Details for: MT1E

Gene ID: 4493

Symbol: MT1E

Ensembl ID: ENSG00000169715

Description: metallothionein 1E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 388.1186
    Cell Significance Index: -60.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 242.2693
    Cell Significance Index: -61.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 145.6981
    Cell Significance Index: -60.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.8950
    Cell Significance Index: -59.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.3860
    Cell Significance Index: -59.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.9717
    Cell Significance Index: -60.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9053
    Cell Significance Index: -61.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4028
    Cell Significance Index: -60.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1646
    Cell Significance Index: -31.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.8328
    Cell Significance Index: 138.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.0634
    Cell Significance Index: 116.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8679
    Cell Significance Index: 159.7200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9036
    Cell Significance Index: 30.1800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 4.8189
    Cell Significance Index: 22.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.8148
    Cell Significance Index: 138.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.6869
    Cell Significance Index: 78.9500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.5953
    Cell Significance Index: 10.3600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.8334
    Cell Significance Index: 39.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3744
    Cell Significance Index: 176.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8074
    Cell Significance Index: 178.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5690
    Cell Significance Index: 73.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4748
    Cell Significance Index: 189.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4666
    Cell Significance Index: 21.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2162
    Cell Significance Index: 157.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0516
    Cell Significance Index: 122.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0133
    Cell Significance Index: 60.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9490
    Cell Significance Index: 43.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8841
    Cell Significance Index: 5.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8785
    Cell Significance Index: 150.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8050
    Cell Significance Index: 726.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7739
    Cell Significance Index: 422.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.7396
    Cell Significance Index: 559.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7017
    Cell Significance Index: 6.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6934
    Cell Significance Index: 10.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6683
    Cell Significance Index: 91.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6284
    Cell Significance Index: 180.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5831
    Cell Significance Index: 40.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5355
    Cell Significance Index: 101.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4813
    Cell Significance Index: 38.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4808
    Cell Significance Index: 15.4000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4801
    Cell Significance Index: 2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4464
    Cell Significance Index: 54.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4464
    Cell Significance Index: 51.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2631
    Cell Significance Index: 52.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2329
    Cell Significance Index: 6.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2238
    Cell Significance Index: 164.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1828
    Cell Significance Index: 80.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0543
    Cell Significance Index: 9.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0155
    Cell Significance Index: 1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0156
    Cell Significance Index: -24.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0232
    Cell Significance Index: -42.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0246
    Cell Significance Index: -46.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0328
    Cell Significance Index: -0.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0345
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0347
    Cell Significance Index: -19.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0506
    Cell Significance Index: -5.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0815
    Cell Significance Index: -51.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1321
    Cell Significance Index: -59.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1358
    Cell Significance Index: -48.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1512
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1562
    Cell Significance Index: -32.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1837
    Cell Significance Index: -7.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2106
    Cell Significance Index: -10.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2220
    Cell Significance Index: -5.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2303
    Cell Significance Index: -23.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2808
    Cell Significance Index: -56.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3009
    Cell Significance Index: -43.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3229
    Cell Significance Index: -7.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3275
    Cell Significance Index: -3.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3451
    Cell Significance Index: -8.4200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3458
    Cell Significance Index: -3.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3659
    Cell Significance Index: -9.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4105
    Cell Significance Index: -29.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4723
    Cell Significance Index: -29.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4918
    Cell Significance Index: -37.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4969
    Cell Significance Index: -6.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5164
    Cell Significance Index: -60.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5382
    Cell Significance Index: -15.0400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.5492
    Cell Significance Index: -7.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5524
    Cell Significance Index: -14.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5862
    Cell Significance Index: -61.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6606
    Cell Significance Index: -42.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7043
    Cell Significance Index: -36.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7100
    Cell Significance Index: -43.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7104
    Cell Significance Index: -24.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8674
    Cell Significance Index: -53.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8901
    Cell Significance Index: -59.8500
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.9471
    Cell Significance Index: -5.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0099
    Cell Significance Index: -29.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0901
    Cell Significance Index: -28.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1590
    Cell Significance Index: -54.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1857
    Cell Significance Index: -61.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1964
    Cell Significance Index: -25.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.2403
    Cell Significance Index: -19.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2651
    Cell Significance Index: -70.9900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -1.2777
    Cell Significance Index: -9.8300
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -1.3376
    Cell Significance Index: -6.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metal ion binding**: MT1E exhibits high affinity for zinc, copper, and cadmium ions, allowing it to bind and sequester these metals within cells. 2. **Detoxification of metal ions**: By binding to metal ions, MT1E facilitates their removal from the cytosol, thereby preventing oxidative stress and cellular damage. 3. **Intracellular zinc ion homeostasis**: MT1E plays a critical role in regulating zinc ion levels within cells, which is essential for various cellular processes, including protein synthesis, enzyme activity, and cell signaling. 4. **Negative regulation of growth**: MT1E has been shown to inhibit cell growth and proliferation in response to metal ion exposure, suggesting its role in preventing metal-induced carcinogenesis. 5. **Cell type-specific expression**: MT1E is expressed in various cell types, including hepatoblasts, epithelial cells of exocrine pancreas, thyroid follicular cells, and skeletal muscle satellite stem cells. **Pathways and Functions:** 1. **Cellular responses to stimuli**: MT1E is involved in the regulation of cellular responses to metal ion exposure, including oxidative stress, inflammation, and apoptosis. 2. **Detoxification of copper ion**: MT1E plays a key role in the removal of copper ions from the cytosol, preventing copper toxicity and oxidative damage. 3. **Intracellular zinc ion homeostasis**: MT1E regulates zinc ion levels within cells, ensuring proper zinc-dependent cellular processes. 4. **Metal ion binding**: MT1E binds to metal ions, facilitating their sequestration and removal from the cytosol. 5. **Negative regulation of growth**: MT1E inhibits cell growth and proliferation in response to metal ion exposure, preventing metal-induced carcinogenesis. **Clinical Significance:** 1. **Metal toxicity**: MT1E's role in regulating metal ion homeostasis and detoxification makes it a potential target for the treatment of metal-related diseases, such as zinc deficiency, copper toxicity, and cadmium-induced nephropathy. 2. **Cancer prevention**: MT1E's ability to inhibit cell growth and proliferation in response to metal ion exposure suggests its potential role in preventing metal-induced carcinogenesis. 3. **Neurodegenerative diseases**: MT1E's involvement in zinc ion homeostasis and metal ion binding may contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Regulation of gene expression**: MT1E's interaction with metal ions may influence gene expression, potentially affecting cellular processes, including cell growth, differentiation, and survival. In conclusion, Metallothionein 1E (MT1E) is a crucial protein involved in maintaining metal ion homeostasis and detoxification within cells. Its unique characteristics and functions have significant implications for our understanding of cellular responses to metal ions and the development of strategies for metal toxicity and disease. Further research is needed to fully elucidate the role of MT1E in human health and disease.

Genular Protein ID: 421004780

Symbol: MT1E_HUMAN

Name: Metallothionein-1E

UniProtKB Accession Codes:

P04732 A2RRF7 Q86YX4 Q8TD51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2581970

Title: Structure and expression of two human metallothionein-I isoform genes and a related pseudogene.

PubMed ID: 2581970

DOI: 10.1016/s0021-9258(17)39668-0

PubMed ID: 1779803

Title: Amino acid sequence determination.

PubMed ID: 1779803

DOI: 10.1016/0076-6879(91)05125-f

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8119276

Title: Induction by zinc of specific metallothionein isoforms in human monocytes.

PubMed ID: 8119276

DOI: 10.1111/j.1432-1033.1994.tb18603.x

Sequence Information:

  • Length: 61
  • Mass: 6014
  • Checksum: 8E0A7C54F623A1D2
  • Sequence:
    • MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC KGASEKCSCC 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.