Details for: MAP3K5

Gene ID: 4217

Symbol: MAP3K5

Ensembl ID: ENSG00000197442

Description: mitogen-activated protein kinase kinase kinase 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.46
    Marker Score: 114,686
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.39
    Marker Score: 3,894
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.75
    Marker Score: 2,467
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.73
    Marker Score: 2,074
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.35
    Marker Score: 2,327
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.15
    Marker Score: 6,061
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.15
    Marker Score: 67,159
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.08
    Marker Score: 1,530
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.91
    Marker Score: 1,052
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.6
    Marker Score: 58,207
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.5
    Marker Score: 37,318
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.45
    Marker Score: 5,369
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.41
    Marker Score: 1,306
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.37
    Marker Score: 47,148
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.3
    Marker Score: 2,191
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.28
    Marker Score: 1,980
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.26
    Marker Score: 653
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.11
    Marker Score: 8,806
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.07
    Marker Score: 8,656
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.04
    Marker Score: 1,187
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.01
    Marker Score: 733
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.97
    Marker Score: 652
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.97
    Marker Score: 511
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.93
    Marker Score: 1,080
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,825
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19,344
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.84
    Marker Score: 67,861
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.82
    Marker Score: 532
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.81
    Marker Score: 2,048
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.8
    Marker Score: 8,332
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15,395
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.79
    Marker Score: 941
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.78
    Marker Score: 4,376
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.75
    Marker Score: 66,379
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.69
    Marker Score: 27,182
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.66
    Marker Score: 4,723
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.64
    Marker Score: 519
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.64
    Marker Score: 1,415
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.62
    Marker Score: 1,998
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.59
    Marker Score: 6,162
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.59
    Marker Score: 948
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,444
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.58
    Marker Score: 1,967
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.56
    Marker Score: 1,793
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.56
    Marker Score: 3,669
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.56
    Marker Score: 565
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.5
    Marker Score: 5,810
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.5
    Marker Score: 2,110
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.49
    Marker Score: 2,199
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,533
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.45
    Marker Score: 466
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.42
    Marker Score: 87,448
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.37
    Marker Score: 2,295
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.36
    Marker Score: 622
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.31
    Marker Score: 1,412
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,392
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.27
    Marker Score: 432
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.26
    Marker Score: 758
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.24
    Marker Score: 250
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.24
    Marker Score: 6,488
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.23
    Marker Score: 314
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.21
    Marker Score: 587
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.2
    Marker Score: 849
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.14
    Marker Score: 357
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.14
    Marker Score: 361
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2,313
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.1
    Marker Score: 4,594
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.09
    Marker Score: 1,989
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.08
    Marker Score: 408
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.03
    Marker Score: 601
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.03
    Marker Score: 5,524
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.03
    Marker Score: 4,178
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.03
    Marker Score: 1,099
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.02
    Marker Score: 4,410
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.02
    Marker Score: 3,624
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.01
    Marker Score: 778
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,714
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,939
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,392
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.98
    Marker Score: 258
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.96
    Marker Score: 536
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1,052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.95
    Marker Score: 5,685
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.95
    Marker Score: 644
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.94
    Marker Score: 7,192
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.93
    Marker Score: 1,089
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.93
    Marker Score: 342
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.92
    Marker Score: 3,984
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.91
    Marker Score: 277
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.91
    Marker Score: 460
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.9
    Marker Score: 1,275
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9
    Marker Score: 4,838
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.88
    Marker Score: 587
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.87
    Marker Score: 431
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,243

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP3K5 is a serine/threonine kinase that belongs to the MAP3K family, which is characterized by the presence of a HEAT (Huntingtin, Elongation protein 1 like 4, Transactivator of transcription) domain. MAP3K5 is highly expressed in various tissues, including the adrenal gland, prostate, brain, and immune cells. It is also highly phosphorylated, which is essential for its activation. **Pathways and Functions:** MAP3K5 is involved in various signaling pathways, including: 1. **Apoptotic Signaling Pathway:** MAP3K5 regulates the activation of downstream kinases, such as JNK and p38, which are involved in the regulation of apoptosis. 2. **Stress Response:** MAP3K5 is activated in response to various forms of stress, including oxidative stress, ischemia, and endoplasmic reticulum stress. 3. **Inflammation:** MAP3K5 regulates the activation of immune cells, such as macrophages and microglia, which are involved in the regulation of inflammation. 4. **Cellular Response to Stimuli:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to stimuli, such as growth factors and cytokines. MAP3K5 plays a crucial role in regulating cell survival, apoptosis, and proliferation. It is also involved in the regulation of various cellular processes, including: 1. **Cellular Response to Amino Acid Starvation:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to amino acid starvation. 2. **Cellular Response to Hydrogen Peroxide:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to hydrogen peroxide. 3. **Cellular Response to Reactive Nitrogen Species:** MAP3K5 regulates the activation of downstream kinases, which are involved in the regulation of cellular responses to reactive nitrogen species. **Clinical Significance:** MAP3K5 has been implicated in various diseases, including: 1. **Cancer:** MAP3K5 is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases:** MAP3K5 is involved in the regulation of apoptosis and inflammation in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Inflammatory Diseases:** MAP3K5 is involved in the regulation of inflammation in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, MAP3K5 is a multifunctional kinase that plays a crucial role in regulating cellular responses to stress, inflammation, and oxidative damage. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 719269440

Symbol: M3K5_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 5

UniProtKB Accession Codes:

Q99683 A6NIA0 B4DGB2 Q5THN3 Q99461

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 48 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 25 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8940179

Title: Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.

PubMed ID: 8940179

DOI: 10.1074/jbc.271.49.31607

PubMed ID: 8974401

Title: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.

PubMed ID: 8974401

DOI: 10.1126/science.275.5296.90

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9564042

Title: Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

PubMed ID: 9564042

DOI: 10.1093/emboj/17.9.2596

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 9743501

Title: Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

PubMed ID: 9743501

DOI: 10.1126/science.281.5384.1860

PubMed ID: 10411906

Title: Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.

PubMed ID: 10411906

DOI: 10.1073/pnas.96.15.8511

PubMed ID: 10849426

Title: Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.

PubMed ID: 10849426

DOI: 10.1074/jbc.m003412200

PubMed ID: 10688666

Title: Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

PubMed ID: 10688666

DOI: 10.1128/mcb.20.6.2198-2208.2000

PubMed ID: 11090355

Title: Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.

PubMed ID: 11090355

DOI: 10.1126/science.290.5496.1574

PubMed ID: 11689443

Title: Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

PubMed ID: 11689443

DOI: 10.1093/emboj/20.21.6028

PubMed ID: 11029458

Title: Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.

PubMed ID: 11029458

DOI: 10.1074/jbc.m003425200

PubMed ID: 11154276

Title: Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

PubMed ID: 11154276

DOI: 10.1128/mcb.21.3.893-901.2001

PubMed ID: 11298454

Title: HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.

PubMed ID: 11298454

DOI: 10.1038/35071111

PubMed ID: 11427728

Title: Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.

PubMed ID: 11427728

DOI: 10.1073/pnas.141224398

PubMed ID: 14749717

Title: Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.

PubMed ID: 14749717

DOI: 10.1038/sj.embor.7400072

PubMed ID: 11920685

Title: Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.

PubMed ID: 11920685

DOI: 10.1002/jcp.10080

PubMed ID: 12556535

Title: Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

PubMed ID: 12556535

DOI: 10.1074/jbc.m211398200

PubMed ID: 12697749

Title: AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

PubMed ID: 12697749

DOI: 10.1074/jbc.m302674200

PubMed ID: 27825085

Title:

PubMed ID: 27825085

DOI: 10.1074/jbc.a116.302674

PubMed ID: 12813029

Title: AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3.

PubMed ID: 12813029

DOI: 10.1172/jci17790

PubMed ID: 15023544

Title: Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.

PubMed ID: 15023544

DOI: 10.1016/j.yexcr.2003.12.009

PubMed ID: 14688258

Title: Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation.

PubMed ID: 14688258

DOI: 10.1074/jbc.m311129200

PubMed ID: 15310755

Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

PubMed ID: 15310755

DOI: 10.1074/jbc.m407617200

PubMed ID: 15094778

Title: Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.

PubMed ID: 15094778

DOI: 10.1038/sj.onc.1207668

PubMed ID: 16038411

Title: C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.

PubMed ID: 16038411

DOI: 10.1379/csc-90r.1

PubMed ID: 15701637

Title: Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.

PubMed ID: 15701637

DOI: 10.1074/jbc.m414262200

PubMed ID: 16129676

Title: Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death.

PubMed ID: 16129676

DOI: 10.1074/jbc.m506771200

PubMed ID: 16407264

Title: SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation.

PubMed ID: 16407264

DOI: 10.1074/jbc.m512338200

PubMed ID: 17456047

Title: Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

PubMed ID: 17456047

DOI: 10.1042/bj20070231

PubMed ID: 17210579

Title: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.

PubMed ID: 17210579

DOI: 10.1074/jbc.m607177200

PubMed ID: 17220297

Title: Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.

PubMed ID: 17220297

DOI: 10.1074/jbc.m609146200

PubMed ID: 17389591

Title: RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.

PubMed ID: 17389591

DOI: 10.1074/jbc.m701148200

PubMed ID: 17724081

Title: Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.

PubMed ID: 17724081

DOI: 10.1128/mcb.00227-07

PubMed ID: 18408005

Title: The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus.

PubMed ID: 18408005

DOI: 10.1074/jbc.m710006200

PubMed ID: 18948261

Title: Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.

PubMed ID: 18948261

DOI: 10.1074/jbc.m807219200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19749799

Title: PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.

PubMed ID: 19749799

DOI: 10.1038/onc.2009.276

PubMed ID: 19590015

Title: Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

PubMed ID: 19590015

DOI: 10.1073/pnas.0901823106

PubMed ID: 17883330

Title: Apoptosis signal-regulating kinase 1 in stress and immune response.

PubMed ID: 17883330

DOI: 10.1146/annurev.pharmtox.48.113006.094606

PubMed ID: 19389260

Title: The roles of ASK family proteins in stress responses and diseases.

PubMed ID: 19389260

DOI: 10.1186/1478-811x-7-9

PubMed ID: 20358250

Title: Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A.

PubMed ID: 20358250

DOI: 10.1007/s00018-010-0353-3

PubMed ID: 22095282

Title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.

PubMed ID: 22095282

DOI: 10.1038/cdd.2011.168

PubMed ID: 23102700

Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

PubMed ID: 23102700

DOI: 10.1016/j.molcel.2012.09.018

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24448648

Title: Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.

PubMed ID: 24448648

DOI: 10.1126/scisignal.2004822

PubMed ID: 26095851

Title: Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1.

PubMed ID: 26095851

DOI: 10.1016/j.bbrc.2015.06.078

PubMed ID: 29186683

Title: TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

PubMed ID: 29186683

DOI: 10.1016/j.celrep.2017.11.007

PubMed ID: 17937911

Title: Structural and functional characterization of the human protein kinase ASK1.

PubMed ID: 17937911

DOI: 10.1016/j.str.2007.08.011

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1374
  • Mass: 154537
  • Checksum: 265BDC65968AF985
  • Sequence:
    • MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP PGSFWNVESA 
AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC 
ETVGATLETL HFGKLDFGET TVLDRFYNAD IAVVEMSDAF RQPSLFYHLG VRESFSMANN 
IILYCDTNSD SLQSLKEIIC QKNTMCTGNY TFVPYMITPH NKVYCCDSSF MKGLTELMQP 
NFELLLGPIC LPLVDRFIQL LKVAQASSSQ YFRESILNDI RKARNLYTGK ELAAELARIR 
QRVDNIEVLT ADIVINLLLS YRDIQDYDSI VKLVETLEKL PTFDLASHHH VKFHYAFALN 
RRNLPGDRAK ALDIMIPMVQ SEGQVASDMY CLVGRIYKDM FLDSNFTDTE SRDHGASWFK 
KAFESEPTLQ SGINYAVLLL AAGHQFESSF ELRKVGVKLS SLLGKKGNLE KLQSYWEVGF 
FLGASVLAND HMRVIQASEK LFKLKTPAWY LKSIVETILI YKHFVKLTTE QPVAKQELVD 
FWMDFLVEAT KTDVTVVRFP VLILEPTKIY QPSYLSINNE VEEKTISIWH VLPDDKKGIH 
EWNFSASSVR GVSISKFEER CCFLYVLHNS DDFQIYFCTE LHCKKFFEMV NTITEEKGRS 
TEEGDCESDL LEYDYEYDEN GDRVVLGKGT YGIVYAGRDL SNQVRIAIKE IPERDSRYSQ 
PLHEEIALHK HLKHKNIVQY LGSFSENGFI KIFMEQVPGG SLSALLRSKW GPLKDNEQTI 
GFYTKQILEG LKYLHDNQIV HRDIKGDNVL INTYSGVLKI SDFGTSKRLA GINPCTETFT 
GTLQYMAPEI IDKGPRGYGK AADIWSLGCT IIEMATGKPP FYELGEPQAA MFKVGMFKVH 
PEIPESMSAE AKAFILKCFE PDPDKRACAN DLLVDEFLKV SSKKKKTQPK LSALSAGSNE 
YLRSISLPVP VLVEDTSSSS EYGSVSPDTE LKVDPFSFKT RAKSCGERDV KGIRTLFLGI 
PDENFEDHSA PPSPEEKDSG FFMLRKDSER RATLHRILTE DQDKIVRNLM ESLAQGAEEP 
KLKWEHITTL IASLREFVRS TDRKIIATTL SKLKLELDFD SHGISQVQVV LFGFQDAVNK 
VLRNHNIKPH WMFALDSIIR KAVQTAITIL VPELRPHFSL ASESDTADQE DLDVEDDHEE 
QPSNQTVRRP QAVIEDAVAT SGVSTLSSTV SHDSQSAHRS LNVQLGRMKI ETNRLLEELV 
RKEKELQALL HRAIEEKDQE IKHLKLKSQP IEIPELPVFH LNSSGTNTED SELTDWLRVN 
GADEDTISRF LAEDYTLLDV LYYVTRDDLK CLRLRGGMLC TLWKAIIDFR NKQT

Genular Protein ID: 2244526037

Symbol: A0A8V8TMH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TMH5

Database IDs:

ARBA 13 CDD 1 CTD 1 ChEBI 12 EC 2 EMBL 2 EPD 1 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 Pfam 5 Proteomes 2 RefSeq 1 Rhea 6 SAM 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 1483
  • Mass: 165913
  • Checksum: F215D01E10E7D228
  • Sequence:
    • MKASCRLRGR RVLSAAAAAV PGRRLGSQPA RKRASGAATE APRRSEPPPG SGVPSGERAP 
ERRRRRGGEG AARDGSCLAR RARSSPELWL ARRCGWAGDA AAVAARPGEM STEADEGITF 
SVPPFAPSGF CTIPEGGICR RGGAAAVGEG EEHQLPPPPP GSFWNVESAA APGIGCPAAT 
SSSSATRGRG SSVGGGSRRT TVAYVINEAS QGQLVVAESE ALQSLREACE TVGATLETLH 
FGKLDFGETT VLDRFYNADI AVVEMSDAFR QPSLFYHLGV RESFSMANNI ILYCDTNSDS 
LQSLKEIICQ KNTMCTGNYT FVPYMITPHN KVYCCDSSFM KGLTELMQPN FELLLGPICL 
PLVDRFIQLL KVAQASSSQY FRESILNDIR KARNLYTGKE LAAELARIRQ RVDNIEVLTA 
DIVINLLLSY RDIQDYDSIV KLVETLEKLP TFDLASHHHV KFHYAFALNR RNLPGDRAKA 
LDIMIPMVQS EGQVASDMYC LVGRIYKDMF LDSNFTDTES RDHGASWFKK AFESEPTLQS 
GINYAVLLLA AGHQFESSFE LRKVGVKLSS LLGKKGNLEK LQSYWEVGFF LGASVLANDH 
MRVIQASEKL FKLKTPAWYL KSIVETILIY KHFVKLTTEQ PVAKQELVDF WMDFLVEATK 
TDVTVVRFPV LILEPTKIYQ PSYLSINNEV EEKTISIWHV LPDDKKGIHE WNFSASSVRG 
VSISKFEERC CFLYVLHNSD DFQIYFCTEL HCKKFFEMVN TITEEKGRST EEGDCESDLL 
EYDYEYDENG DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH 
LKHKNIVQYL GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL 
KYLHDNQIVH RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII 
DKGPRGYGKA ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA 
KAFILKCFEP DPDKRACAND LLVDEFLKVS SKKKKTQPKL SALSAGSNEY LRSISLPVPV 
LVEDTSSSSE YGSVSPDTEL KVDPFSFKTR AKSCGERDVK GIRTLFLGIP DENFEDHSAP 
PSPEEKDSGF FMLRKDSERR ATLHRILTED QDKIVRNLME SLAQGAEEPK LKWEHITTLI 
ASLREFVRST DRKIIATTLS KLKLELDFDS HGISQVQVVL FGFQDAVNKV LRNHNIKPHW 
MFALDSIIRK AVQTAITILV PELRPHFSLA SESDTADQED LDVEDDHEEQ PSNQTVRRPQ 
AVIEDAVATS GVSTLSSTVS HDSQSAHRSL NVQLGRMKIE TNRLLEELVR KEKELQALLH 
RAIEEKDQEI KHLKLKSQPI EIPELPVFHL NSSGTNTEDS ELTDWLRVNG ADEDTISRFL 
AEDYTLLDVL YYVTRDDLKC LRLRGGMLCT LWKAIIDFRN KQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.