Details for: MCM6

Gene ID: 4175

Symbol: MCM6

Ensembl ID: ENSG00000076003

Description: minichromosome maintenance complex component 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.7102
    Cell Significance Index: -7.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.9881
    Cell Significance Index: -10.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 36.8251
    Cell Significance Index: -15.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.9410
    Cell Significance Index: -13.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2551
    Cell Significance Index: -13.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1683
    Cell Significance Index: -13.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2485
    Cell Significance Index: -14.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7607
    Cell Significance Index: -14.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9823
    Cell Significance Index: -9.1600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.6984
    Cell Significance Index: 20.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.8553
    Cell Significance Index: 47.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6266
    Cell Significance Index: -3.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4542
    Cell Significance Index: 38.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3616
    Cell Significance Index: 81.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1703
    Cell Significance Index: 222.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9684
    Cell Significance Index: 105.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9103
    Cell Significance Index: 107.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8998
    Cell Significance Index: 50.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7834
    Cell Significance Index: 127.4200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.6482
    Cell Significance Index: 4.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5989
    Cell Significance Index: 20.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5147
    Cell Significance Index: 15.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4944
    Cell Significance Index: 5.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4893
    Cell Significance Index: 97.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4328
    Cell Significance Index: 50.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4152
    Cell Significance Index: 8.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3101
    Cell Significance Index: 8.2800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3039
    Cell Significance Index: 1.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2878
    Cell Significance Index: 19.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2644
    Cell Significance Index: 17.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2145
    Cell Significance Index: 6.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2068
    Cell Significance Index: 91.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1790
    Cell Significance Index: 161.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1703
    Cell Significance Index: 34.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1625
    Cell Significance Index: 88.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1542
    Cell Significance Index: 21.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1425
    Cell Significance Index: 14.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1238
    Cell Significance Index: 3.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1174
    Cell Significance Index: 3.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1133
    Cell Significance Index: 2.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1124
    Cell Significance Index: 2.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1059
    Cell Significance Index: 3.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1056
    Cell Significance Index: 2.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1019
    Cell Significance Index: 1.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0992
    Cell Significance Index: 2.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0991
    Cell Significance Index: 5.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0686
    Cell Significance Index: 24.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0470
    Cell Significance Index: 5.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0382
    Cell Significance Index: 71.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0323
    Cell Significance Index: 4.1400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0237
    Cell Significance Index: 0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0204
    Cell Significance Index: 3.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0202
    Cell Significance Index: 1.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0104
    Cell Significance Index: 7.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0005
    Cell Significance Index: 0.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0070
    Cell Significance Index: -4.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0122
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0147
    Cell Significance Index: -2.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0165
    Cell Significance Index: -12.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0297
    Cell Significance Index: -0.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0298
    Cell Significance Index: -1.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0356
    Cell Significance Index: -3.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0401
    Cell Significance Index: -11.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0659
    Cell Significance Index: -7.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0741
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0759
    Cell Significance Index: -8.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0847
    Cell Significance Index: -3.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1144
    Cell Significance Index: -1.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1170
    Cell Significance Index: -7.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1240
    Cell Significance Index: -6.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1287
    Cell Significance Index: -13.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1445
    Cell Significance Index: -6.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1556
    Cell Significance Index: -10.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1647
    Cell Significance Index: -12.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1672
    Cell Significance Index: -12.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1684
    Cell Significance Index: -8.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1713
    Cell Significance Index: -10.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1747
    Cell Significance Index: -3.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1828
    Cell Significance Index: -14.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2117
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2288
    Cell Significance Index: -5.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2299
    Cell Significance Index: -14.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2326
    Cell Significance Index: -10.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2811
    Cell Significance Index: -4.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2915
    Cell Significance Index: -11.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3080
    Cell Significance Index: -5.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3087
    Cell Significance Index: -4.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3112
    Cell Significance Index: -15.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** MCM6 is primarily located in the nucleus, where it is involved in DNA replication and cell cycle regulation. 2. **Protein structure:** MCM6 is a member of the MCM complex, which consists of six subunits (MCM2-7). MCM6 is a helicase-primase enzyme that unwinds DNA and synthesizes new strands during replication. 3. **Expression pattern:** MCM6 is highly expressed in cells undergoing rapid division, such as oogonial cells, male germ cells, and immune cells. 4. **Pathway involvement:** MCM6 is involved in various cellular pathways, including DNA replication, cell cycle progression, and DNA damage response. **Pathways and Functions:** 1. **Activation of the pre-replicative complex:** MCM6 is essential for the assembly and activation of the pre-replicative complex, which is the first step in DNA replication. 2. **DNA replication initiation:** MCM6 unwinds DNA and synthesizes new strands during replication. 3. **Cell cycle regulation:** MCM6 is involved in the regulation of the cell cycle, particularly during the G1/S transition and G2/M checkpoints. 4. **DNA damage response:** MCM6 is also involved in the response to DNA damage, including double-strand break repair via break-induced replication. **Clinical Significance:** 1. **Cancer:** MCM6 has been implicated in various types of cancer, including breast, lung, and colon cancer. Its overexpression has been associated with tumorigenesis and poor prognosis. 2. **Genetic disorders:** Mutations in MCM6 have been linked to genetic disorders, such as premature aging and cancer susceptibility. 3. **Immunology:** MCM6 is expressed in immune cells, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Reproductive health:** MCM6 is essential for the development and function of reproductive cells, and its dysregulation has been linked to infertility and reproductive disorders. In conclusion, MCM6 plays a critical role in DNA replication and cell cycle regulation. Its dysregulation has been implicated in various diseases, including cancer, genetic disorders, and immunological disorders. Further research is needed to fully understand the mechanisms of MCM6 and its clinical significance.

Genular Protein ID: 364858846

Symbol: MCM6_HUMAN

Name: DNA replication licensing factor MCM6

UniProtKB Accession Codes:

Q14566 B2R6H2 Q13504 Q99859

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EMDB 6 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9286856

Title: HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5.

PubMed ID: 9286856

DOI: 10.1046/j.1365-2443.1997.1290327.x

PubMed ID: 9516426

Title: Human protein MCM6 on HeLa cell chromatin.

PubMed ID: 9516426

DOI: 10.1074/jbc.273.13.7320

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8977093

Title: Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21.

PubMed ID: 8977093

DOI: 10.1016/s0014-5793(96)01189-1

PubMed ID: 9305914

Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.

PubMed ID: 9305914

DOI: 10.1074/jbc.272.39.24508

PubMed ID: 11095689

Title: The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

PubMed ID: 11095689

DOI: 10.1093/nar/28.23.4769

PubMed ID: 11788828

Title: Identification of a variant associated with adult-type hypolactasia.

PubMed ID: 11788828

DOI: 10.1038/ng826

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16899510

Title: Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

PubMed ID: 16899510

DOI: 10.1091/mbc.e06-03-0241

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17116885

Title: Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.

PubMed ID: 17116885

DOI: 10.1073/pnas.0609251103

PubMed ID: 17296731

Title: Identification and characterization of a novel component of the human minichromosome maintenance complex.

PubMed ID: 17296731

DOI: 10.1128/mcb.02384-06

PubMed ID: 17159977

Title: Convergent adaptation of human lactase persistence in Africa and Europe.

PubMed ID: 17159977

DOI: 10.1038/ng1946

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22967762

Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.

PubMed ID: 22967762

DOI: 10.1016/j.bbagen.2012.08.024

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25661590

Title: G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.

PubMed ID: 25661590

DOI: 10.1093/jb/mvv015

PubMed ID: 29290612

Title: Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.

PubMed ID: 29290612

DOI: 10.1016/j.molcel.2017.11.035

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 20202939

Title: Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.

PubMed ID: 20202939

DOI: 10.1074/jbc.c109.094599

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

PubMed ID: 37198333

Title: De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues.

PubMed ID: 37198333

DOI: 10.1007/s00439-023-02569-7

Sequence Information:

  • Length: 821
  • Mass: 92889
  • Checksum: F94968EB25A3E501
  • Sequence:
    • MDLAAAAEPG AGSQHLEVRD EVAEKCQKLF LDFLEEFQSS DGEIKYLQLA EELIRPERNT 
LVVSFVDLEQ FNQQLSTTIQ EEFYRVYPYL CRALKTFVKD RKEIPLAKDF YVAFQDLPTR 
HKIRELTSSR IGLLTRISGQ VVRTHPVHPE LVSGTFLCLD CQTVIRDVEQ QFKYTQPNIC 
RNPVCANRRR FLLDTNKSRF VDFQKVRIQE TQAELPRGSI PRSLEVILRA EAVESAQAGD 
KCDFTGTLIV VPDVSKLSTP GARAETNSRV SGVDGYETEG IRGLRALGVR DLSYRLVFLA 
CCVAPTNPRF GGKELRDEEQ TAESIKNQMT VKEWEKVFEM SQDKNLYHNL CTSLFPTIHG 
NDEVKRGVLL MLFGGVPKTT GEGTSLRGDI NVCIVGDPST AKSQFLKHVE EFSPRAVYTS 
GKASSAAGLT AAVVRDEESH EFVIEAGALM LADNGVCCID EFDKMDVRDQ VAIHEAMEQQ 
TISITKAGVK ATLNARTSIL AAANPISGHY DRSKSLKQNI NLSAPIMSRF DLFFILVDEC 
NEVTDYAIAR RIVDLHSRIE ESIDRVYSLD DIRRYLLFAR QFKPKISKES EDFIVEQYKH 
LRQRDGSGVT KSSWRITVRQ LESMIRLSEA MARMHCCDEV QPKHVKEAFR LLNKSIIRVE 
TPDVNLDQEE EIQMEVDEGA GGINGHADSP APVNGINGYN EDINQESAPK ASLRLGFSEY 
CRISNLIVLH LRKVEEEEDE SALKRSELVN WYLKEIESEI DSEEELINKK RIIEKVIHRL 
THYDHVLIEL TQAGLKGSTE GSESYEEDPY LVVNPNYLLE D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.