Details for: MSI1

Gene ID: 4440

Symbol: MSI1

Ensembl ID: ENSG00000135097

Description: musashi RNA binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.9319
    Cell Significance Index: -16.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 6.9258
    Cell Significance Index: 436.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.3346
    Cell Significance Index: 39.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2420
    Cell Significance Index: 125.8100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.1449
    Cell Significance Index: 30.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6874
    Cell Significance Index: 321.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1.5542
    Cell Significance Index: 9.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2642
    Cell Significance Index: 36.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2401
    Cell Significance Index: 122.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0031
    Cell Significance Index: 15.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8062
    Cell Significance Index: 727.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7250
    Cell Significance Index: 78.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7101
    Cell Significance Index: 42.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6602
    Cell Significance Index: 14.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6545
    Cell Significance Index: 129.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6273
    Cell Significance Index: 102.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5196
    Cell Significance Index: 18.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4922
    Cell Significance Index: 10.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3053
    Cell Significance Index: 21.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2507
    Cell Significance Index: 3.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2382
    Cell Significance Index: 5.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1296
    Cell Significance Index: 16.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0825
    Cell Significance Index: 57.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0759
    Cell Significance Index: 3.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0737
    Cell Significance Index: 2.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0703
    Cell Significance Index: 4.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0617
    Cell Significance Index: 22.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0592
    Cell Significance Index: 3.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0443
    Cell Significance Index: 8.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0433
    Cell Significance Index: 66.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0354
    Cell Significance Index: 4.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0353
    Cell Significance Index: 47.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0322
    Cell Significance Index: 59.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0260
    Cell Significance Index: 11.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0236
    Cell Significance Index: 15.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0230
    Cell Significance Index: 43.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0096
    Cell Significance Index: 0.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0060
    Cell Significance Index: 0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0031
    Cell Significance Index: 1.7000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0034
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0044
    Cell Significance Index: -0.0400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0104
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0140
    Cell Significance Index: -0.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0204
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0206
    Cell Significance Index: -15.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0221
    Cell Significance Index: -16.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0234
    Cell Significance Index: -17.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0261
    Cell Significance Index: -14.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0289
    Cell Significance Index: -4.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0296
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0315
    Cell Significance Index: -19.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0361
    Cell Significance Index: -2.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0363
    Cell Significance Index: -4.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0408
    Cell Significance Index: -11.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0693
    Cell Significance Index: -2.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0743
    Cell Significance Index: -13.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0848
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0878
    Cell Significance Index: -10.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0886
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0979
    Cell Significance Index: -20.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1075
    Cell Significance Index: -7.6000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1122
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1128
    Cell Significance Index: -13.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1285
    Cell Significance Index: -2.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1334
    Cell Significance Index: -1.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1424
    Cell Significance Index: -14.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1641
    Cell Significance Index: -16.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1867
    Cell Significance Index: -3.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1872
    Cell Significance Index: -8.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1949
    Cell Significance Index: -4.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2120
    Cell Significance Index: -5.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2133
    Cell Significance Index: -16.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2137
    Cell Significance Index: -14.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2169
    Cell Significance Index: -13.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2312
    Cell Significance Index: -10.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2655
    Cell Significance Index: -4.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2740
    Cell Significance Index: -14.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2877
    Cell Significance Index: -4.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2908
    Cell Significance Index: -1.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2936
    Cell Significance Index: -7.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3056
    Cell Significance Index: -4.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3358
    Cell Significance Index: -5.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3370
    Cell Significance Index: -9.6600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3425
    Cell Significance Index: -2.4900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3517
    Cell Significance Index: -4.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3599
    Cell Significance Index: -15.9200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3639
    Cell Significance Index: -4.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3648
    Cell Significance Index: -12.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3850
    Cell Significance Index: -11.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3908
    Cell Significance Index: -4.4400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.3923
    Cell Significance Index: -2.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3932
    Cell Significance Index: -9.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3987
    Cell Significance Index: -5.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4149
    Cell Significance Index: -10.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4270
    Cell Significance Index: -16.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4403
    Cell Significance Index: -14.4200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4411
    Cell Significance Index: -3.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4506
    Cell Significance Index: -14.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MSI1 is a member of the Musashi family of RNA-binding proteins, which are known for their ability to bind to specific RNA sequences and regulate gene expression. MSI1 is composed of three RNA recognition motifs (RRMs) and a poly(C)-binding domain, which allow it to interact with various RNAs and modulate their translation. MSI1 is highly expressed in cells of neural crest origin, where it is involved in the regulation of axon guidance and neuronal differentiation. MSI1 has also been shown to regulate the expression of genes involved in immune cell development and function, such as those involved in the regulation of translation and response to hormone signals. **Pathways and Functions:** MSI1 is involved in several key pathways and processes, including: 1. **Axon guidance**: MSI1 regulates the expression of genes involved in axon guidance, such as Slits and Robos, which are critical for the proper formation of neural connections. 2. **Neuronal differentiation**: MSI1 promotes the differentiation of neural crest-derived cells into neurons, where it regulates the expression of genes involved in neuronal development and function. 3. **Immune cell development**: MSI1 regulates the expression of genes involved in immune cell development, such as those involved in the regulation of translation and response to hormone signals. 4. **Regulation of translation**: MSI1 modulates the translation of specific mRNAs, which is critical for the proper development and function of cells. **Clinical Significance:** MSI1 has been implicated in various neurological and immunological disorders, including: 1. **Neurodevelopmental disorders**: MSI1 has been linked to neurodevelopmental disorders, such as autism spectrum disorder (ASD) and schizophrenia, where disruptions in neural development and function are thought to contribute to the pathogenesis of these disorders. 2. **Immune-mediated disorders**: MSI1 has been implicated in the regulation of immune cell development and function, and dysregulation of MSI1 has been linked to immune-mediated disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: MSI1 has been shown to be overexpressed in certain types of cancer, including glioblastoma and melanoma, where it may contribute to tumorigenesis and cancer progression. In conclusion, MSI1 is a critical RNA-binding protein that plays a pivotal role in regulating gene expression and cellular differentiation in various tissues, including the nervous system and immune cells. Further studies are needed to fully elucidate the mechanisms by which MSI1 regulates gene expression and to explore its potential as a therapeutic target for neurological and immunological disorders.

Genular Protein ID: 82068645

Symbol: MSI1H_HUMAN

Name: RNA-binding protein Musashi homolog 1

UniProtKB Accession Codes:

O43347 Q96PU0 Q96PU1 Q96PU2 Q96PU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790759

Title: The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells.

PubMed ID: 9790759

DOI: 10.1006/geno.1998.5456

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 12054577

Title: Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines.

PubMed ID: 12054577

DOI: 10.1016/s0006-291x(02)00175-4

PubMed ID: 11896183

Title: Musashi: a translational regulator of cell fate.

PubMed ID: 11896183

DOI: 10.1242/jcs.115.7.1355

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 362
  • Mass: 39125
  • Checksum: 26487B0A32CF1F40
  • Sequence:
    • METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS 
RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT 
TVEDVKQYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE 
CKKAQPKEVM SPTGSARGRS RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT 
YQFPEFRVER TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST 
PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG PLIATAFTNG 
YH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.