Details for: NAP1L2

Gene ID: 4674

Symbol: NAP1L2

Ensembl ID: ENSG00000186462

Description: nucleosome assembly protein 1 like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.9499
    Cell Significance Index: -16.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.8298
    Cell Significance Index: -16.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3744
    Cell Significance Index: -16.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 7.8297
    Cell Significance Index: 117.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.8535
    Cell Significance Index: 135.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.3655
    Cell Significance Index: 69.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.3085
    Cell Significance Index: 57.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6562
    Cell Significance Index: 101.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5680
    Cell Significance Index: 33.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1308
    Cell Significance Index: 32.2700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0379
    Cell Significance Index: 8.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9632
    Cell Significance Index: 50.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8571
    Cell Significance Index: 171.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4261
    Cell Significance Index: 152.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3928
    Cell Significance Index: 26.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3348
    Cell Significance Index: 209.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3072
    Cell Significance Index: 19.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2492
    Cell Significance Index: 24.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2424
    Cell Significance Index: 218.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1692
    Cell Significance Index: 2.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1388
    Cell Significance Index: 22.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1357
    Cell Significance Index: 14.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1286
    Cell Significance Index: 24.4800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1280
    Cell Significance Index: 1.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1265
    Cell Significance Index: 2.7700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0886
    Cell Significance Index: 1.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0423
    Cell Significance Index: 2.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0235
    Cell Significance Index: 10.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0153
    Cell Significance Index: 0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0028
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0044
    Cell Significance Index: -0.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0045
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0060
    Cell Significance Index: -11.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0092
    Cell Significance Index: -0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0114
    Cell Significance Index: -7.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0119
    Cell Significance Index: -1.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0129
    Cell Significance Index: -23.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0168
    Cell Significance Index: -22.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0191
    Cell Significance Index: -14.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0267
    Cell Significance Index: -12.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0268
    Cell Significance Index: -0.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0313
    Cell Significance Index: -17.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0363
    Cell Significance Index: -7.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0364
    Cell Significance Index: -1.6500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0399
    Cell Significance Index: -0.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0401
    Cell Significance Index: -11.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0483
    Cell Significance Index: -8.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0570
    Cell Significance Index: -5.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0759
    Cell Significance Index: -15.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0827
    Cell Significance Index: -12.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0984
    Cell Significance Index: -2.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1011
    Cell Significance Index: -13.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1012
    Cell Significance Index: -12.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1044
    Cell Significance Index: -11.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1089
    Cell Significance Index: -12.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1105
    Cell Significance Index: -14.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1162
    Cell Significance Index: -5.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1250
    Cell Significance Index: -14.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1261
    Cell Significance Index: -8.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1294
    Cell Significance Index: -10.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1296
    Cell Significance Index: -2.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1330
    Cell Significance Index: -2.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1410
    Cell Significance Index: -5.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1493
    Cell Significance Index: -3.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1593
    Cell Significance Index: -16.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1616
    Cell Significance Index: -7.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1701
    Cell Significance Index: -7.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1798
    Cell Significance Index: -5.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1807
    Cell Significance Index: -2.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1905
    Cell Significance Index: -14.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2132
    Cell Significance Index: -3.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2161
    Cell Significance Index: -16.5800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2163
    Cell Significance Index: -1.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2252
    Cell Significance Index: -11.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2304
    Cell Significance Index: -12.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2376
    Cell Significance Index: -4.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2550
    Cell Significance Index: -14.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2590
    Cell Significance Index: -8.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2674
    Cell Significance Index: -5.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2758
    Cell Significance Index: -12.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2858
    Cell Significance Index: -6.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2963
    Cell Significance Index: -9.7000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3070
    Cell Significance Index: -2.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3275
    Cell Significance Index: -11.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3326
    Cell Significance Index: -11.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3388
    Cell Significance Index: -8.7100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3659
    Cell Significance Index: -6.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3743
    Cell Significance Index: -10.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3965
    Cell Significance Index: -11.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3965
    Cell Significance Index: -5.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4029
    Cell Significance Index: -10.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4052
    Cell Significance Index: -4.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4086
    Cell Significance Index: -8.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4144
    Cell Significance Index: -11.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4210
    Cell Significance Index: -11.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nucleosome Assembly Protein 1-Like 2**: The NAP1L2 protein is a member of the nucleosome assembly protein 1-like family, which plays a crucial role in the assembly of nucleosomes. 2. **Histone Binding**: NAP1L2 binds to histones, regulating their interaction with DNA and modulating chromatin structure. 3. **Chromatin Regulation**: NAP1L2 is involved in the regulation of chromatin structure and function, influencing gene expression and cellular differentiation. 4. **Neuronal Differentiation**: NAP1L2 is essential for the positive regulation of neuron differentiation, highlighting its role in the development of the nervous system. 5. **Cell Type-Specific Expression**: NAP1L2 is expressed in various cell types, including GABAergic amacrine cells, respiratory basal cells, and intestinal crypt stem cells, underscoring its broad functional significance. **Pathways and Functions:** 1. **Chromatin Assembly**: NAP1L2 is involved in the assembly of nucleosomes, which is essential for the regulation of gene expression and chromatin structure. 2. **Histone Acetyltransferase Regulation**: NAP1L2 regulates the activity of histone acetyltransferases (HATs), enzymes that modify histones and modulate chromatin structure. 3. **Neuron Differentiation**: NAP1L2 is essential for the positive regulation of neuron differentiation, influencing the development and maintenance of neurons. 4. **Stem Cell Regulation**: NAP1L2 is involved in the regulation of stem cell division and differentiation, highlighting its role in the maintenance of tissue homeostasis. **Clinical Significance:** 1. **Neurodevelopmental Disorders**: Alterations in NAP1L2 expression have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: NAP1L2 has been implicated in the development and progression of various cancers, including colorectal cancer and glioblastoma. 3. **Neurodegenerative Diseases**: NAP1L2 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in the development of these conditions. 4. **Therapeutic Targeting**: NAP1L2 has emerged as a potential therapeutic target for the treatment of various diseases, including neurodevelopmental disorders and cancers. In conclusion, the NAP1L2 gene plays a critical role in the regulation of neuronal differentiation, chromatin structure, and histone modification. Its expression in various cell types and its involvement in various cellular processes highlight its significance in development and disease. Further research is needed to fully elucidate the functional significance of NAP1L2 and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3929565449

Symbol: NP1L2_HUMAN

Name: Nucleosome assembly protein 1-like 2

UniProtKB Accession Codes:

Q9ULW6 B2RE61 B4E161 Q8TAN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 460
  • Mass: 52542
  • Checksum: 36BE77964B5096C6
  • Sequence:
    • MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE AAAGLGEEGE 
NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF VESLPVKVKY RVLALKKLQT 
RAANLESKFL REFHDIERKF AEMYQPLLEK RRQIINAIYE PTEEECEYKS DSEDCDDEEM 
CHEEMYGNEE GMVHEYVDED DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI 
PDFWLTVLKN VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE 
LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ KHRIWGTIRT 
VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI IPRSVLFFSG DALESQQEGV 
VREVNDAIYD KIIYDNWMAA IEEVKACCKN LEALVEDIDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.