Details for: LSAMP

Gene ID: 4045

Symbol: LSAMP

Ensembl ID: ENSG00000185565

Description: limbic system associated membrane protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 9.11
    Marker Score: 20936
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.81
    Marker Score: 156431
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 8.53
    Marker Score: 45815
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 8.27
    Marker Score: 5439
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.56
    Marker Score: 57004
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.53
    Marker Score: 25234
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 6.62
    Marker Score: 3683
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.38
    Marker Score: 33449
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 6.17
    Marker Score: 2037
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.9
    Marker Score: 22660
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.77
    Marker Score: 3592
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.66
    Marker Score: 2241
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.61
    Marker Score: 2680
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.43
    Marker Score: 10611
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.18
    Marker Score: 5208
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.07
    Marker Score: 1825
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.93
    Marker Score: 1019
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.85
    Marker Score: 2156
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 3.39
    Marker Score: 1029
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69860
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.19
    Marker Score: 9108.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.14
    Marker Score: 5271
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.9
    Marker Score: 5499
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.9
    Marker Score: 57672
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22049
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42801
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.85
    Marker Score: 904
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.84
    Marker Score: 2463
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.79
    Marker Score: 1634
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104361
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.68
    Marker Score: 3317
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.67
    Marker Score: 5133
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.61
    Marker Score: 10816
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.53
    Marker Score: 1060
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.52
    Marker Score: 2905
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.5
    Marker Score: 3524
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90629
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9117
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.34
    Marker Score: 1325
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.27
    Marker Score: 2738
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.26
    Marker Score: 575
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.24
    Marker Score: 3856
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20639
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.19
    Marker Score: 4458
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.19
    Marker Score: 3040
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.12
    Marker Score: 21847
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127941
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.07
    Marker Score: 2505
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.07
    Marker Score: 1950
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.05
    Marker Score: 1224
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.04
    Marker Score: 8299.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18302
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.92
    Marker Score: 8031
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.89
    Marker Score: 3848
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.89
    Marker Score: 517
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.86
    Marker Score: 715
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15947
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.79
    Marker Score: 646.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.75
    Marker Score: 7294
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.7
    Marker Score: 695
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.69
    Marker Score: 1017
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.68
    Marker Score: 871
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.65
    Marker Score: 1405
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.61
    Marker Score: 1476
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.6
    Marker Score: 776
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2390
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.53
    Marker Score: 4015.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.53
    Marker Score: 491
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.53
    Marker Score: 1887
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.52
    Marker Score: 1624
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.45
    Marker Score: 1439
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.45
    Marker Score: 1945
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165367
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.44
    Marker Score: 499
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.43
    Marker Score: 418
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.41
    Marker Score: 1322
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.38
    Marker Score: 5356
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.38
    Marker Score: 1667
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.37
    Marker Score: 21985
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3072
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20236
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.28
    Marker Score: 2820
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.25
    Marker Score: 831
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.23
    Marker Score: 385
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.23
    Marker Score: 1377
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.21
    Marker Score: 383
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.2
    Marker Score: 1566
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.19
    Marker Score: 494
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.17
    Marker Score: 679
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.17
    Marker Score: 468
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.14
    Marker Score: 1096
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.13
    Marker Score: 38277
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11203
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1
    Marker Score: 6587
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.09
    Marker Score: 1414
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.08
    Marker Score: 14185
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251692
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.04
    Marker Score: 1507
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.01
    Marker Score: 295

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Other Information

**Key characteristics:** * LSAMP is a type I transmembrane protein. * It is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. * It is a key component of the post-translational modification of proteins. **Pathways and functions:** * LSAMP is involved in cell adhesion. It is a component of the cadherin family of cell adhesion molecules. * It is also involved in the cytosol, extracellular region, and plasma membrane. * It is a key regulator of synaptic plasticity and memory. * It is involved in the regulation of neurotransmitter release and uptake. * It is also involved in the development and function of the cardiovascular and pulmonary systems. **Clinical significance:** * Mutations in the LSAMP gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * LSAMP is a potential therapeutic target for these disorders. **Additional information:** * The LSAMP gene is located on chromosome 19q21.1. * It is a relatively large protein, with a molecular weight of approximately 150 kDa. * It is a transmembrane protein that is expressed in both the extracellular and intracellular domains. * It is a highly conserved protein, with a similar sequence found in mammals, birds, and fish.

Genular Protein ID: 659216728

Symbol: LSAMP_HUMAN

Name: Limbic system-associated membrane protein

UniProtKB Accession Codes:

Q13449 Q8IV49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666243

Title: cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP).

PubMed ID: 8666243

DOI: 10.1016/0378-1119(96)84698-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 32383616

Title: Limbic System Associated Membrane Protein Mutation in an Iranian Family Diagnosed with Meniere's Disease.

PubMed ID: 32383616

DOI: 10.34172/aim.2020.21

Sequence Information:

  • Length: 338
  • Mass: 37393
  • Checksum: 88CF00E07302817B
  • Sequence:
    • MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS 
KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK 
TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE 
YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE 
ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN 
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

Genular Protein ID: 864117913

Symbol: B7Z661_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z661

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 358
  • Mass: 39714
  • Checksum: 0D21313EE36C52B2
  • Sequence:
    • MRTYWLHSVW VLGFFLSLFS LQGLPVRSVD FNRGTDNITV RQGDTAILRC VVEDKNSKVA 
WLNRSGIIFA GHDKWSLDPR VELEKRHSLE YSLRIQKVDV YDEGSYTCSV QTQHEPKTSQ 
VYLIVQVPPK ISNISSDVTV NEGSNVTLVC MANGRPEPVI TWRHLTPTGR EFEGEEEYLE 
ILGITREQSG KYECKAANEV PSADVKQVKV TVNYPPTITE SKSNEATTGR QASLKCEASA 
VPAPDFEWYR DDTRINSANG LEIKSTEGQS SLTVTNVTEE HYGNYTCVAA NKLGVTNASL 
VLFKRVLPTI PHPIQEIGTT VHFKQKGPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.