Details for: LRP6

Gene ID: 4040

Symbol: LRP6

Ensembl ID: ENSG00000070018

Description: LDL receptor related protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 317.6568
    Cell Significance Index: -49.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 192.9481
    Cell Significance Index: -48.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.2412
    Cell Significance Index: -44.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.7006
    Cell Significance Index: -51.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.4732
    Cell Significance Index: -44.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.2285
    Cell Significance Index: -49.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5721
    Cell Significance Index: -49.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.9107
    Cell Significance Index: 287.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7528
    Cell Significance Index: 154.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6992
    Cell Significance Index: 535.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7757
    Cell Significance Index: 356.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0248
    Cell Significance Index: 51.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9590
    Cell Significance Index: 343.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9412
    Cell Significance Index: 18.3700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9228
    Cell Significance Index: 15.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8725
    Cell Significance Index: 94.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8536
    Cell Significance Index: 24.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8339
    Cell Significance Index: 37.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7206
    Cell Significance Index: 498.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.6836
    Cell Significance Index: 4.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5546
    Cell Significance Index: 25.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4610
    Cell Significance Index: 35.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4228
    Cell Significance Index: 58.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3947
    Cell Significance Index: 215.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3771
    Cell Significance Index: 14.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3661
    Cell Significance Index: 24.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3644
    Cell Significance Index: 65.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3397
    Cell Significance Index: 23.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3232
    Cell Significance Index: 14.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2603
    Cell Significance Index: 235.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2466
    Cell Significance Index: 11.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2419
    Cell Significance Index: 6.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2072
    Cell Significance Index: 7.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2036
    Cell Significance Index: 25.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2030
    Cell Significance Index: 89.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1261
    Cell Significance Index: 24.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0616
    Cell Significance Index: 39.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0600
    Cell Significance Index: 92.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0550
    Cell Significance Index: 9.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0503
    Cell Significance Index: 92.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0487
    Cell Significance Index: 91.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0171
    Cell Significance Index: 23.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0103
    Cell Significance Index: 4.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0089
    Cell Significance Index: 1.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0048
    Cell Significance Index: 3.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0248
    Cell Significance Index: -18.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0343
    Cell Significance Index: -4.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0426
    Cell Significance Index: -32.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0484
    Cell Significance Index: -0.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0541
    Cell Significance Index: -30.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0574
    Cell Significance Index: -1.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0624
    Cell Significance Index: -1.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0654
    Cell Significance Index: -8.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1029
    Cell Significance Index: -13.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1540
    Cell Significance Index: -44.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1657
    Cell Significance Index: -34.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1752
    Cell Significance Index: -11.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2672
    Cell Significance Index: -5.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2767
    Cell Significance Index: -32.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2773
    Cell Significance Index: -31.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3289
    Cell Significance Index: -33.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3366
    Cell Significance Index: -38.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3452
    Cell Significance Index: -5.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3484
    Cell Significance Index: -24.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3896
    Cell Significance Index: -20.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4026
    Cell Significance Index: -41.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4217
    Cell Significance Index: -9.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4250
    Cell Significance Index: -50.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4748
    Cell Significance Index: -16.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4923
    Cell Significance Index: -36.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5148
    Cell Significance Index: -14.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5243
    Cell Significance Index: -8.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5345
    Cell Significance Index: -13.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5653
    Cell Significance Index: -8.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5785
    Cell Significance Index: -45.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6387
    Cell Significance Index: -33.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6811
    Cell Significance Index: -17.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6870
    Cell Significance Index: -21.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6964
    Cell Significance Index: -44.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7065
    Cell Significance Index: -23.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7417
    Cell Significance Index: -38.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.7436
    Cell Significance Index: -11.9300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8091
    Cell Significance Index: -13.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8271
    Cell Significance Index: -50.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8311
    Cell Significance Index: -17.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8781
    Cell Significance Index: -28.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9060
    Cell Significance Index: -25.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9317
    Cell Significance Index: -32.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9538
    Cell Significance Index: -18.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0166
    Cell Significance Index: -27.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0394
    Cell Significance Index: -22.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0640
    Cell Significance Index: -28.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0804
    Cell Significance Index: -24.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0828
    Cell Significance Index: -29.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0864
    Cell Significance Index: -21.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1222
    Cell Significance Index: -23.4900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.1372
    Cell Significance Index: -16.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1714
    Cell Significance Index: -29.2200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -1.1941
    Cell Significance Index: -11.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** LRP6 is a transmembrane protein with a large extracellular domain, a single transmembrane domain, and a cytoplasmic tail. 2. **Cellular expression:** LRP6 is widely expressed in various cell types, including neurons, astrocytes, oligodendrocytes, and epithelial cells. 3. **Function:** LRP6 acts as a co-receptor in the Wnt signaling pathway, interacting with Frizzled receptors and Wnt ligands to transmit signals. 4. **Cholesterol transport:** LRP6 is involved in the receptor-mediated endocytosis of low-density lipoprotein (LDL) particles, influencing cholesterol transport and metabolism. **Pathways and Functions:** 1. **Wnt signaling pathway:** LRP6 collaborates with Frizzled receptors to transmit signals from Wnt ligands, influencing cell fate, differentiation, and survival. 2. **Cholesterol transport:** LRP6 is involved in the receptor-mediated endocytosis of LDL particles, influencing cholesterol transport and metabolism. 3. **Neural crest cell development:** LRP6 plays a role in the development of neural crest cells, influencing their migration, differentiation, and survival. 4. **Cancer:** LRP6 is implicated in cancer, influencing tumor growth, metastasis, and treatment resistance. 5. **Cell-cell adhesion:** LRP6 interacts with other proteins to regulate cell-cell adhesion, influencing tissue development and maintenance. **Clinical Significance:** 1. **Wnt signaling disorders:** Mutations in LRP6 have been associated with Wnt signaling disorders, including Wnt1-related disorders and Wnt5a-related disorders. 2. **Cancer:** LRP6 is overexpressed in various types of cancer, including colorectal, breast, and lung cancer, influencing tumor growth and metastasis. 3. **Cholesterol metabolism:** LRP6 mutations have been associated with cholesterol metabolism disorders, including familial hypercholesterolemia. 4. **Neurological disorders:** LRP6 is implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 5. **Regenerative medicine:** LRP6 is being explored as a potential target for regenerative medicine, particularly in the development of therapies for neural crest cell disorders. In conclusion, the LRP6 gene plays a crucial role in various cellular processes, including Wnt signaling, cholesterol transport, and neural crest cell development. Its clinical significance is evident in its involvement in various diseases, including cancer, cholesterol metabolism disorders, and neurological disorders. Further research is needed to fully understand the functions and implications of LRP6 in human disease.

Genular Protein ID: 322401176

Symbol: LRP6_HUMAN

Name: Low-density lipoprotein receptor-related protein 6

UniProtKB Accession Codes:

O75581 Q17RZ2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9704021

Title: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.

PubMed ID: 9704021

DOI: 10.1006/bbrc.1998.9061

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11448771

Title: Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

PubMed ID: 11448771

DOI: 10.1016/s0960-9822(01)00290-1

PubMed ID: 11357136

Title: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.

PubMed ID: 11357136

DOI: 10.1038/35077108

PubMed ID: 12857724

Title: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.

PubMed ID: 12857724

DOI: 10.1074/jbc.m300191200

PubMed ID: 15778503

Title: Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.

PubMed ID: 15778503

DOI: 10.1074/jbc.m413274200

PubMed ID: 15908424

Title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

PubMed ID: 15908424

DOI: 10.1074/jbc.m504308200

PubMed ID: 16341017

Title: A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.

PubMed ID: 16341017

DOI: 10.1038/nature04185

PubMed ID: 16815997

Title: The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

PubMed ID: 16815997

DOI: 10.1101/gad.1411206

PubMed ID: 16513652

Title: Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.

PubMed ID: 16513652

DOI: 10.1074/jbc.m510580200

PubMed ID: 17400545

Title: R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

PubMed ID: 17400545

DOI: 10.1074/jbc.m701927200

PubMed ID: 17326769

Title: Regulated proteolytic processing of LRP6 results in release of its intracellular domain.

PubMed ID: 17326769

DOI: 10.1111/j.1471-4159.2007.04447.x

PubMed ID: 17698587

Title: Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.

PubMed ID: 17698587

DOI: 10.1128/mcb.00773-07

PubMed ID: 17804805

Title: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.

PubMed ID: 17804805

DOI: 10.1073/pnas.0702305104

PubMed ID: 17569865

Title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

PubMed ID: 17569865

DOI: 10.1126/science.1137065

PubMed ID: 18362152

Title: Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

PubMed ID: 18362152

DOI: 10.1074/jbc.m800327200

PubMed ID: 18762581

Title: Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.

PubMed ID: 18762581

DOI: 10.1083/jcb.200803147

PubMed ID: 19107203

Title: Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.

PubMed ID: 19107203

DOI: 10.1371/journal.pone.0004046

PubMed ID: 18378904

Title: Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum.

PubMed ID: 18378904

DOI: 10.1073/pnas.0710389105

PubMed ID: 20059949

Title: Cell cycle control of wnt receptor activation.

PubMed ID: 20059949

DOI: 10.1016/j.devcel.2009.11.006

PubMed ID: 19801552

Title: G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

PubMed ID: 19801552

DOI: 10.1074/jbc.m109.047456

PubMed ID: 19293931

Title: Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

PubMed ID: 19293931

DOI: 10.1371/journal.pone.0004926

PubMed ID: 20093360

Title: Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

PubMed ID: 20093360

DOI: 10.1074/jbc.m109.092130

PubMed ID: 21536646

Title: Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.

PubMed ID: 21536646

DOI: 10.1128/mcb.05103-11

PubMed ID: 22491013

Title: Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin.

PubMed ID: 22491013

DOI: 10.1038/emboj.2012.83

PubMed ID: 22575959

Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

PubMed ID: 22575959

DOI: 10.1038/nature11019

PubMed ID: 23987510

Title: Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

PubMed ID: 23987510

DOI: 10.1016/j.devcel.2013.07.020

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25331957

Title: Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.

PubMed ID: 25331957

DOI: 10.1074/jbc.m114.591636

PubMed ID: 27821587

Title: Caprin-2 positively regulates CDK14/Cyclin Y-mediated LRP5/6 constitutive phosphorylation.

PubMed ID: 27821587

DOI: 10.1074/jbc.m116.744607

PubMed ID: 27524201

Title: Structure of the dual-mode wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and Dickkopf.

PubMed ID: 27524201

DOI: 10.1016/j.str.2016.06.020

PubMed ID: 28341812

Title: Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.

PubMed ID: 28341812

DOI: 10.15252/embr.201643585

PubMed ID: 30069874

Title: Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.

PubMed ID: 30069874

DOI: 10.1002/1873-3468.13212

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 22000856

Title: Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

PubMed ID: 22000856

DOI: 10.1016/j.devcel.2011.09.003

PubMed ID: 17332414

Title: LRP6 mutation in a family with early coronary disease and metabolic risk factors.

PubMed ID: 17332414

DOI: 10.1126/science.1136370

PubMed ID: 23703864

Title: Rare nonconservative LRP6 mutations are associated with metabolic syndrome.

PubMed ID: 23703864

DOI: 10.1002/humu.22360

PubMed ID: 26387593

Title: Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.

PubMed ID: 26387593

DOI: 10.1016/j.ajhg.2015.08.014

PubMed ID: 29983323

Title: De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

PubMed ID: 29983323

DOI: 10.1016/j.neuron.2018.06.019

Sequence Information:

  • Length: 1613
  • Mass: 180429
  • Checksum: 413D2CF70A5D8B5C
  • Sequence:
    • MGAVLRSLLA CSFCVLLRAA PLLLYANRRD LRLVDATNGK ENATIVVGGL EDAAAVDFVF 
SHGLIYWSDV SEEAIKRTEF NKTESVQNVV VSGLLSPDGL ACDWLGEKLY WTDSETNRIE 
VSNLDGSLRK VLFWQELDQP RAIALDPSSG FMYWTDWGEV PKIERAGMDG SSRFIIINSE 
IYWPNGLTLD YEEQKLYWAD AKLNFIHKSN LDGTNRQAVV KGSLPHPFAL TLFEDILYWT 
DWSTHSILAC NKYTGEGLRE IHSDIFSPMD IHAFSQQRQP NATNPCGIDN GGCSHLCLMS 
PVKPFYQCAC PTGVKLLENG KTCKDGATEL LLLARRTDLR RISLDTPDFT DIVLQLEDIR 
HAIAIDYDPV EGYIYWTDDE VRAIRRSFID GSGSQFVVTA QIAHPDGIAV DWVARNLYWT 
DTGTDRIEVT RLNGTMRKIL ISEDLEEPRA IVLDPMVGYM YWTDWGEIPK IERAALDGSD 
RVVLVNTSLG WPNGLALDYD EGKIYWGDAK TDKIEVMNTD GTGRRVLVED KIPHIFGFTL 
LGDYVYWTDW QRRSIERVHK RSAEREVIID QLPDLMGLKA TNVHRVIGSN PCAEENGGCS 
HLCLYRPQGL RCACPIGFEL ISDMKTCIVP EAFLLFSRRA DIRRISLETN NNNVAIPLTG 
VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV EFGLDYPEGM AVDWLGKNLY 
WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP RALALDPAEG FMYWTEWGGK PKIDRAAMDG 
SERTTLVPNV GRANGLTIDY AKRRLYWTDL DTNLIESSNM LGLNREVIAD DLPHPFGLTQ 
YQDYIYWTDW SRRSIERANK TSGQNRTIIQ GHLDYVMDIL VFHSSRQSGW NECASSNGHC 
SHLCLAVPVG GFVCGCPAHY SLNADNRTCS APTTFLLFSQ KSAINRMVID EQQSPDIILP 
IHSLRNVRAI DYDPLDKQLY WIDSRQNMIR KAQEDGSQGF TVVVSSVPSQ NLEIQPYDLS 
IDIYSRYIYW TCEATNVINV TRLDGRSVGV VLKGEQDRPR AVVVNPEKGY MYFTNLQERS 
PKIERAALDG TEREVLFFSG LSKPIALALD SRLGKLFWAD SDLRRIESSD LSGANRIVLE 
DSNILQPVGL TVFENWLYWI DKQQQMIEKI DMTGREGRTK VQARIAQLSD IHAVKELNLQ 
EYRQHPCAQD NGGCSHICLV KGDGTTRCSC PMHLVLLQDE LSCGEPPTCS PQQFTCFTGE 
IDCIPVAWRC DGFTECEDHS DELNCPVCSE SQFQCASGQC IDGALRCNGD ANCQDKSDEK 
NCEVLCLIDQ FRCANGQCIG KHKKCDHNVD CSDKSDELDC YPTEEPAPQA TNTVGSVIGV 
IVTIFVSGTV YFICQRMLCP RMKGDGETMT NDYVVHGPAS VPLGYVPHPS SLSGSLPGMS 
RGKSMISSLS IMGGSSGPPY DRAHVTGASS SSSSSTKGTY FPAILNPPPS PATERSHYTM 
EFGYSSNSPS THRSYSYRPY SYRHFAPPTT PCSTDVCDSD YAPSRRMTSV ATAKGYTSDL 
NYDSEPVPPP PTPRSQYLSA EENYESCPPS PYTERSYSHH LYPPPPSPCT DSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.