Details for: MGAT2

Gene ID: 4247

Symbol: MGAT2

Ensembl ID: ENSG00000168282

Description: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.6641
    Cell Significance Index: -16.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.8120
    Cell Significance Index: -14.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.5654
    Cell Significance Index: -16.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.2226
    Cell Significance Index: -18.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.4916
    Cell Significance Index: -16.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.0046
    Cell Significance Index: -18.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 6.3571
    Cell Significance Index: 101.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0413
    Cell Significance Index: -13.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8530
    Cell Significance Index: -19.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4344
    Cell Significance Index: -13.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3613
    Cell Significance Index: 163.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4034
    Cell Significance Index: 163.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9341
    Cell Significance Index: 151.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7734
    Cell Significance Index: 21.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6066
    Cell Significance Index: 16.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4838
    Cell Significance Index: 47.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4028
    Cell Significance Index: 11.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4002
    Cell Significance Index: 20.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3914
    Cell Significance Index: 8.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3898
    Cell Significance Index: 10.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3817
    Cell Significance Index: 7.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3800
    Cell Significance Index: 52.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3644
    Cell Significance Index: 16.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3480
    Cell Significance Index: 42.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3084
    Cell Significance Index: 19.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2883
    Cell Significance Index: 157.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2706
    Cell Significance Index: 17.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2620
    Cell Significance Index: 236.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2164
    Cell Significance Index: 16.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1854
    Cell Significance Index: 21.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1840
    Cell Significance Index: 23.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1807
    Cell Significance Index: 8.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1743
    Cell Significance Index: 1.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1480
    Cell Significance Index: 26.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1430
    Cell Significance Index: 4.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1346
    Cell Significance Index: 59.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1301
    Cell Significance Index: 16.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1288
    Cell Significance Index: 4.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1164
    Cell Significance Index: 5.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1126
    Cell Significance Index: 22.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0898
    Cell Significance Index: 17.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0419
    Cell Significance Index: 2.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0373
    Cell Significance Index: 7.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0305
    Cell Significance Index: 10.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0230
    Cell Significance Index: 0.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0175
    Cell Significance Index: 0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0066
    Cell Significance Index: -1.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0085
    Cell Significance Index: -15.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0126
    Cell Significance Index: -23.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0152
    Cell Significance Index: -23.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0152
    Cell Significance Index: -20.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0157
    Cell Significance Index: -11.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0207
    Cell Significance Index: -14.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0219
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0251
    Cell Significance Index: -15.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0276
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0291
    Cell Significance Index: -16.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0316
    Cell Significance Index: -19.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0341
    Cell Significance Index: -1.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0382
    Cell Significance Index: -10.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0392
    Cell Significance Index: -17.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0574
    Cell Significance Index: -6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0614
    Cell Significance Index: -3.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0659
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1009
    Cell Significance Index: -21.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1038
    Cell Significance Index: -2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1109
    Cell Significance Index: -16.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1156
    Cell Significance Index: -3.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1355
    Cell Significance Index: -3.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1681
    Cell Significance Index: -2.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1813
    Cell Significance Index: -4.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1840
    Cell Significance Index: -19.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1946
    Cell Significance Index: -11.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2089
    Cell Significance Index: -2.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2191
    Cell Significance Index: -17.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2265
    Cell Significance Index: -2.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2331
    Cell Significance Index: -3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2380
    Cell Significance Index: -18.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2391
    Cell Significance Index: -16.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2398
    Cell Significance Index: -5.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2520
    Cell Significance Index: -14.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2806
    Cell Significance Index: -17.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3294
    Cell Significance Index: -1.9900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3420
    Cell Significance Index: -5.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3876
    Cell Significance Index: -14.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3950
    Cell Significance Index: -17.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4192
    Cell Significance Index: -2.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4247
    Cell Significance Index: -8.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4636
    Cell Significance Index: -17.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4700
    Cell Significance Index: -12.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4759
    Cell Significance Index: -10.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4831
    Cell Significance Index: -7.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4896
    Cell Significance Index: -14.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4930
    Cell Significance Index: -4.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5019
    Cell Significance Index: -7.7700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5026
    Cell Significance Index: -5.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MGAT2 is a member of the glycosyltransferase family, specifically involved in the elongation of the N-glycan antennae in the medial/trans-Golgi compartment. Its primary function is to catalyze the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to the asparagine (Asn) residue in the growing N-glycan chain. This process is essential for the formation of complex N-glycans, which are characterized by the presence of multiple branches and a terminal GlcNAc residue. MGAT2 is specifically expressed in various cell types, including pancreatic A cells, pancreatic acinar cells, and neoplastic cells, highlighting its role in maintaining tissue homeostasis and cellular function. The enzyme's expression is also observed in decidual cells, absorptive cells, and cerebral cortex GABAergic interneurons, suggesting its involvement in various physiological processes. **Pathways and Functions:** MGAT2 is involved in the following pathways: 1. **Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity:** MGAT2 catalyzes the transfer of GlcNAc from UDP-GlcNAc to the Asn residue in the growing N-glycan chain, resulting in the formation of complex N-glycans. 2. **Asparagine n-linked glycosylation:** MGAT2 is essential for the synthesis of N-glycans, which play a crucial role in protein function, stability, and cell signaling. 3. **Golgi apparatus:** MGAT2 is localized to the Golgi membrane, where it participates in the elongation of the N-glycan antennae. **Clinical Significance:** MGAT2 plays a critical role in maintaining cellular homeostasis and function. Defects in MGAT2 have been associated with congenital disorders of glycosylation (CDG), specifically CDG-2A. CDG-2A is characterized by impaired N-glycosylation of proteins, leading to a range of clinical symptoms, including developmental delays, intellectual disability, and cardiovascular anomalies. Furthermore, MGAT2 has been implicated in the maturation of the SARS-CoV-2 spike protein, which is essential for viral entry into host cells. Mutations in MGAT2 may contribute to the emergence of viral variants with altered N-glycosylation patterns, potentially affecting the severity of COVID-19. In conclusion, MGAT2 is a vital enzyme involved in the synthesis of complex N-glycans, which play a critical role in protein function, stability, and cell signaling. Defects in MGAT2 have been associated with congenital disorders of glycosylation and may contribute to the emergence of viral variants with altered N-glycosylation patterns. Further research is necessary to fully elucidate the role of MGAT2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 45016944

Symbol: MGAT2_HUMAN

Name: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

Q10469 B3KPC5 B3KQM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 GO 11 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7635144

Title: The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

PubMed ID: 7635144

DOI: 10.1111/j.1432-1033.1995.tb20703.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20378551

Title: Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.

PubMed ID: 20378551

DOI: 10.1074/jbc.m110.103184

PubMed ID: 29666272

Title: Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.

PubMed ID: 29666272

DOI: 10.1073/pnas.1716988115

PubMed ID: 8808595

Title: Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development.

PubMed ID: 8808595

PubMed ID: 11228641

Title: Congenital disorders of glycosylation IIa cause growth retardation, mental retardation, and facial dysmorphism.

PubMed ID: 11228641

DOI: 10.1136/jmg.37.11.875

Sequence Information:

  • Length: 447
  • Mass: 51550
  • Checksum: 533B76D08BD8A572
  • Sequence:
    • MRFRIYKRKV LILTLVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPARGA GGRGGDHPSV 
AVGIRRVSNV SAASLVPAVP QPEADNLTLR YRSLVYQLNF DQTLRNVDKA GTWAPRELVL 
VVQVHNRPEY LRLLLDSLRK AQGIDNVLVI FSHDFWSTEI NQLIAGVNFC PVLQVFFPFS 
IQLYPNEFPG SDPRDCPRDL PKNAALKLGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF 
VWERVKILRD YAGLILFLEE DHYLAPDFYH VFKKMWKLKQ QECPECDVLS LGTYSASRSF 
YGMADKVDVK TWKSTEHNMG LALTRNAYQK LIECTDTFCT YDDYNWDWTL QYLTVSCLPK 
FWKVLVPQIP RIFHAGDCGM HHKKTCRPST QSAQIESLLN NNKQYMFPET LTISEKFTVV 
AISPPRKNGG WGDIRDHELC KSYRRLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.