Details for: MX1

Gene ID: 4599

Symbol: MX1

Ensembl ID: ENSG00000157601

Description: MX dynamin like GTPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.2323
    Cell Significance Index: -25.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.4957
    Cell Significance Index: -22.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.2236
    Cell Significance Index: -24.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.8677
    Cell Significance Index: -26.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.3367
    Cell Significance Index: -24.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.7266
    Cell Significance Index: -25.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4047
    Cell Significance Index: -22.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5018
    Cell Significance Index: -19.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4976
    Cell Significance Index: -25.6400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.7818
    Cell Significance Index: 41.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.3306
    Cell Significance Index: 41.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9720
    Cell Significance Index: 320.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9434
    Cell Significance Index: 101.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7147
    Cell Significance Index: 326.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6372
    Cell Significance Index: 30.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4703
    Cell Significance Index: 1327.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3828
    Cell Significance Index: 71.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2790
    Cell Significance Index: 17.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1169
    Cell Significance Index: 121.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9267
    Cell Significance Index: 109.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7835
    Cell Significance Index: 22.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7521
    Cell Significance Index: 96.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6143
    Cell Significance Index: 42.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6114
    Cell Significance Index: 39.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5126
    Cell Significance Index: 4.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5032
    Cell Significance Index: 49.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4724
    Cell Significance Index: 58.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3639
    Cell Significance Index: 10.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3466
    Cell Significance Index: 69.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3122
    Cell Significance Index: 14.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2956
    Cell Significance Index: 53.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2275
    Cell Significance Index: 6.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2268
    Cell Significance Index: 5.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2056
    Cell Significance Index: 28.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1971
    Cell Significance Index: 3.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1927
    Cell Significance Index: 6.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1612
    Cell Significance Index: 4.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1420
    Cell Significance Index: 3.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0884
    Cell Significance Index: 1.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0884
    Cell Significance Index: 39.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0827
    Cell Significance Index: 16.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0601
    Cell Significance Index: 32.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0371
    Cell Significance Index: 4.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0050
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0097
    Cell Significance Index: -1.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0125
    Cell Significance Index: -1.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0129
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0133
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0160
    Cell Significance Index: -9.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0202
    Cell Significance Index: -14.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0212
    Cell Significance Index: -28.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0518
    Cell Significance Index: -23.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0559
    Cell Significance Index: -2.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0628
    Cell Significance Index: -18.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0657
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0737
    Cell Significance Index: -15.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0839
    Cell Significance Index: -2.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0894
    Cell Significance Index: -10.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0945
    Cell Significance Index: -13.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0987
    Cell Significance Index: -1.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1051
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1236
    Cell Significance Index: -3.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1285
    Cell Significance Index: -5.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1294
    Cell Significance Index: -1.4700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1368
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1583
    Cell Significance Index: -18.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1935
    Cell Significance Index: -14.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1938
    Cell Significance Index: -1.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2047
    Cell Significance Index: -14.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2054
    Cell Significance Index: -4.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2195
    Cell Significance Index: -13.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2231
    Cell Significance Index: -5.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2418
    Cell Significance Index: -6.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2449
    Cell Significance Index: -3.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2465
    Cell Significance Index: -25.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3021
    Cell Significance Index: -23.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3108
    Cell Significance Index: -8.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3223
    Cell Significance Index: -21.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3240
    Cell Significance Index: -24.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3527
    Cell Significance Index: -9.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3580
    Cell Significance Index: -14.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4025
    Cell Significance Index: -25.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4060
    Cell Significance Index: -17.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4076
    Cell Significance Index: -25.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4160
    Cell Significance Index: -21.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4336
    Cell Significance Index: -16.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4381
    Cell Significance Index: -11.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4795
    Cell Significance Index: -26.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4964
    Cell Significance Index: -17.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5928
    Cell Significance Index: -21.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6317
    Cell Significance Index: -20.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6369
    Cell Significance Index: -18.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6848
    Cell Significance Index: -22.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Inducibility by interferons**: The MX1 gene is induced by IFN-α/β, which are key cytokines involved in the antiviral innate immune response. 2. **GTPase activity**: The MX1 protein possesses GTPase activity, which is essential for regulating the uncoating of viral capsids and the replication of viral genomes. 3. **Apoptosis induction**: The MX1 protein induces apoptosis in infected cells, thereby limiting the spread of viral infections. 4. **Cytokine signaling**: The MX1 protein regulates cytokine signaling pathways, including the IFN-α/β signaling pathway. **Pathways and Functions** 1. **Antiviral innate immune response**: The MX1 gene is induced by IFN-α/β, which activates the MX1 protein, leading to the regulation of viral genome replication and apoptosis. 2. **Apoptotic process**: The MX1 protein induces apoptosis in infected cells, thereby limiting the spread of viral infections. 3. **Cytokine signaling**: The MX1 protein regulates cytokine signaling pathways, including the IFN-α/β signaling pathway. 4. **Viral genome replication**: The MX1 protein regulates the uncoating of viral capsids and the replication of viral genomes. **Clinical Significance** 1. **Viral infections**: The MX1 gene and its protein play a critical role in regulating viral genome replication and apoptosis, thereby limiting the spread of viral infections. 2. **Cancer therapy**: The MX1 protein has been shown to induce apoptosis in cancer cells, making it a potential target for cancer therapy. 3. **Autoimmune diseases**: The MX1 protein has been implicated in the regulation of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Immunotherapy**: The MX1 gene and its protein have been explored as a potential target for immunotherapy, including checkpoint inhibitors and cancer vaccines. In conclusion, the MX1 gene is a critical regulator of antiviral immunity and innate response. Its expression is induced by interferons, and it plays a pivotal role in regulating viral genome replication, apoptosis, and cytokine signaling. The clinical significance of the MX1 gene and its protein is vast, with potential applications in cancer therapy, autoimmune diseases, and immunotherapy. Further research is necessary to fully elucidate the mechanisms of action of the MX1 gene and its protein, and to explore their potential as therapeutic targets.

Genular Protein ID: 3208158819

Symbol: MX1_HUMAN

Name: Interferon-induced GTP-binding protein Mx1

UniProtKB Accession Codes:

P20591 B2RDA5 B3KU10 C9IYV7 C9J8D6 C9JN19 C9JN88 C9JUL1 C9JZS6 D3DSI8 Q86YP5 Q96CI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 17 EMDB 1 Ensembl 31 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 12 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2481229

Title: cDNA structures and regulation of two interferon-induced human Mx proteins.

PubMed ID: 2481229

DOI: 10.1128/mcb.9.11.5062-5072.1989

PubMed ID: 2154602

Title: Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter.

PubMed ID: 2154602

DOI: 10.1128/jvi.64.3.1171-1181.1990

PubMed ID: 10942113

Title: Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region.

PubMed ID: 10942113

DOI: 10.1007/s004390000318

PubMed ID: 20603636

Title: Herpes simplex virus-1 induces expression of a novel MxA isoform that enhances viral replication.

PubMed ID: 20603636

DOI: 10.1038/icb.2010.83

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2607176

Title: Purification and characterization of a human Mx protein.

PubMed ID: 2607176

DOI: 10.1089/jir.1989.9.679

PubMed ID: 2161946

Title: Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein.

PubMed ID: 2161946

DOI: 10.1128/jvi.64.7.3370-3375.1990

PubMed ID: 8411374

Title: A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.

PubMed ID: 8411374

DOI: 10.1128/jvi.67.11.6726-6732.1993

PubMed ID: 9060610

Title: Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity.

PubMed ID: 9060610

DOI: 10.1128/jvi.71.4.2591-2599.1997

PubMed ID: 9933640

Title: GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae).

PubMed ID: 9933640

DOI: 10.1074/jbc.274.7.4370

PubMed ID: 11880649

Title: Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.

PubMed ID: 11880649

DOI: 10.1073/pnas.052430399

PubMed ID: 15047845

Title: Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus.

PubMed ID: 15047845

DOI: 10.1128/jvi.78.8.4323-4329.2004

PubMed ID: 14752052

Title: Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.

PubMed ID: 14752052

DOI: 10.1093/nar/gkh192

PubMed ID: 15355513

Title: Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes.

PubMed ID: 15355513

DOI: 10.1111/j.1600-0854.2004.00219.x

PubMed ID: 14687945

Title: Inhibition of Dugbe nairovirus replication by human MxA protein.

PubMed ID: 14687945

DOI: 10.1016/j.virusres.2003.10.002

PubMed ID: 15757897

Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

PubMed ID: 15757897

DOI: 10.1074/jbc.m500391200

PubMed ID: 16413306

Title: Assay and functional analysis of dynamin-like Mx proteins.

PubMed ID: 16413306

DOI: 10.1016/s0076-6879(05)04055-3

PubMed ID: 16009940

Title: Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

PubMed ID: 16009940

DOI: 10.1073/pnas.0504754102

PubMed ID: 16978069

Title: Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum.

PubMed ID: 16978069

DOI: 10.1089/jir.2006.26.650

PubMed ID: 16202617

Title: Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus.

PubMed ID: 16202617

DOI: 10.1016/j.nbd.2005.08.015

PubMed ID: 17374778

Title: Human MxA protein confers resistance to double-stranded RNA viruses of two virus families.

PubMed ID: 17374778

DOI: 10.1099/vir.0.82526-0

PubMed ID: 18062906

Title: The Mx GTPase family of interferon-induced antiviral proteins.

PubMed ID: 18062906

DOI: 10.1016/j.micinf.2007.09.010

PubMed ID: 18668195

Title: GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus.

PubMed ID: 18668195

DOI: 10.1007/s00705-008-0168-9

PubMed ID: 19109387

Title: Inhibition of a large double-stranded DNA virus by MxA protein.

PubMed ID: 19109387

DOI: 10.1128/jvi.00781-08

PubMed ID: 20538602

Title: Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.

PubMed ID: 20538602

DOI: 10.1074/jbc.r110.145839

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21859714

Title: Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.

PubMed ID: 21859714

DOI: 10.1074/jbc.m111.251843

PubMed ID: 21900240

Title: Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop.

PubMed ID: 21900240

DOI: 10.1074/jbc.m111.249037

PubMed ID: 21166595

Title: Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

PubMed ID: 21166595

DOI: 10.1089/jir.2010.0076

PubMed ID: 21992152

Title: Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress.

PubMed ID: 21992152

DOI: 10.1089/jir.2010.0132

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 20428112

Title: Structural basis of oligomerization in the stalk region of dynamin-like MxA.

PubMed ID: 20428112

DOI: 10.1038/nature08972

PubMed ID: 21962493

Title: Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.

PubMed ID: 21962493

DOI: 10.1016/j.immuni.2011.07.012

Sequence Information:

  • Length: 662
  • Mass: 75520
  • Checksum: 626A7DD946F89384
  • Sequence:
    • MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR PCIDLIDSLR 
ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG IVTRCPLVLK LKKLVNEDKW 
RGKVSYQDYE IEISDASEVE KEINKAQNAI AGEGMGISHE LITLEISSRD VPDLTLIDLP 
GITRVAVGNQ PADIGYKIKT LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD 
RTIGILTKPD LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK 
IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH QRITEELQKY 
GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED IRLFTRLRHE FHKWSTIIEN 
NFQEGHKILS RKIQKFENQY RGRELPGFVN YRTFETIVKQ QIKALEEPAV DMLHTVTDMV 
RLAFTDVSIK NFEEFFNLHR TAKSKIEDIR AEQEREGEKL IRLHFQMEQI VYCQDQVYRG 
ALQKVREKEL EEEKKKKSWD FGAFQSSSAT DSSMEEIFQH LMAYHQEASK RISSHIPLII 
QFFMLQTYGQ QLQKAMLQLL QDKDTYSWLL KERSDTSDKR KFLKERLARL TQARRRLAQF 
PG

Genular Protein ID: 3226713645

Symbol: H9KVC7_HUMAN

Name: N/A

UniProtKB Accession Codes:

H9KVC7

Database IDs:

Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 2 RuleBase 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 609
  • Mass: 69279
  • Checksum: 63702C4195151865
  • Sequence:
    • MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR PCIDLIDSLR 
ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG IVTRCPLVLK LKKLVNEDKW 
RGKVSYQDYE IEISDASEVE KEINKAQNAI AGEGMGISHE LITLEISSRD VPDLTLIDLP 
GITRVAVGNQ PADIGYKIKT LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD 
RTIGILTKPD LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK 
IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH QRITEELQKY 
GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED IRLFTRLRHE FHKWSTIIEN 
NFQEDMVRLA FTDVSIKNFE EFFNLHRTAK SKIEDIRAEQ EREGEKLIRL HFQMEQIVYC 
QDQVYRGALQ KVREKELEEE KKKKSWDFGA FQSSSATDSS MEEIFQHLMA YHQEASKRIS 
SHIPLIIQFF MLQTYGQQLQ KAMLQLLQDK DTYSWLLKER SDTSDKRKFL KERLARLTQA 
RRRLAQFPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.