATILA VIWLHSNGKD LKCEWELLER KAVAWMRAHA GSTMPSVVKA AITFLKSSVD 
PAIFAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.