Details for: LTBP1

Gene ID: 4052

Symbol: LTBP1

Ensembl ID: ENSG00000049323

Description: latent transforming growth factor beta binding protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.9
    Marker Score: 32,971
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.87
    Marker Score: 2,188
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.76
    Marker Score: 83,954
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.53
    Marker Score: 10,467
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.29
    Marker Score: 3,136
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.21
    Marker Score: 13,450
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.07
    Marker Score: 5,912
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.79
    Marker Score: 882
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.58
    Marker Score: 7,356
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.56
    Marker Score: 9,090
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.16
    Marker Score: 6,195
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.14
    Marker Score: 1,158
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.02
    Marker Score: 4,747
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.01
    Marker Score: 35,609
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.97
    Marker Score: 5,162
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.89
    Marker Score: 2,092
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.88
    Marker Score: 2,339
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.84
    Marker Score: 39,178
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.83
    Marker Score: 624
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.83
    Marker Score: 1,019
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.77
    Marker Score: 3,880
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.76
    Marker Score: 2,422
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.74
    Marker Score: 1,863
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.73
    Marker Score: 1,137
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.67
    Marker Score: 1,102
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.67
    Marker Score: 385
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.66
    Marker Score: 968
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.65
    Marker Score: 1,355
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.62
    Marker Score: 419
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.6
    Marker Score: 665
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.57
    Marker Score: 2,958
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.57
    Marker Score: 1,115
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.57
    Marker Score: 1,475
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.56
    Marker Score: 590
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.5
    Marker Score: 1,278
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.49
    Marker Score: 1,712
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.47
    Marker Score: 1,783
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,890
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.46
    Marker Score: 414
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.46
    Marker Score: 2,960
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.35
    Marker Score: 1,818
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.35
    Marker Score: 21,057
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.34
    Marker Score: 342
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.34
    Marker Score: 844
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.33
    Marker Score: 3,629
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.33
    Marker Score: 2,262
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.28
    Marker Score: 1,102
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.27
    Marker Score: 2,643
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.24
    Marker Score: 389
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.24
    Marker Score: 18,558
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.22
    Marker Score: 511
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.19
    Marker Score: 5,150
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.19
    Marker Score: 15,775
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.19
    Marker Score: 7,711
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.16
    Marker Score: 7,449
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.13
    Marker Score: 6,086
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.12
    Marker Score: 327
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.11
    Marker Score: 744
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.11
    Marker Score: 963
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.09
    Marker Score: 6,573
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.08
    Marker Score: 1,046
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.08
    Marker Score: 603
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.07
    Marker Score: 267
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2,514
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.06
    Marker Score: 595
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.06
    Marker Score: 267
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.05
    Marker Score: 694
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 632
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.05
    Marker Score: 236
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.04
    Marker Score: 1,826
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 258
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.04
    Marker Score: 1,288
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.04
    Marker Score: 4,084
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.04
    Marker Score: 721
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,740
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,764
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1
    Marker Score: 429
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,988
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.99
    Marker Score: 747
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.97
    Marker Score: 1,034
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1,494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.95
    Marker Score: 2,387
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.95
    Marker Score: 471
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.93
    Marker Score: 445
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 260
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.92
    Marker Score: 1,132
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.9
    Marker Score: 1,059
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.9
    Marker Score: 1,389
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.89
    Marker Score: 180
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 282
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.87
    Marker Score: 408
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,946
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.86
    Marker Score: 3,724

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LTBP1 is a secreted protein that belongs to the latent transforming growth factor beta binding protein family. It is characterized by its ability to bind to TGF-β, preventing its activation and subsequent signaling. LTBP1 is highly expressed in various tissues, including the retina, heart, kidney, and smooth muscle cells. It is also involved in the regulation of insulin-like growth factor (IGF) transport and uptake, as well as the sequestration of TGF-β in the extracellular matrix. **Pathways and Functions:** LTBP1 is involved in several signaling pathways, including: 1. **TGF-β signaling**: LTBP1 binds to TGF-β, preventing its activation and subsequent signaling. This modulates TGF-β's role in tissue development, fibrosis, and cell growth. 2. **IGF signaling**: LTBP1 regulates IGF transport and uptake, influencing cell growth and differentiation. 3. **Extracellular matrix organization**: LTBP1 is involved in the formation and organization of the extracellular matrix, which provides structural support and regulates cell signaling. 4. **Cell adhesion and migration**: LTBP1 interacts with cell surface receptors, influencing cell adhesion and migration. **Clinical Significance:** Dysregulation of LTBP1 has been implicated in various diseases, including: 1. **Fibrosis**: LTBP1 plays a critical role in regulating fibrogenesis, and its dysregulation can lead to fibrotic diseases, such as pulmonary fibrosis and liver cirrhosis. 2. **Cardiovascular disease**: LTBP1 is involved in the regulation of cardiac development and function, and its dysregulation can contribute to cardiac fibrosis and dysfunction. 3. **Cancer**: LTBP1 has been implicated in cancer progression, as it regulates cell growth, differentiation, and migration. 4. **Ocular diseases**: LTBP1 is involved in the regulation of retinal development and function, and its dysregulation can contribute to ocular diseases, such as glaucoma and age-related macular degeneration. In conclusion, LTBP1 is a multifunctional protein that plays a critical role in regulating TGF-β signaling, IGF transport, and extracellular matrix organization. Its dysregulation has been implicated in various diseases, highlighting the importance of LTBP1 in maintaining tissue homeostasis and preventing disease pathogenesis.

Genular Protein ID: 2847119477

Symbol: LTBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14766 A1L3V1 P22064 Q53SD8 Q53SF3 Q53SG1 Q59HF7 Q8TD95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 6 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2350783

Title: TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.

PubMed ID: 2350783

DOI: 10.1016/0092-8674(90)90069-q

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8537398

Title: Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.

PubMed ID: 8537398

DOI: 10.1074/jbc.270.52.31294

PubMed ID: 2022183

Title: A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

PubMed ID: 2022183

DOI: 10.1002/j.1460-2075.1991.tb08049.x

PubMed ID: 8617200

Title: Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

PubMed ID: 8617200

DOI: 10.1002/j.1460-2075.1996.tb00355.x

PubMed ID: 8939931

Title: Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1.

PubMed ID: 8939931

DOI: 10.1074/jbc.271.47.29891

PubMed ID: 10743502

Title: Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action.

PubMed ID: 10743502

DOI: 10.1016/s1359-6101(99)00010-6

PubMed ID: 11104663

Title: The latent transforming growth factor beta binding protein (LTBP) family.

PubMed ID: 11104663

DOI: 10.1042/bj3520601

PubMed ID: 10677208

Title: Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells.

PubMed ID: 10677208

DOI: 10.1021/bi9918285

PubMed ID: 10930463

Title: Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

PubMed ID: 10930463

DOI: 10.1091/mbc.11.8.2691

PubMed ID: 12429738

Title: Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

PubMed ID: 12429738

DOI: 10.1074/jbc.m209256200

PubMed ID: 15184403

Title: Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

PubMed ID: 15184403

DOI: 10.1083/jcb.200312172

PubMed ID: 16157329

Title: Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

PubMed ID: 16157329

DOI: 10.1016/j.yexcr.2005.08.008

PubMed ID: 15567420

Title: Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.

PubMed ID: 15567420

DOI: 10.1016/j.jmb.2004.10.039

PubMed ID: 17293099

Title: LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

PubMed ID: 17293099

DOI: 10.1016/j.matbio.2006.12.006

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18677313

Title: ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation.

PubMed ID: 18677313

DOI: 10.1038/ng.199

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 34411563

Title: POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

PubMed ID: 34411563

DOI: 10.1016/j.jbc.2021.101055

PubMed ID: 14607119

Title: Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta.

PubMed ID: 14607119

DOI: 10.1016/j.jmb.2003.09.053

PubMed ID: 33991472

Title: Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome.

PubMed ID: 33991472

DOI: 10.1016/j.ajhg.2021.04.016

Sequence Information:

  • Length: 1721
  • Mass: 186796
  • Checksum: 432489CAC3023754
  • Sequence:
    • MAGAWLRWGL LLWAGLLASS AHGRLRRITY VVHPGPGLAA GALPLSGPPR SRTFNVALNA 
RYSRSSAAAG APSRASPGVP SERTRRTSKP GGAALQGLRP PPPPPPEPAR PAVPGGQLHP 
NPGGHPAAAP FTKQGRQVVR SKVPQETQSG GGSRLQVHQK QQLQGVNVCG GRCCHGWSKA 
PGSQRCTKPS CVPPCQNGGM CLRPQLCVCK PGTKGKACET IAAQDTSSPV FGGQSPGAAS 
SWGPPEQAAK HTSSKKADTL PRVSPVAQMT LTLKPKPSVG LPQQIHSQVT PLSSQSVVIH 
HGQTQEYVLK PKYFPAQKGI SGEQSTEGSF PLRYVQDQVA APFQLSNHTG RIKVVFTPSI 
CKVTCTKGSC QNSCEKGNTT TLISENGHAA DTLTATNFRV VICHLPCMNG GQCSSRDKCQ 
CPPNFTGKLC QIPVHGASVP KLYQHSQQPG KALGTHVIHS THTLPLTVTS QQGVKVKFPP 
NIVNIHVKHP PEASVQIHQV SRIDGPTGQK TKEAQPGQSQ VSYQGLPVQK TQTIHSTYSH 
QQVIPHVYPV AAKTQLGRCF QETIGSQCGK ALPGLSKQED CCGTVGTSWG FNKCQKCPKK 
PSYHGYNQMM ECLPGYKRVN NTFCQDINEC QLQGVCPNGE CLNTMGSYRC TCKIGFGPDP 
TFSSCVPDPP VISEEKGPCY RLVSSGRQCM HPLSVHLTKQ LCCCSVGKAW GPHCEKCPLP 
GTAAFKEICP GGMGYTVSGV HRRRPIHHHV GKGPVFVKPK NTQPVAKSTH PPPLPAKEEP 
VEALTFSREH GPGVAEPEVA TAPPEKEIPS LDQEKTKLEP GQPQLSPGIS TIHLHPQFPV 
VIEKTSPPVP VEVAPEASTS SASQVIAPTQ VTEINECTVN PDICGAGHCI NLPVRYTCIC 
YEGYRFSEQQ RKCVDIDECT QVQHLCSQGR CENTEGSFLC ICPAGFMASE EGTNCIDVDE 
CLRPDVCGEG HCVNTVGAFR CEYCDSGYRM TQRGRCEDID ECLNPSTCPD EQCVNSPGSY 
QCVPCTEGFR GWNGQCLDVD ECLEPNVCAN GDCSNLEGSY MCSCHKGYTR TPDHKHCRDI 
DECQQGNLCV NGQCKNTEGS FRCTCGQGYQ LSAAKDQCED IDECQHRHLC AHGQCRNTEG 
SFQCVCDQGY RASGLGDHCE DINECLEDKS VCQRGDCINT AGSYDCTCPD GFQLDDNKTC 
QDINECEHPG LCGPQGECLN TEGSFHCVCQ QGFSISADGR TCEDIDECVN NTVCDSHGFC 
DNTAGSFRCL CYQGFQAPQD GQGCVDVNEC ELLSGVCGEA FCENVEGSFL CVCADENQEY 
SPMTGQCRSR TSTDLDVDVD QPKEEKKECY YNLNDASLCD NVLAPNVTKQ ECCCTSGVGW 
GDNCEIFPCP VLGTAEFTEM CPKGKGFVPA GESSSEAGGE NYKDADECLL FGQEICKNGF 
CLNTRPGYEC YCKQGTYYDP VKLQCFDMDE CQDPSSCIDG QCVNTEGSYN CFCTHPMVLD 
ASEKRCIRPA ESNEQIEETD VYQDLCWEHL SDEYVCSRPL VGKQTTYTEC CCLYGEAWGM 
QCALCPLKDS DDYAQLCNIP VTGRRQPYGR DALVDFSEQY TPEADPYFIQ DRFLNSFEEL 
QAEECGILNG CENGRCVRVQ EGYTCDCFDG YHLDTAKMTC VDVNECDELN NRMSLCKNAK 
CINTDGSYKC LCLPGYVPSD KPNYCTPLNT ALNLEKDSDL E

Genular Protein ID: 3637505196

Symbol: B7ZLY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLY3

Database IDs:

ARBA 9 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1353
  • Mass: 148464
  • Checksum: 6E6E816C37B74D2E
  • Sequence:
    • MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN 
GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG ASVPKLYQHS 
QQPGKALGTH VIHSTHTLPL TVTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP 
TGQKTKEAQP GQSQVSYQGL PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS 
QCGKALPGLS KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD 
INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK GPCYRLVSSG 
RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK EICPGGMGYT VSGVHRRRPI 
HHHVGKGPVF VKPKNTQPVA KSTHPPPLPA KEEPVEALTF SREHGPGVAE PEVATAPPEK 
EIPSLDQEKT KLEPGQPQLS PDISTIHLHP QFPVVIEKTS PPVPVEVAPE ASTSSASQVI 
APTQVTEINE CTVNPDICGA GHCINLPVRY TCICYEGYRF SEQQRKCVDI DECTQVQHLC 
SQGRCENTEG SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCVNTV GAFRCEYCDS 
GYRMTQRGRC EDIDECLNPS TCPDEQCVNS PGSYQCVPCT EGFRGWNGQC LDVDECLEPN 
VCANGDCSNL EGSYMCSCHK GYTRTPDHKH CRDIDECQQG NLCVNGQCKN TEGSFRCTCG 
QGYQLSAAKD QCEDIDECQH RHLCAHGQCR NTEGSFQCVC DQGYRASGLG DHCEDINECL 
EDKSVCQRGD CINTAGSYDC TCPDGFQLDD NKTCQDINEC EHPGLCGPQG ECLNTEGSFH 
CVCQQGFSIS ADGRTCEDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ EYSPMTGQCR 
SRTSTDLDVD VDQPKEEKKE CYYNLNDASL CDNVLAPNVT KQECCCTSGA GWGDNCEIFP 
CPVLGTAEFT EMCPKGKGFV PAGESSSEAG GENYKDADEC LLFGQEICKN GFCLNTRPGY 
ECYCKQGTYY DPVKLQCFDM DECQDPSSCI DGQCVNTEGS YNCFCTHPMV LDASEKRCIR 
PAESNEQIEE TDVYQDLCWE HLSDEYVCSR PLVGKQTTYT ECCCLYGEAW GMQCALCPLK 
DSDDYAQLCN IPVTGRRQPY GRDALVDFSE QYTPEADPYF IQDRFLNSFE ELQAEECGIL 
NGCENGRCVR VQEGYTCDCF DGYHLDTAKM TCVDVNECDE LNNRMSLCKN AKCINTDGSY 
KCLCLPGYVP SDKPNYCTPL NTALNLEKDS DLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.