Details for: MST1R

Gene ID: 4486

Symbol: MST1R

Ensembl ID: ENSG00000164078

Description: macrophage stimulating 1 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.6623
    Cell Significance Index: -7.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 14.1912
    Cell Significance Index: -6.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 9.9997
    Cell Significance Index: -6.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.7607
    Cell Significance Index: -5.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.5076
    Cell Significance Index: 101.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.3402
    Cell Significance Index: 50.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.7358
    Cell Significance Index: 59.2700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.8199
    Cell Significance Index: 13.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7670
    Cell Significance Index: 80.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6011
    Cell Significance Index: 83.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4239
    Cell Significance Index: 140.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3193
    Cell Significance Index: 18.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9039
    Cell Significance Index: 25.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8467
    Cell Significance Index: 92.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8325
    Cell Significance Index: 49.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7686
    Cell Significance Index: 125.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7429
    Cell Significance Index: 26.1100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.7319
    Cell Significance Index: 1.6500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6994
    Cell Significance Index: 7.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6917
    Cell Significance Index: 6.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6645
    Cell Significance Index: 13.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6104
    Cell Significance Index: 13.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5641
    Cell Significance Index: 509.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4861
    Cell Significance Index: 33.6200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3112
    Cell Significance Index: 4.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2900
    Cell Significance Index: 4.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1773
    Cell Significance Index: 1.8400
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1553
    Cell Significance Index: 0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1285
    Cell Significance Index: 15.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1185
    Cell Significance Index: 22.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0928
    Cell Significance Index: 2.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0875
    Cell Significance Index: 15.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0581
    Cell Significance Index: 1.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0570
    Cell Significance Index: 31.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0509
    Cell Significance Index: 10.2200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0485
    Cell Significance Index: 0.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0432
    Cell Significance Index: 19.1100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0399
    Cell Significance Index: 0.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0213
    Cell Significance Index: 1.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0147
    Cell Significance Index: 5.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0084
    Cell Significance Index: 0.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0061
    Cell Significance Index: 0.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0058
    Cell Significance Index: 0.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0028
    Cell Significance Index: 0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0068
    Cell Significance Index: -0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0069
    Cell Significance Index: -0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0084
    Cell Significance Index: -11.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0111
    Cell Significance Index: -2.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0113
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0143
    Cell Significance Index: -1.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0179
    Cell Significance Index: -3.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0231
    Cell Significance Index: -0.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0242
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0246
    Cell Significance Index: -3.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0337
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0348
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0390
    Cell Significance Index: -8.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0420
    Cell Significance Index: -5.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0483
    Cell Significance Index: -6.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0502
    Cell Significance Index: -5.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0502
    Cell Significance Index: -2.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0613
    Cell Significance Index: -4.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0644
    Cell Significance Index: -0.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0656
    Cell Significance Index: -3.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0698
    Cell Significance Index: -7.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0718
    Cell Significance Index: -4.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0754
    Cell Significance Index: -5.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0838
    Cell Significance Index: -6.6400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0887
    Cell Significance Index: -0.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0914
    Cell Significance Index: -5.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1040
    Cell Significance Index: -7.9800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1070
    Cell Significance Index: -0.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1133
    Cell Significance Index: -7.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1241
    Cell Significance Index: -3.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1254
    Cell Significance Index: -5.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1277
    Cell Significance Index: -6.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1329
    Cell Significance Index: -7.4600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1352
    Cell Significance Index: -1.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1358
    Cell Significance Index: -3.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1484
    Cell Significance Index: -5.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1504
    Cell Significance Index: -5.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1540
    Cell Significance Index: -6.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1611
    Cell Significance Index: -3.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1627
    Cell Significance Index: -4.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1674
    Cell Significance Index: -5.4800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1706
    Cell Significance Index: -2.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1711
    Cell Significance Index: -5.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1712
    Cell Significance Index: -3.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1737
    Cell Significance Index: -9.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor Tyrosine Kinase**: MST1R is a member of the receptor tyrosine kinase (RTK) family, characterized by its ability to phosphorylate tyrosine residues on target proteins. 2. **Macrophage Colony-Stimulating Factor Receptor**: MST1R is a specific receptor for macrophage colony-stimulating factor (M-CSF), which is involved in the regulation of macrophage development, differentiation, and function. 3. **Signaling Pathways**: MST1R is involved in various signaling pathways, including the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway, the MAPK/ERK pathway, and the JAK/STAT pathway. 4. **Cellular Expression**: MST1R is expressed in various cell types, including retinal bipolar neurons, cerebral cortex GABAergic interneurons, intestinal epithelial cells, and macrophages. **Pathways and Functions:** 1. **Innate Immune Response**: MST1R is involved in the regulation of immune responses against viruses and pathogens, including the activation of macrophages and the production of cytokines. 2. **Cell Migration and Proliferation**: MST1R is involved in the regulation of cell migration and proliferation, which is essential for tissue development and repair. 3. **Developmental Processes**: MST1R is involved in the regulation of developmental processes, including nervous system development and multicellular organism development. 4. **Neuroprotection**: MST1R has been shown to have neuroprotective effects, including the regulation of neuronal survival and differentiation. 5. **Intestinal Homeostasis**: MST1R is involved in the regulation of intestinal homeostasis, including the maintenance of the intestinal epithelial barrier and the regulation of immune responses. **Clinical Significance:** 1. **Cancer**: MST1R has been implicated in the development and progression of various cancers, including breast cancer, colon cancer, and lung cancer. 2. **Neurological Disorders**: MST1R has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune-Mediated Diseases**: MST1R has been implicated in the pathogenesis of immune-mediated diseases, including rheumatoid arthritis and lupus. 4. **Infectious Diseases**: MST1R has been implicated in the regulation of immune responses against infectious diseases, including HIV and tuberculosis. In conclusion, the Macrophage Stimulating 1 Receptor (MST1R) is a multifaceted receptor that plays a crucial role in various biological processes, including immune response, development, and cellular regulation. Further research is needed to fully understand the mechanisms of MST1R and its clinical significance in various diseases.

Genular Protein ID: 1288507368

Symbol: RON_HUMAN

Name: Macrophage-stimulating protein receptor

UniProtKB Accession Codes:

Q04912 A0A087WZG2 B5A944 B5A945 B5A946 B5A947

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CPTAC 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8386824

Title: A novel putative receptor protein tyrosine kinase of the met family.

PubMed ID: 8386824

PubMed ID: 8816464

Title: A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.

PubMed ID: 8816464

DOI: 10.1128/mcb.16.10.5518

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 7687741

Title: A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.

PubMed ID: 7687741

DOI: 10.1128/mcb.13.8.4600-4608.1993

PubMed ID: 8062829

Title: RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.

PubMed ID: 8062829

DOI: 10.1002/j.1460-2075.1994.tb06659.x

PubMed ID: 7939629

Title: Identification of the ron gene product as the receptor for the human macrophage stimulating protein.

PubMed ID: 7939629

DOI: 10.1126/science.7939629

PubMed ID: 9764835

Title: Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury.

PubMed ID: 9764835

DOI: 10.1046/j.1523-1747.1998.00332.x

PubMed ID: 10222149

Title: Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism.

PubMed ID: 10222149

DOI: 10.1006/excr.1999.4429

PubMed ID: 10514476

Title: Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding.

PubMed ID: 10514476

DOI: 10.1074/jbc.274.42.29937

PubMed ID: 12472665

Title: Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities.

PubMed ID: 12472665

DOI: 10.1046/j.1365-3083.2002.01177.x

PubMed ID: 12802274

Title: c-Cbl is a critical modulator of the Ron tyrosine kinase receptor.

PubMed ID: 12802274

DOI: 10.1038/sj.onc.1206585

PubMed ID: 12676986

Title: Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.

PubMed ID: 12676986

DOI: 10.1073/pnas.0837136100

PubMed ID: 15184888

Title: Interplay between scatter factor receptors and B plexins controls invasive growth.

PubMed ID: 15184888

DOI: 10.1038/sj.onc.1207650

PubMed ID: 15632155

Title: The C terminus of RON tyrosine kinase plays an autoinhibitory role.

PubMed ID: 15632155

DOI: 10.1074/jbc.m412623200

PubMed ID: 18836480

Title: The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells.

PubMed ID: 18836480

DOI: 10.1038/onc.2008.383

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21784853

Title: Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.

PubMed ID: 21784853

DOI: 10.1074/jbc.m111.239384

PubMed ID: 37186866

Title: The SHDRA syndrome-associated geDne TMEM260 encodes a protein-specific O-mannosyltransferase.

PubMed ID: 37186866

DOI: 10.1073/pnas.2302584120

PubMed ID: 20726546

Title: The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.

PubMed ID: 20726546

DOI: 10.1021/bi100409w

PubMed ID: 22848655

Title: Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase.

PubMed ID: 22848655

DOI: 10.1371/journal.pone.0041912

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 26951679

Title: Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.

PubMed ID: 26951679

DOI: 10.1073/pnas.1523436113

Sequence Information:

  • Length: 1400
  • Mass: 152241
  • Checksum: 358672D466B8E70D
  • Sequence:
    • MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT 
YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 
KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS 
PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK 
HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC 
RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV 
GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT 
SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL 
NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIQGPGCRHF LTCGRCLRAW 
HFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG 
LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT 
NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN 
GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG 
YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG 
NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV 
GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP DGVPQSTLLG 
ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG 
LALPAIDGLD STTCVHGASF SDSEDESCVP LLRKESIQLR DLDSALLAEV KDVLIPHERV 
VTHSDRVIGK GHFGVVYHGE YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH 
PNVLALIGIM LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA 
EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP VKWMALESLQ 
TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL AQGRRLPQPE YCPDSLYQVM 
QQCWEADPAV RPTFRVLVGE VEQIVSALLG DHYVQLPATY MNLGPSTSHE MNVRPEQPQF 
SPMPGNVRRP RPLSEPPRPT

Genular Protein ID: 915126186

Symbol: G9JXB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

G9JXB8

Database IDs:

ARBA 13 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 3 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 3 SAM 3 SMART 4 SUPFAM 4

Citations:

PubMed ID: 22975341

Title: A novel variant of the RON receptor tyrosine kinase derived from colorectal carcinoma cells which lacks tyrosine phosphorylation but induces cell migration.

PubMed ID: 22975341

DOI: 10.1016/j.yexcr.2012.08.006

Sequence Information:

  • Length: 1294
  • Mass: 140655
  • Checksum: 18A35FB4DACDFF82
  • Sequence:
    • MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT 
YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 
KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS 
PLGTRVTVVE QGQASYFYVA SSLDAAVAGS FSPRSVSIRR LKADASGFAP GFVALSVLPK 
HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC 
RFAPKRRRRG APEGGQPYPV LQVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV 
GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP VFQVPIQGPG 
CRHFLTCGRC LRAWHFMGCG WCGNMCGQQK ECPGSWQQDH CPPKLTEFHP HSGPLRGSTR 
LTLCGSNFYL HPSGLVPEGT HQVTVGQSPC RPLPKDSSKL RPVPRKDFVE EFECELEPLG 
TQAVGPTNVS LTVTNMPPGK HFRVDGTSVL RGFSFMEPVL IAVQPLFGPR AGGTCLTLEG 
QSLSVGTSRA VLVNGTECLL ARVSEGQLLC ATPPGATVAS VPLSLQVGGA QVPGSWTFQY 
REDPVVLSIS PNCGYINSHI TICGQHLTSA WHLVLSFHDG LRAVESRCER QLPEQQLCRL 
PEYVVRDPQG WVAGNLSARG DGAAGFTLPG FRFLPPPHPP SANLVPLKPE EHAIKFEYIG 
LGAVADCVGI NVTVGGESCQ HEFRGDMVVC PLPPSLQLGQ DGAPLQVCVD GECHILGRVV 
RPGPDGVPQS TLLGILLPLL LLVAALATAL VFSYWWRRKQ LVLPPNLNDL ASLDQTAGAT 
PLPILYSGSD YRSGLALPAI DGLDSTTCVH GASFSDSEDE SCVPLLRKES IQLRDLDSAL 
LAEVKDVLIP HERVVTHSDR VIGKGHFGVV YHGEYIDQAQ NRIQCAIKSL SRITEMQQVE 
AFLREGLLMR GLNHPNVLAL IGIMLPPEGL PHVLLPYMCH GDLLQFIRSP QRNPTVKDLI 
SFGLQVARGM EYLAEQKFVH RDLAARNCML DESFTVKVAD FGLARDILDR EYYSVQQHRH 
ARLPVKWMAL ESLQTYRFTT KSDVWSFGVL LWELLTRGAP PYRHIDPFDL THFLAQGRRL 
PQPEYCPDSL YQVMQQCWEA DPAVRPTFRV LVGEVEQIVS ALLGDHYVQL PATYMNLGPS 
TSHEMNVRPE QPQFSPMPGN VRRPRPLSEP PRPT

Genular Protein ID: 2460151106

Symbol: B4E058_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E058

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 279
  • Mass: 32095
  • Checksum: 674739723F05DA2B
  • Sequence:
    • MQQVEAFLRE GLLMRGLNHP NVLALIGIML PPEGLPHVLL PYMCHGDLLQ FIRSPQRNPT 
VKDLISFGLQ VARGMEYLAE QKFVHRDLAA RNCMLDESFT VKVADFGLAR DILDREYYSV 
QQHRHARLPV KWMALESLQT YRFTTKSDVW SFGVLLWELL TRGAPPYRHI DPFDLTHFLA 
QGRRLPQPEY CPDSLYQVMQ QCWEADPAVR PTFRVLVGEV EQIVSALLGD HYVQLPATYM 
NLGPSTSHEM NVRPEQPQFS PMPGNVRRPR PLSEPPRPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.