Details for: SMAD3

Gene ID: 4088

Symbol: SMAD3

Ensembl ID: ENSG00000166949

Description: SMAD family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 234.7227
    Cell Significance Index: -36.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.0391
    Cell Significance Index: -35.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.4301
    Cell Significance Index: -38.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.5279
    Cell Significance Index: -31.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.7578
    Cell Significance Index: -36.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5636
    Cell Significance Index: -36.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.4829
    Cell Significance Index: -27.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3473
    Cell Significance Index: -36.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.3679
    Cell Significance Index: 94.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.9325
    Cell Significance Index: 75.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.6648
    Cell Significance Index: 52.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6458
    Cell Significance Index: 100.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6404
    Cell Significance Index: 116.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5845
    Cell Significance Index: 301.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4364
    Cell Significance Index: 463.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.2472
    Cell Significance Index: 54.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1783
    Cell Significance Index: 432.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8326
    Cell Significance Index: 95.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4545
    Cell Significance Index: 39.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4119
    Cell Significance Index: 283.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3973
    Cell Significance Index: 251.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.3876
    Cell Significance Index: 29.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3646
    Cell Significance Index: 91.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3125
    Cell Significance Index: 213.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.1226
    Cell Significance Index: 56.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0844
    Cell Significance Index: 133.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.0787
    Cell Significance Index: 15.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0702
    Cell Significance Index: 82.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9364
    Cell Significance Index: 69.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8538
    Cell Significance Index: 55.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7876
    Cell Significance Index: 1482.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7269
    Cell Significance Index: 79.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7120
    Cell Significance Index: 642.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6873
    Cell Significance Index: 14.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5755
    Cell Significance Index: 34.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5429
    Cell Significance Index: 13.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4965
    Cell Significance Index: 271.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4480
    Cell Significance Index: 284.5200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.4438
    Cell Significance Index: 7.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4409
    Cell Significance Index: 4.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4004
    Cell Significance Index: 738.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3772
    Cell Significance Index: 5.4300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3627
    Cell Significance Index: 3.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3616
    Cell Significance Index: 2.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3454
    Cell Significance Index: 531.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3414
    Cell Significance Index: 19.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3163
    Cell Significance Index: 5.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2940
    Cell Significance Index: 40.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2843
    Cell Significance Index: 125.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2523
    Cell Significance Index: 4.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2332
    Cell Significance Index: 105.8300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1892
    Cell Significance Index: 2.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1651
    Cell Significance Index: 114.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1298
    Cell Significance Index: 16.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1273
    Cell Significance Index: 3.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1263
    Cell Significance Index: 12.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1178
    Cell Significance Index: 20.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1056
    Cell Significance Index: 3.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0738
    Cell Significance Index: 1.9400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0674
    Cell Significance Index: 0.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0668
    Cell Significance Index: 90.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0533
    Cell Significance Index: 3.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0081
    Cell Significance Index: -0.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0093
    Cell Significance Index: -3.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0111
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0226
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0280
    Cell Significance Index: -17.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0345
    Cell Significance Index: -25.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0416
    Cell Significance Index: -31.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0439
    Cell Significance Index: -24.7600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0590
    Cell Significance Index: -0.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0668
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0681
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0939
    Cell Significance Index: -10.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0997
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1032
    Cell Significance Index: -21.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1170
    Cell Significance Index: -33.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1376
    Cell Significance Index: -14.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1490
    Cell Significance Index: -0.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1696
    Cell Significance Index: -20.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1841
    Cell Significance Index: -3.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2008
    Cell Significance Index: -2.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2144
    Cell Significance Index: -7.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2300
    Cell Significance Index: -3.8500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2451
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2854
    Cell Significance Index: -32.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3032
    Cell Significance Index: -4.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3071
    Cell Significance Index: -21.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3131
    Cell Significance Index: -6.5000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3232
    Cell Significance Index: -4.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3321
    Cell Significance Index: -8.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3427
    Cell Significance Index: -9.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3644
    Cell Significance Index: -5.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3669
    Cell Significance Index: -11.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3940
    Cell Significance Index: -18.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4089
    Cell Significance Index: -32.3900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4320
    Cell Significance Index: -5.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4552
    Cell Significance Index: -27.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **SMAD structure**: SMAD3 is a 415-amino acid protein that belongs to the SMAD family of proteins. It consists of an N-terminal domain, a central domain, and a C-terminal domain. 2. **TGF-β binding**: SMAD3 binds to TGF-β receptors, which triggers a cascade of phosphorylation events that activate SMAD3. 3. **Phosphorylation**: SMAD3 is phosphorylated at specific serine residues by TGF-β receptors, which enables its activation and interaction with downstream transcription factors. 4. **Transcriptional regulation**: SMAD3 regulates gene expression by interacting with transcription factors, such as Smad4, and activating or repressing the expression of target genes. **Pathways and Functions** 1. **TGF-β signaling pathway**: SMAD3 is a key component of the TGF-β signaling pathway, which regulates cell growth, differentiation, and immune responses. 2. **Cell growth and differentiation**: SMAD3 regulates cell growth and differentiation by modulating the expression of target genes involved in cell cycle progression, apoptosis, and cell fate determination. 3. **Immune responses**: SMAD3 plays a crucial role in regulating immune responses, including the activation of immune cells and the production of cytokines. 4. **Developmental biology**: SMAD3 is involved in the development of various tissues and organs, including the formation of axial mesoderm, definitive endoderm, and germ layers. 5. **Cancer**: SMAD3 is often dysregulated in cancer, leading to the loss of its tumor suppressor function and contributing to tumorigenesis. **Clinical Significance** 1. **Cancer**: SMAD3 mutations or alterations are associated with various types of cancer, including lung, breast, and colon cancer. 2. **Autoimmune diseases**: SMAD3 dysregulation is implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases**: SMAD3 plays a role in the regulation of immune responses to viral infections, such as SARS-CoV-1. 4. **Regenerative medicine**: SMAD3 is involved in the regulation of tissue repair and regeneration, making it a potential target for therapeutic interventions. 5. **Immunotherapy**: SMAD3 is a potential target for immunotherapies, such as checkpoint inhibitors, which can restore immune function in cancer patients. In conclusion, SMAD3 is a critical regulator of various cellular processes, including cell growth, differentiation, and immune responses. Its dysregulation is implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the functional significance of SMAD3 and its potential as a therapeutic target.

Genular Protein ID: 2988299668

Symbol: SMAD3_HUMAN

Name: Mothers against decapentaplegic homolog 3

UniProtKB Accession Codes:

P84022 A8K4B6 B7Z4Z5 B7Z6M9 B7Z9Q2 F5H383 O09064 O09144 O14510 O35273 Q92940 Q93002 Q9GKR4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 19 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 22 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8774881

Title: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

PubMed ID: 8774881

DOI: 10.1038/383168a0

PubMed ID: 8673135

Title: Mad-related genes in the human.

PubMed ID: 8673135

DOI: 10.1038/ng0796-347

PubMed ID: 9464505

Title: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.

PubMed ID: 9464505

DOI: 10.1016/s0304-3835(97)00384-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9311995

Title: TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

PubMed ID: 9311995

DOI: 10.1093/emboj/16.17.5353

PubMed ID: 9865696

Title: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

PubMed ID: 9865696

DOI: 10.1016/s0092-8674(00)81701-8

PubMed ID: 9670020

Title: Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.

PubMed ID: 9670020

DOI: 10.1093/emboj/17.14.4056

PubMed ID: 9843571

Title: TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.

PubMed ID: 9843571

DOI: 10.1091/mbc.9.12.3309

PubMed ID: 9665135

Title: The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3.

PubMed ID: 9665135

DOI: 10.1038/27945

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 9892009

Title: Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

PubMed ID: 9892009

DOI: 10.1210/mend.13.1.0218

PubMed ID: 10995748

Title: Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

PubMed ID: 10995748

DOI: 10.1074/jbc.m004731200

PubMed ID: 11387212

Title: The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.

PubMed ID: 11387212

DOI: 10.1093/emboj/20.11.2789

PubMed ID: 11278756

Title: Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription.

PubMed ID: 11278756

DOI: 10.1074/jbc.m010815200

PubMed ID: 11427533

Title: TGIF2 interacts with histone deacetylase 1 and represses transcription.

PubMed ID: 11427533

DOI: 10.1074/jbc.m103377200

PubMed ID: 11224571

Title: The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.

PubMed ID: 11224571

DOI: 10.1038/84995

PubMed ID: 11274402

Title: Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling.

PubMed ID: 11274402

DOI: 10.1073/pnas.061358098

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 14525983

Title: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

PubMed ID: 14525983

DOI: 10.1074/jbc.m310021200

PubMed ID: 15051726

Title: Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.

PubMed ID: 15051726

DOI: 10.1074/jbc.m403221200

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 15588252

Title: The Smad3 linker region contains a transcriptional activation domain.

PubMed ID: 15588252

DOI: 10.1042/bj20041820

PubMed ID: 16156666

Title: Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.

PubMed ID: 16156666

DOI: 10.1021/bi050560g

PubMed ID: 15601644

Title: MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.

PubMed ID: 15601644

DOI: 10.1093/hmg/ddi040

PubMed ID: 15561701

Title: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling.

PubMed ID: 15561701

DOI: 10.1074/jbc.m411575200

PubMed ID: 15647271

Title: The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.

PubMed ID: 15647271

DOI: 10.1074/jbc.m411234200

PubMed ID: 15799969

Title: Nuclear targeting of transforming growth factor-beta-activated Smad complexes.

PubMed ID: 15799969

DOI: 10.1074/jbc.m500362200

PubMed ID: 16200078

Title: Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.

PubMed ID: 16200078

DOI: 10.1038/labinvest.3700344

PubMed ID: 15897867

Title: Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.

PubMed ID: 15897867

DOI: 10.1038/sj.onc.1208754

PubMed ID: 16751101

Title: PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.

PubMed ID: 16751101

DOI: 10.1016/j.cell.2006.03.044

PubMed ID: 16751102

Title: Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

PubMed ID: 16751102

DOI: 10.1016/j.cell.2006.03.045

PubMed ID: 16777850

Title: The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.

PubMed ID: 16777850

DOI: 10.1074/jbc.m508365200

PubMed ID: 16449645

Title: The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.

PubMed ID: 16449645

DOI: 10.1128/mcb.26.4.1318-1332.2006

PubMed ID: 17099224

Title: Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.

PubMed ID: 17099224

DOI: 10.1093/nar/gkl914

PubMed ID: 17327236

Title: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.

PubMed ID: 17327236

DOI: 10.1074/jbc.m609279200

PubMed ID: 17292623

Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.

PubMed ID: 17292623

DOI: 10.1016/j.mcn.2007.01.002

PubMed ID: 16862174

Title: Smad3 is acetylated by p300/CBP to regulate its transactivation activity.

PubMed ID: 16862174

DOI: 10.1038/sj.onc.1209826

PubMed ID: 18568018

Title: TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

PubMed ID: 18568018

DOI: 10.1038/ncb1748

PubMed ID: 18055455

Title: Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling.

PubMed ID: 18055455

DOI: 10.1074/jbc.m708033200

PubMed ID: 18794808

Title: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.

PubMed ID: 18794808

DOI: 10.1038/onc.2008.337

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19289081

Title: Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.

PubMed ID: 19289081

DOI: 10.1016/j.devcel.2009.01.022

PubMed ID: 19049980

Title: SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

PubMed ID: 19049980

DOI: 10.1074/jbc.m808989200

PubMed ID: 19218245

Title: Transforming growth factor-{beta}-inducible phosphorylation of Smad3.

PubMed ID: 19218245

DOI: 10.1074/jbc.m809281200

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20061380

Title: MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes.

PubMed ID: 20061380

DOI: 10.1074/jbc.m109.075036

PubMed ID: 20129061

Title: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.

PubMed ID: 20129061

DOI: 10.1016/j.molcel.2009.10.028

PubMed ID: 20935647

Title: IL-37 is a fundamental inhibitor of innate immunity.

PubMed ID: 20935647

DOI: 10.1038/ni.1944

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21947082

Title: USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

PubMed ID: 21947082

DOI: 10.1038/ncb2346

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24324267

Title: Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.

PubMed ID: 24324267

DOI: 10.1074/jbc.m113.526905

PubMed ID: 24627487

Title: C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.

PubMed ID: 24627487

DOI: 10.1074/jbc.m114.558981

PubMed ID: 25105025

Title: TGF-beta signaling cooperates with AT motif-binding factor-1 for repression of the alpha -fetoprotein promoter.

PubMed ID: 25105025

DOI: 10.1155/2014/970346

PubMed ID: 25133494

Title: Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor beta Signaling.

PubMed ID: 25133494

DOI: 10.1371/journal.pone.0103651

PubMed ID: 29899023

Title: NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

PubMed ID: 29899023

DOI: 10.1126/scitranslmed.aap7294

PubMed ID: 9741623

Title: Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.

PubMed ID: 9741623

DOI: 10.1016/s0092-8674(00)81600-1

PubMed ID: 12154125

Title: Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control.

PubMed ID: 12154125

DOI: 10.1101/gad.1002002

PubMed ID: 12686552

Title: Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.

PubMed ID: 12686552

DOI: 10.1074/jbc.c300134200

PubMed ID: 15350224

Title: Structural basis of heteromeric smad protein assembly in TGF-beta signaling.

PubMed ID: 15350224

DOI: 10.1016/j.molcel.2004.07.016

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21778426

Title: Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms.

PubMed ID: 21778426

DOI: 10.1161/circresaha.111.248161

PubMed ID: 21217753

Title: Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis.

PubMed ID: 21217753

DOI: 10.1038/ng.744

Sequence Information:

  • Length: 425
  • Mass: 48081
  • Checksum: 46DF5E8B371321AC
  • Sequence:
    • MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV 
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP 
PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL 
NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF 
EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR 
CSSVS

Genular Protein ID: 291317886

Symbol: Q9P0T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P0T0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

Sequence Information:

  • Length: 118
  • Mass: 13213
  • Checksum: 1BC47C9C869A6EB5
  • Sequence:
    • MRVSTGPELR LHHSFVLTGD VGRRICRLLV GLFTKGDTSS KRVHPFSPGP CFLLCDLARV 
GSSPKINVSP FYQNPNLNTA KLTVFVWQRC SLVGPFQVTV FTMYFHHSLR SISRFSSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.