Details for: LTBP2

Gene ID: 4053

Symbol: LTBP2

Ensembl ID: ENSG00000119681

Description: latent transforming growth factor beta binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.32
    Marker Score: 1289
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.28
    Marker Score: 666
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.23
    Marker Score: 1466
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.95
    Marker Score: 2680
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.85
    Marker Score: 7176
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.74
    Marker Score: 400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.72
    Marker Score: 4515
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.63
    Marker Score: 3305
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1160
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.5
    Marker Score: 4317.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169159
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1427.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.43
    Marker Score: 1120
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.42
    Marker Score: 351
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18147
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.15
    Marker Score: 723
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 497
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 342
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6352
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251786
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.01
    Marker Score: 605
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.98
    Marker Score: 4083
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 643
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.93
    Marker Score: 210
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.93
    Marker Score: 855
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5285
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.88
    Marker Score: 1018
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.88
    Marker Score: 779
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.86
    Marker Score: 4224.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.84
    Marker Score: 1853.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.77
    Marker Score: 7718.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.69
    Marker Score: 203
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.69
    Marker Score: 664
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.69
    Marker Score: 421
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 327
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.68
    Marker Score: 908
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.66
    Marker Score: 172
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.65
    Marker Score: 160.5
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.59
    Marker Score: 167
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.58
    Marker Score: 616
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.57
    Marker Score: 1524
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.56
    Marker Score: 1083
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1323
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 356
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.56
    Marker Score: 144
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.55
    Marker Score: 155
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.52
    Marker Score: 629
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.51
    Marker Score: 546
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.51
    Marker Score: 636
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 224
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5
    Marker Score: 224
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.49
    Marker Score: 263
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.49
    Marker Score: 279
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.48
    Marker Score: 7638
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.48
    Marker Score: 16163
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.47
    Marker Score: 310
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.46
    Marker Score: 301
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.43
    Marker Score: 482
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.39
    Marker Score: 2517
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.38
    Marker Score: 220
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.37
    Marker Score: 4151
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.36
    Marker Score: 90
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.36
    Marker Score: 90
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.36
    Marker Score: 138
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.35
    Marker Score: 856
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.35
    Marker Score: 99
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.34
    Marker Score: 117
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.34
    Marker Score: 199
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.34
    Marker Score: 168
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.33
    Marker Score: 390
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 882
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.32
    Marker Score: 307
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.32
    Marker Score: 394.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.31
    Marker Score: 268
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.31
    Marker Score: 118

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Other Information

**Key characteristics:** - LTBP2 is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is a member of the immunoglobulin superfamily and is expressed in both soluble and membrane-bound forms. - The protein is a key regulator of the assembly and remodeling of the ECM, and it is involved in the regulation of cell migration, proliferation, and differentiation. **Pathways and functions:** - LTBP2 is a key regulator of the formation of elastic fibers, which are important for the structural integrity and elasticity of the ECM. - It is also involved in the regulation of cell migration, proliferation, and differentiation. - LTBP2 is a key regulator of the assembly and remodeling of the ECM in various tissues, including the skin, lungs, and cardiovascular tissue. - It is also involved in the regulation of cell migration and tissue repair. **Clinical significance:** - Mutations in the LTBP2 gene have been linked to a number of human diseases, including pulmonary fibrosis, atherosclerosis, and cancer. - LTBP2 is a potential target for the treatment of these diseases. **Additional information:** - LTBP2 is a highly conserved protein, with similar genes found in other species. - It is a key regulator of cell migration and differentiation, and its expression is often upregulated in cancer cells. - LTBP2 is a promising target for the treatment of cancer and other diseases that are characterized by abnormal cell migration and proliferation.

Genular Protein ID: 1362242699

Symbol: LTBP2_HUMAN

Name: Latent-transforming growth factor beta-binding protein 2

UniProtKB Accession Codes:

Q14767 Q99907 Q9NS51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 6 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7798248

Title: Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.

PubMed ID: 7798248

DOI: 10.1016/s0021-9258(18)31659-4

PubMed ID: 8697098

Title: Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2.

PubMed ID: 8697098

DOI: 10.1016/1357-2725(95)00167-0

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 10930463

Title: Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

PubMed ID: 10930463

DOI: 10.1091/mbc.11.8.2691

PubMed ID: 10743502

Title: Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action.

PubMed ID: 10743502

DOI: 10.1016/s1359-6101(99)00010-6

PubMed ID: 11104663

Title: The latent transforming growth factor beta binding protein (LTBP) family.

PubMed ID: 11104663

DOI: 10.1042/bj3520601

PubMed ID: 17293099

Title: LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

PubMed ID: 17293099

DOI: 10.1016/j.matbio.2006.12.006

PubMed ID: 19361779

Title: Null mutations in LTBP2 cause primary congenital glaucoma.

PubMed ID: 19361779

DOI: 10.1016/j.ajhg.2009.03.017

PubMed ID: 20617341

Title: A homozygous mutation in LTBP2 causes isolated microspherophakia.

PubMed ID: 20617341

DOI: 10.1007/s00439-010-0858-8

PubMed ID: 20382221

Title: LTBP-2 has multiple heparin/heparan sulfate binding sites.

PubMed ID: 20382221

DOI: 10.1016/j.matbio.2010.03.005

PubMed ID: 22539340

Title: LTBP2 mutations cause Weill-Marchesani and Weill-Marchesani-like syndrome and affect disruptions in the extracellular matrix.

PubMed ID: 22539340

DOI: 10.1002/humu.22105

Sequence Information:

  • Length: 1821
  • Mass: 195052
  • Checksum: 3D6952B39885E1A6
  • Sequence:
    • MRPRTKARSP GRALRNPWRG FLPLTLALFV GAGHAQRDPV GRYEPAGGDA NRLRRPGGSY 
PAAAAAKVYS LFREQDAPVA GLQPVERAQP GWGSPRRPTE AEARRPSRAQ QSRRVQPPAQ 
TRRSTPLGQQ QPAPRTRAAP ALPRLGTPQR SGAAPPTPPR GRLTGRNVCG GQCCPGWTTA 
NSTNHCIKPV CEPPCQNRGS CSRPQLCVCR SGFRGARCEE VIPDEEFDPQ NSRLAPRRWA 
ERSPNLRRSS AAGEGTLARA QPPAPQSPPA PQSPPAGTLS GLSQTHPSQQ HVGLSRTVRL 
HPTATASSQL SSNALPPGPG LEQRDGTQQA VPLEHPSSPW GLNLTEKIKK IKIVFTPTIC 
KQTCARGHCA NSCERGDTTT LYSQGGHGHD PKSGFRIYFC QIPCLNGGRC IGRDECWCPA 
NSTGKFCHLP IPQPDREPPG RGSRPRALLE APLKQSTFTL PLSNQLASVN PSLVKVHIHH 
PPEASVQIHQ VAQVRGGVEE ALVENSVETR PPPWLPASPG HSLWDSNNIP ARSGEPPRPL 
PPAAPRPRGL LGRCYLNTVN GQCANPLLEL TTQEDCCGSV GAFWGVTLCA PCPPRPASPV 
IENGQLECPQ GYKRLNLTHC QDINECLTLG LCKDAECVNT RGSYLCTCRP GLMLDPSRSR 
CVSDKAISML QGLCYRSLGP GTCTLPLAQR ITKQICCCSR VGKAWGSECE KCPLPGTEAF 
REICPAGHGY TYASSDIRLS MRKAEEEELA RPPREQGQRS SGALPGPAER QPLRVVTDTW 
LEAGTIPDKG DSQAGQVTTS VTHAPAWVTG NATTPPMPEQ GIAEIQEEQV TPSTDVLVTL 
STPGIDRCAA GATNVCGPGT CVNLPDGYRC VCSPGYQLHP SQAYCTDDNE CLRDPCKGKG 
RCINRVGSYS CFCYPGYTLA TSGATQECQD INECEQPGVC SGGQCTNTEG SYHCECDQGY 
IMVRKGHCQD INECRHPGTC PDGRCVNSPG SYTCLACEEG YRGQSGSCVD VNECLTPGVC 
AHGKCTNLEG SFRCSCEQGY EVTSDEKGCQ DVDECASRAS CPTGLCLNTE GSFACSACEN 
GYWVNEDGTA CEDLDECAFP GVCPSGVCTN TAGSFSCKDC DGGYRPSPLG DSCEDVDECE 
DPQSSCLGGE CKNTVGSYQC LCPQGFQLAN GTVCEDVNEC MGEEHCAPHG ECLNSHGSFF 
CLCAPGFVSA EGGTSCQDVD ECATTDPCVG GHCVNTEGSF NCLCETGFQP SPESGECVDI 
DECEDYGDPV CGTWKCENSP GSYRCVLGCQ PGFHMAPNGD CIDIDECAND TMCGSHGFCD 
NTDGSFRCLC DQGFEISPSG WDCVDVNECE LMLAVCGAAL CENVEGSFLC LCASDLEEYD 
AQEGHCRPRG AGGQSMSEAP TGDHAPAPTR MDCYSGQKGH APCSSVLGRN TTQAECCCTQ 
GASWGDACDL CPSEDSAEFS EICPSGKGYI PVEGAWTFGQ TMYTDADECV IFGPGLCPNG 
RCLNTVPGYV CLCNPGFHYD ASHKKCEDHD ECQDLACENG ECVNTEGSFH CFCSPPLTLD 
LSQQRCMNST SSTEDLPDHD IHMDICWKKV TNDVCSEPLR GHRTTYTECC CQDGEAWSQQ 
CALCPPRSSE VYAQLCNVAR IEAEREAGVH FRPGYEYGPG PDDLHYSIYG PDGAPFYNYL 
GPEDTVPEPA FPNTAGHSAD RTPILESPLQ PSELQPHYVA SHPEPPAGFE GLQAEECGIL 
NGCENGRCVR VREGYTCDCF EGFQLDAAHM ACVDVNECDD LNGPAVLCVH GYCENTEGSY 
RCHCSPGYVA EAGPPHCTAK E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.