Details for: LSAMP

Gene ID: 4045

Symbol: LSAMP

Ensembl ID: ENSG00000185565

Description: limbic system associated membrane protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 9.11
    Marker Score: 20,936
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.81
    Marker Score: 156,431
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 8.53
    Marker Score: 45,815
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 8.27
    Marker Score: 5,439
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.56
    Marker Score: 57,004
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.53
    Marker Score: 25,234
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 6.62
    Marker Score: 3,683
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.38
    Marker Score: 33,449
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 6.17
    Marker Score: 2,037
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.9
    Marker Score: 22,660
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.77
    Marker Score: 3,592
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.66
    Marker Score: 2,241
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.61
    Marker Score: 2,680
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.43
    Marker Score: 10,611
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.18
    Marker Score: 5,208
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.07
    Marker Score: 1,825
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.93
    Marker Score: 1,019
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.85
    Marker Score: 2,156
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 3.39
    Marker Score: 1,029
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69,860
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.19
    Marker Score: 9,109
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.14
    Marker Score: 5,271
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.9
    Marker Score: 5,499
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.9
    Marker Score: 57,672
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,049
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42,801
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.85
    Marker Score: 904
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.84
    Marker Score: 2,463
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.79
    Marker Score: 1,634
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,361
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.68
    Marker Score: 3,317
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.67
    Marker Score: 5,133
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.61
    Marker Score: 10,816
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.53
    Marker Score: 1,060
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.52
    Marker Score: 2,905
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.5
    Marker Score: 3,524
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,629
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9,117
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.34
    Marker Score: 1,325
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.27
    Marker Score: 2,738
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.26
    Marker Score: 575
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.24
    Marker Score: 3,856
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,639
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.19
    Marker Score: 4,458
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.19
    Marker Score: 3,040
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.12
    Marker Score: 21,847
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,941
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.07
    Marker Score: 2,505
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.07
    Marker Score: 1,950
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.05
    Marker Score: 1,224
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.04
    Marker Score: 8,300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,302
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.92
    Marker Score: 8,031
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.89
    Marker Score: 3,848
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.89
    Marker Score: 517
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.86
    Marker Score: 715
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,947
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.79
    Marker Score: 647
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.75
    Marker Score: 7,294
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.7
    Marker Score: 695
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.69
    Marker Score: 1,017
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.68
    Marker Score: 871
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.65
    Marker Score: 1,405
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.61
    Marker Score: 1,476
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.6
    Marker Score: 776
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,390
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.53
    Marker Score: 4,016
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.53
    Marker Score: 491
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.53
    Marker Score: 1,887
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.52
    Marker Score: 1,624
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.45
    Marker Score: 1,439
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.45
    Marker Score: 1,945
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165,367
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.44
    Marker Score: 499
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.43
    Marker Score: 418
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.41
    Marker Score: 1,322
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.38
    Marker Score: 5,356
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.38
    Marker Score: 1,667
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.37
    Marker Score: 21,985
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3,072
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20,236
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.28
    Marker Score: 2,820
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.25
    Marker Score: 831
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.23
    Marker Score: 385
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.23
    Marker Score: 1,377
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.21
    Marker Score: 383
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.2
    Marker Score: 1,566
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.19
    Marker Score: 494
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.17
    Marker Score: 679
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.17
    Marker Score: 468
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.14
    Marker Score: 1,096
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.13
    Marker Score: 38,277
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11,203
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1
    Marker Score: 6,587
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.09
    Marker Score: 1,414
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.08
    Marker Score: 14,185
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,692
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.04
    Marker Score: 1,507
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.01
    Marker Score: 295

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The LSAMP protein exhibits several distinct characteristics that set it apart from other transmembrane proteins. Its extracellular domain is rich in cysteine residues, which are crucial for the formation of disulfide bonds, essential for protein stability and function. The cytoplasmic tail of LSAMP contains a unique motif, which is involved in the regulation of protein synthesis and modification. Notably, LSAMP is a GPI-anchored protein, meaning that it is attached to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor, which enables its tethering to the plasma membrane. **Pathways and Functions** LSAMP is implicated in various cellular processes, including cell adhesion, protein binding, and post-translational modification. The protein's extracellular domain interacts with other proteins, such as cadherins and integrins, to regulate cell-cell adhesion and migration. The cytoplasmic tail of LSAMP is involved in the regulation of protein synthesis and modification, including the synthesis of GPI-anchored proteins. Additionally, LSAMP has been shown to interact with other proteins involved in the nervous system, such as B7Z661, which is a member of the B7 family of immune regulatory molecules. **Clinical Significance** The clinical significance of LSAMP is an area of active research, with potential implications for the diagnosis and treatment of various neurological disorders. Studies have shown that LSAMP is significantly expressed in cells associated with the limbic system, which is involved in emotion, motivation, and memory. Abnormalities in LSAMP expression have been linked to several neurological conditions, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Furthermore, the protein's interaction with other immune regulatory molecules, such as B7Z661, suggests that LSAMP may play a role in the regulation of the immune response in the nervous system. In conclusion, LSAMP is a complex protein that plays a critical role in various cellular processes, including cell adhesion, protein binding, and post-translational modification. Its clinical significance is an area of active research, with potential implications for the diagnosis and treatment of various neurological disorders. Further studies are needed to fully elucidate the functions and mechanisms of LSAMP, but its unique characteristics and widespread expression make it an exciting area of investigation for immunologists and neuroscientists alike.

Genular Protein ID: 659216728

Symbol: LSAMP_HUMAN

Name: Limbic system-associated membrane protein

UniProtKB Accession Codes:

Q13449 Q8IV49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666243

Title: cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP).

PubMed ID: 8666243

DOI: 10.1016/0378-1119(96)84698-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 32383616

Title: Limbic System Associated Membrane Protein Mutation in an Iranian Family Diagnosed with Meniere's Disease.

PubMed ID: 32383616

DOI: 10.34172/aim.2020.21

Sequence Information:

  • Length: 338
  • Mass: 37393
  • Checksum: 88CF00E07302817B
  • Sequence:
    • MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS 
KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK 
TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE 
YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE 
ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN 
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

Genular Protein ID: 864117913

Symbol: B7Z661_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z661

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 358
  • Mass: 39714
  • Checksum: 0D21313EE36C52B2
  • Sequence:
    • MRTYWLHSVW VLGFFLSLFS LQGLPVRSVD FNRGTDNITV RQGDTAILRC VVEDKNSKVA 
WLNRSGIIFA GHDKWSLDPR VELEKRHSLE YSLRIQKVDV YDEGSYTCSV QTQHEPKTSQ 
VYLIVQVPPK ISNISSDVTV NEGSNVTLVC MANGRPEPVI TWRHLTPTGR EFEGEEEYLE 
ILGITREQSG KYECKAANEV PSADVKQVKV TVNYPPTITE SKSNEATTGR QASLKCEASA 
VPAPDFEWYR DDTRINSANG LEIKSTEGQS SLTVTNVTEE HYGNYTCVAA NKLGVTNASL 
VLFKRVLPTI PHPIQEIGTT VHFKQKGPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.