Details for: MBD1

Gene ID: 4152

Symbol: MBD1

Ensembl ID: ENSG00000141644

Description: methyl-CpG binding domain protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.3024
    Cell Significance Index: -22.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.0226
    Cell Significance Index: -22.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.8904
    Cell Significance Index: -25.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.9806
    Cell Significance Index: -21.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.0185
    Cell Significance Index: -24.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1790
    Cell Significance Index: -22.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9926
    Cell Significance Index: -24.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4514
    Cell Significance Index: -22.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4039
    Cell Significance Index: -25.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1702
    Cell Significance Index: -15.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4004
    Cell Significance Index: 37.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3163
    Cell Significance Index: 214.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0049
    Cell Significance Index: 13.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9803
    Cell Significance Index: 96.9700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8770
    Cell Significance Index: 14.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7487
    Cell Significance Index: 150.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5999
    Cell Significance Index: 17.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5992
    Cell Significance Index: 16.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5981
    Cell Significance Index: 31.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5327
    Cell Significance Index: 11.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4924
    Cell Significance Index: 88.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4362
    Cell Significance Index: 19.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4344
    Cell Significance Index: 86.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4247
    Cell Significance Index: 29.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4168
    Cell Significance Index: 21.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4058
    Cell Significance Index: 49.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3013
    Cell Significance Index: 108.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2938
    Cell Significance Index: 8.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2735
    Cell Significance Index: 7.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2616
    Cell Significance Index: 142.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2383
    Cell Significance Index: 32.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2271
    Cell Significance Index: 205.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2160
    Cell Significance Index: 5.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2042
    Cell Significance Index: 141.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1875
    Cell Significance Index: 8.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1748
    Cell Significance Index: 20.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1745
    Cell Significance Index: 77.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1623
    Cell Significance Index: 10.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1514
    Cell Significance Index: 9.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1267
    Cell Significance Index: 21.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1256
    Cell Significance Index: 4.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1185
    Cell Significance Index: 9.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0963
    Cell Significance Index: 12.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0903
    Cell Significance Index: 17.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0854
    Cell Significance Index: 1.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0849
    Cell Significance Index: 5.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0438
    Cell Significance Index: 2.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0404
    Cell Significance Index: 3.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0299
    Cell Significance Index: 1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0268
    Cell Significance Index: 1.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0149
    Cell Significance Index: 27.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0047
    Cell Significance Index: 0.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0038
    Cell Significance Index: 0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0026
    Cell Significance Index: 1.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -3.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0030
    Cell Significance Index: -0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0103
    Cell Significance Index: -1.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0158
    Cell Significance Index: -9.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0173
    Cell Significance Index: -12.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0190
    Cell Significance Index: -14.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0201
    Cell Significance Index: -9.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0285
    Cell Significance Index: -16.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0395
    Cell Significance Index: -1.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0608
    Cell Significance Index: -12.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0755
    Cell Significance Index: -21.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0824
    Cell Significance Index: -9.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0833
    Cell Significance Index: -2.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0991
    Cell Significance Index: -14.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1017
    Cell Significance Index: -3.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1204
    Cell Significance Index: -2.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1285
    Cell Significance Index: -14.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1430
    Cell Significance Index: -4.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1511
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1535
    Cell Significance Index: -17.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1540
    Cell Significance Index: -3.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1570
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1698
    Cell Significance Index: -5.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1985
    Cell Significance Index: -5.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2042
    Cell Significance Index: -1.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2285
    Cell Significance Index: -23.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2754
    Cell Significance Index: -21.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3000
    Cell Significance Index: -7.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3305
    Cell Significance Index: -3.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3427
    Cell Significance Index: -9.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3583
    Cell Significance Index: -4.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3621
    Cell Significance Index: -22.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3656
    Cell Significance Index: -6.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3976
    Cell Significance Index: -7.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4104
    Cell Significance Index: -10.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4415
    Cell Significance Index: -4.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4420
    Cell Significance Index: -10.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4636
    Cell Significance Index: -9.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4772
    Cell Significance Index: -10.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4999
    Cell Significance Index: -15.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5277
    Cell Significance Index: -19.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5305
    Cell Significance Index: -17.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MBD Domain:** MBD1 contains a CXXC-type zinc finger domain, which is essential for its binding to methylated CpG dinucleotides. 2. **Chromatin Association:** MBD1 associates with chromatin, influencing the accessibility of transcription factors to their target genes. 3. **Transcriptional Regulation:** MBD1 modulates gene expression by interacting with transcription factors, influencing the recruitment of the transcriptional machinery. 4. **Sumoylation:** MBD1 is a substrate for sumoylation, a post-translational modification that regulates protein-protein interactions and subcellular localization. 5. **Cellular Expression:** MBD1 is expressed in various cell types, including neurons, cardiomyocytes, and immune cells. **Pathways and Functions:** 1. **Chromatin Remodeling:** MBD1 participates in chromatin remodeling, influencing the accessibility of transcription factors to their target genes. 2. **DNA Methylation Regulation:** MBD1 regulates DNA methylation by interacting with methylated CpG dinucleotides, influencing gene expression and chromatin dynamics. 3. **Transcriptional Regulation:** MBD1 modulates gene expression by interacting with transcription factors, influencing the recruitment of the transcriptional machinery. 4. **Neurodevelopment:** MBD1 plays a crucial role in neurodevelopment, regulating the expression of genes involved in neuronal differentiation and survival. 5. **Cardiac Development:** MBD1 is involved in cardiac development, influencing the expression of genes involved in cardiac morphogenesis and function. **Clinical Significance:** 1. **Cancer:** MBD1's role in regulating DNA methylation and chromatin dynamics makes it a potential target for cancer therapy. 2. **Neurological Disorders:** MBD1's involvement in neurodevelopment and neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlights its potential as a therapeutic target. 3. **Cardiovascular Diseases:** MBD1's role in cardiac development and function makes it a potential target for cardiovascular disease therapy. 4. **Immunological Disorders:** MBD1's involvement in immune cell development and function makes it a potential target for immunological disorders, such as autoimmune diseases. In conclusion, MBD1 is a key regulator of gene expression and chromatin dynamics, with significant implications for various cellular processes, including development, differentiation, and disease. Further research is necessary to fully elucidate the mechanisms by which MBD1 regulates gene expression and chromatin dynamics, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 310103912

Symbol: MBD1_HUMAN

Name: CXXC-type zinc finger protein 3

UniProtKB Accession Codes:

Q9UIS9 A4UTZ0 B4DXJ5 E9PEC5 K7ELI2 K7EQZ4 K7ESN0 O15248 O95241 Q7Z7B5 Q8N4W4 Q9UNZ6 Q9UNZ7 Q9UNZ8 Q9UNZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 11 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 24 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 16 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 1 RefSeq 22 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9207790

Title: A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins.

PubMed ID: 9207790

DOI: 10.1038/ng0797-256

PubMed ID: 10441743

Title: Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes.

PubMed ID: 10441743

DOI: 10.1007/s003359901112

PubMed ID: 10454587

Title: Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms.

PubMed ID: 10454587

DOI: 10.1128/mcb.19.9.6415

PubMed ID: 14728690

Title: Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1.

PubMed ID: 14728690

DOI: 10.1046/j.1432-1033.2003.03966.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9774669

Title: Identification and characterization of a family of mammalian methyl-CpG binding proteins.

PubMed ID: 9774669

DOI: 10.1128/mcb.18.11.6538

PubMed ID: 10648624

Title: Active repression of methylated genes by the chromosomal protein MBD1.

PubMed ID: 10648624

DOI: 10.1128/mcb.20.4.1394-1406.2000

PubMed ID: 12711603

Title: Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.

PubMed ID: 12711603

DOI: 10.1074/jbc.m302283200

PubMed ID: 12665582

Title: MCAF mediates MBD1-dependent transcriptional repression.

PubMed ID: 12665582

DOI: 10.1128/mcb.23.8.2834-2843.2003

PubMed ID: 12697822

Title: The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1.

PubMed ID: 12697822

DOI: 10.1128/mcb.23.9.3226-3236.2003

PubMed ID: 14610093

Title: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.

PubMed ID: 14610093

DOI: 10.1074/jbc.m309393200

PubMed ID: 15327775

Title: Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.

PubMed ID: 15327775

DOI: 10.1016/j.molcel.2004.06.043

PubMed ID: 30849389

Title: Retraction Notice to: Methyl-CpG Binding Protein MBD1 Couples Histone H3 Methylation at Lysine 9 by SETDB1 to DNA Replication and Chromatin Assembly.

PubMed ID: 30849389

DOI: 10.1016/j.molcel.2019.02.023

PubMed ID: 15691849

Title: Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.

PubMed ID: 15691849

DOI: 10.1074/jbc.m413654200

PubMed ID: 17066076

Title: Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.

PubMed ID: 17066076

DOI: 10.1038/sj.emboj.7601404

PubMed ID: 31612521

Title: Retraction: Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.

PubMed ID: 31612521

DOI: 10.15252/embj.2019103220

PubMed ID: 16757475

Title: Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.

PubMed ID: 16757475

DOI: 10.1074/jbc.m602280200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19666599

Title: Human BAHD1 promotes heterochromatic gene silencing.

PubMed ID: 19666599

DOI: 10.1073/pnas.0901259106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10581239

Title: Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1.

PubMed ID: 10581239

DOI: 10.1093/emboj/18.23.6653

PubMed ID: 11371345

Title: Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA.

PubMed ID: 11371345

DOI: 10.1016/s0092-8674(01)00324-5

PubMed ID: 14555760

Title: Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.

PubMed ID: 14555760

DOI: 10.1073/pnas.2131819100

PubMed ID: 26354109

Title: Solution structure of human MBD1 CXXC1.

PubMed ID: 26354109

DOI: 10.1007/s10858-015-9986-8

PubMed ID: 29276034

Title: DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

PubMed ID: 29276034

DOI: 10.1016/j.str.2017.11.022

Sequence Information:

  • Length: 605
  • Mass: 66607
  • Checksum: 665732782CC6A32A
  • Sequence:
    • MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT 
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT 
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA 
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC 
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP 
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP 
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT 
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL 
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE 
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP 
GARKQ

Genular Protein ID: 2368029207

Symbol: B4DUR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUR3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 535
  • Mass: 58824
  • Checksum: BE11139254A0875D
  • Sequence:
    • MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT 
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT 
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA 
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC 
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP 
TEPHPRALAP SPPAEFIYYC VDEDELKRLL PSVWSESEDG AGSPPPYRRR KRPSSARRHH 
LGPTLKPTLA TRTAQPDHTQ APTKQEAGGG FVLPPPGTDL VFLREGASSP VQVPGPVAAS 
TEALLQAVDP GLPSVKQEPP DPEEDKEENK DDSASKLAPE EEAGGAGTPV ITEIFSLGET 
RFRDTAVWLP RAGTREGKMD VKCGRPRTQW SPRARAGTHE DGLEPMSVSH HLQLR

Genular Protein ID: 340654573

Symbol: A8K654_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K654

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 7 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 605
  • Mass: 66617
  • Checksum: D914EEE7C3C671E4
  • Sequence:
    • MAEDWLDCPA LGPGWKRREV FRKPGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT 
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT 
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA 
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC 
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP 
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP 
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT 
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL 
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE 
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP 
GARKQ

Genular Protein ID: 3309463603

Symbol: B4DI41_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DI41

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 656
  • Mass: 72398
  • Checksum: 55C091585876E644
  • Sequence:
    • MGGFRLRTGR NAALNSDRLL LLPVASMAED WLDCPALGPG WKRREVFRKS GATCGRSDTY 
YQSPTGDRIR SKVELTRYLG PACDLTLFDF KQGILCYPAP KAHPVAVASK KRKKPSRPAK 
TRKRQVGPQS GEVRKEAPRD ETKADTDTAP ASFPAPGCCE NCGISFSGDG TQRQRLKTLC 
KDCRAQRIAF NREQRMFKRV GCGECAACQV TEDCGACSTC LLQLPHDVAS GLFCKCERRR 
CLRIVERSRG CGVCRGCQTQ EDCGHCPICL RPPRPGLRRQ WKCVQRRCLR HLAHRLRRRH 
QRCQRRTPLA VAPPTGKHAR RKGGCDSKMA ARRRPGAQPL PPPPPSQSPE PTEPHPRALA 
PSPPAEFIYY CVDEDELQPY TNRRQNRKCG ACAACLRRMD CGRCDFCCDK PKFGGSNQKR 
QKCRWRQCLQ FAMKRLLPSV WSESEDGAGS PPPYRRRKRP SSARRHHLGP TLKPTLATRT 
AQPDHTQAPT KQEAGGGFVL PPPGTDLVFL REGASSPVQV PGPVAASTEA LLQEAQCSGL 
SWVVALPQVK QEKADTQDEW TPGTAVLTSP VLVPGCPSKA VDPGLPSVKQ EPPDPEEDKE 
ENKDDSASKL APEEEAGGAG TPVITEIFSL GGTRFRDTAV WLPRSKDLKK PGARKQ

Genular Protein ID: 3873171884

Symbol: A0A994J7H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J7H0

Database IDs:

ARBA 4 CDD 1 CTD 1 EMBL 1 Ensembl 2 GO 3 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 680
  • Mass: 75136
  • Checksum: B43EBF631FBF9409
  • Sequence:
    • MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT 
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT 
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA 
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC 
PICLRPPRPG LRRQWKCVQR RCLRHLAHRL RRRHQRCQRR TPLAVAPPTG KHARRKGGCD 
SKMAARRRPG AQPLPPPPPS QSPEPTEPHP RALAPSPPAE FIYYCVDEDE LQPYTNRRQN 
RKCGACAACL RRMDCGRCDF CCDKPKFGGS NQKRQKCRWR QCLQFAMKRL LPSVWSESED 
GAGSPPPYRR RKRPSSARRH HLGPTLKPTL ATRTAQPDHT QAPTKQEAGG GFVLPPPGTD 
LVFLREGASS PVQVPGPVAA STEALLQEAQ CSGLSWVVAL PQVKQEKADT QDEWTPGTAV 
LTSPVLVPGC PSKAVDPGLP SVKQEPPDPE EDKEENKDDS ASKLAPEEEA GGAGTPVITE 
IFSLGGTRFR DTAVWLPSLQ GRHSGREDGC KVWETEDTVE PTSTSWNPRG WPGTHVSLSP 
PPASMMWVSC RRSWCPSSQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.