Details for: MNT

Gene ID: 4335

Symbol: MNT

Ensembl ID: ENSG00000070444

Description: MAX network transcriptional repressor

Associated with

  • Cellular senescence
    (GO:0090398)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of apoptotic signaling pathway
    (GO:2001234)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.0568
    Cell Significance Index: -16.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.2421
    Cell Significance Index: -15.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.7855
    Cell Significance Index: -16.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4068
    Cell Significance Index: -16.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7879
    Cell Significance Index: -15.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2346
    Cell Significance Index: -16.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4248
    Cell Significance Index: 177.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.2154
    Cell Significance Index: 43.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8308
    Cell Significance Index: 52.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6547
    Cell Significance Index: 192.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5969
    Cell Significance Index: 72.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8920
    Cell Significance Index: 24.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8908
    Cell Significance Index: 88.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7756
    Cell Significance Index: 46.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7145
    Cell Significance Index: 645.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6338
    Cell Significance Index: 68.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5650
    Cell Significance Index: 113.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4816
    Cell Significance Index: 78.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4388
    Cell Significance Index: 8.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4385
    Cell Significance Index: 6.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4279
    Cell Significance Index: 77.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3949
    Cell Significance Index: 8.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3639
    Cell Significance Index: 9.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3252
    Cell Significance Index: 3.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3216
    Cell Significance Index: 39.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3078
    Cell Significance Index: 58.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2319
    Cell Significance Index: 31.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2227
    Cell Significance Index: 44.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2053
    Cell Significance Index: 112.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1996
    Cell Significance Index: 12.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1968
    Cell Significance Index: 86.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1877
    Cell Significance Index: 5.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1740
    Cell Significance Index: 12.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1723
    Cell Significance Index: 6.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1616
    Cell Significance Index: 57.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1528
    Cell Significance Index: 4.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1138
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0816
    Cell Significance Index: 2.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0766
    Cell Significance Index: 3.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0701
    Cell Significance Index: 48.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0450
    Cell Significance Index: 0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0360
    Cell Significance Index: 48.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0345
    Cell Significance Index: 2.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0339
    Cell Significance Index: 2.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0250
    Cell Significance Index: 3.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0227
    Cell Significance Index: 42.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0144
    Cell Significance Index: 1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0140
    Cell Significance Index: 0.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0098
    Cell Significance Index: 15.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0067
    Cell Significance Index: 0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0044
    Cell Significance Index: 8.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0027
    Cell Significance Index: 1.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0044
    Cell Significance Index: -0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0058
    Cell Significance Index: -2.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0157
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0266
    Cell Significance Index: -15.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0269
    Cell Significance Index: -4.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0274
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0303
    Cell Significance Index: -18.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0357
    Cell Significance Index: -3.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0408
    Cell Significance Index: -2.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0428
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0474
    Cell Significance Index: -13.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0609
    Cell Significance Index: -3.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0689
    Cell Significance Index: -8.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0838
    Cell Significance Index: -17.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0848
    Cell Significance Index: -1.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0874
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0880
    Cell Significance Index: -10.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0897
    Cell Significance Index: -1.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0985
    Cell Significance Index: -6.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1210
    Cell Significance Index: -7.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1231
    Cell Significance Index: -4.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1346
    Cell Significance Index: -4.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1362
    Cell Significance Index: -2.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1379
    Cell Significance Index: -14.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1509
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1803
    Cell Significance Index: -14.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1842
    Cell Significance Index: -6.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2046
    Cell Significance Index: -5.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2265
    Cell Significance Index: -2.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2507
    Cell Significance Index: -13.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2557
    Cell Significance Index: -7.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2700
    Cell Significance Index: -7.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2761
    Cell Significance Index: -16.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2972
    Cell Significance Index: -7.6400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3221
    Cell Significance Index: -2.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3336
    Cell Significance Index: -10.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3461
    Cell Significance Index: -11.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3499
    Cell Significance Index: -6.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3526
    Cell Significance Index: -12.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3538
    Cell Significance Index: -12.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3568
    Cell Significance Index: -18.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3570
    Cell Significance Index: -9.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3619
    Cell Significance Index: -10.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3913
    Cell Significance Index: -8.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Repressor Function:** MNT acts as a transcriptional repressor by binding to specific DNA sequences and inhibiting the transcription of target genes. 2. **Cell Cycle Regulation:** MNT regulates cell cycle progression by modulating the expression of genes involved in cell proliferation and apoptosis. 3. **Apoptosis Modulation:** MNT inhibits apoptotic signaling pathways, preventing excessive cell death and promoting cell survival. 4. **DNA Binding:** MNT interacts with DNA-binding transcription factors, such as MAX, to regulate transcriptional activity. 5. **Protein Interactions:** MNT forms dimers with other proteins, including MAX, to modulate its transcriptional activity. **Pathways and Functions:** 1. **Cellular Senescence:** MNT regulates the expression of genes involved in cellular senescence, a state of permanent cell cycle arrest. 2. **Chromatin Remodeling:** MNT interacts with chromatin remodeling complexes to regulate gene expression and transcriptional activity. 3. **Apoptosis Signaling:** MNT inhibits apoptotic signaling pathways by modulating the expression of pro-apoptotic genes. 4. **Transcriptional Regulation:** MNT regulates the expression of target genes by interacting with RNA polymerase II and other transcription factors. 5. **Immune Response:** MNT is highly expressed in immune cells, suggesting its importance in regulating immune responses and inflammation. **Clinical Significance:** 1. **Cancer:** Dysregulation of the MNT gene has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular Disease:** MNT regulates the expression of genes involved in cardiovascular disease, including those involved in inflammation and cell proliferation. 3. **Immune Disorders:** MNT is expressed in immune cells, suggesting its importance in regulating immune responses and inflammation in diseases such as rheumatoid arthritis and lupus. 4. **Neurological Disorders:** MNT has been implicated in the regulation of gene expression in neurons, suggesting its potential role in neurological disorders such as Alzheimer's disease and Parkinson's disease. 5. **Developmental Biology:** MNT regulates the expression of genes involved in development and cell differentiation, highlighting its importance in embryonic development and tissue homeostasis. In conclusion, the MNT gene plays a critical role in regulating various cellular processes, including cell cycle progression, transcriptional activity, and apoptosis. Dysregulation of the MNT gene has been implicated in various human diseases, emphasizing the importance of understanding its mechanisms of action and its clinical significance.

Genular Protein ID: 2972162769

Symbol: MNT_HUMAN

Name: Max-binding protein MNT

UniProtKB Accession Codes:

Q99583 A8K6D1 D3DTI7 Q1ED38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9184233

Title: Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.

PubMed ID: 9184233

DOI: 10.1093/emboj/16.10.2892

PubMed ID: 9598315

Title: The human ROX gene: genomic structure and mutation analysis in human breast tumors.

PubMed ID: 9598315

DOI: 10.1006/geno.1998.5241

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 582
  • Mass: 62300
  • Checksum: 06AC320D79BF18A0
  • Sequence:
    • MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEQEREQEQ KKANSLARLA HTLPVEEPRM 
EAPPLPLSPP APPPAPPPPL ATPAPLTVIP IPVVTNSPQP LPPPPPLPAA AQPLPLAPRQ 
PALVGAPGLS IKEPAPLPSR PQVPTPAPLL PDSKATIPPN GSPKPLQPLP TPVLTIAPHP 
GVQPQLAPQQ PPPPTLGTLK LAPAEEVKSS EQKKRPGGIG TREVHNKLEK NRRAHLKECF 
ETLKRNIPNV DDKKTSNLSV LRTALRYIQS LKRKEKEYEH EMERLAREKI ATQQRLAELK 
HELSQWMDVL EIDRVLRQTG QPEDDQASTS TASEGEDNID EDMEEDRAGL GPPKLSHRPQ 
PELLKSTLPP PSTTPAPLPP HPHPHPHSVA LPPAHLPVQQ QQPQQKTPLP APPPPPAAPA 
QTLVPAPAHL VATAGGGSTV IAHTATTHAS VIQTVNHVLQ GPGGKHIAHI APSAPSPAVQ 
LAPATPPIGH ITVHPATLNH VAHLGSQLPL YPQPVAVSHI AHTLSHQQVN GTAGLGPPAT 
VMAKPAVGAQ VVHHPQLVGQ TVLNPVTMVT MPSFPVSTLK LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.