Details for: NELL2

Gene ID: 4753

Symbol: NELL2

Ensembl ID: ENSG00000184613

Description: neural EGFL like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.6076
    Cell Significance Index: -34.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5617
    Cell Significance Index: -36.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 8.1568
    Cell Significance Index: 232.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 7.6029
    Cell Significance Index: 511.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.7284
    Cell Significance Index: 321.4500
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 5.0365
    Cell Significance Index: 38.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9210
    Cell Significance Index: -10.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.5369
    Cell Significance Index: 77.7500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 4.1358
    Cell Significance Index: 55.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.1890
    Cell Significance Index: 120.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9833
    Cell Significance Index: 131.9600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.9827
    Cell Significance Index: 31.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.9772
    Cell Significance Index: 35.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.3300
    Cell Significance Index: 146.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1529
    Cell Significance Index: 47.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1233
    Cell Significance Index: 761.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8709
    Cell Significance Index: 44.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5684
    Cell Significance Index: 96.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3353
    Cell Significance Index: 254.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0514
    Cell Significance Index: 210.9000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.9281
    Cell Significance Index: 10.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7856
    Cell Significance Index: 543.3400
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.6790
    Cell Significance Index: 7.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4694
    Cell Significance Index: 28.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.4305
    Cell Significance Index: 13.7100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4062
    Cell Significance Index: 5.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4050
    Cell Significance Index: 221.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3412
    Cell Significance Index: 11.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3285
    Cell Significance Index: 296.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2608
    Cell Significance Index: 8.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1997
    Cell Significance Index: 21.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1607
    Cell Significance Index: 16.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1482
    Cell Significance Index: 4.2700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1146
    Cell Significance Index: 1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1081
    Cell Significance Index: 68.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1023
    Cell Significance Index: 192.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0656
    Cell Significance Index: 10.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0580
    Cell Significance Index: 1.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0441
    Cell Significance Index: 0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0097
    Cell Significance Index: 15.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0079
    Cell Significance Index: 0.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0066
    Cell Significance Index: 12.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0300
    Cell Significance Index: -13.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0459
    Cell Significance Index: -33.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0514
    Cell Significance Index: -38.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0521
    Cell Significance Index: -39.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0531
    Cell Significance Index: -1.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0539
    Cell Significance Index: -24.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0622
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0638
    Cell Significance Index: -39.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0656
    Cell Significance Index: -37.0000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0720
    Cell Significance Index: -0.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0770
    Cell Significance Index: -0.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0941
    Cell Significance Index: -5.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0956
    Cell Significance Index: -1.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1014
    Cell Significance Index: -29.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1024
    Cell Significance Index: -20.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1121
    Cell Significance Index: -2.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1250
    Cell Significance Index: -14.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1391
    Cell Significance Index: -25.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1650
    Cell Significance Index: -7.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1736
    Cell Significance Index: -12.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1909
    Cell Significance Index: -40.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2171
    Cell Significance Index: -37.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2325
    Cell Significance Index: -28.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2349
    Cell Significance Index: -5.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2575
    Cell Significance Index: -35.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2591
    Cell Significance Index: -7.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2786
    Cell Significance Index: -35.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2830
    Cell Significance Index: -33.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2978
    Cell Significance Index: -38.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3397
    Cell Significance Index: -34.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3415
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3463
    Cell Significance Index: -39.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3804
    Cell Significance Index: -3.1400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3840
    Cell Significance Index: -4.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4453
    Cell Significance Index: -5.6200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4504
    Cell Significance Index: -2.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4520
    Cell Significance Index: -23.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4560
    Cell Significance Index: -35.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4846
    Cell Significance Index: -36.1200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4909
    Cell Significance Index: -6.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4953
    Cell Significance Index: -35.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5015
    Cell Significance Index: -17.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5065
    Cell Significance Index: -10.7500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5074
    Cell Significance Index: -7.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5647
    Cell Significance Index: -36.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5653
    Cell Significance Index: -12.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5667
    Cell Significance Index: -29.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5744
    Cell Significance Index: -5.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6087
    Cell Significance Index: -28.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6427
    Cell Significance Index: -16.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6514
    Cell Significance Index: -33.8400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.7117
    Cell Significance Index: -6.4700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.7121
    Cell Significance Index: -7.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7183
    Cell Significance Index: -24.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7291
    Cell Significance Index: -9.2000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.7317
    Cell Significance Index: -5.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7691
    Cell Significance Index: -16.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NELL2 is a member of the epidermal growth factor-like (EGFL) family of proteins, characterized by its ability to bind to protein kinase C (PKC) and other signaling molecules. Its expression is widespread in the nervous system, with significant levels detected in granule cells, macroglial cells, neurons, and Purkinje cells. NELL2 has also been found to be expressed in other tissues, including epithelial cells of the alveoli and photoreceptor cells. **Pathways and Functions:** NELL2 is involved in various signaling pathways that regulate axon guidance, commissural neuron development, and neuron cellular homeostasis. Specifically, it is known to interact with the robo receptors, which are crucial for the regulation of commissural axon pathfinding. NELL2 also binds to PKC, which is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. Additionally, NELL2 has been shown to interact with heparin-binding proteins, which are involved in the regulation of axon guidance and neuronal development. **Clinical Significance:** NELL2 has been implicated in various neurological disorders, including autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Studies have shown that NELL2 is significantly reduced in individuals with ASD, suggesting that it may play a role in the development and function of the nervous system. Furthermore, NELL2 has been found to be expressed in the brains of individuals with schizophrenia, suggesting that it may be involved in the pathophysiology of the disorder. These findings highlight the importance of NELL2 in understanding the development and function of the nervous system, and its potential role in various neurological disorders. In conclusion, NELL2 is a critical protein that plays a key role in the development and function of the nervous system. Its involvement in axon guidance, commissural neuron development, and its interaction with various signaling molecules make it an important player in regulating cellular processes. Further research is needed to fully understand the role of NELL2 in neurological disorders, but its significance in understanding the nervous system is clear. **References:** * [Insert references to studies that have investigated the role of NELL2 in neurological disorders] Note: As an expert immunologist, I would like to emphasize the importance of further research on NELL2 to fully understand its role in the nervous system and its potential implications for neurological disorders.

Genular Protein ID: 2591442636

Symbol: NELL2_HUMAN

Name: Protein kinase C-binding protein NELL2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8975702

Title: Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.

PubMed ID: 8975702

DOI: 10.1006/geno.1996.0628

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 32198364

Title: NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.

PubMed ID: 32198364

DOI: 10.1038/s41467-020-15211-1

Sequence Information:

  • Length: 816
  • Mass: 91346
  • Checksum: 89370B987DC7A324
  • Sequence:
  • MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF 
    QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG 
    HRNEVRLHYR SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS 
    TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK 
    IMELQDILAK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT 
    IQCETLICPN PDCPLKSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE 
    CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SICRNLNDRA 
    VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC 
    TEHDECITNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV 
    CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 
    EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC 
    SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ 
    QCRCLQGEVD CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV 
    RFTGSSWIKH GTECTLCQCK NGHICCSVDP QCLQEL

Genular Protein ID: 4015880335

Symbol: B7Z625_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 866
  • Mass: 96849
  • Checksum: 5CC916276A4C8A43
  • Sequence:
  • MGFPPLLKGQ ASATRSSLAS CSWVVFFLSC LSRHAPEIEG GRRWTELIRT MESRVLLRTF 
    CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF QDTPRSIKAS 
    TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG HRNEVRLHYR 
    SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTTFW 
    LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 
    TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT IQCETLICPN 
    PDCPLKSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE CKDQTMELVE 
    SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SICRNLNDRA VCSCRDGSRA 
    LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECITNQ 
    HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV CACPQGFTGP 
    SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC EDIDECGTGR 
    HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC SVCSCQNGFV 
    MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD 
    CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH 
    GTECTLCQCK NGHICCSVDP RCLQEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.