Details for: MAN2A1

Gene ID: 4124

Symbol: MAN2A1

Ensembl ID: ENSG00000112893

Description: mannosidase alpha class 2A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 331.8649
    Cell Significance Index: -51.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.2989
    Cell Significance Index: -52.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.5664
    Cell Significance Index: -56.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 117.6595
    Cell Significance Index: -47.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.1352
    Cell Significance Index: -54.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.2439
    Cell Significance Index: -47.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.3511
    Cell Significance Index: -53.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7700
    Cell Significance Index: -55.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.7077
    Cell Significance Index: -57.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1415
    Cell Significance Index: -30.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6972
    Cell Significance Index: -54.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.0542
    Cell Significance Index: 606.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.8914
    Cell Significance Index: 77.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5467
    Cell Significance Index: 142.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1441
    Cell Significance Index: 430.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0381
    Cell Significance Index: 221.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4906
    Cell Significance Index: 37.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0945
    Cell Significance Index: 31.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0902
    Cell Significance Index: 75.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9686
    Cell Significance Index: 669.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9314
    Cell Significance Index: 41.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8992
    Cell Significance Index: 17.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8892
    Cell Significance Index: 33.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8619
    Cell Significance Index: 155.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7722
    Cell Significance Index: 16.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7242
    Cell Significance Index: 15.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6906
    Cell Significance Index: 18.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6749
    Cell Significance Index: 6.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6439
    Cell Significance Index: 16.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5942
    Cell Significance Index: 10.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5839
    Cell Significance Index: 57.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5392
    Cell Significance Index: 66.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4840
    Cell Significance Index: 21.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4434
    Cell Significance Index: 6.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3617
    Cell Significance Index: 129.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3318
    Cell Significance Index: 56.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3308
    Cell Significance Index: 9.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3129
    Cell Significance Index: 170.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2812
    Cell Significance Index: 53.5100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2285
    Cell Significance Index: 1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2240
    Cell Significance Index: 6.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2012
    Cell Significance Index: 273.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1530
    Cell Significance Index: 69.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1284
    Cell Significance Index: 17.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1164
    Cell Significance Index: 219.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1059
    Cell Significance Index: 3.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0810
    Cell Significance Index: 4.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0776
    Cell Significance Index: 49.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0561
    Cell Significance Index: 6.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0320
    Cell Significance Index: 1.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0163
    Cell Significance Index: 25.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0051
    Cell Significance Index: 9.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0057
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -18.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0271
    Cell Significance Index: -11.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0437
    Cell Significance Index: -32.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0539
    Cell Significance Index: -33.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0561
    Cell Significance Index: -8.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0687
    Cell Significance Index: -51.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0708
    Cell Significance Index: -3.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0821
    Cell Significance Index: -46.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0858
    Cell Significance Index: -5.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0946
    Cell Significance Index: -9.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1158
    Cell Significance Index: -8.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1450
    Cell Significance Index: -23.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1655
    Cell Significance Index: -47.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1727
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1810
    Cell Significance Index: -38.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1817
    Cell Significance Index: -21.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2216
    Cell Significance Index: -14.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2850
    Cell Significance Index: -8.1700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2929
    Cell Significance Index: -3.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2930
    Cell Significance Index: -30.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3175
    Cell Significance Index: -36.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3180
    Cell Significance Index: -41.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3554
    Cell Significance Index: -7.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3575
    Cell Significance Index: -16.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3760
    Cell Significance Index: -5.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3941
    Cell Significance Index: -50.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4133
    Cell Significance Index: -10.0900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4239
    Cell Significance Index: -5.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4471
    Cell Significance Index: -12.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4747
    Cell Significance Index: -35.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4880
    Cell Significance Index: -55.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6334
    Cell Significance Index: -9.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7016
    Cell Significance Index: -22.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7561
    Cell Significance Index: -24.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7610
    Cell Significance Index: -18.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7733
    Cell Significance Index: -54.6900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.7772
    Cell Significance Index: -7.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8052
    Cell Significance Index: -17.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8540
    Cell Significance Index: -43.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8995
    Cell Significance Index: -55.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9413
    Cell Significance Index: -30.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9525
    Cell Significance Index: -60.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.0434
    Cell Significance Index: -14.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0609
    Cell Significance Index: -55.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1494
    Cell Significance Index: -16.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1735
    Cell Significance Index: -41.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2208
    Cell Significance Index: -24.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycosylation Enzyme:** MAN2A1 is a member of the alpha-mannosidase family, which is responsible for the removal of alpha-mannose residues from N-glycans. 2. **Golgi Apparatus Localization:** The enzyme is predominantly localized in the Golgi apparatus, where it participates in the processing and modification of glycoproteins. 3. **Cellular Expression:** MAN2A1 is significantly expressed in various cell types, including oligodendrocytes, retinal bipolar neurons, and vascular leptomeningeal cells. 4. **Pathway Involvement:** The gene is involved in multiple signaling pathways, including alpha-mannosidase activity, asparagine n-linked glycosylation, and protein deglycosylation. **Pathways and Functions:** 1. **Glycosylation and Protein Processing:** MAN2A1 is essential for the proper processing and modification of glycoproteins in the Golgi apparatus, which is crucial for their correct folding and function. 2. **Immune Function:** The enzyme plays a role in regulating immune responses, particularly in the context of viral infections, by modulating the processing and presentation of glycoproteins on the surface of antigen-presenting cells. 3. **Viral Infection Pathways:** MAN2A1 is involved in the processing and modification of viral proteins, which is essential for their entry into host cells and successful infection. 4. **Neurogenesis and Development:** The gene is also implicated in the regulation of neurogenesis and development, particularly in the context of retinal development and camera-type eye morphogenesis. **Clinical Significance:** 1. **Infectious Diseases:** MAN2A1 has been implicated in the context of SARS-CoV-2 infection, and its dysregulation may contribute to the severity of the disease. 2. **Neurological Disorders:** The gene's role in neurogenesis and development suggests that dysregulation of MAN2A1 may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The enzyme's involvement in protein deglycosylation and protein modification may also have implications for cancer development and progression. 4. **Therapeutic Targets:** The identification of MAN2A1 as a key enzyme in immune function and viral infection pathways highlights its potential as a therapeutic target for the treatment of related disorders. In conclusion, MAN2A1 is a critical gene that plays a pivotal role in immune function, protein processing, and viral infection pathways. Its dysregulation may contribute to various diseases, including infectious diseases, neurological disorders, and cancer. Further research is necessary to fully elucidate the functions of MAN2A1 and to explore its potential as a therapeutic target.

Genular Protein ID: 3034971806

Symbol: MA2A1_HUMAN

Name: Alpha-mannosidase 2

UniProtKB Accession Codes:

Q16706 Q16767

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EC 1 EMBL 2 Ensembl 1 GO 23 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524845

Title: Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.

PubMed ID: 8524845

DOI: 10.1073/pnas.92.25.11766

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 1144
  • Mass: 131141
  • Checksum: A1814C63D1CE4FAC
  • Sequence:
    • MKLSRQFTVF GSAIFCVVIF SLYLMLDRGH LDYPRNPRRE GSFPQGQLSM LQEKIDHLER 
LLAENNEIIS NIRDSVINLS ESVEDGPKSS QSNFSQGAGS HLLPSQLSLS VDTADCLFAS 
QSGSHNSDVQ MLDVYSLISF DNPDGGVWKQ GFDITYESNE WDTEPLQVFV VPHSHNDPGW 
LKTFNDYFRD KTQYIFNNMV LKLKEDSRRK FIWSEISYLS KWWDIIDIQK KDAVKSLIEN 
GQLEIVTGGW VMPDEATPHY FALIDQLIEG HQWLENNIGV KPRSGWAIDP FGHSPTMAYL 
LNRAGLSHML IQRVHYAVKK HFALHKTLEF FWRQNWDLGS VTDILCHMMP FYSYDIPHTC 
GPDPKICCQF DFKRLPGGRF GCPWGVPPET IHPGNVQSRA RMLLDQYRKK SKLFRTKVLL 
APLGDDFRYC EYTEWDLQFK NYQQLFDYMN SQSKFKVKIQ FGTLSDFFDA LDKADETQRD 
KGQSMFPVLS GDFFTYADRD DHYWSGYFTS RPFYKRMDRI MESHLRAAEI LYYFALRQAH 
KYKINKFLSS SLYTALTEAR RNLGLFQHHD AITGTAKDWV VVDYGTRLFH SLMVLEKIIG 
NSAFLLILKD KLTYDSYSPD TFLEMDLKQK SQDSLPQKNI IRLSAEPRYL VVYNPLEQDR 
ISLVSVYVSS PTVQVFSASG KPVEVQVSAV WDTANTISET AYEISFRAHI PPLGLKVYKI 
LESASSNSHL ADYVLYKNKV EDSGIFTIKN MINTEEGITL ENSFVLLRFD QTGLMKQMMT 
KEDGKHHEVN VQFSWYGTTI KRDKSGAYLF LPDGNAKPYV YTTPPFVRVT HGRIYSEVTC 
FFDHVTHRVR LYHIQGIEGQ SVEVSNIVDI RKVYNREIAM KISSDIKSQN RFYTDLNGYQ 
IQPRMTLSKL PLQANVYPMT TMAYIQDAKH RLTLLSAQSL GVSSLNSGQI EVIMDRRLMQ 
DDNRGLEQGI QDNKITANLF RILLEKRSAV NTEEEKKSVS YPSLLSHITS SLMNHPVIPM 
ANKFSSPTLE LQGEFSPLQS SLPCDIHLVN LRTIQSKVGN GHSNEAALIL HRKGFDCRFS 
SKGTGLFCST TQGKILVQKL LNKFIVESLT PSSLSLMHSP PGTQNISEIN LSPMEISTFR 
IQLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.