Details for: MPP3

Gene ID: 4356

Symbol: MPP3

Ensembl ID: ENSG00000161647

Description: MAGUK p55 scaffold protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.0416
    Cell Significance Index: -13.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.5195
    Cell Significance Index: -11.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.7152
    Cell Significance Index: -11.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.0064
    Cell Significance Index: 307.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3538
    Cell Significance Index: -7.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.9723
    Cell Significance Index: 33.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1457
    Cell Significance Index: 70.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5951
    Cell Significance Index: 17.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5410
    Cell Significance Index: 102.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4550
    Cell Significance Index: 20.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3945
    Cell Significance Index: 39.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3589
    Cell Significance Index: 10.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2695
    Cell Significance Index: 5.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2660
    Cell Significance Index: 16.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2608
    Cell Significance Index: 3.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2359
    Cell Significance Index: 5.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2133
    Cell Significance Index: 192.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2069
    Cell Significance Index: 12.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2005
    Cell Significance Index: 39.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1893
    Cell Significance Index: 20.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1864
    Cell Significance Index: 30.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1700
    Cell Significance Index: 2.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1514
    Cell Significance Index: 30.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1319
    Cell Significance Index: 91.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1264
    Cell Significance Index: 3.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1188
    Cell Significance Index: 6.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1005
    Cell Significance Index: 3.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0987
    Cell Significance Index: 5.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0948
    Cell Significance Index: 11.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0696
    Cell Significance Index: 1.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0673
    Cell Significance Index: 42.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0667
    Cell Significance Index: 1.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0551
    Cell Significance Index: 2.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0525
    Cell Significance Index: 18.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0219
    Cell Significance Index: 1.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0166
    Cell Significance Index: 31.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0077
    Cell Significance Index: 3.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0075
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0036
    Cell Significance Index: 6.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0090
    Cell Significance Index: -0.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0095
    Cell Significance Index: -12.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0116
    Cell Significance Index: -0.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0160
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -12.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0217
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0232
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0235
    Cell Significance Index: -14.6500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0308
    Cell Significance Index: -0.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0313
    Cell Significance Index: -5.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0375
    Cell Significance Index: -4.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0377
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0410
    Cell Significance Index: -4.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0431
    Cell Significance Index: -5.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0444
    Cell Significance Index: -5.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0450
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0521
    Cell Significance Index: -8.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0521
    Cell Significance Index: -7.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0661
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0683
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0699
    Cell Significance Index: -14.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0784
    Cell Significance Index: -1.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0823
    Cell Significance Index: -1.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0823
    Cell Significance Index: -6.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0837
    Cell Significance Index: -5.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1107
    Cell Significance Index: -5.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1117
    Cell Significance Index: -5.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1128
    Cell Significance Index: -3.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1152
    Cell Significance Index: -11.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1161
    Cell Significance Index: -11.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1475
    Cell Significance Index: -2.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1677
    Cell Significance Index: -2.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1964
    Cell Significance Index: -2.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2029
    Cell Significance Index: -12.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2032
    Cell Significance Index: -2.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2118
    Cell Significance Index: -9.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2153
    Cell Significance Index: -13.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2199
    Cell Significance Index: -3.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2264
    Cell Significance Index: -5.8200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2275
    Cell Significance Index: -2.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2398
    Cell Significance Index: -9.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2537
    Cell Significance Index: -7.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2575
    Cell Significance Index: -9.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2581
    Cell Significance Index: -8.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2659
    Cell Significance Index: -3.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2826
    Cell Significance Index: -9.0000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2872
    Cell Significance Index: -3.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2907
    Cell Significance Index: -7.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2911
    Cell Significance Index: -7.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3004
    Cell Significance Index: -7.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3053
    Cell Significance Index: -6.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3209
    Cell Significance Index: -11.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3345
    Cell Significance Index: -9.5900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3367
    Cell Significance Index: -4.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3383
    Cell Significance Index: -6.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3449
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Scaffold Protein Function:** MPP3 acts as a scaffold protein, bringing together multiple signaling molecules, adhesion complexes, and cytoskeletal elements to form complex protein assemblies. 2. **Cellular Expression:** MPP3 is widely expressed in various cell types, including cardiac myocytes, neural progenitor cells, GABAergic interneurons, and other cell types. 3. **Molecular Interactions:** MPP3 interacts with a range of proteins, including PDZ domain-containing proteins, guanylate kinases, and cytoskeletal elements, such as actin and myosin. 4. **Cell-Cell Junctions:** MPP3 is associated with cell-cell junctions, including adherens junctions and tight junctions, where it plays a crucial role in maintaining tissue integrity. **Pathways and Functions:** 1. **Cell Signaling:** MPP3 regulates cell signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, to modulate cell growth, differentiation, and survival. 2. **Cell Adhesion:** MPP3 plays a critical role in maintaining cell-cell adhesion and the integrity of cell-cell junctions, which is essential for tissue homeostasis. 3. **Cytoskeletal Organization:** MPP3 regulates the organization of the cytoskeleton, including actin and myosin filaments, to maintain cell shape and motility. 4. **Neurotransmission:** MPP3 has been implicated in neurotransmission, particularly in GABAergic interneurons, where it regulates the assembly of neurotransmitter receptors and ion channels. **Clinical Significance:** 1. **Cardiac Disease:** MPP3 has been implicated in cardiac disease, including heart failure and arrhythmias, where disruptions in cell-cell junctions and signaling pathways can contribute to disease progression. 2. **Neurological Disorders:** MPP3 has been implicated in neurological disorders, including epilepsy and schizophrenia, where disruptions in neurotransmission and cell-cell junctions can contribute to disease pathology. 3. **Cancer:** MPP3 has been implicated in cancer, particularly in the regulation of cell growth, differentiation, and survival, where dysregulation of MPP3 can contribute to tumorigenesis. 4. **Neurodevelopmental Disorders:** MPP3 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and intellectual disability, where disruptions in cell-cell junctions and signaling pathways can contribute to disease pathology. In conclusion, MPP3 is a critical component of the MAGUK family of proteins, playing a pivotal role in maintaining cell-cell junctions, regulating cell signaling, and organizing the cytoskeleton. Its dysregulation has been implicated in various diseases, including cardiac disease, neurological disorders, cancer, and neurodevelopmental disorders. Further research is needed to fully elucidate the functional significance of MPP3 and its role in maintaining tissue integrity and function.

Genular Protein ID: 3603732582

Symbol: MPP3_HUMAN

Name: Discs large homolog 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8824795

Title: Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21.

PubMed ID: 8824795

DOI: 10.1006/geno.1996.0025

PubMed ID: 16519681

Title: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane.

PubMed ID: 16519681

DOI: 10.1111/j.1742-4658.2006.05140.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 13679854

Title: Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.

PubMed ID: 13679854

DOI: 10.1038/sj.onc.1206744

PubMed ID: 24503895

Title: Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

PubMed ID: 24503895

DOI: 10.1371/journal.pone.0082894

PubMed ID: 25268382

Title: Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

PubMed ID: 25268382

DOI: 10.1371/journal.pone.0110062

Sequence Information:

  • Length: 585
  • Mass: 66152
  • Checksum: 782DAE54096A4993
  • Sequence:
  • MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH EKLRYYERQS 
    PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL RAVLMVHDTV AQKNFDPVLP 
    PLPDNIDEDF DEESVKIVRL VKNKEPLGAT IRRDEHSGAV VVARIMRGGA ADRSGLVHVG 
    DELREVNGIA VLHKRPDEIS QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR 
    EDRAIPCQEA GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR 
    AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER LGGSQEGKMS 
    SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE LKQKVVAENP QHFGVAVPHT 
    TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL 
    VDVEPEALKQ LRTSEFKPYI IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF 
    IDRHYGHLVD AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR

Genular Protein ID: 1003080654

Symbol: D3DX46_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 610
  • Mass: 68889
  • Checksum: EF72998CA9F5D5D7
  • Sequence:
  • MELQYPPPPP SPRICRERSG GDNASMPVLS EDSGLHETLA LLTSQLRPDS NHKEEMGFLR 
    DVFSEKSLSY LMKIHEKLRY YERQSPTPVL HSAVALAEDV MEELQAASVH SDERELLQLL 
    STPHLRAVLM VHDTVAQKNF DPVLPPLPDN IDEDFDEESV KIVRLVKNKE PLGATIRRDE 
    HSGAVVVARI MRGGAADRSG LVHVGDELRE VNGIAVLHKR PDEISQILAQ SQGSITLKII 
    PATQEEDRLK ESKVFMRALF HYNPREDRAI PCQEAGLPFQ RRQVLEVVSQ DDPTWWQAKR 
    VGDTNLRAGL IPSKGFQERR LSYRRAAGTL PSPQSLRKPP YDQPCDKETC DCEGYLKGHY 
    VAGLRRSFRL GCRERLGGSQ EGKMSSGAES PELLTYEEVA RYQHQPGERP RLVVLIGSLG 
    ARLHELKQKV VAENPQHFGV AVPHTTRPRK SHEKEGVEYH FVSKQAFEAD LHHNKFLEHG 
    EYKENLYGTS LEAIQAVMAK NKVCLVDVEP EALKQLRTSE FKPYIIFVKP AIQEKRKTPP 
    MSPACEDTAA PFDEQQQEMA ASAAFIDRHY GHLVDAVLVK EDLQGAYSQL KVVLEKLSKD 
    THWVPVSWVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.