Details for: MAP6

Gene ID: 4135

Symbol: MAP6

Ensembl ID: ENSG00000171533

Description: microtubule associated protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.8389
    Cell Significance Index: -25.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1618
    Cell Significance Index: -25.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.6884
    Cell Significance Index: 28.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2121
    Cell Significance Index: 196.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2676
    Cell Significance Index: 454.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.8409
    Cell Significance Index: 40.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7736
    Cell Significance Index: 67.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7399
    Cell Significance Index: 76.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3710
    Cell Significance Index: 17.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1571
    Cell Significance Index: 37.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9821
    Cell Significance Index: 66.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9577
    Cell Significance Index: 27.3300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.8822
    Cell Significance Index: 9.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8251
    Cell Significance Index: 46.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6258
    Cell Significance Index: 432.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5931
    Cell Significance Index: 535.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5511
    Cell Significance Index: 54.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5451
    Cell Significance Index: 195.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4297
    Cell Significance Index: 26.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2959
    Cell Significance Index: 48.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1683
    Cell Significance Index: 18.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1639
    Cell Significance Index: 3.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1397
    Cell Significance Index: 26.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1274
    Cell Significance Index: 69.5900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1254
    Cell Significance Index: 1.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0146
    Cell Significance Index: 0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0046
    Cell Significance Index: 7.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0041
    Cell Significance Index: 7.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0004
    Cell Significance Index: 0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -9.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0096
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0133
    Cell Significance Index: -8.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0167
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0232
    Cell Significance Index: -13.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0266
    Cell Significance Index: -16.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0381
    Cell Significance Index: -27.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0391
    Cell Significance Index: -17.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0401
    Cell Significance Index: -17.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0459
    Cell Significance Index: -34.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0500
    Cell Significance Index: -1.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0623
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0726
    Cell Significance Index: -12.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0824
    Cell Significance Index: -23.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0852
    Cell Significance Index: -15.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0859
    Cell Significance Index: -11.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0977
    Cell Significance Index: -4.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1029
    Cell Significance Index: -2.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1053
    Cell Significance Index: -5.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1213
    Cell Significance Index: -7.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1234
    Cell Significance Index: -4.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1482
    Cell Significance Index: -29.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1735
    Cell Significance Index: -4.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1743
    Cell Significance Index: -5.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1800
    Cell Significance Index: -22.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2137
    Cell Significance Index: -16.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2180
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2356
    Cell Significance Index: -26.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2406
    Cell Significance Index: -31.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2438
    Cell Significance Index: -4.8200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2579
    Cell Significance Index: -3.4400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2628
    Cell Significance Index: -2.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2674
    Cell Significance Index: -31.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2730
    Cell Significance Index: -19.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2741
    Cell Significance Index: -32.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2748
    Cell Significance Index: -31.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2930
    Cell Significance Index: -30.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3097
    Cell Significance Index: -31.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3382
    Cell Significance Index: -6.7900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3429
    Cell Significance Index: -2.8300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3581
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3845
    Cell Significance Index: -30.4500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3926
    Cell Significance Index: -4.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4026
    Cell Significance Index: -5.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4055
    Cell Significance Index: -21.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4113
    Cell Significance Index: -8.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4119
    Cell Significance Index: -30.7000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4120
    Cell Significance Index: -2.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4186
    Cell Significance Index: -26.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4200
    Cell Significance Index: -21.8200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4502
    Cell Significance Index: -5.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4753
    Cell Significance Index: -16.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4923
    Cell Significance Index: -12.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5148
    Cell Significance Index: -10.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5180
    Cell Significance Index: -4.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5200
    Cell Significance Index: -11.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5493
    Cell Significance Index: -25.6100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5585
    Cell Significance Index: -6.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5878
    Cell Significance Index: -16.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5995
    Cell Significance Index: -8.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6332
    Cell Significance Index: -29.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6475
    Cell Significance Index: -13.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6489
    Cell Significance Index: -8.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6901
    Cell Significance Index: -10.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7306
    Cell Significance Index: -4.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7411
    Cell Significance Index: -19.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7489
    Cell Significance Index: -27.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule-binding protein:** MAP6 is a microtubule-associated protein that interacts with microtubules, stabilizing their structure and facilitating their dynamic organization. 2. **Cytoskeletal organization:** MAP6 plays a crucial role in regulating the cytoskeleton-dependent intracellular transport of vesicles and organelles, ensuring the proper distribution of cellular components. 3. **Neuronal specificity:** MAP6 is highly expressed in neuronal cells, including brainstem motor neurons, Purkinje cells, and dopaminergic neurons, highlighting its specialized function in neuronal development and maintenance. 4. **Regulatory role:** MAP6 is involved in the positive regulation of axonogenesis and dendrite morphogenesis, ensuring the proper formation and maintenance of axons and dendrites. **Pathways and Functions:** 1. **Calmodulin binding:** MAP6 interacts with calmodulin, a calcium-binding protein, to regulate the activity of various cellular processes, including microtubule dynamics and cytoskeletal organization. 2. **Cytoskeleton-dependent intracellular transport:** MAP6 facilitates the transport of vesicles and organelles along microtubules, ensuring the proper distribution of cellular components. 3. **Lysosome localization:** MAP6 regulates the localization of lysosomes, which are essential for cellular digestion and degradation of waste products. 4. **Microtubule cytoskeleton organization:** MAP6 plays a crucial role in regulating the organization of microtubules, ensuring their proper dynamics and structure. **Clinical Significance:** Dysregulation of MAP6 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases:** Alterations in MAP6 expression and function have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Developmental disorders:** MAP6 mutations have been associated with developmental disorders, such as autism spectrum disorder and intellectual disability. 3. **Cancer:** MAP6 has been implicated in the development and progression of certain types of cancer, including glioblastoma and breast cancer. In conclusion, MAP6 is a complex protein that plays a critical role in maintaining the structural integrity and dynamic organization of microtubules in neurons. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the functions and mechanisms of MAP6.

Genular Protein ID: 3735668820

Symbol: MAP6_HUMAN

Name: Microtubule-associated protein 6

UniProtKB Accession Codes:

Q96JE9 A7E2A1 Q6P3T0 Q6ZWB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 14692697

Title: Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis.

PubMed ID: 14692697

DOI: 10.1093/jnen/62.12.1211

PubMed ID: 16624526

Title: Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia.

PubMed ID: 16624526

DOI: 10.1016/j.schres.2006.03.017

PubMed ID: 24357581

Title: The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.

PubMed ID: 24357581

DOI: 10.1002/embj.201385857

PubMed ID: 26198635

Title: Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases.

PubMed ID: 26198635

DOI: 10.1074/jbc.m115.657668

Sequence Information:

  • Length: 813
  • Mass: 86505
  • Checksum: 9680ACAFDB5694D1
  • Sequence:
    • MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ QQAQPALAPP 
SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG RSGPGPGLGS GSTSGPADSV 
MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF ERETQYQKDF RAWPLPRRGD HPWIPKPVQI 
SAASQASAPI LGAPKRRPQS QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR 
KAGPAWIVRR AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS 
YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA DNKVIDRRRI 
RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK QAVSGQAAKK KSAEGPSTTK 
PDDKEQSKEM NNKLAEAKES LAQPVSDSSK TQGPVATEPD KDQGSVVPGL LKGQGPMVQE 
PLKKQGSVVP GPPKDLGPMI PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ 
SPMVPAKVKD QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS 
APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE SAMATAPIKN 
QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA PVKNQGPVVP ESVKNQDPIL 
PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK 
TQGPRDPQLP TVSPLPRVMI PTAPHTEYIE SSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.