Details for: LRP6

Gene ID: 4040

Symbol: LRP6

Ensembl ID: ENSG00000070018

Description: LDL receptor related protein 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.97
    Marker Score: 42032
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.8
    Marker Score: 26962
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.77
    Marker Score: 4243
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.74
    Marker Score: 13316
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.72
    Marker Score: 1377
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.7
    Marker Score: 2118
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.68
    Marker Score: 6851
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.67
    Marker Score: 15904
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.62
    Marker Score: 6772
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.61
    Marker Score: 939
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.6
    Marker Score: 15069
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.57
    Marker Score: 96811
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.57
    Marker Score: 13450
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.56
    Marker Score: 59226
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.55
    Marker Score: 2983.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.54
    Marker Score: 4124
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55868
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.51
    Marker Score: 9728
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5
    Marker Score: 5804.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.5
    Marker Score: 8038
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.49
    Marker Score: 15418
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.49
    Marker Score: 784
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.47
    Marker Score: 29300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.44
    Marker Score: 2224
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.41
    Marker Score: 6105
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.4
    Marker Score: 5791.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.39
    Marker Score: 4567
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.39
    Marker Score: 687
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.37
    Marker Score: 21927
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.35
    Marker Score: 755.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.31
    Marker Score: 1619
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.29
    Marker Score: 1214
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.28
    Marker Score: 2812
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1428
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.23
    Marker Score: 720
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.23
    Marker Score: 1354.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1239
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.21
    Marker Score: 1468
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1305.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.2
    Marker Score: 531
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.2
    Marker Score: 715
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.18
    Marker Score: 345
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.15
    Marker Score: 997
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.14
    Marker Score: 791
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.13
    Marker Score: 657
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.13
    Marker Score: 850
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.13
    Marker Score: 974
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.13
    Marker Score: 1516
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.12
    Marker Score: 1193
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.1
    Marker Score: 846
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2583
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1033
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.08
    Marker Score: 337
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.07
    Marker Score: 5630
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.05
    Marker Score: 989.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.05
    Marker Score: 242
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.05
    Marker Score: 1126
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.04
    Marker Score: 270
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.02
    Marker Score: 1082
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.01
    Marker Score: 4690
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.01
    Marker Score: 5413
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.01
    Marker Score: 3372
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1
    Marker Score: 385
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1
    Marker Score: 234
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47976
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2269
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.96
    Marker Score: 2001
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.95
    Marker Score: 32021
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.95
    Marker Score: 1334
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.93
    Marker Score: 347
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.93
    Marker Score: 1120
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1506
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.92
    Marker Score: 1412
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.92
    Marker Score: 812
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.92
    Marker Score: 504
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.91
    Marker Score: 262
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.91
    Marker Score: 330
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.9
    Marker Score: 511
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9
    Marker Score: 601
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.89
    Marker Score: 2539
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.89
    Marker Score: 956
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.89
    Marker Score: 942
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.88
    Marker Score: 19727
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.87
    Marker Score: 5644
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.87
    Marker Score: 3623
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4939
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.86
    Marker Score: 9731
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1220
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.86
    Marker Score: 588
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.86
    Marker Score: 892
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.86
    Marker Score: 942
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.86
    Marker Score: 563

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Other Information

**Key characteristics:** - LRP6 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the LDL receptor family of proteins. - LRP6 is expressed in high levels in the cerebral cortex, where it is thought to play a role in neuronal development and function. - It is also expressed in other tissues, such as the lung, heart, and kidney. **Pathways and functions:** - LRP6 is a coreceptor for Wnt proteins, which are important growth factors for many cell types. - Wnt proteins bind to LRP6 on the surface of cells, which triggers a signaling cascade that leads to the activation of downstream targets. - These targets include the transcription factor beta-catenin, which is a key regulator of cell growth and differentiation. - Activation of beta-catenin leads to the expression of genes that promote cell growth and proliferation. **Clinical significance:** - Mutations in the LRP6 gene have been linked to a number of human diseases, including cerebral palsy, autism, and heart disease. - These mutations can lead to the loss of LRP6 function, which can result in cell growth abnormalities and developmental disorders. - Therefore, LRP6 is a potential therapeutic target for a variety of human diseases. **Additional information:** - LRP6 is a ubiquitin-dependent protein, which means that it is targeted for degradation by the proteasome when it is no longer needed. - It is also a member of the WD repeat protein family, which are involved in the regulation of cell growth and differentiation. - LRP6 is a highly conserved protein, with a similar protein found in other mammals.

Genular Protein ID: 322401176

Symbol: LRP6_HUMAN

Name: Low-density lipoprotein receptor-related protein 6

UniProtKB Accession Codes:

O75581 Q17RZ2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 23 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9704021

Title: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.

PubMed ID: 9704021

DOI: 10.1006/bbrc.1998.9061

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11448771

Title: Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

PubMed ID: 11448771

DOI: 10.1016/s0960-9822(01)00290-1

PubMed ID: 11357136

Title: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.

PubMed ID: 11357136

DOI: 10.1038/35077108

PubMed ID: 12857724

Title: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.

PubMed ID: 12857724

DOI: 10.1074/jbc.m300191200

PubMed ID: 15778503

Title: Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.

PubMed ID: 15778503

DOI: 10.1074/jbc.m413274200

PubMed ID: 15908424

Title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

PubMed ID: 15908424

DOI: 10.1074/jbc.m504308200

PubMed ID: 16341017

Title: A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.

PubMed ID: 16341017

DOI: 10.1038/nature04185

PubMed ID: 16815997

Title: The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

PubMed ID: 16815997

DOI: 10.1101/gad.1411206

PubMed ID: 16513652

Title: Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.

PubMed ID: 16513652

DOI: 10.1074/jbc.m510580200

PubMed ID: 17400545

Title: R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

PubMed ID: 17400545

DOI: 10.1074/jbc.m701927200

PubMed ID: 17326769

Title: Regulated proteolytic processing of LRP6 results in release of its intracellular domain.

PubMed ID: 17326769

DOI: 10.1111/j.1471-4159.2007.04447.x

PubMed ID: 17698587

Title: Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.

PubMed ID: 17698587

DOI: 10.1128/mcb.00773-07

PubMed ID: 17804805

Title: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.

PubMed ID: 17804805

DOI: 10.1073/pnas.0702305104

PubMed ID: 17569865

Title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

PubMed ID: 17569865

DOI: 10.1126/science.1137065

PubMed ID: 18362152

Title: Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

PubMed ID: 18362152

DOI: 10.1074/jbc.m800327200

PubMed ID: 18762581

Title: Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.

PubMed ID: 18762581

DOI: 10.1083/jcb.200803147

PubMed ID: 19107203

Title: Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.

PubMed ID: 19107203

DOI: 10.1371/journal.pone.0004046

PubMed ID: 18378904

Title: Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum.

PubMed ID: 18378904

DOI: 10.1073/pnas.0710389105

PubMed ID: 20059949

Title: Cell cycle control of wnt receptor activation.

PubMed ID: 20059949

DOI: 10.1016/j.devcel.2009.11.006

PubMed ID: 19801552

Title: G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

PubMed ID: 19801552

DOI: 10.1074/jbc.m109.047456

PubMed ID: 19293931

Title: Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

PubMed ID: 19293931

DOI: 10.1371/journal.pone.0004926

PubMed ID: 20093360

Title: Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

PubMed ID: 20093360

DOI: 10.1074/jbc.m109.092130

PubMed ID: 21536646

Title: Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.

PubMed ID: 21536646

DOI: 10.1128/mcb.05103-11

PubMed ID: 22491013

Title: Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin.

PubMed ID: 22491013

DOI: 10.1038/emboj.2012.83

PubMed ID: 22575959

Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

PubMed ID: 22575959

DOI: 10.1038/nature11019

PubMed ID: 23987510

Title: Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

PubMed ID: 23987510

DOI: 10.1016/j.devcel.2013.07.020

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25331957

Title: Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.

PubMed ID: 25331957

DOI: 10.1074/jbc.m114.591636

PubMed ID: 27821587

Title: Caprin-2 positively regulates CDK14/Cyclin Y-mediated LRP5/6 constitutive phosphorylation.

PubMed ID: 27821587

DOI: 10.1074/jbc.m116.744607

PubMed ID: 27524201

Title: Structure of the dual-mode wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and Dickkopf.

PubMed ID: 27524201

DOI: 10.1016/j.str.2016.06.020

PubMed ID: 28341812

Title: Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.

PubMed ID: 28341812

DOI: 10.15252/embr.201643585

PubMed ID: 30069874

Title: Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.

PubMed ID: 30069874

DOI: 10.1002/1873-3468.13212

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 22000856

Title: Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

PubMed ID: 22000856

DOI: 10.1016/j.devcel.2011.09.003

PubMed ID: 17332414

Title: LRP6 mutation in a family with early coronary disease and metabolic risk factors.

PubMed ID: 17332414

DOI: 10.1126/science.1136370

PubMed ID: 23703864

Title: Rare nonconservative LRP6 mutations are associated with metabolic syndrome.

PubMed ID: 23703864

DOI: 10.1002/humu.22360

PubMed ID: 26387593

Title: Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.

PubMed ID: 26387593

DOI: 10.1016/j.ajhg.2015.08.014

PubMed ID: 29983323

Title: De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

PubMed ID: 29983323

DOI: 10.1016/j.neuron.2018.06.019

Sequence Information:

  • Length: 1613
  • Mass: 180429
  • Checksum: 413D2CF70A5D8B5C
  • Sequence:
    • MGAVLRSLLA CSFCVLLRAA PLLLYANRRD LRLVDATNGK ENATIVVGGL EDAAAVDFVF 
SHGLIYWSDV SEEAIKRTEF NKTESVQNVV VSGLLSPDGL ACDWLGEKLY WTDSETNRIE 
VSNLDGSLRK VLFWQELDQP RAIALDPSSG FMYWTDWGEV PKIERAGMDG SSRFIIINSE 
IYWPNGLTLD YEEQKLYWAD AKLNFIHKSN LDGTNRQAVV KGSLPHPFAL TLFEDILYWT 
DWSTHSILAC NKYTGEGLRE IHSDIFSPMD IHAFSQQRQP NATNPCGIDN GGCSHLCLMS 
PVKPFYQCAC PTGVKLLENG KTCKDGATEL LLLARRTDLR RISLDTPDFT DIVLQLEDIR 
HAIAIDYDPV EGYIYWTDDE VRAIRRSFID GSGSQFVVTA QIAHPDGIAV DWVARNLYWT 
DTGTDRIEVT RLNGTMRKIL ISEDLEEPRA IVLDPMVGYM YWTDWGEIPK IERAALDGSD 
RVVLVNTSLG WPNGLALDYD EGKIYWGDAK TDKIEVMNTD GTGRRVLVED KIPHIFGFTL 
LGDYVYWTDW QRRSIERVHK RSAEREVIID QLPDLMGLKA TNVHRVIGSN PCAEENGGCS 
HLCLYRPQGL RCACPIGFEL ISDMKTCIVP EAFLLFSRRA DIRRISLETN NNNVAIPLTG 
VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV EFGLDYPEGM AVDWLGKNLY 
WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP RALALDPAEG FMYWTEWGGK PKIDRAAMDG 
SERTTLVPNV GRANGLTIDY AKRRLYWTDL DTNLIESSNM LGLNREVIAD DLPHPFGLTQ 
YQDYIYWTDW SRRSIERANK TSGQNRTIIQ GHLDYVMDIL VFHSSRQSGW NECASSNGHC 
SHLCLAVPVG GFVCGCPAHY SLNADNRTCS APTTFLLFSQ KSAINRMVID EQQSPDIILP 
IHSLRNVRAI DYDPLDKQLY WIDSRQNMIR KAQEDGSQGF TVVVSSVPSQ NLEIQPYDLS 
IDIYSRYIYW TCEATNVINV TRLDGRSVGV VLKGEQDRPR AVVVNPEKGY MYFTNLQERS 
PKIERAALDG TEREVLFFSG LSKPIALALD SRLGKLFWAD SDLRRIESSD LSGANRIVLE 
DSNILQPVGL TVFENWLYWI DKQQQMIEKI DMTGREGRTK VQARIAQLSD IHAVKELNLQ 
EYRQHPCAQD NGGCSHICLV KGDGTTRCSC PMHLVLLQDE LSCGEPPTCS PQQFTCFTGE 
IDCIPVAWRC DGFTECEDHS DELNCPVCSE SQFQCASGQC IDGALRCNGD ANCQDKSDEK 
NCEVLCLIDQ FRCANGQCIG KHKKCDHNVD CSDKSDELDC YPTEEPAPQA TNTVGSVIGV 
IVTIFVSGTV YFICQRMLCP RMKGDGETMT NDYVVHGPAS VPLGYVPHPS SLSGSLPGMS 
RGKSMISSLS IMGGSSGPPY DRAHVTGASS SSSSSTKGTY FPAILNPPPS PATERSHYTM 
EFGYSSNSPS THRSYSYRPY SYRHFAPPTT PCSTDVCDSD YAPSRRMTSV ATAKGYTSDL 
NYDSEPVPPP PTPRSQYLSA EENYESCPPS PYTERSYSHH LYPPPPSPCT DSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.