Details for: MAP3K5

Gene ID: 4217

Symbol: MAP3K5

Ensembl ID: ENSG00000197442

Description: mitogen-activated protein kinase kinase kinase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 301.7772
    Cell Significance Index: -46.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.2457
    Cell Significance Index: -47.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.2260
    Cell Significance Index: -38.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.9691
    Cell Significance Index: -45.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.1365
    Cell Significance Index: -38.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.7037
    Cell Significance Index: -47.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.6206
    Cell Significance Index: -45.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.4868
    Cell Significance Index: -53.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1387
    Cell Significance Index: -47.9000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 12.0118
    Cell Significance Index: 106.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.9839
    Cell Significance Index: 267.5200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 7.8043
    Cell Significance Index: 48.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 5.1368
    Cell Significance Index: 71.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.9406
    Cell Significance Index: 149.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.4341
    Cell Significance Index: 151.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9855
    Cell Significance Index: 229.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5540
    Cell Significance Index: 512.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9883
    Cell Significance Index: 56.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9247
    Cell Significance Index: 129.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.8731
    Cell Significance Index: 32.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8076
    Cell Significance Index: 35.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3790
    Cell Significance Index: 494.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3397
    Cell Significance Index: 37.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2492
    Cell Significance Index: 64.8900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.2412
    Cell Significance Index: 15.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1439
    Cell Significance Index: 113.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9241
    Cell Significance Index: 23.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6362
    Cell Significance Index: 1197.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6288
    Cell Significance Index: 102.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6273
    Cell Significance Index: 113.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6034
    Cell Significance Index: 544.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5497
    Cell Significance Index: 59.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5373
    Cell Significance Index: 11.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5360
    Cell Significance Index: 370.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5231
    Cell Significance Index: 64.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4839
    Cell Significance Index: 307.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4642
    Cell Significance Index: 210.7000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3851
    Cell Significance Index: 5.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3259
    Cell Significance Index: 5.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2391
    Cell Significance Index: 32.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2095
    Cell Significance Index: 114.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1964
    Cell Significance Index: 37.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1572
    Cell Significance Index: 10.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1374
    Cell Significance Index: 3.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1363
    Cell Significance Index: 23.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1293
    Cell Significance Index: 5.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0689
    Cell Significance Index: 30.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0360
    Cell Significance Index: 2.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0231
    Cell Significance Index: 0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0173
    Cell Significance Index: -31.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0317
    Cell Significance Index: -23.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0330
    Cell Significance Index: -44.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0425
    Cell Significance Index: -26.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0498
    Cell Significance Index: -36.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0528
    Cell Significance Index: -39.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0556
    Cell Significance Index: -31.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0954
    Cell Significance Index: -18.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0960
    Cell Significance Index: -2.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0969
    Cell Significance Index: -10.0900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1080
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1166
    Cell Significance Index: -5.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1187
    Cell Significance Index: -17.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1408
    Cell Significance Index: -40.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1506
    Cell Significance Index: -31.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2093
    Cell Significance Index: -21.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2271
    Cell Significance Index: -26.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2655
    Cell Significance Index: -2.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2753
    Cell Significance Index: -2.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2953
    Cell Significance Index: -38.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2981
    Cell Significance Index: -6.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3457
    Cell Significance Index: -40.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3626
    Cell Significance Index: -46.4800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3977
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3994
    Cell Significance Index: -45.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4040
    Cell Significance Index: -24.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4180
    Cell Significance Index: -6.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4262
    Cell Significance Index: -26.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4473
    Cell Significance Index: -51.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4821
    Cell Significance Index: -10.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5034
    Cell Significance Index: -37.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5111
    Cell Significance Index: -23.8300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5247
    Cell Significance Index: -7.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5283
    Cell Significance Index: -41.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5348
    Cell Significance Index: -11.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5408
    Cell Significance Index: -17.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5437
    Cell Significance Index: -14.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5492
    Cell Significance Index: -10.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5649
    Cell Significance Index: -8.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6234
    Cell Significance Index: -44.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6452
    Cell Significance Index: -20.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6672
    Cell Significance Index: -9.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6988
    Cell Significance Index: -36.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7134
    Cell Significance Index: -37.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7242
    Cell Significance Index: -20.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7453
    Cell Significance Index: -41.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7574
    Cell Significance Index: -16.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7715
    Cell Significance Index: -25.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7739
    Cell Significance Index: -18.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8423
    Cell Significance Index: -53.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP3K5 is a serine/threonine kinase that belongs to the MAP3K family, which is characterized by the presence of a HEAT (Huntingtin, Elongation protein 1 like 4, Transactivator of transcription) domain. MAP3K5 is highly expressed in various tissues, including the adrenal gland, prostate, brain, and immune cells. It is also highly phosphorylated, which is essential for its activation. **Pathways and Functions:** MAP3K5 is involved in various signaling pathways, including: 1. **Apoptotic Signaling Pathway:** MAP3K5 regulates the activation of downstream kinases, such as JNK and p38, which are involved in the regulation of apoptosis. 2. **Stress Response:** MAP3K5 is activated in response to various forms of stress, including oxidative stress, ischemia, and endoplasmic reticulum stress. 3. **Inflammation:** MAP3K5 regulates the activation of immune cells, such as macrophages and microglia, which are involved in the regulation of inflammation. 4. **Cellular Response to Stimuli:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to stimuli, such as growth factors and cytokines. MAP3K5 plays a crucial role in regulating cell survival, apoptosis, and proliferation. It is also involved in the regulation of various cellular processes, including: 1. **Cellular Response to Amino Acid Starvation:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to amino acid starvation. 2. **Cellular Response to Hydrogen Peroxide:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to hydrogen peroxide. 3. **Cellular Response to Reactive Nitrogen Species:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to reactive nitrogen species. **Clinical Significance:** MAP3K5 has been implicated in various diseases, including: 1. **Cancer:** MAP3K5 is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases:** MAP3K5 is involved in the regulation of apoptosis and inflammation in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Inflammatory Diseases:** MAP3K5 is involved in the regulation of inflammation in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, MAP3K5 is a multifunctional kinase that plays a crucial role in regulating cellular responses to stress, inflammation, and oxidative damage. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 719269440

Symbol: M3K5_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 5

UniProtKB Accession Codes:

Q99683 A6NIA0 B4DGB2 Q5THN3 Q99461

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 7 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 48 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8940179

Title: Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.

PubMed ID: 8940179

DOI: 10.1074/jbc.271.49.31607

PubMed ID: 8974401

Title: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.

PubMed ID: 8974401

DOI: 10.1126/science.275.5296.90

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9564042

Title: Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

PubMed ID: 9564042

DOI: 10.1093/emboj/17.9.2596

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 9743501

Title: Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

PubMed ID: 9743501

DOI: 10.1126/science.281.5384.1860

PubMed ID: 10411906

Title: Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.

PubMed ID: 10411906

DOI: 10.1073/pnas.96.15.8511

PubMed ID: 10849426

Title: Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.

PubMed ID: 10849426

DOI: 10.1074/jbc.m003412200

PubMed ID: 10688666

Title: Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

PubMed ID: 10688666

DOI: 10.1128/mcb.20.6.2198-2208.2000

PubMed ID: 11090355

Title: Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.

PubMed ID: 11090355

DOI: 10.1126/science.290.5496.1574

PubMed ID: 11689443

Title: Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

PubMed ID: 11689443

DOI: 10.1093/emboj/20.21.6028

PubMed ID: 11029458

Title: Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.

PubMed ID: 11029458

DOI: 10.1074/jbc.m003425200

PubMed ID: 11154276

Title: Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

PubMed ID: 11154276

DOI: 10.1128/mcb.21.3.893-901.2001

PubMed ID: 11298454

Title: HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.

PubMed ID: 11298454

DOI: 10.1038/35071111

PubMed ID: 11427728

Title: Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.

PubMed ID: 11427728

DOI: 10.1073/pnas.141224398

PubMed ID: 14749717

Title: Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.

PubMed ID: 14749717

DOI: 10.1038/sj.embor.7400072

PubMed ID: 11920685

Title: Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.

PubMed ID: 11920685

DOI: 10.1002/jcp.10080

PubMed ID: 12556535

Title: Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

PubMed ID: 12556535

DOI: 10.1074/jbc.m211398200

PubMed ID: 12697749

Title: AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

PubMed ID: 12697749

DOI: 10.1074/jbc.m302674200

PubMed ID: 27825085

Title:

PubMed ID: 27825085

DOI: 10.1074/jbc.a116.302674

PubMed ID: 12813029

Title: AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3.

PubMed ID: 12813029

DOI: 10.1172/jci17790

PubMed ID: 15023544

Title: Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.

PubMed ID: 15023544

DOI: 10.1016/j.yexcr.2003.12.009

PubMed ID: 14688258

Title: Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation.

PubMed ID: 14688258

DOI: 10.1074/jbc.m311129200

PubMed ID: 15310755

Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

PubMed ID: 15310755

DOI: 10.1074/jbc.m407617200

PubMed ID: 15094778

Title: Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.

PubMed ID: 15094778

DOI: 10.1038/sj.onc.1207668

PubMed ID: 16038411

Title: C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.

PubMed ID: 16038411

DOI: 10.1379/csc-90r.1

PubMed ID: 15701637

Title: Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.

PubMed ID: 15701637

DOI: 10.1074/jbc.m414262200

PubMed ID: 16129676

Title: Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death.

PubMed ID: 16129676

DOI: 10.1074/jbc.m506771200

PubMed ID: 16407264

Title: SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation.

PubMed ID: 16407264

DOI: 10.1074/jbc.m512338200

PubMed ID: 17456047

Title: Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

PubMed ID: 17456047

DOI: 10.1042/bj20070231

PubMed ID: 17210579

Title: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.

PubMed ID: 17210579

DOI: 10.1074/jbc.m607177200

PubMed ID: 17220297

Title: Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.

PubMed ID: 17220297

DOI: 10.1074/jbc.m609146200

PubMed ID: 17389591

Title: RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.

PubMed ID: 17389591

DOI: 10.1074/jbc.m701148200

PubMed ID: 17724081

Title: Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.

PubMed ID: 17724081

DOI: 10.1128/mcb.00227-07

PubMed ID: 18408005

Title: The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus.

PubMed ID: 18408005

DOI: 10.1074/jbc.m710006200

PubMed ID: 18948261

Title: Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.

PubMed ID: 18948261

DOI: 10.1074/jbc.m807219200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19749799

Title: PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.

PubMed ID: 19749799

DOI: 10.1038/onc.2009.276

PubMed ID: 19590015

Title: Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

PubMed ID: 19590015

DOI: 10.1073/pnas.0901823106

PubMed ID: 17883330

Title: Apoptosis signal-regulating kinase 1 in stress and immune response.

PubMed ID: 17883330

DOI: 10.1146/annurev.pharmtox.48.113006.094606

PubMed ID: 19389260

Title: The roles of ASK family proteins in stress responses and diseases.

PubMed ID: 19389260

DOI: 10.1186/1478-811x-7-9

PubMed ID: 20358250

Title: Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A.

PubMed ID: 20358250

DOI: 10.1007/s00018-010-0353-3

PubMed ID: 22095282

Title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.

PubMed ID: 22095282

DOI: 10.1038/cdd.2011.168

PubMed ID: 23102700

Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

PubMed ID: 23102700

DOI: 10.1016/j.molcel.2012.09.018

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24448648

Title: Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.

PubMed ID: 24448648

DOI: 10.1126/scisignal.2004822

PubMed ID: 26095851

Title: Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1.

PubMed ID: 26095851

DOI: 10.1016/j.bbrc.2015.06.078

PubMed ID: 29186683

Title: TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

PubMed ID: 29186683

DOI: 10.1016/j.celrep.2017.11.007

PubMed ID: 17937911

Title: Structural and functional characterization of the human protein kinase ASK1.

PubMed ID: 17937911

DOI: 10.1016/j.str.2007.08.011

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1374
  • Mass: 154537
  • Checksum: 265BDC65968AF985
  • Sequence:
    • MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP PGSFWNVESA 
AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC 
ETVGATLETL HFGKLDFGET TVLDRFYNAD IAVVEMSDAF RQPSLFYHLG VRESFSMANN 
IILYCDTNSD SLQSLKEIIC QKNTMCTGNY TFVPYMITPH NKVYCCDSSF MKGLTELMQP 
NFELLLGPIC LPLVDRFIQL LKVAQASSSQ YFRESILNDI RKARNLYTGK ELAAELARIR 
QRVDNIEVLT ADIVINLLLS YRDIQDYDSI VKLVETLEKL PTFDLASHHH VKFHYAFALN 
RRNLPGDRAK ALDIMIPMVQ SEGQVASDMY CLVGRIYKDM FLDSNFTDTE SRDHGASWFK 
KAFESEPTLQ SGINYAVLLL AAGHQFESSF ELRKVGVKLS SLLGKKGNLE KLQSYWEVGF 
FLGASVLAND HMRVIQASEK LFKLKTPAWY LKSIVETILI YKHFVKLTTE QPVAKQELVD 
FWMDFLVEAT KTDVTVVRFP VLILEPTKIY QPSYLSINNE VEEKTISIWH VLPDDKKGIH 
EWNFSASSVR GVSISKFEER CCFLYVLHNS DDFQIYFCTE LHCKKFFEMV NTITEEKGRS 
TEEGDCESDL LEYDYEYDEN GDRVVLGKGT YGIVYAGRDL SNQVRIAIKE IPERDSRYSQ 
PLHEEIALHK HLKHKNIVQY LGSFSENGFI KIFMEQVPGG SLSALLRSKW GPLKDNEQTI 
GFYTKQILEG LKYLHDNQIV HRDIKGDNVL INTYSGVLKI SDFGTSKRLA GINPCTETFT 
GTLQYMAPEI IDKGPRGYGK AADIWSLGCT IIEMATGKPP FYELGEPQAA MFKVGMFKVH 
PEIPESMSAE AKAFILKCFE PDPDKRACAN DLLVDEFLKV SSKKKKTQPK LSALSAGSNE 
YLRSISLPVP VLVEDTSSSS EYGSVSPDTE LKVDPFSFKT RAKSCGERDV KGIRTLFLGI 
PDENFEDHSA PPSPEEKDSG FFMLRKDSER RATLHRILTE DQDKIVRNLM ESLAQGAEEP 
KLKWEHITTL IASLREFVRS TDRKIIATTL SKLKLELDFD SHGISQVQVV LFGFQDAVNK 
VLRNHNIKPH WMFALDSIIR KAVQTAITIL VPELRPHFSL ASESDTADQE DLDVEDDHEE 
QPSNQTVRRP QAVIEDAVAT SGVSTLSSTV SHDSQSAHRS LNVQLGRMKI ETNRLLEELV 
RKEKELQALL HRAIEEKDQE IKHLKLKSQP IEIPELPVFH LNSSGTNTED SELTDWLRVN 
GADEDTISRF LAEDYTLLDV LYYVTRDDLK CLRLRGGMLC TLWKAIIDFR NKQT

Genular Protein ID: 2244526037

Symbol: A0A8V8TMH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TMH5

Database IDs:

ARBA 11 CDD 1 CTD 1 ChEBI 12 EC 2 EMBL 2 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1483
  • Mass: 165913
  • Checksum: F215D01E10E7D228
  • Sequence:
    • MKASCRLRGR RVLSAAAAAV PGRRLGSQPA RKRASGAATE APRRSEPPPG SGVPSGERAP 
ERRRRRGGEG AARDGSCLAR RARSSPELWL ARRCGWAGDA AAVAARPGEM STEADEGITF 
SVPPFAPSGF CTIPEGGICR RGGAAAVGEG EEHQLPPPPP GSFWNVESAA APGIGCPAAT 
SSSSATRGRG SSVGGGSRRT TVAYVINEAS QGQLVVAESE ALQSLREACE TVGATLETLH 
FGKLDFGETT VLDRFYNADI AVVEMSDAFR QPSLFYHLGV RESFSMANNI ILYCDTNSDS 
LQSLKEIICQ KNTMCTGNYT FVPYMITPHN KVYCCDSSFM KGLTELMQPN FELLLGPICL 
PLVDRFIQLL KVAQASSSQY FRESILNDIR KARNLYTGKE LAAELARIRQ RVDNIEVLTA 
DIVINLLLSY RDIQDYDSIV KLVETLEKLP TFDLASHHHV KFHYAFALNR RNLPGDRAKA 
LDIMIPMVQS EGQVASDMYC LVGRIYKDMF LDSNFTDTES RDHGASWFKK AFESEPTLQS 
GINYAVLLLA AGHQFESSFE LRKVGVKLSS LLGKKGNLEK LQSYWEVGFF LGASVLANDH 
MRVIQASEKL FKLKTPAWYL KSIVETILIY KHFVKLTTEQ PVAKQELVDF WMDFLVEATK 
TDVTVVRFPV LILEPTKIYQ PSYLSINNEV EEKTISIWHV LPDDKKGIHE WNFSASSVRG 
VSISKFEERC CFLYVLHNSD DFQIYFCTEL HCKKFFEMVN TITEEKGRST EEGDCESDLL 
EYDYEYDENG DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH 
LKHKNIVQYL GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL 
KYLHDNQIVH RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII 
DKGPRGYGKA ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA 
KAFILKCFEP DPDKRACAND LLVDEFLKVS SKKKKTQPKL SALSAGSNEY LRSISLPVPV 
LVEDTSSSSE YGSVSPDTEL KVDPFSFKTR AKSCGERDVK GIRTLFLGIP DENFEDHSAP 
PSPEEKDSGF FMLRKDSERR ATLHRILTED QDKIVRNLME SLAQGAEEPK LKWEHITTLI 
ASLREFVRST DRKIIATTLS KLKLELDFDS HGISQVQVVL FGFQDAVNKV LRNHNIKPHW 
MFALDSIIRK AVQTAITILV PELRPHFSLA SESDTADQED LDVEDDHEEQ PSNQTVRRPQ 
AVIEDAVATS GVSTLSSTVS HDSQSAHRSL NVQLGRMKIE TNRLLEELVR KEKELQALLH 
RAIEEKDQEI KHLKLKSQPI EIPELPVFHL NSSGTNTEDS ELTDWLRVNG ADEDTISRFL 
AEDYTLLDVL YYVTRDDLKC LRLRGGMLCT LWKAIIDFRN KQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.