Details for: LTBP1

Gene ID: 4052

Symbol: LTBP1

Ensembl ID: ENSG00000049323

Description: latent transforming growth factor beta binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 294.8982
    Cell Significance Index: -45.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.6755
    Cell Significance Index: -50.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 116.7503
    Cell Significance Index: -48.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 105.2904
    Cell Significance Index: -49.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 100.5644
    Cell Significance Index: -40.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.1840
    Cell Significance Index: -49.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.8774
    Cell Significance Index: -50.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.0514
    Cell Significance Index: -35.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8787
    Cell Significance Index: -50.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.7938
    Cell Significance Index: 367.8700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.7952
    Cell Significance Index: 40.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.7601
    Cell Significance Index: 287.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.7114
    Cell Significance Index: 69.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.7006
    Cell Significance Index: 39.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7823
    Cell Significance Index: 47.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7686
    Cell Significance Index: 3330.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8408
    Cell Significance Index: 22.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8084
    Cell Significance Index: 11.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6204
    Cell Significance Index: 12.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5346
    Cell Significance Index: 191.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4589
    Cell Significance Index: 92.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4460
    Cell Significance Index: 57.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3892
    Cell Significance Index: 47.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3684
    Cell Significance Index: 20.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3638
    Cell Significance Index: 72.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3578
    Cell Significance Index: 12.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3402
    Cell Significance Index: 46.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3248
    Cell Significance Index: 143.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2688
    Cell Significance Index: 122.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2503
    Cell Significance Index: 225.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2168
    Cell Significance Index: 1.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2111
    Cell Significance Index: 11.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2074
    Cell Significance Index: 143.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1937
    Cell Significance Index: 34.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1931
    Cell Significance Index: 31.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1495
    Cell Significance Index: 6.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1226
    Cell Significance Index: 188.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1009
    Cell Significance Index: 186.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0833
    Cell Significance Index: 113.2100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0815
    Cell Significance Index: 1.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0657
    Cell Significance Index: 35.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0653
    Cell Significance Index: 41.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0552
    Cell Significance Index: 1.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0544
    Cell Significance Index: 10.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0111
    Cell Significance Index: -1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0170
    Cell Significance Index: -1.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0451
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0562
    Cell Significance Index: -35.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0641
    Cell Significance Index: -47.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0709
    Cell Significance Index: -53.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0772
    Cell Significance Index: -43.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1437
    Cell Significance Index: -8.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1461
    Cell Significance Index: -42.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1610
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1766
    Cell Significance Index: -30.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2136
    Cell Significance Index: -44.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2610
    Cell Significance Index: -16.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2611
    Cell Significance Index: -4.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2703
    Cell Significance Index: -16.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3009
    Cell Significance Index: -35.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3530
    Cell Significance Index: -45.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3577
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3631
    Cell Significance Index: -41.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3645
    Cell Significance Index: -25.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3717
    Cell Significance Index: -43.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3936
    Cell Significance Index: -27.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4240
    Cell Significance Index: -8.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4503
    Cell Significance Index: -51.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4623
    Cell Significance Index: -47.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4811
    Cell Significance Index: -9.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4835
    Cell Significance Index: -10.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4971
    Cell Significance Index: -33.4300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.5226
    Cell Significance Index: -2.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5632
    Cell Significance Index: -18.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5990
    Cell Significance Index: -47.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6018
    Cell Significance Index: -31.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6626
    Cell Significance Index: -49.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6860
    Cell Significance Index: -32.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7165
    Cell Significance Index: -10.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7211
    Cell Significance Index: -20.6700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7650
    Cell Significance Index: -9.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7816
    Cell Significance Index: -50.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8487
    Cell Significance Index: -12.7900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8555
    Cell Significance Index: -6.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8656
    Cell Significance Index: -24.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8978
    Cell Significance Index: -12.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9128
    Cell Significance Index: -11.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9836
    Cell Significance Index: -21.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9943
    Cell Significance Index: -24.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9973
    Cell Significance Index: -17.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0055
    Cell Significance Index: -44.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0133
    Cell Significance Index: -17.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0200
    Cell Significance Index: -53.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.0555
    Cell Significance Index: -16.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1287
    Cell Significance Index: -71.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1487
    Cell Significance Index: -24.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1493
    Cell Significance Index: -30.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LTBP1 is a secreted protein that belongs to the latent transforming growth factor beta binding protein family. It is characterized by its ability to bind to TGF-β, preventing its activation and subsequent signaling. LTBP1 is highly expressed in various tissues, including the retina, heart, kidney, and smooth muscle cells. It is also involved in the regulation of insulin-like growth factor (IGF) transport and uptake, as well as the sequestration of TGF-β in the extracellular matrix. **Pathways and Functions:** LTBP1 is involved in several signaling pathways, including: 1. **TGF-β signaling**: LTBP1 binds to TGF-β, preventing its activation and subsequent signaling. This modulates TGF-β's role in tissue development, fibrosis, and cell growth. 2. **IGF signaling**: LTBP1 regulates IGF transport and uptake, influencing cell growth and differentiation. 3. **Extracellular matrix organization**: LTBP1 is involved in the formation and organization of the extracellular matrix, which provides structural support and regulates cell signaling. 4. **Cell adhesion and migration**: LTBP1 interacts with cell surface receptors, influencing cell adhesion and migration. **Clinical Significance:** Dysregulation of LTBP1 has been implicated in various diseases, including: 1. **Fibrosis**: LTBP1 plays a critical role in regulating fibrogenesis, and its dysregulation can lead to fibrotic diseases, such as pulmonary fibrosis and liver cirrhosis. 2. **Cardiovascular disease**: LTBP1 is involved in the regulation of cardiac development and function, and its dysregulation can contribute to cardiac fibrosis and dysfunction. 3. **Cancer**: LTBP1 has been implicated in cancer progression, as it regulates cell growth, differentiation, and migration. 4. **Ocular diseases**: LTBP1 is involved in the regulation of retinal development and function, and its dysregulation can contribute to ocular diseases, such as glaucoma and age-related macular degeneration. In conclusion, LTBP1 is a multifunctional protein that plays a critical role in regulating TGF-β signaling, IGF transport, and extracellular matrix organization. Its dysregulation has been implicated in various diseases, highlighting the importance of LTBP1 in maintaining tissue homeostasis and preventing disease pathogenesis.

Genular Protein ID: 2847119477

Symbol: LTBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14766 A1L3V1 P22064 Q53SD8 Q53SF3 Q53SG1 Q59HF7 Q8TD95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2350783

Title: TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.

PubMed ID: 2350783

DOI: 10.1016/0092-8674(90)90069-q

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8537398

Title: Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.

PubMed ID: 8537398

DOI: 10.1074/jbc.270.52.31294

PubMed ID: 2022183

Title: A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

PubMed ID: 2022183

DOI: 10.1002/j.1460-2075.1991.tb08049.x

PubMed ID: 8617200

Title: Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

PubMed ID: 8617200

DOI: 10.1002/j.1460-2075.1996.tb00355.x

PubMed ID: 8939931

Title: Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1.

PubMed ID: 8939931

DOI: 10.1074/jbc.271.47.29891

PubMed ID: 10743502

Title: Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action.

PubMed ID: 10743502

DOI: 10.1016/s1359-6101(99)00010-6

PubMed ID: 11104663

Title: The latent transforming growth factor beta binding protein (LTBP) family.

PubMed ID: 11104663

DOI: 10.1042/bj3520601

PubMed ID: 10677208

Title: Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells.

PubMed ID: 10677208

DOI: 10.1021/bi9918285

PubMed ID: 10930463

Title: Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

PubMed ID: 10930463

DOI: 10.1091/mbc.11.8.2691

PubMed ID: 12429738

Title: Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

PubMed ID: 12429738

DOI: 10.1074/jbc.m209256200

PubMed ID: 15184403

Title: Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

PubMed ID: 15184403

DOI: 10.1083/jcb.200312172

PubMed ID: 16157329

Title: Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

PubMed ID: 16157329

DOI: 10.1016/j.yexcr.2005.08.008

PubMed ID: 15567420

Title: Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.

PubMed ID: 15567420

DOI: 10.1016/j.jmb.2004.10.039

PubMed ID: 17293099

Title: LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

PubMed ID: 17293099

DOI: 10.1016/j.matbio.2006.12.006

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18677313

Title: ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation.

PubMed ID: 18677313

DOI: 10.1038/ng.199

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 34411563

Title: POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

PubMed ID: 34411563

DOI: 10.1016/j.jbc.2021.101055

PubMed ID: 38237698

Title: Analysis of the Healthy Platelet Proteome Identifies a New Form of Domain-Specific O-Fucosylation.

PubMed ID: 38237698

DOI: 10.1016/j.mcpro.2024.100717

PubMed ID: 14607119

Title: Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta.

PubMed ID: 14607119

DOI: 10.1016/j.jmb.2003.09.053

PubMed ID: 33991472

Title: Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome.

PubMed ID: 33991472

DOI: 10.1016/j.ajhg.2021.04.016

Sequence Information:

  • Length: 1721
  • Mass: 186796
  • Checksum: 432489CAC3023754
  • Sequence:
    • MAGAWLRWGL LLWAGLLASS AHGRLRRITY VVHPGPGLAA GALPLSGPPR SRTFNVALNA 
RYSRSSAAAG APSRASPGVP SERTRRTSKP GGAALQGLRP PPPPPPEPAR PAVPGGQLHP 
NPGGHPAAAP FTKQGRQVVR SKVPQETQSG GGSRLQVHQK QQLQGVNVCG GRCCHGWSKA 
PGSQRCTKPS CVPPCQNGGM CLRPQLCVCK PGTKGKACET IAAQDTSSPV FGGQSPGAAS 
SWGPPEQAAK HTSSKKADTL PRVSPVAQMT LTLKPKPSVG LPQQIHSQVT PLSSQSVVIH 
HGQTQEYVLK PKYFPAQKGI SGEQSTEGSF PLRYVQDQVA APFQLSNHTG RIKVVFTPSI 
CKVTCTKGSC QNSCEKGNTT TLISENGHAA DTLTATNFRV VICHLPCMNG GQCSSRDKCQ 
CPPNFTGKLC QIPVHGASVP KLYQHSQQPG KALGTHVIHS THTLPLTVTS QQGVKVKFPP 
NIVNIHVKHP PEASVQIHQV SRIDGPTGQK TKEAQPGQSQ VSYQGLPVQK TQTIHSTYSH 
QQVIPHVYPV AAKTQLGRCF QETIGSQCGK ALPGLSKQED CCGTVGTSWG FNKCQKCPKK 
PSYHGYNQMM ECLPGYKRVN NTFCQDINEC QLQGVCPNGE CLNTMGSYRC TCKIGFGPDP 
TFSSCVPDPP VISEEKGPCY RLVSSGRQCM HPLSVHLTKQ LCCCSVGKAW GPHCEKCPLP 
GTAAFKEICP GGMGYTVSGV HRRRPIHHHV GKGPVFVKPK NTQPVAKSTH PPPLPAKEEP 
VEALTFSREH GPGVAEPEVA TAPPEKEIPS LDQEKTKLEP GQPQLSPGIS TIHLHPQFPV 
VIEKTSPPVP VEVAPEASTS SASQVIAPTQ VTEINECTVN PDICGAGHCI NLPVRYTCIC 
YEGYRFSEQQ RKCVDIDECT QVQHLCSQGR CENTEGSFLC ICPAGFMASE EGTNCIDVDE 
CLRPDVCGEG HCVNTVGAFR CEYCDSGYRM TQRGRCEDID ECLNPSTCPD EQCVNSPGSY 
QCVPCTEGFR GWNGQCLDVD ECLEPNVCAN GDCSNLEGSY MCSCHKGYTR TPDHKHCRDI 
DECQQGNLCV NGQCKNTEGS FRCTCGQGYQ LSAAKDQCED IDECQHRHLC AHGQCRNTEG 
SFQCVCDQGY RASGLGDHCE DINECLEDKS VCQRGDCINT AGSYDCTCPD GFQLDDNKTC 
QDINECEHPG LCGPQGECLN TEGSFHCVCQ QGFSISADGR TCEDIDECVN NTVCDSHGFC 
DNTAGSFRCL CYQGFQAPQD GQGCVDVNEC ELLSGVCGEA FCENVEGSFL CVCADENQEY 
SPMTGQCRSR TSTDLDVDVD QPKEEKKECY YNLNDASLCD NVLAPNVTKQ ECCCTSGVGW 
GDNCEIFPCP VLGTAEFTEM CPKGKGFVPA GESSSEAGGE NYKDADECLL FGQEICKNGF 
CLNTRPGYEC YCKQGTYYDP VKLQCFDMDE CQDPSSCIDG QCVNTEGSYN CFCTHPMVLD 
ASEKRCIRPA ESNEQIEETD VYQDLCWEHL SDEYVCSRPL VGKQTTYTEC CCLYGEAWGM 
QCALCPLKDS DDYAQLCNIP VTGRRQPYGR DALVDFSEQY TPEADPYFIQ DRFLNSFEEL 
QAEECGILNG CENGRCVRVQ EGYTCDCFDG YHLDTAKMTC VDVNECDELN NRMSLCKNAK 
CINTDGSYKC LCLPGYVPSD KPNYCTPLNT ALNLEKDSDL E

Genular Protein ID: 3637505196

Symbol: B7ZLY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLY3

Database IDs:

ARBA 7 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 IntAct 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1353
  • Mass: 148464
  • Checksum: 6E6E816C37B74D2E
  • Sequence:
    • MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN 
GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG ASVPKLYQHS 
QQPGKALGTH VIHSTHTLPL TVTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP 
TGQKTKEAQP GQSQVSYQGL PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS 
QCGKALPGLS KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD 
INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK GPCYRLVSSG 
RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK EICPGGMGYT VSGVHRRRPI 
HHHVGKGPVF VKPKNTQPVA KSTHPPPLPA KEEPVEALTF SREHGPGVAE PEVATAPPEK 
EIPSLDQEKT KLEPGQPQLS PDISTIHLHP QFPVVIEKTS PPVPVEVAPE ASTSSASQVI 
APTQVTEINE CTVNPDICGA GHCINLPVRY TCICYEGYRF SEQQRKCVDI DECTQVQHLC 
SQGRCENTEG SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCVNTV GAFRCEYCDS 
GYRMTQRGRC EDIDECLNPS TCPDEQCVNS PGSYQCVPCT EGFRGWNGQC LDVDECLEPN 
VCANGDCSNL EGSYMCSCHK GYTRTPDHKH CRDIDECQQG NLCVNGQCKN TEGSFRCTCG 
QGYQLSAAKD QCEDIDECQH RHLCAHGQCR NTEGSFQCVC DQGYRASGLG DHCEDINECL 
EDKSVCQRGD CINTAGSYDC TCPDGFQLDD NKTCQDINEC EHPGLCGPQG ECLNTEGSFH 
CVCQQGFSIS ADGRTCEDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ EYSPMTGQCR 
SRTSTDLDVD VDQPKEEKKE CYYNLNDASL CDNVLAPNVT KQECCCTSGA GWGDNCEIFP 
CPVLGTAEFT EMCPKGKGFV PAGESSSEAG GENYKDADEC LLFGQEICKN GFCLNTRPGY 
ECYCKQGTYY DPVKLQCFDM DECQDPSSCI DGQCVNTEGS YNCFCTHPMV LDASEKRCIR 
PAESNEQIEE TDVYQDLCWE HLSDEYVCSR PLVGKQTTYT ECCCLYGEAW GMQCALCPLK 
DSDDYAQLCN IPVTGRRQPY GRDALVDFSE QYTPEADPYF IQDRFLNSFE ELQAEECGIL 
NGCENGRCVR VQEGYTCDCF DGYHLDTAKM TCVDVNECDE LNNRMSLCKN AKCINTDGSY 
KCLCLPGYVP SDKPNYCTPL NTALNLEKDS DLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.