Details for: MYT1

Gene ID: 4661

Symbol: MYT1

Ensembl ID: ENSG00000196132

Description: myelin transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.8762
    Cell Significance Index: -11.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.4251
    Cell Significance Index: -12.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8463
    Cell Significance Index: -12.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4817
    Cell Significance Index: 93.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4047
    Cell Significance Index: 44.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2464
    Cell Significance Index: 15.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8572
    Cell Significance Index: 14.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8195
    Cell Significance Index: 155.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7466
    Cell Significance Index: 8.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6413
    Cell Significance Index: 15.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5705
    Cell Significance Index: 204.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4942
    Cell Significance Index: 21.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4608
    Cell Significance Index: 17.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4353
    Cell Significance Index: 393.0500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3994
    Cell Significance Index: 5.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3114
    Cell Significance Index: 2.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2470
    Cell Significance Index: 40.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2259
    Cell Significance Index: 22.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2219
    Cell Significance Index: 11.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2107
    Cell Significance Index: 22.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1638
    Cell Significance Index: 113.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1155
    Cell Significance Index: 1.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1052
    Cell Significance Index: 21.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0839
    Cell Significance Index: 5.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0747
    Cell Significance Index: 5.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0605
    Cell Significance Index: 0.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0521
    Cell Significance Index: 1.1100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0267
    Cell Significance Index: 0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0245
    Cell Significance Index: 46.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0191
    Cell Significance Index: 0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0178
    Cell Significance Index: 3.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0082
    Cell Significance Index: -0.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0102
    Cell Significance Index: -0.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0114
    Cell Significance Index: -7.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0118
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0176
    Cell Significance Index: -2.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0196
    Cell Significance Index: -10.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0240
    Cell Significance Index: -10.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0259
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0338
    Cell Significance Index: -9.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0376
    Cell Significance Index: -1.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0501
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0553
    Cell Significance Index: -0.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0591
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0631
    Cell Significance Index: -10.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0702
    Cell Significance Index: -10.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0728
    Cell Significance Index: -1.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0751
    Cell Significance Index: -10.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0753
    Cell Significance Index: -8.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0756
    Cell Significance Index: -9.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0874
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0988
    Cell Significance Index: -11.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0992
    Cell Significance Index: -11.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1026
    Cell Significance Index: -1.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1034
    Cell Significance Index: -13.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1105
    Cell Significance Index: -8.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1181
    Cell Significance Index: -12.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1236
    Cell Significance Index: -12.8700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1351
    Cell Significance Index: -1.7700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1393
    Cell Significance Index: -1.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1475
    Cell Significance Index: -3.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1490
    Cell Significance Index: -3.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1569
    Cell Significance Index: -3.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1607
    Cell Significance Index: -5.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1755
    Cell Significance Index: -3.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1802
    Cell Significance Index: -13.4300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1893
    Cell Significance Index: -2.4700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1902
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1915
    Cell Significance Index: -2.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1964
    Cell Significance Index: -4.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2000
    Cell Significance Index: -5.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2041
    Cell Significance Index: -6.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2139
    Cell Significance Index: -13.8000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2226
    Cell Significance Index: -2.5200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2349
    Cell Significance Index: -2.7400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2451
    Cell Significance Index: -3.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2457
    Cell Significance Index: -9.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2469
    Cell Significance Index: -6.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2478
    Cell Significance Index: -8.6800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2563
    Cell Significance Index: -2.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2657
    Cell Significance Index: -13.8000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2732
    Cell Significance Index: -4.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2768
    Cell Significance Index: -13.0100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2830
    Cell Significance Index: -2.8000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2947
    Cell Significance Index: -3.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3000
    Cell Significance Index: -6.2800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3083
    Cell Significance Index: -3.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3350
    Cell Significance Index: -3.6500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3353
    Cell Significance Index: -6.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYT1 is a transcription factor that belongs to the MYT family of proteins, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. The gene is primarily expressed in cells of the nervous system, kidney, and gastrointestinal tract, where it plays a crucial role in the development and maintenance of these tissues. Notably, MYT1 is also expressed in immune cells, including granulocyte-monocyte progenitor cells, suggesting a potential role in immune system function. **Pathways and Functions:** The MYT1 gene is involved in several key pathways, including: 1. **Cell differentiation**: MYT1 regulates the expression of genes involved in the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes, which are responsible for myelinating neurons in the central nervous system. 2. **Chromatin remodeling**: MYT1 interacts with chromatin-modifying enzymes to regulate the structure and function of chromatin, allowing for the coordinated expression of genes involved in nervous system development and maintenance. 3. **RNA polymerase II-specific transcription**: MYT1 acts as a co-activator of RNA polymerase II, a key enzyme involved in the transcription of DNA into RNA, to regulate the expression of genes involved in nervous system development and function. 4. **DNA binding and transcriptional regulation**: MYT1 binds to specific DNA sequences and recruits other transcription factors to regulate the expression of target genes involved in nervous system development and maintenance. **Clinical Significance:** The MYT1 gene has several potential implications for human health and disease: 1. **Neurological disorders**: Mutations in the MYT1 gene have been associated with neurological disorders, such as cerebral palsy and schizophrenia, suggesting a potential role in the development of these conditions. 2. **Immune system dysfunction**: The expression of MYT1 in immune cells suggests a potential role in immune system function and dysfunction, which may contribute to the development of autoimmune diseases. 3. **Cancer**: The expression of MYT1 in various types of cancer cells suggests a potential role in cancer development and progression. 4. **Neurodevelopmental disorders**: The role of MYT1 in nervous system development and maintenance suggests a potential role in the development of neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, the MYT1 gene is a complex transcription factor that plays a multifaceted role in nervous system development, immune system function, and cellular biology. Further research is needed to fully elucidate the functions and implications of MYT1 in human health and disease.

Genular Protein ID: 3422065913

Symbol: MYT1_HUMAN

Name: Myelin transcription factor 1

UniProtKB Accession Codes:

Q01538 E1P5H0 F5H7M8 O94922 Q7Z5W2 Q9UPV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 28 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1280325

Title: Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene.

PubMed ID: 1280325

DOI: 10.1128/mcb.12.12.5632-5639.1992

PubMed ID: 8530187

Title: Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes.

PubMed ID: 8530187

DOI: 10.1002/glia.440140407

PubMed ID: 12606722

Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

PubMed ID: 12606722

DOI: 10.1073/pnas.0530298100

PubMed ID: 14962745

Title: Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells.

PubMed ID: 14962745

DOI: 10.1016/j.mcn.2003.10.001

Sequence Information:

  • Length: 1121
  • Mass: 122329
  • Checksum: D4AF1F8C7D4EC01E
  • Sequence:
    • MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS LQSCPLAKKR 
KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK DASVSDESEG TLEGAEAETS 
GQDEIHRPET AEGRSPVKSH FGSNPIGSAT ASSKGSYSSY QGIIATSLLN LGQIAEETLV 
EEDLGQAAKP GPGIVHLLQE AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL 
EDAASEESSK QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE 
EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD DKDEDTHSRK 
STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC PPAEQSQLGL GEPGKAAKPL 
DTVRKSYYSK DPSRAEKREI KCPTPGCDGT GHVTGLYPHH RSLSGCPHKD RIPPEILAMH 
ENVLKCPTPG CTGQGHVNSN RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD 
RILRPMCFVK QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML 
APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK PQDLPSKSVD 
IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA SQRHSSTSAP SSSMTSPQSS 
QASRQDEWDR PLDYTKPSRL REEEPEESEP AAHSFASSEA DDQEVSEENF EERKYPGEVT 
LTNFKLKFLS KDIKKELLTC PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA 
DLKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG 
LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG CDGSGHANGS 
FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN DEEIKQLNQE IRDLNESNSE 
MEAAMVQLQS QISSMEKNLK NIEEENKLIE EQNEALFLEL SGLSQALIQS LANIRLPHME 
PICEQNFDAY VSTLTDMYSN QDPENKDLLE SIKQAVRGIQ V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.