Details for: MIPEP

Gene ID: 4285

Symbol: MIPEP

Ensembl ID: ENSG00000027001

Description: mitochondrial intermediate peptidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 142.5309
    Cell Significance Index: -22.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.7072
    Cell Significance Index: -22.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.4106
    Cell Significance Index: -23.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.0607
    Cell Significance Index: -19.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4034
    Cell Significance Index: -19.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9301
    Cell Significance Index: -23.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2759
    Cell Significance Index: -22.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9987
    Cell Significance Index: -10.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9389
    Cell Significance Index: 130.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6466
    Cell Significance Index: 330.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.0662
    Cell Significance Index: 154.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0608
    Cell Significance Index: 104.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0160
    Cell Significance Index: 44.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9935
    Cell Significance Index: 37.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8178
    Cell Significance Index: 565.6300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7874
    Cell Significance Index: 16.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7618
    Cell Significance Index: 21.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7452
    Cell Significance Index: 267.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7266
    Cell Significance Index: 55.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7204
    Cell Significance Index: 43.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6818
    Cell Significance Index: 135.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6306
    Cell Significance Index: 569.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6284
    Cell Significance Index: 68.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5239
    Cell Significance Index: 85.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5127
    Cell Significance Index: 14.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5072
    Cell Significance Index: 6.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3669
    Cell Significance Index: 20.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3223
    Cell Significance Index: 16.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3198
    Cell Significance Index: 14.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2601
    Cell Significance Index: 17.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2172
    Cell Significance Index: 25.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2144
    Cell Significance Index: 117.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2136
    Cell Significance Index: 5.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2136
    Cell Significance Index: 9.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1933
    Cell Significance Index: 5.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1858
    Cell Significance Index: 82.1300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1817
    Cell Significance Index: 2.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1648
    Cell Significance Index: 3.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1483
    Cell Significance Index: 4.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1382
    Cell Significance Index: 8.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1351
    Cell Significance Index: 254.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1168
    Cell Significance Index: 2.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1116
    Cell Significance Index: 20.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0931
    Cell Significance Index: 1.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0806
    Cell Significance Index: 148.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0767
    Cell Significance Index: 34.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0758
    Cell Significance Index: 48.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0751
    Cell Significance Index: 1.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0706
    Cell Significance Index: 8.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0571
    Cell Significance Index: 10.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0561
    Cell Significance Index: 86.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0455
    Cell Significance Index: 1.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0365
    Cell Significance Index: 0.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0263
    Cell Significance Index: 0.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0205
    Cell Significance Index: 1.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0087
    Cell Significance Index: 11.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0144
    Cell Significance Index: -1.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0261
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0262
    Cell Significance Index: -19.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0406
    Cell Significance Index: -22.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0416
    Cell Significance Index: -25.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0525
    Cell Significance Index: -3.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0671
    Cell Significance Index: -8.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0684
    Cell Significance Index: -19.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0758
    Cell Significance Index: -7.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0881
    Cell Significance Index: -11.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1112
    Cell Significance Index: -2.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1130
    Cell Significance Index: -13.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1155
    Cell Significance Index: -3.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1161
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1167
    Cell Significance Index: -13.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1177
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1181
    Cell Significance Index: -24.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1257
    Cell Significance Index: -13.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1291
    Cell Significance Index: -9.6200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1487
    Cell Significance Index: -1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1569
    Cell Significance Index: -4.1900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1675
    Cell Significance Index: -2.2400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1684
    Cell Significance Index: -2.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1759
    Cell Significance Index: -8.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2027
    Cell Significance Index: -12.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2081
    Cell Significance Index: -2.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2089
    Cell Significance Index: -5.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2145
    Cell Significance Index: -13.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2406
    Cell Significance Index: -19.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2756
    Cell Significance Index: -8.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2908
    Cell Significance Index: -3.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3023
    Cell Significance Index: -7.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3180
    Cell Significance Index: -10.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3211
    Cell Significance Index: -8.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3432
    Cell Significance Index: -7.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3550
    Cell Significance Index: -18.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3636
    Cell Significance Index: -7.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3641
    Cell Significance Index: -7.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3732
    Cell Significance Index: -12.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3852
    Cell Significance Index: -19.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3951
    Cell Significance Index: -13.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIPEP is a metalloendopeptidase that belongs to the mitochondrial matrix and is involved in the degradation of peptides. It is highly expressed in neurons, particularly in GABAergic neurons, and is also found in other cell types, such as mural cells. The enzyme has a high affinity for metal ions, which are essential for its enzymatic activity. MIPEP has been shown to be involved in the regulation of neurotransmitter processing and degradation, and its dysfunction has been implicated in various neurological disorders. **Pathways and Functions:** MIPEP is involved in several key pathways, including: 1. **Metal ion binding:** MIPEP binds to metal ions, such as zinc and calcium, which are essential for its enzymatic activity. 2. **Metalloendopeptidase activity:** MIPEP is a metalloendopeptidase that cleaves peptides, including neurotransmitters, and regulates their processing and degradation. 3. **Mitochondrial matrix:** MIPEP is located in the mitochondrial matrix and is involved in the regulation of mitochondrial function and homeostasis. 4. **Peptide metabolic process:** MIPEP is involved in the degradation of peptides, including neurotransmitters, and regulates their levels in the synaptic cleft. 5. **Protein processing involved in protein targeting to mitochondrion:** MIPEP is involved in the processing and degradation of proteins that are targeted to the mitochondrion. **Clinical Significance:** Dysregulation of MIPEP has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases:** MIPEP dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by the degeneration of neurons and the disruption of neurotransmitter homeostasis. 2. **Neuropsychiatric disorders:** MIPEP dysfunction has also been implicated in neuropsychiatric disorders, such as anxiety and depression, which are characterized by the disruption of neurotransmitter homeostasis and the regulation of neuronal excitability. 3. **Neurodevelopmental disorders:** MIPEP dysfunction has also been linked to neurodevelopmental disorders, such as autism spectrum disorder, which are characterized by the disruption of neurotransmitter homeostasis and the regulation of neuronal excitability. In conclusion, MIPEP is a critical enzyme that plays a key role in the regulation of neurotransmission and mitochondrial function. Its dysfunction has been implicated in various neurological disorders, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 671757852

Symbol: MIPEP_HUMAN

Name: Mitochondrial intermediate peptidase

UniProtKB Accession Codes:

Q99797 Q5JV15 Q5T9Q9 Q96G65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9073519

Title: Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP).

PubMed ID: 9073519

DOI: 10.1006/geno.1996.4586

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27799064

Title: MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death.

PubMed ID: 27799064

DOI: 10.1186/s13073-016-0360-6

Sequence Information:

  • Length: 713
  • Mass: 80641
  • Checksum: 9DBB26B74355B9C1
  • Sequence:
    • MLCVGRLGGL GARAAALPPR RAGRGSLEAG IRARRVSTSW SPVGAAFNVK PQGSRLDLFG 
ERRGLFGVPE LSAPEGFHIA QEKALRKTEL LVDRACSTPP GPQTVLIFDE LSDSLCRVAD 
LADFVKIAHP EPAFREAAEE ACRSIGTMVE KLNTNVDLYQ SLQKLLADKK LVDSLDPETR 
RVAELFMFDF EISGIHLDKE KRKRAVDLNV KILDLSSTFL MGTNFPNKIE KHLLPEHIRR 
NFTSAGDHII IDGLHAESPD DLVREAAYKI FLYPNAGQLK CLEELLSSRD LLAKLVGYST 
FSHRALQGTI AKNPETVMQF LEKLSDKLSE RTLKDFEMIR GMKMKLNPQN SEVMPWDPPY 
YSGVIRAERY NIEPSLYCPF FSLGACMEGL NILLNRLLGI SLYAEQPAKG EVWSEDVRKL 
AVVHESEGLL GYIYCDFFQR ADKPHQDCHF TIRGGRLKED GDYQLPVVVL MLNLPRSSRS 
SPTLLTPSMM ENLFHEMGHA MHSMLGRTRY QHVTGTRCPT DFAEVPSILM EYFANDYRVV 
NQFARHYQTG QPLPKNMVSR LCESKKVCAA ADMQLQVFYA TLDQIYHGKH PLRNSTTDIL 
KETQEKFYGL PYVPNTAWQL RFSHLVGYGA RYYSYLMSRA VASMVWKECF LQDPFNRAAG 
ERYRREMLAH GGGREPMLMV EGMLQKCPSV DDFVSALVSD LDLDFETFLM DSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.