Details for: LSAMP

Gene ID: 4045

Symbol: LSAMP

Ensembl ID: ENSG00000185565

Description: limbic system associated membrane protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1136.8398
    Cell Significance Index: -176.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 698.5792
    Cell Significance Index: -177.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 451.4895
    Cell Significance Index: -185.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 368.2729
    Cell Significance Index: -173.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 361.5444
    Cell Significance Index: -146.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 35.6360
    Cell Significance Index: 48454.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.3274
    Cell Significance Index: -72.9400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 11.9033
    Cell Significance Index: 166.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 10.8483
    Cell Significance Index: 608.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 8.6078
    Cell Significance Index: 578.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 7.8540
    Cell Significance Index: 2817.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 7.5639
    Cell Significance Index: 181.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 7.3799
    Cell Significance Index: 210.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 6.7193
    Cell Significance Index: 413.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.3233
    Cell Significance Index: 201.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.0013
    Cell Significance Index: 221.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.3162
    Cell Significance Index: 2985.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.7261
    Cell Significance Index: 747.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.8410
    Cell Significance Index: 31.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7428
    Cell Significance Index: 1398.6000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.7382
    Cell Significance Index: 7.6900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.6655
    Cell Significance Index: 8.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5948
    Cell Significance Index: 377.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0638
    Cell Significance Index: 98.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0120
    Cell Significance Index: 22.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1697
    Cell Significance Index: -125.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2042
    Cell Significance Index: -115.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2059
    Cell Significance Index: -128.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.2207
    Cell Significance Index: -161.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.2644
    Cell Significance Index: -200.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2986
    Cell Significance Index: -15.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.3245
    Cell Significance Index: -177.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.3517
    Cell Significance Index: -155.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4074
    Cell Significance Index: -80.8500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4595
    Cell Significance Index: -5.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4928
    Cell Significance Index: -71.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4941
    Cell Significance Index: -57.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5279
    Cell Significance Index: -151.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5623
    Cell Significance Index: -72.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.5705
    Cell Significance Index: -102.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.6450
    Cell Significance Index: -88.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.7248
    Cell Significance Index: -74.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.8178
    Cell Significance Index: -172.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.9971
    Cell Significance Index: -122.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0262
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -1.0675
    Cell Significance Index: -182.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -1.2587
    Cell Significance Index: -162.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.2639
    Cell Significance Index: -16.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2846
    Cell Significance Index: -98.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.3945
    Cell Significance Index: -164.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5318
    Cell Significance Index: -159.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.5411
    Cell Significance Index: -19.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.7367
    Cell Significance Index: -198.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.8234
    Cell Significance Index: -208.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.9759
    Cell Significance Index: -39.0700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.9766
    Cell Significance Index: -23.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.0222
    Cell Significance Index: -54.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.0805
    Cell Significance Index: -164.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -2.1535
    Cell Significance Index: -160.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.1567
    Cell Significance Index: -37.2900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -2.2448
    Cell Significance Index: -16.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.3274
    Cell Significance Index: -26.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.4383
    Cell Significance Index: -51.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.4835
    Cell Significance Index: -49.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.4852
    Cell Significance Index: -79.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -2.6120
    Cell Significance Index: -184.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.6964
    Cell Significance Index: -88.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.7994
    Cell Significance Index: -40.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.8046
    Cell Significance Index: -146.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -2.9040
    Cell Significance Index: -44.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -2.9109
    Cell Significance Index: -36.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.9203
    Cell Significance Index: -179.0400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -2.9702
    Cell Significance Index: -28.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.9732
    Cell Significance Index: -83.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -3.1287
    Cell Significance Index: -98.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -3.2753
    Cell Significance Index: -170.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -3.2946
    Cell Significance Index: -71.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.3222
    Cell Significance Index: -209.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -3.3426
    Cell Significance Index: -42.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -3.3824
    Cell Significance Index: -158.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -3.4011
    Cell Significance Index: -32.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.4289
    Cell Significance Index: -120.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -3.6817
    Cell Significance Index: -166.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -3.7689
    Cell Significance Index: -163.8800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -3.8833
    Cell Significance Index: -46.4400
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -4.0500
    Cell Significance Index: -45.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -4.2408
    Cell Significance Index: -105.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -4.3807
    Cell Significance Index: -91.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -4.4383
    Cell Significance Index: -154.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -4.8740
    Cell Significance Index: -227.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.0644
    Cell Significance Index: -185.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -5.2037
    Cell Significance Index: -111.2300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -5.2463
    Cell Significance Index: -56.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -5.3617
    Cell Significance Index: -140.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -5.4312
    Cell Significance Index: -155.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.7812
    Cell Significance Index: -170.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -5.8366
    Cell Significance Index: -97.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -5.8734
    Cell Significance Index: -48.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -5.9087
    Cell Significance Index: -151.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The LSAMP protein exhibits several distinct characteristics that set it apart from other transmembrane proteins. Its extracellular domain is rich in cysteine residues, which are crucial for the formation of disulfide bonds, essential for protein stability and function. The cytoplasmic tail of LSAMP contains a unique motif, which is involved in the regulation of protein synthesis and modification. Notably, LSAMP is a GPI-anchored protein, meaning that it is attached to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor, which enables its tethering to the plasma membrane. **Pathways and Functions** LSAMP is implicated in various cellular processes, including cell adhesion, protein binding, and post-translational modification. The protein's extracellular domain interacts with other proteins, such as cadherins and integrins, to regulate cell-cell adhesion and migration. The cytoplasmic tail of LSAMP is involved in the regulation of protein synthesis and modification, including the synthesis of GPI-anchored proteins. Additionally, LSAMP has been shown to interact with other proteins involved in the nervous system, such as B7Z661, which is a member of the B7 family of immune regulatory molecules. **Clinical Significance** The clinical significance of LSAMP is an area of active research, with potential implications for the diagnosis and treatment of various neurological disorders. Studies have shown that LSAMP is significantly expressed in cells associated with the limbic system, which is involved in emotion, motivation, and memory. Abnormalities in LSAMP expression have been linked to several neurological conditions, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Furthermore, the protein's interaction with other immune regulatory molecules, such as B7Z661, suggests that LSAMP may play a role in the regulation of the immune response in the nervous system. In conclusion, LSAMP is a complex protein that plays a critical role in various cellular processes, including cell adhesion, protein binding, and post-translational modification. Its clinical significance is an area of active research, with potential implications for the diagnosis and treatment of various neurological disorders. Further studies are needed to fully elucidate the functions and mechanisms of LSAMP, but its unique characteristics and widespread expression make it an exciting area of investigation for immunologists and neuroscientists alike.

Genular Protein ID: 659216728

Symbol: LSAMP_HUMAN

Name: Limbic system-associated membrane protein

UniProtKB Accession Codes:

Q13449 Q8IV49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666243

Title: cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP).

PubMed ID: 8666243

DOI: 10.1016/0378-1119(96)84698-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 32383616

Title: Limbic System Associated Membrane Protein Mutation in an Iranian Family Diagnosed with Meniere's Disease.

PubMed ID: 32383616

DOI: 10.34172/aim.2020.21

Sequence Information:

  • Length: 338
  • Mass: 37393
  • Checksum: 88CF00E07302817B
  • Sequence:
    • MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS 
KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK 
TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE 
YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE 
ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN 
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

Genular Protein ID: 864117913

Symbol: B7Z661_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z661

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 358
  • Mass: 39714
  • Checksum: 0D21313EE36C52B2
  • Sequence:
    • MRTYWLHSVW VLGFFLSLFS LQGLPVRSVD FNRGTDNITV RQGDTAILRC VVEDKNSKVA 
WLNRSGIIFA GHDKWSLDPR VELEKRHSLE YSLRIQKVDV YDEGSYTCSV QTQHEPKTSQ 
VYLIVQVPPK ISNISSDVTV NEGSNVTLVC MANGRPEPVI TWRHLTPTGR EFEGEEEYLE 
ILGITREQSG KYECKAANEV PSADVKQVKV TVNYPPTITE SKSNEATTGR QASLKCEASA 
VPAPDFEWYR DDTRINSANG LEIKSTEGQS SLTVTNVTEE HYGNYTCVAA NKLGVTNASL 
VLFKRVLPTI PHPIQEIGTT VHFKQKGPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.