Details for: LTBP2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 88.3987
Cell Significance Index: -13.7500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 55.1168
Cell Significance Index: -13.9800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.1358
Cell Significance Index: -13.7300 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.6853
Cell Significance Index: 71.0300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 6.1191
Cell Significance Index: 41.4600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.6599
Cell Significance Index: -8.0100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.3882
Cell Significance Index: -13.3700 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.9055
Cell Significance Index: 30.2300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4776
Cell Significance Index: 66.9800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.3174
Cell Significance Index: 42.2000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0858
Cell Significance Index: 206.6400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.0682
Cell Significance Index: 15.3400 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.8731
Cell Significance Index: 7.7500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8567
Cell Significance Index: 16.7200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8014
Cell Significance Index: 79.2800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7886
Cell Significance Index: 55.7700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.7707
Cell Significance Index: 489.4900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.7003
Cell Significance Index: 35.3900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6577
Cell Significance Index: 593.8800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4035
Cell Significance Index: 65.6200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4022
Cell Significance Index: 11.2400 - Cell Name: fibroblast of the aortic adventitia (CL0002547)
Fold Change: 0.3468
Cell Significance Index: 3.5000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3016
Cell Significance Index: 32.8100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2866
Cell Significance Index: 39.3600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2191
Cell Significance Index: 6.2800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1564
Cell Significance Index: 69.1600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1432
Cell Significance Index: 3.0500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1379
Cell Significance Index: 9.5400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1361
Cell Significance Index: 256.2700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0500
Cell Significance Index: 31.2300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0438
Cell Significance Index: 30.3200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0412
Cell Significance Index: 5.2800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0402
Cell Significance Index: 18.2600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0398
Cell Significance Index: 73.4200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0387
Cell Significance Index: 7.7700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0320
Cell Significance Index: 1.9200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0285
Cell Significance Index: 43.9500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0277
Cell Significance Index: 0.4200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0248
Cell Significance Index: 0.6200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0231
Cell Significance Index: 4.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0115
Cell Significance Index: 0.3300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0091
Cell Significance Index: 1.1200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0047
Cell Significance Index: 0.3600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0025
Cell Significance Index: 0.3600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0004
Cell Significance Index: 0.0100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0010
Cell Significance Index: -0.0600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0030
Cell Significance Index: -2.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0043
Cell Significance Index: -1.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0059
Cell Significance Index: -7.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0067
Cell Significance Index: -5.0000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0091
Cell Significance Index: -5.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0142
Cell Significance Index: -0.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0180
Cell Significance Index: -13.6400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0219
Cell Significance Index: -11.9700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0259
Cell Significance Index: -5.1400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0314
Cell Significance Index: -0.1900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0343
Cell Significance Index: -5.8500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0368
Cell Significance Index: -7.7600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0460
Cell Significance Index: -13.2400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0506
Cell Significance Index: -5.9000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0561
Cell Significance Index: -6.4000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0665
Cell Significance Index: -1.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0690
Cell Significance Index: -7.0500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0860
Cell Significance Index: -1.3300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0897
Cell Significance Index: -1.8600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0957
Cell Significance Index: -1.3700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1077
Cell Significance Index: -13.9200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1216
Cell Significance Index: -12.6600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1240
Cell Significance Index: -6.4400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1259
Cell Significance Index: -3.3100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1301
Cell Significance Index: -1.9600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1306
Cell Significance Index: -15.4000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1356
Cell Significance Index: -15.5300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1492
Cell Significance Index: -4.0600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1581
Cell Significance Index: -3.8300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1581
Cell Significance Index: -7.4300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1590
Cell Significance Index: -12.5900 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1706
Cell Significance Index: -1.6500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1734
Cell Significance Index: -11.6600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1911
Cell Significance Index: -14.2400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1975
Cell Significance Index: -9.2100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1975
Cell Significance Index: -12.4500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2028
Cell Significance Index: -5.4400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2031
Cell Significance Index: -8.8300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2041
Cell Significance Index: -13.1700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2160
Cell Significance Index: -11.2500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2241
Cell Significance Index: -5.7600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2268
Cell Significance Index: -10.0300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2296
Cell Significance Index: -2.9400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2500
Cell Significance Index: -15.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2539
Cell Significance Index: -14.2500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2741
Cell Significance Index: -10.3800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2796
Cell Significance Index: -4.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2903
Cell Significance Index: -15.2400 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.2971
Cell Significance Index: -2.9400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3071
Cell Significance Index: -10.7600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3221
Cell Significance Index: -10.2600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3359
Cell Significance Index: -12.3300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3365
Cell Significance Index: -11.0200 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3647
Cell Significance Index: -5.3000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1362242699
Symbol: LTBP2_HUMAN
Name: Latent-transforming growth factor beta-binding protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7798248
Title: Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.
PubMed ID: 7798248
PubMed ID: 8697098
Title: Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2.
PubMed ID: 8697098
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 10930463
Title: Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.
PubMed ID: 10930463
PubMed ID: 10743502
Title: Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action.
PubMed ID: 10743502
PubMed ID: 11104663
Title: The latent transforming growth factor beta binding protein (LTBP) family.
PubMed ID: 11104663
DOI: 10.1042/bj3520601
PubMed ID: 17293099
Title: LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.
PubMed ID: 17293099
PubMed ID: 19361779
Title: Null mutations in LTBP2 cause primary congenital glaucoma.
PubMed ID: 19361779
PubMed ID: 20617341
Title: A homozygous mutation in LTBP2 causes isolated microspherophakia.
PubMed ID: 20617341
PubMed ID: 20382221
Title: LTBP-2 has multiple heparin/heparan sulfate binding sites.
PubMed ID: 20382221
PubMed ID: 22539340
Title: LTBP2 mutations cause Weill-Marchesani and Weill-Marchesani-like syndrome and affect disruptions in the extracellular matrix.
PubMed ID: 22539340
DOI: 10.1002/humu.22105
Sequence Information:
- Length: 1821
- Mass: 195052
- Checksum: 3D6952B39885E1A6
- Sequence:
MRPRTKARSP GRALRNPWRG FLPLTLALFV GAGHAQRDPV GRYEPAGGDA NRLRRPGGSY PAAAAAKVYS LFREQDAPVA GLQPVERAQP GWGSPRRPTE AEARRPSRAQ QSRRVQPPAQ TRRSTPLGQQ QPAPRTRAAP ALPRLGTPQR SGAAPPTPPR GRLTGRNVCG GQCCPGWTTA NSTNHCIKPV CEPPCQNRGS CSRPQLCVCR SGFRGARCEE VIPDEEFDPQ NSRLAPRRWA ERSPNLRRSS AAGEGTLARA QPPAPQSPPA PQSPPAGTLS GLSQTHPSQQ HVGLSRTVRL HPTATASSQL SSNALPPGPG LEQRDGTQQA VPLEHPSSPW GLNLTEKIKK IKIVFTPTIC KQTCARGHCA NSCERGDTTT LYSQGGHGHD PKSGFRIYFC QIPCLNGGRC IGRDECWCPA NSTGKFCHLP IPQPDREPPG RGSRPRALLE APLKQSTFTL PLSNQLASVN PSLVKVHIHH PPEASVQIHQ VAQVRGGVEE ALVENSVETR PPPWLPASPG HSLWDSNNIP ARSGEPPRPL PPAAPRPRGL LGRCYLNTVN GQCANPLLEL TTQEDCCGSV GAFWGVTLCA PCPPRPASPV IENGQLECPQ GYKRLNLTHC QDINECLTLG LCKDAECVNT RGSYLCTCRP GLMLDPSRSR CVSDKAISML QGLCYRSLGP GTCTLPLAQR ITKQICCCSR VGKAWGSECE KCPLPGTEAF REICPAGHGY TYASSDIRLS MRKAEEEELA RPPREQGQRS SGALPGPAER QPLRVVTDTW LEAGTIPDKG DSQAGQVTTS VTHAPAWVTG NATTPPMPEQ GIAEIQEEQV TPSTDVLVTL STPGIDRCAA GATNVCGPGT CVNLPDGYRC VCSPGYQLHP SQAYCTDDNE CLRDPCKGKG RCINRVGSYS CFCYPGYTLA TSGATQECQD INECEQPGVC SGGQCTNTEG SYHCECDQGY IMVRKGHCQD INECRHPGTC PDGRCVNSPG SYTCLACEEG YRGQSGSCVD VNECLTPGVC AHGKCTNLEG SFRCSCEQGY EVTSDEKGCQ DVDECASRAS CPTGLCLNTE GSFACSACEN GYWVNEDGTA CEDLDECAFP GVCPSGVCTN TAGSFSCKDC DGGYRPSPLG DSCEDVDECE DPQSSCLGGE CKNTVGSYQC LCPQGFQLAN GTVCEDVNEC MGEEHCAPHG ECLNSHGSFF CLCAPGFVSA EGGTSCQDVD ECATTDPCVG GHCVNTEGSF NCLCETGFQP SPESGECVDI DECEDYGDPV CGTWKCENSP GSYRCVLGCQ PGFHMAPNGD CIDIDECAND TMCGSHGFCD NTDGSFRCLC DQGFEISPSG WDCVDVNECE LMLAVCGAAL CENVEGSFLC LCASDLEEYD AQEGHCRPRG AGGQSMSEAP TGDHAPAPTR MDCYSGQKGH APCSSVLGRN TTQAECCCTQ GASWGDACDL CPSEDSAEFS EICPSGKGYI PVEGAWTFGQ TMYTDADECV IFGPGLCPNG RCLNTVPGYV CLCNPGFHYD ASHKKCEDHD ECQDLACENG ECVNTEGSFH CFCSPPLTLD LSQQRCMNST SSTEDLPDHD IHMDICWKKV TNDVCSEPLR GHRTTYTECC CQDGEAWSQQ CALCPPRSSE VYAQLCNVAR IEAEREAGVH FRPGYEYGPG PDDLHYSIYG PDGAPFYNYL GPEDTVPEPA FPNTAGHSAD RTPILESPLQ PSELQPHYVA SHPEPPAGFE GLQAEECGIL NGCENGRCVR VREGYTCDCF EGFQLDAAHM ACVDVNECDD LNGPAVLCVH GYCENTEGSY RCHCSPGYVA EAGPPHCTAK E
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.